7MOP


Conserved Protein Domain Family
RTP801_C
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pfam07809: RTP801_C 
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RTP801 C-terminal region
The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.
Links
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Statistics
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PSSM-Id: 462274
Aligned: 38 rows
Threshold Bit Score: 113.836
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7MOP_B       131 LAqAR-LGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQG-KSCH-SVGQLAL-DPSLVPTFQLTLVL 206
BAH72677      45 LRaAK-RAQLSCGEVLLPPDLLHRIAHDVLKMAESEPCGLRGCTLYLNFEGE-QECR-KIGTIKC-DTNTVSTFELFLTL 120
XP_967838     48 IRkAK-RTHLSCGEVLLPCGLLQKVAEDVLEIAETELYGLKGCTLYLLYEGE-EDCR-RLSNFKI-DPTTPSTFEIYLTF 123
EFA08259      75 LRaAK-RTHLSCGEVLLPSGLLHRIARDVLGMAESEPCGIRGCLIYVNFEGV-EQCR-KLASFKC-DPETATTFELKLTF 150
OWR50883      46 LRaAKgASDLATAEVLVPAELLARAARQALVLAEGEPCGARGAAVLVDVAGR------RLAAFKI-DPNTVTTHEIHLHL 118
XP_015795877   7 EEvLK-QTKVIQSESDLPANLTKKIAQDIIGMSETEPCGLQGCLLYISLEDE-NHKPqTIGYVKLgEKTIVPTFVIYLHL 84 
XP_001956516 133 LRaAK-SRHLTCTEVSLPCDLTPNVARDIVRVSEKEPCGIRGCTIYIEFEDEpQNSR-RIATIKV-DPDTVSTFEVYLTL 209
XP_002024017 172 LRdAK-QRHLACTEVNLPADLTERIAAEIIRMSDREPCGERACTLFIEFESEpNNVR-RIASFKV-DPDTVSIFELYLTL 248
1_pfamImport   1 LRaAK-SRNLDCTEVLLPDDLLTKIAAEIYNLSEKEPCGLKGCAIFIGFEDEyANMR-RIASLKM-DPNTLSTFELYLVI 77 
Q16ZV0       126 LRtAK-RRHLACTEVLLPADLLPRIASQMFELSEKEPCGIRGCTVYIEFEDEpDNSR-RIATMKT-DPTTVSTFELYLTL 202 yellow fever mo...

7MOP_B       207 RLDSRL-WPKIQGLFSsan----spFLPGF--SQSL---TLSTGFRVIKKKLYS 250
BAH72677     121 KQNPRNaWSLIPLFI----------RNFTS--GGTI---VIDHEFTIEKRKLYR 159
XP_967838    124 KQANAG-WTFLPQFLK----------KITR--GSTV---VISTEYELTKKKLYR 161
EFA08259     151 KQNPTG-WNFIPQFLK----------NLAT--GGTI---VVSPAYVLTKKKLYR 188
OWR50883     119 EHDATN-WTSLLPQFL---------KNLTR--GGTI---IISPQFTIEKKKLFR 157
XP_015795877  85 RRR----YSDWFKFIAtr-----flRHLFR--DSSF---TIHDVYNLYKRKLFR 124
XP_001956516 210 RQDHRG-WTSLLPQFMks-------------lARTI---TISPEYTITKNKLYS 246
XP_002024017 249 KQDKSG-WTSLLPQFI---------KNLTR--SNTI---NISPDFTLTKNKLYS 287
1_pfamImport  78 KQDGSG-WHNILPQFL---------KNLAK--SSTI---VISSNYELTKTKLY- 115
Q16ZV0       203 RQDRSG-WTSILATVSqvaiavegnFQTNYpeGKTIschMGAVNGQHIDPALFS 255 yellow fever mosquito
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