Conserved Protein Domain Family
CRIM1_C
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pfam19442: CRIM1_C 
Cysteine-rich motor neuron 1 protein C-terminal
Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.
Links
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Statistics
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PSSM-Id: 437274
Aligned: 8 rows
Threshold Bit Score: 247.457
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014066561  896 ENDIMPQFKgNFGSLQMPFLDgKTPVPREDTTLHSVAWVALPIIMMLFTITALLFINQKKQWIPVLC-YRTPTKPTCLNN 974 
XP_028906771  893 ENEIGHLPR-DMAHLQVGYRD-SEPHLNEDTSFDSVAWVTVPVVIALILIIALLLINRKKQWIPVPC-YRTPTKPSCLNN 969 
XP_016859747  867 ENDIVHLPR-DMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNN 944 
XP_007521065  907 ENDIIHGPR-DMGHLQVDPRE-SRPRPSEDSSVDPITWVVLSVTMFGIVIIVFLFINQRRQWVPLHCwYPTPTKPSSLNN 984 
ACJ64924      900 ENDIVHHHR-DMGHLQANYREvERPRLTEEDSLHSVAWVAVPIMIALVILIVLFMINQKKQWIPVPC-YRTPNKPTCLNN 977 
XP_005989783  901 ENEIASQRR-GMSNLQVDYREsNGPLPNDESPLHSIAWVTVPVMTALVLIIALLLVNQKKQWIPVPC-YRAPTKPTCLNN 978 
XP_025958446 1055 ENDIIHIHR-DMSHLQGEYRSgSGPHPSEDASVSSVALVTIPIMIALLLIIVLLLVNQKKQWIPVSC-YKAPTKPSCLNN 1132
XP_008123835  913 ENDIVHIHR-DMGHLQGDYREtRGSQPSTEASLSSLAWVTVPIMTALVLIIALLLVNQKKQWIPVSC-YRAPTKPSCLNN 990 

XP_014066561  975 QLVYVDCQKGTKVQVDSSQCMIRIADPDSRYSGYYSMqkqNNLNNLQADNFYQTQ 1029
XP_028906771  970 QLVYVDCKKGTMVQVDSSQRMLRIADPDARFSGFYSM---QKQNNLQADNFYQTV 1021
XP_016859747  945 QLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSM---QKQNHLQADNFYQTV 996 
XP_007521065  985 QLVSVDCKKGNRAQADSSQRMLRMAEPDARFSGLYSM---QKQNHLQADNFYQTV 1036
ACJ64924      978 QLVYVDCKKGTMVQVDSSQRMLRMADPDSRYSGFYSM---QKQNNLQADNFYQTV 1029
XP_005989783  979 QLVYVDCKKGTMVPVDSSQRMLRMADPDSRYSGFYSM---QKQNNLQADNFYQTV 1030
XP_025958446 1133 QLVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSM---QKQNNLQADNFYQTV 1184
XP_008123835  991 QLVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSM---QKQNNLQADNFYQTV 1042
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