Conserved Protein Domain Family
DRY_EERY

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pfam09750: DRY_EERY 
Alternative splicing regulator
This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.
Statistics
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PSSM-Id: 462881
Aligned: 65 rows
Threshold Bit Score: 86.9852
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005848655   30 LSIFGVPAEIFCDAAAAAELEEGSHLVPCW--GDPDDLTDRWDARLLL-DPLSLAA-----SARQRRqppssaaaEEAaa 101 
XP_009412426    3 LAVEGRHALLFDDDATAAFVNARDALVPWS--GDPALLIDRYDVRHLL-DRIPPRPpv--rAASRLCevpavdgvTSS-- 75  
XP_004969650    3 LEIVGRHALLFDDDATAEVVNSGGSLVPWAaiGAADLLLDRHDVRHLL-DCVPPRPrr--aYSAAILyvpssdgvSEA-- 77  
Q5N8K0          3 LEIVGRHALLFDDDPTAEVVNSGGSLVPWAavGADDLLLDRHDVRHLL-DRVPPRPrr--sYSAALLsapsldgvSEA-- 77   Japanese rice
XP_004248293    3 LVVVGRHALFFDDDSLAAFVNSGDALVDWN-----SLQIDRYDVRHLL-SAPPPSRr----RSNSSSssnlvdasIQL-- 70  
CBI26667        3 LEVLGRHALLFDDDANSAFVNSNDALVEWN-----SLLIDRYDVRHLLpTPLPPLKr----RRHHSSalpaeisqLEL-- 71  
EEF32910        3 LEVIGRHALLFDDDALAAFVNSPEALVDWN-----SLSIDRYDVRHLL-SSPPPPRnrhhrRNQHRSpshnlddsLES-- 74  
BAH19551        3 LEIVGRHALFFDDDSMATFVNSPTALVDWN-----SLFIDRYDVRHLL-SSPPP-------PRIKRRrpnsndadLES-- 67  
VDC86908        3 LEIVGRHALFFDDDSMATFVNSPTALVDWN-----SLFIDRYDVRHLL-SSLPP-------PRPKRRrsvsddpdLDA-- 67  
ERN09155       29 LEVAGRHAFLFDDDSTSQFVDSSDALVPWN--GDSHLSIDRYDVRHLL-SDLSSLR-----KKQKLPsskspdavSES-- 98  
XP_005848655  102 laaagasweELERERYRDL--------DPSREHElqRHGRLLPPAGRMYFSGARegddqaeegyqgalpppgLPPpaaSr 173 
XP_009412426   76 ---------QLDRERYLDLp------lSGPDAd--------------------------------------------pGg 96  
XP_004969650   78 ---------ELDRERYLDLp------dADGDGe--------------------------------------------dEg 98  
Q5N8K0         78 ---------ELDRERFLDLt------aDDFGG----------------------------------------------Eg 96   Japanese rice
XP_004248293   71 ---------ELDKERYLDLp------lPSDe----------------------------------------------pDl 89  
CBI26667       72 ---------ELDQERFLDLp------pPSDe----------------------------------------------qEl 90  
EEF32910       75 ---------DLDHERYLDLp------sTSDDe---------------------------------------------qDl 94  
BAH19551       68 ---------ELDHERYLDLpsespspsDDDe----------------------------------------------hDm 92  
VDC86908       68 ---------DLDHERYLDLpadspspsHDESGKDceLRRNLSVLSIVDLVQTLG------------------SYVr-dDm 119 
ERN09155       99 ---------DLDFERFRDL--------------------------------R---------------------KSddpEg 116 
XP_005848655  174 faavahDYSGArdgggtgqYAAVGFSYGD 202 
XP_009412426   97 dddargSLSGTtkds-dgtYQAVPFSYGN 124 
XP_004969650   99 sgdaapSGNGTdtr--qsdCSSVPFSYGS 125 
Q5N8K0         97 sqdavsSGNGTdtg--wadYNSVPFSYGS 123  Japanese rice
XP_004248293   90 eegdesADAGA--------YRAVGFSYGN 110 
CBI26667       91 dnglekADAAG--------YHTVAFSYGN 111 
EEF32910       95 eteaeaKNAGG--------YNAVAFSYGA 115 
BAH19551       93 nedsanTNADG--------YRAVSFSYGS 113 
VDC86908      120 ndgsasTNAAG--------FRAVPYSYGS 140 
ERN09155      117 ggrgaeMASGS--------YQAVPFSYGN 137 
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