Conserved Protein Domain Family
bHLH_TS_PTF1A
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cd11417: bHLH_TS_PTF1A 
basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins
PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is a bHLH transcription factor implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.
Links
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Statistics
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PSSM-Id: 381423
Aligned: 18 rows
Threshold Bit Score: 96.8332
Created: 25-Oct-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   # ### #    #                 ####                  
Q7RTS3       164 LRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELV 219 human
NP_996177     82 QRQAANLRERRRMQSINEAFEGLRTHIPTLPYEKRLSKVDTLKLAISYITFLSEMV 137 fruit fly
XP_787068     66 QRQAANLRERKRMSSINDAFEGLREHIPTLPYEKRLSKVDTLRLAIGYINFLAEMI 121 purple urchin
GAA53846     194 QRQAANLRERRRMQSINKAFEGLRAHIPTLPYEKRLSKVDTLRLAIGYIHFLQELV 249 Clonorchis sinensis
XP_003376510 144 QRRAANLRERRRMQSINDAFDGLRHRIPTLPYEKRLSKVDTLKLAIGYIQFLQEVL 199 Trichinella spiralis
XP_002596972  78 QRQAANLRERRRMQSINDAFDGLRQRIPTLPYEKRLSKVDTLRLAIGYINFLSDLL 133 Florida lancelet
ADB22620     108 QRQAANQRERKRMQSINEAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYIGFLSELV 163 Saccoglossus kowalevskii
EFX68239       3 QRQAANLRERRRMQSINDAFEGLRTHIPTLPYEKRLSKVDTLRLAIGYIGFLAELV 58  common water flea
XP_001635912   3 QRHAANLRERKRMQSINEAFEGLRKHIPTLPYEKRLSKVDTLRLAIGYIGFLTEMI 58  starlet sea anemone
ESP01785      61 QRHAANMRERKRMQSINDAFEGLRTHIPTLPYEKRLSKVDTLRLAIGYIGFLAELV 116 owl limpet

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