Conserved Protein Domain Family
TCRP1

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pfam14944: TCRP1 
Tongue Cancer Chemotherapy Resistant Protein 1
This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.
Statistics
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PSSM-Id: 434335
Aligned: 8 rows
Threshold Bit Score: 190.52
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ACH43659       1 MNPVYSPVQPGAPYGNPKNMAY-TGYPTGYPTAAPAYNPNMYPTSSPGYAPATL-----------LMKQAWPQTSSSCAT 68 
3_pfamImport   1 MNPVYSHAPSGVPYANPKGISYpAGFPVGYAAAAPAYSPNIYPGANPAFQTGHQae-------esLFEAVLRGWNYHNND 73 
2_pfamImport   1 MNPVYSPAPTGVPYPNSKGIGYpAGFPVGYAAAAPAYSPNMYPGASTAFQTASQgytsspagplrVHETACVLWDSWSSP 80 
1_pfamImport   1 MNPVYSPGSSGVPYANAKGIGYpAGFPMGYAAAAPAYSPNMYPGANPTFQTELRmkks----cwgLQEHLLCGFSSVAHV 76 
5_pfamImport   1 MNPVYSPVQPGTPYGNPKNMAF-TGYPGGYPATAPTYTPNLYQTGSPGYPPAFSflf------wrLLKFAFKNRWDGSMC 73 
XP_005809068  29 MNPVYSPVQPGTPYGNPKNMAF-TAYPGGYPATAPTYTPNLYQTGSPGYPPG---------------------------- 79 
XP_004075789  29 MNPLYSPVQPGTPYGNPKNMAF-TGYPGAYPATAPTYTPNIYQTGSPGYPPG---------------------------- 79  Japanese medaka
CAG12699       1 MNPVYSPASTGVPFTNTKGMGYpAGFPVGYAAAAPAYTPGVYAGANQAFPSGepphgspwghfgr--------------- 65  spotted green p...
ACH43659      69 EGT--------FHLPVDTGTENRTYQASSAAF--RYTA-GTPYKVPPTQSNNAPPPYSPSPNPYQTAMYPIRSAYPQQNL 137
3_pfamImport  74 RSCwq----avLSFKMDQLTKRRTEPSSSDSF--CYTP-GTPYKMSCSPTSGTVPPYSSSPNPYQTTVYPVRSPYPQQNP 146
2_pfamImport  81 AKNlaltlsgqYDLTCTWSKKSQNTDFRSQMLefWYTP-GTPYKV--SPTTGAVPPYSSSPNPYQAAVYPVRSAYPQQNP 157
1_pfamImport  77 RPEi------sLVHRCFLGTKSSEWKS--------YTP-GTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQNP 141
5_pfamImport  74 GQQgv-----iHLFVPLSLCERRAFISSSAAT--RYTSaGTPYKVPPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNL 146
XP_005809068  80 -----------------------------------YTPaGTPYKVPPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNI 124
XP_004075789  80 -----------------------------------YTSaGTPYKVSPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNI 124 Japanese medaka
CAG12699      66 ----------------------wlapltdavpppgYAP-ATPFKVSCSPNTGTVPAFSSSPSPYPAAVYPLRGTYPQQSP 122 spotted green p...
ACH43659     138 YT--------QGAYYTQPVYAaqPHVIHHTTVVQPNSIPS-AIYPAPVA--APRTNGV-AMGMVAGTTMAMSA--GTLLT 203
3_pfamImport 147 YAq-------QGTYYTQPLYG--PHVIHHTTVVQPNGMPA-AMYPPAIP--PPRANSV-TMGMLAGTTMALSAvlGTLLT 213
2_pfamImport 158 YAq-------QGTYYTQPLYAtpPHVIHHTTVVQPNGMPA-AMYAPPIP--PPRANGV-TMGMVAGTTMAMSA--GTLLT 224
1_pfamImport 142 YAq-------QGTYYTQPLYAapPHVIHHTTVVQPNGMPA-TMYPAPIP--PPRGNGV-TMGMVAGTTMAMSA--GTLLT 208
5_pfamImport 147 YA--------QGAYYTQPVYAaqPHVIHHTTVVQPNSIPStALYPAPVPvnAPRNNGMaAMGMVAGTTMAMSA--GTLLT 216
XP_005809068 125 YA--------QGAYYTQPVYAaqPHVIHHTTVVQPNSIPStALYPAPVPvpAPRNNGMpTMGMVAGTTMAMSA--GTLLT 194
XP_004075789 125 YA--------QGAYYTQPVYAaqPHVIHHTTVVQPNSIPStALYPAPVPvpAPRNNGMaAMGMVAGTTMAMSA--GTLLT 194 Japanese medaka
CAG12699     123 YAqalmpsqqQGAYYTQPLYAapPHVIHHTTVVQPNGMPA-AMYAPHIP--PNRHSGV-AMGMVAGATMAMSA--GTLLA 196 spotted green p...
ACH43659     204 tPQHTAIGAHPVSVPTYRAQGTPTYSYVPPHW 235
3_pfamImport 214 -HSPTPVAPHAVTMPTYRPPGTPTYSYVPTQW 244
2_pfamImport 225 tHSPTPVAPHPVTMPTYRPPGTPTYSYVPPQW 256
1_pfamImport 209 tHSPTPVAPHPVTMPTYRAPGTPTYSYVPPQW 240
5_pfamImport 217 tPQHAQIGGHPVTVPTYRPQGTPGYSYVPPHW 248
XP_005809068 195 tPQHPPIGAHPVTVPTYRPQGTPGYSYVPPHW 226
XP_004075789 195 tPQHPQIGAHQVTVPTYRPQGTPGYSYVPPHW 226 Japanese medaka
CAG12699     197 sPSPAPVTPHPVSVPTYRPPGTPSYSYVPPQW 228 spotted green pufferfish
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