Conserved Protein Domain Family
TFP_LU_ECD_SPACA4
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cd23574: TFP_LU_ECD_SPACA4 
extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4)
SPACA4 (also called SAMP14) is a sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. SPACA4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467104
Aligned: 10 rows
Threshold Bit Score: 112.081
Created: 29-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8TDM5        19 GVKDCVFCELTdsMQCPGTYMHCGdDEDCFTGHGVAPGtgpVINKGCLRATsCGLE-EPVSYRGVtYSLTTNCCtGRLCN 97  human
EMP41026      17 SPKECFFCEVTssRYCPSTRMSCApDEDCFVGHGAALGvslIQTKGCTRAIrCGKE-HPITHLGVtYSLVTQCCkGSLCN 95  Green sea turtle
XP_007507575  22 TTKKCYYCDVTvaYHCVGIPMICEdEEDCYVGRGTAKGfpgIIKKGCIQAVsCTWP-QSITFRDVtYNLTTYCCqEELCN 100 gray short-tail...
XP_023362942  22 VAKNCYYCDLTntPNCMGIPMYCGkEEDCYQGRGVASGisyIINKGCVEATnCGKE-QLVDYMGVtYNFITYCCsGELCN 100 Tasmanian devil
XP_023362965  21 EARRCYYCDVAnvENCPGVQITCAeKDDCYTGRGAVLGlpmVITKGCVESSqCGLE-RQFTYMNTnYTVLNYCCrSELCN 99  Tasmanian devil
XP_020819050  20 EARRCYYCDIAnfRTCVGVQITCAeENDCYIGRGAVRGlptIISKGCSKAShCGRV-RHVTYMGTaYNLITSCCqAELCN 98  koala
XP_012409037  22 AAKTCYYCDTIevGYCTGIPDDCEeEQECYTGLGLAPLfpgITQKGCVAPRvCGEE-RSVTYMGIhYMLTIYCCeGELCN 100 Tasmanian devil
XP_029440300  18 CKNECHYCEITs-TDCSSAQVSCKpDERCYTGTGSSWDmalLTAKGCIEKKnCGKE-EEITYMGSqYVMYYKCCeGSLCN 95  two-lined caeci...
OCT73178      22 QALTCAYCELTedSDCLERPVICQdEEMCYTAKGMLLGvtvLQSNSCIEITrCGRK-ENQTHFGSnYLLSYSCCpGKLCN 100 African clawed ...
EPQ10600      39 GIKVCEFCDMIksSTCTGISVPCAdNDHCFTSYGIIPGfgpIINKGCKSPSlCGHDvESVLYKDVtYKISSSCCkSELCN 118 Brandt's bat
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