1FW1,2JL4


Conserved Protein Domain Family
maiA
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TIGR01262: maiA 
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maleylacetoacetate isomerase
Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. [Energy metabolism, Amino acids and amines]
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Statistics
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PSSM-Id: 273527
Aligned: 15 rows
Threshold Bit Score: 289.611
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1FW1_A         7 ILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKdggQQFSKDFQALNPMKQVPTLKIDg-------ITIHQSLAIIEYL 79  human
Q18938         7 VLYSYWRSSCSWRVRIALALKNVDYEYKTVDLLS---EEAKSKLKEINPAAKVPTFVVDg-------QVITESLAIIEYL 76  Caenorhabditis ...
O43708         7 ILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKdrgQQFSKDFQALNPMKQVPTLKIDg-------ITIHQSLAIIEYL 79  human
AAF60754       6 ILYSSWSSGCSSRVRTALALKKIDYEYQPVNLLN---KQKEQEFHGNNPAEKVPILKINg-------LTLTESMAIIEYL 75  Caenorhabditis ...
CAA73584       2 LYYGYWRSSAAWRCRIAFNLKKIAPEFVAVHLTRdggAQRTEEFRVINPQKRVPALDLNg-------AVLTQSLAIIEWL 74  Sphingomonas sp.
AAD12621       2 KLYNFWRSGTSHRLRIALNLKGVPYEYLAVHLGKe--EHLKDAFKALNPQQLVPALDTGa-------QVLIQSPAIIEWL 72  Ralstonia sp. U2
Q9X4F7         6 VLYDYWRSSASYRVRIALNLCGEAYRSVPVDLLAk--AHRAPEHLARNPQGLVPVLDIDg-------ERLTQSLAIIEYL 76  Sinorhizobium m...
O43123        10 TLYTYFRSSCSARLRIALALRSISYTSVPINLLKg--EQSSTKNTAVNPSATVPTLIIEhvdrsqspITITQSLAALEYL 87  Aspergillus nid...
2JL4_A         3 KLYNFWRSGTSHRLRIALNLKGVPYEYLAVHLGKe--EHLKDAFKALNPQQLVPALDTGa-------QVLIQSPAIIEWL 73  Ralstonia sp. U2
WP_003113505   2 KLYTYYRSTSSYRVRIALALKGLDYQSLPVNLIRdggEHRQPAYLALNPQGRVPALQVDe------gELLIQSPAIIEYL 75  Pseudomonas aer...

1FW1_A        80 EETRPTPR--LLP--QDPKKRASVRMISDLIAGGIQPLQNLSVLKQVG------EEMQLTWAQNAITCGFNALEQILQ-- 147 human
Q18938        77 EETHPDVP--LLP--KDPIKRAHARAISLLVASGIQPLHNLKVLQLLNkk---eAGFGGQFAKQFVVEGLTALEILLK-- 147 Caenorhabditis ...
O43708        80 EEMRP-TPr-LLP--QDPKKRASVRMISDLIAGGIQPLQNLSVLKQVG------EEMQLTWAQNAITCGFNALEQILQ-- 147 human
AAF60754      76 DEIYPDPP--LLP--KEPELKARARAIAFHIASNIQPLQNKPIYLMLNek---ePGYGDFWCQHFISKGFKALEELLQ-- 146 Caenorhabditis ...
CAA73584      75 EETIPEPA--LLP--DDPWSRAQVRAFALAIACDIHPLQNLEVQQYLRgklnleQSAVSDWLGHWIGNGLLACEALLGsq 150 Sphingomonas sp.
AAD12621      73 EEQYPTPA--LLP--ADADGRQRVRALAAIVGCDIHPINNRRILEYLRktfgadEAAINAWCGTWISAGFDAYEALLAvd 148 Ralstonia sp. U2
Q9X4F7        77 AETRDGTG--LLP--AHPIDRQRVRALSYAVAMDIHPVCNLGVVARVMagagdgEAARREWMQKFIGEGLAAFERMLDh- 151 Sinorhizobium m...
O43123        88 DEAFPDNPnpLLPpiSNPQQRALVRSLASIIACDIQPVTNLRILQRVAp----fGVDRAAWSKDLIEAGFAAYEAIAR-- 161 Aspergillus nid...
2JL4_A        74 EEQYPTPA--LLP--ADADGRQRVRALAAIVGCDIHPINNRRILEYLRktfgadEAAINAWCGTWISAGFDAYEALLAvd 149 Ralstonia sp. U2
WP_003113505  76 EERYPQPA--LLS--SDPLRRARERGVAALVGCDIHPLHNASVLNLLRqwg-hdEEQVRQWIGHWVGQGLAAVEQLIG-- 148 Pseudomonas aer...

1FW1_A       148 STAGIYCVGDEVTMADLCLVPQVANAE-RFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTP 211 human
Q18938       148 QHSGKYAVGDDVTIADLSIPPLIYSAN-RFNLDLSPYPTVNRINETLADIPAFIAAHPDNQPDTG 211 Caenorhabditis elegans
O43708       148 STAGIYCVGDEVTMADLCLVPQVANAE-RFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTP 211 human
AAF60754     147 MHSGDFCVGNQISIADICLPSIVYNAIeKYHVDMTPYPIITRISNKLAELPEFQVAHPNNQPDAP 211 Caenorhabditis elegans
CAA73584     151 PSNQAFAFGASPTLADICLAPQLYSAE-RFGISLNDMPRLRTLGASYADHPAFVDAHAHNQPDSE 214 Sphingomonas sp.
AAD12621     149 PKRGRYSFGDTPTLADCYLVPQVESAR-RFQVDLTPYPLIRAVDAACGELDAFRRAAPAAQPDSA 212 Ralstonia sp. U2
Q9X4F7       152 PATGAFCHGDRPTMADLCLVPQVYNAR-RWDVDLAACPLLVAIDRRCAGIDAFQRAHPDRAKP-- 213 Sinorhizobium meliloti 1021
O43123       162 DSAGVFSVGDTITMADVCLIPAVWGAE-RAGVNLGQYPTIKRVAEALEKENAVKEGHWRTQQDTP 225 Aspergillus nidulans FGSC A4
2JL4_A       150 PKRGRYSFGDTPTLADCYLVPQVESAR-RFQVDLTPYPLIRAVDAACGELDAFRRAAPAAQPDSA 213 Ralstonia sp. U2
WP_003113505 149 DQG--WCFGDRPGLADVYLVPQLYAAE-RFGVALDAWPRIRRVADLAAAHPAFRQAHPANQPDTP 210 Pseudomonas aeruginosa
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