Conserved Protein Domain Family
zf-4CXXC_R1

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pfam10497: zf-4CXXC_R1 
Zinc-finger domain of monoamine-oxidase A repressor R1
R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.
Statistics
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PSSM-Id: 463117
Aligned: 47 rows
Threshold Bit Score: 127.763
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002955702  143 LLDLIGLTCHFCRQKMLCSEEDCPRcstrnsaaqclgkstcSSCKsa---------tGIFCRACLWVRYGQVLEEVREDP 213 
XP_002504705  196 PGCTECTSCHFCRQKTADVKTSC-------------------QCArwrktppggrgrGAWCGWCLEMRMGENIDEALADA 256 
XP_006341500   91 NRLRVGVCCHSCMEKKFCDEEDCKRcgdldmdqpclgmtdcSICHss---------nGFLCRECLKNRYGEELEEVRANK 161 
XP_007260759  350 LDKDHGSTCHQCRQKTLDTKTECRN----------------PYCQgv---------kGQFCGPCLRNRYGEDVRTALLDP 404 
EHA98244      419 YDKVLGNTCHQCRQKTIDTKTVCRN----------------QSCGgv---------rGQFCGPCLRNRYGEDVRSALLDP 473 
ELW64161      508 ALLDPGSTCHQCRQKTIDTKTNCRN----------------PDCWgv---------rGQFCGPCLRNRYGEEVKDALLDP 562 
CAF96519       83 YSSVAGSTCHQCRQKTVDTKTCCRS----------------EDCRgi---------qGQFCGPCLRNRYGEDVRKALTDP 137 
XP_001121657  192 YCKINGTCCHQCRQKTLDTKTVCRS----------------GECVgl---------rGQFCGPCLKGRYGENAVDALKDP 246 
XP_001944678  197 VYSQSGTTCHQCRQKTADQKSYCRY----------------KGCSgv---------rGNFCGFCLGRRYGENVASVLVNP 251 
XP_003245746  165 YSTDKGTTCHQCRQKTLDQKSYCRH----------------QSCKgm---------rGMFCGFCLGKRYGEDVAEALLNP 219 
XP_002955702  214 DWLCPHCYEkkhgnwrkhgwFCNSS--ICMR-KEGRLPTGIAFHKAQERGYASVAHML 268 
XP_002504705  257 EWRCPVCRD-----------ICNCSgaNCLRaKRGLFPTQQLTHEAIEHGWQSVAHYL 303 
XP_006341500  162 EWICPHCTEekgi---npywFCNRL--LCLK-KRNIALT-VNTFKARKMGYKSVAHML 212 
XP_007260759  405 EWECPICRG-----------VCNCS--LCRK-RDGRCATGALTNLAKYYGYHNVKEYL 448 
EHA98244      474 DWMCPPCRG-----------ICNCS--YCRK-RDGRCATGILIHLAKFYGYDNVKEYL 517 
ELW64161      563 NWRCPPCRG-----------ICNCS--FCRQ-RDGRCATGVLVYLAKYHGFGNVHAYL 606 
CAF96519      138 EWKCPPCRG-----------ICNCS--FCRQ-REGRCPTGILFPLAQYHGFSDVHSYL 181 
XP_001121657  247 NWTCPPCRG-----------LCNCS--ICRT-RNGLPPTGILAPLAQEEGYSSVMDYL 290 
XP_001944678  252 KWACPPCRG-----------YCNCS--ICRR-RKGMAPTGQLAQQAVAGGYESVRHML 295 
XP_003245746  220 VWACPPCRG-----------QCNCS--ICRR-HQGKDPTGQMAQEAKAKGYNSVCDML 263 
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