Conserved Protein Domain Family
GSG-1

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pfam07803: GSG-1 
GSG1-like protein
This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.
Statistics
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PSSM-Id: 462270
Aligned: 32 rows
Threshold Bit Score: 144.7
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008121446  23 RRGRALLAVGLNLLALLFSATAFGTTHWCEGTQRVPKPTCGP----LARTNCLDYgyreeeeaaaarlhgnGSA-NASap 97 
NP_001333986   4 ARWQRMLTLLPICLALAFSLTAMGSSHWCEGIRRMTKPLCQDl---LGGLNCIHF----------------SRSsSSTgs 64 
XP_019648784   4 ARRQPALTVLPVCLALAFSLTALGSSHWCEGTRKVAKPLCLDe---PGRLQCIHFsgs-----------hgSGGrRDN-- 67 
XP_014953911   5 TRQQRALALLPVCLALAFSLTAVGSSYWCEGTRRVAKPLCRDr---PGVLHCIHY---------------------SRgg 60 
XP_023369754   4 ARRQRALTLLPVCLALAFSLTALGSSHWCEGTRQVVKPLCQDq---LGGLHCIHF------------------SqGGGgr 62 
XP_006635169   5 RRQRASLALTLNFIALIFAISALSTSYWCEGTRKVVKPFCKGpv-tLKQSYCIRF----------------NSS-NIN-- 64 
XP_005815150   5 RGRRASLAITLNFVALAFAVSAVTTSYWCEGTRKVAKPFCSGppvqMKQMYCIRF----------------N-StNLN-- 65 
XP_021330414   5 RAQRASLALTLNYVAFVMAVSAVTTSYWCEGTRKVVKPFCMGpv-kGKQTYCIRF----------------NST-NVN-- 64 
XP_003199601   4 RRRRASLALLLNLLALLLAVSALSSSYWCDGERKVVKPFCTGpv-tGKQTHCIRY----------------NSS-NAN-- 63 
XP_003961606   5 RQRRASLALTLNFVALFLAVSALTTSYWCEGTRKVVKPFCTGpv-tTKQSFCIRF----------------NSS-NLN-- 64 
XP_008121446  98 hgpSDSVVHYSWETGDDRFLFRYFHAGIWYSCEENINDPGEKCRSFIDLAPASEK 152
NP_001333986  65 khdDSQAVQYIWETGDDKFIQRRFHAGLWQSCEESLNSTGERCRCFLGIVPAEGQ 119
XP_019648784  68 ---GSQAVQYIWETGDDKFLQCRFHVGLWQSCEESLGSAGEKCRSFQSVIPAEEQ 119
XP_014953911  61 sdnSSQAVQYIWEMGDDKFVQRRFHVGLWQSCEETLGSTGENCRSFQSVIPAEEQ 115
XP_023369754  63 rddESRAVQYIWEVGDDKFIQHRFHVGLWQSCEESFHSTDEKCRSFWTIIPAEEQ 117
XP_006635169  65 ---DSRIVQYIWETGDDKFLMRHFHTGIWFSCEENINGIGESCRSFLNIAPSHER 116
XP_005815150  66 ---DSRQVQYIFETGEEKFILRKFHTGIFYSCEQAVDMNGFDCRSFAEIAPEHQR 117
XP_021330414  65 ---DTKLVQYIYETGEEKFLMRKFHAGIWFSCEQTMDLIGFNCRSFFEIAPDHER 116
XP_003199601  64 ---DSRLVQYIWETGEDKFVLRKFHTGIWFSCEQNVDLVGEKCRSFITVAPPHER 115
XP_003961606  65 ---DTRLVQYIWETGEDKYVMRKFHTGIWFSCEQNVNMTGEKCRSFLYVAPSNER 116
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