Conserved Protein Domain Family
Sprouty

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pfam05210: Sprouty 
Sprouty protein (Spry)
This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.
Statistics
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PSSM-Id: 461589
Aligned: 40 rows
Threshold Bit Score: 61.9639
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX84664     356 RVRCKHCqdtyRPEENYRGA----------CDhapdcVRSTIDAVSCVSCAECLMYHCYadAEGD---FAP--QPCVcgs 420
ESN92576     615 RCRCDSC----TRPKRLPRTwlgsarcrfeCS-----AEEAVRVCSCLCFIQAFFYHCFyhPDDDd--DYLmtEPCAc-- 681
XP_009022324 410 RCRCKDCmnssRRTGRIASS----------IQ-----DESLLDCLSCMCAIKPIFYHCLkdSNGE---DDCseEPCAc-- 469
XP_002815170 186 KCKCGEC----TAPRTLPSClacn--rqclCS-----AESMVEYGTCMCLVKGIFYHCS--NDDEg--DSYsdNPCS--- 247
NP_001116072 154 KCKCSEC----TAPRALPARlacn--glclCS-----AENVIEQGTCMCLVKGIFYHCS--KDDDdvgDACadRPCS--- 217
CAG04685     230 KCKCSDC----TAPRSLPSClacn--gqclCS-----AESALEHGTCMCLVKGIFYHCS--NDDEg--DSCadHPCS--- 291
NP_001163980 152 RCKCNEC----AQVRNLPSCwvcn--drciCS-----AENVIDYGTCLCCIKGLFYHCS--TDDE---DNCadDPCS--- 212
XP_014343108 158 RCKCNDC----TAPRSLPSRwicd--qrclCS-----PENVLDYGTCLCCIKGLFYHCS--SDDE---DNCadDPCS--- 218
XP_005342132 152 RCKCVPC----TAARPLPSCwlcn--qrclCS-----AESLLDYGTCLCCVKGLFYHCS--TDDE---DNCadEPCS--- 212
XP_007244508 148 RCKCQEC----CAPRSLPSCwacg--qrclCS-----AENAVEYGTCLCCVKGLFYHCS--ADDE---DNCadRPCS--- 208
EFX84664     421 gsvrrhngsgCCSiESSPKRWFGLALLSLVVPCLWCYLPLRACYRCGVRCGC--------CG 474
ESN92576     682 ----------CER-PRCCLRWGLMTLLTPILPCLCCYCPLQCCVDSLTACYDsctnegcrCE 732
XP_009022324 470 ----------CSQ-PNCFPRWAILGMFLPCLPCLCFYLPLRCLLDVCLGCFSndi--gcqCE 518
XP_002815170 248 ----------CSQ-SHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDwihrpgcrCK 298
NP_001116072 218 ----------LSH-PQCCSRFLCMGLMATLFPCLLCYLPAKGCVKACNSCHDrltrpgcrCK 268
CAG04685     292 ----------LSH-SHCCSRFLCMGLMSVLFPCLLCYPPVKGCLKACQGCYDrvnrpgcrCK 342
NP_001163980 213 ----------CSQ-GSCCARWAAMSLLSFFMPCLCCYLPAKGCLKLCQKAYDrvkrpgcrCE 263
XP_014343108 219 ----------CNQgGQCCSRWAAISFFSVLMPCLCCYLPAKGCLKLCQKCYDgikrpgcrCK 270
XP_005342132 213 ----------CGP-SSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDslrrpgcrCK 263
XP_007244508 209 ----------CAP-AHACARWGTMALLALCLPCLCCYPPAKLCLTLCQRGYDrtk--rpgCR 257
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