Conserved Protein Domain Family
SCAMP
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pfam04144: SCAMP 
SCAMP family
In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain proteins to the N-terminal NPF repeats but may have additional functions mediated by their other sequences.
Links
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Statistics
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PSSM-Id: 461193
Aligned: 122 rows
Threshold Bit Score: 81.8159
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KJE95585     119 KPNFPF----FYPIVYISIAHDMPEQtMRNQIRLALTLWF---FMMAAFIWGFLSV-MIPFFDGDAlnksagwdndtaAF 190
XP_001580313  36 KPNFPS----FWPLVYHNINTEIQQG-FSFLVRMTYFTAV---SITYCFFWTLLGS-IFNFQIKDNkss-------lgQD 99 
Q4CVB4        46 PPNFPPaflcIRPQVYHNIKEQVPVH-LQRFMYTLCALYI---CLIVMIIYNIACA-FVNFLMGgs-----------tMQ 109 Trypanosoma cruzi
Q38E22        30 EPNFPPqflcIKPLVYHNIKEQVPVP-SQRFMYTLAFMYF---ALIAIIIYNISIA-LLSFVFGgs-----------gMH 93  Trypanosoma brucei
XP_001568573  37 DPNFPPecccVKPIIYHNIREQVPVP-QQRFMYILAGLYI---TLMVLIVYNIVAA-LVAFILGgn-----------vTH 100
XP_001469285  37 EPNFPPecccVKPVIYHNIREQVPVT-QQRFMYILAGLYV---TLMALIIYNIVAA-LVAFALGgs-----------aLH 100
Q387I0       202 EANFPPkflcIKPLVNHTIG-MVPEP-RRKYVKFNYVIWM---VNCVLLVANASVA-ITVAFSPYEnefegpkasnkaQA 275 Trypanosoma brucei
XP_001565560  45 LPNFPRkflcIHPLVYHSIS-VVPEH-RQLFVKMAFWDWV---AVCILLVANCVVA-IGVTSAPIRsnvavnhdinkvLN 118
Q4QA24       163 TPNFPPkflcIHPLVHHSIS-TVPEH-RQLFVKMAFWDWV---AVCILLLANCGIA-IGVSSAPVRsnivvhddinkaQN 236 Leishmania major
EFC39977      87 KKNFPR----CYPLVYHNIA-DVPNEfLRR--KIAYWGFIsaiVFQVVVFLNCVSAyITAFSTTPNafpkdvslmnliQF 159

KJE95585     191 -FLALIWMLAGVPLSFY-FwFFRLYTLHRDlgadktpgVSYf--FWFFHGLVNFLWCCIYAIGPPqIPGMAGFVVAVNIF 266
XP_001580313 100 iIMSLSY-CVIFPAALFyIqYYPLYVNLRdgk----siGGCilaQLFVVFFAGVTF-----TGFR-GTGFIGIQYTLSAF 168
Q4CVB4       110 fALSFLY-LLGIPGAFV-VwYYNVYCATKDss-----qSRKl--MSYFGLLVGLIFDVWMAVGLS-GFGGCGWIITLGL- 178 Trypanosoma cruzi
Q38E22        94 fGLSFVY-LVGIPGAFV-VwYYNVYSSVVNea-----nSRRw--LGYVGLALGVIFDIWMAVGVS-GLGGCGWIMALG-- 161 Trypanosoma brucei
XP_001568573 101 fGLSFLF-LLGIPGAWI-VwYYNVYCAIVYss-----rPRQk--LALLGLFLGVAFDVWMAVGVT-GFGGCGWLYAFSL- 169
XP_001469285 101 fGLSFVY-LLGLPGAWI-SwYYNVYCAIVYas-----rSRQl--IALLGLLVGVVFDVWMTIGIT-GFGGCGWIYALSL- 169
Q387I0       276 tALSIAY-LLGVPLSFF-VwHWPIYKACITgl-----aTRHl--VSLCGLLVALAFAIFMLVGLP-DTGACGAILAMEVY 345 Trypanosoma brucei
XP_001565560 119 gVLAILY-LIGIPLSFL-LwYWRIYRGCSTgr-----pPQHi--LALCGLFIALAQAIFALVGSE-SYGVCGIILAKWIQ 188
Q4QA24       237 gVLAILH-LTGIPLSFL-IwYWRIYQGCSTgr-----pPQHi--LALSGLLVALAHAIFALVGPK-NYGLSGIALAKWIQ 306 Leishmania major
EFC39977     160 cIVSTILFLISGIAHFF-LgYWPLYKAMdtg-----aiPRFi--IFFIAYAVSIIFCALGVAGYL-TYGFSGIVTAIYYF 230

KJE95585     267 nasEDSNKLYATFIVISGVIWTVCAGFSL-LFLLWIVRWYRSS 308
XP_001580313 169 ----ANGSLINRIVGVVITVWEIFNFILEiIILIHMNEIEDSQ 207
Q4CVB4       179 ----THNAPVFIPFLISSILWSLHGAIFF-IMLLRFWRYQSHS 216 Trypanosoma cruzi
Q38E22       162 ----EKNFLVFILAIISASLWTAHCLMLL-LLGIKYFRMASSA 199 Trypanosoma brucei
XP_001568573 170 ----MRTVTSFVMILISAILWSLHGFALC-VVMLRYWRVSGTL 207
XP_001469285 170 ----TRNVAPFVLVLISAILWPLHGFALC-VMLLRYWRLSRVL 207
Q387I0       346 ---EGKSNYLLIPLGVVISLWCFETAYFF-YCMVVQWKFYRLD 384 Trypanosoma brucei
XP_001565560 189 ---ETRATGVVVPVAVIAVLWAVQAVFTC-YMITKMFIFYRRD 227
Q4QA24       307 ---ATRESGVAAPVAIMAVLWAAQAVFTG-FMIFKVFVFYRRD 345 Leishmania major
EFC39977     231 ptgTYGSIAGFVCNLIMAVIWFALMINYI-IIFIMVIKVFRAL 272
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