6NMY


Conserved Protein Domain Family
IL3Ra_N
?
pfam18611: IL3Ra_N 
Click on image for an interactive view with Cn3D
IL-3 receptor alpha chain N-terminal domain
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.
Links
?
Statistics
?
PSSM-Id: 436618
Aligned: 22 rows
Threshold Bit Score: 78.1585
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
6NMY_F         8 ITNLRMKAKAQQLTWDLNRNVTDIECVKDADY-------------SMPAVNNSY-CQFGAISlCEVTNYTVRVA--NpPF 71 
XP_023398511  74 IINVDLDPRKKMLRWNCRGNVTEERCEIKTPLesfl------ipsAQVQEDGTHyCMFPNAVlHQGALLSVAVTsdGdTF 147
XP_027819122  29 IVNLTLDPRKRILSWNSRRTVTQQTCTIATPLdpdt------sqePQVRNNDTYfCWFPNAVlHRGATLTVNATseGqEF 102
XP_003435540  32 IINMQLDSRKKMLSWNYIRNVSEQECVIYTPLgspt------sqpPQVTEDDTHyCIFRNHVlHRGANLTVNVTcdGnVF 105
KYO41147      54 ITNLTVNLKKLELTWDSSLNFTKYQCTL-KTKnss--------veKKENKKNCIfSR---KPiHEGAIFRVEGN------ 115
XP_023397670  25 RLHVTFDPREMTLAWDCRENATVVKCLMSHREegq--------isMKPIDKQCS-CTFELRSlHRGVVLTVEANtsQgLF 95 
XP_021789208  98 SLNVRFDARTMNLTWDCQENTTFTRCFLTDKKnrv--------vePRVTKKECS-CTFHEVClHGGVTFEVHVNtsQrAF 168
XP_008249544  41 SLNVTFNSRTMNLSWDCPENMTEARCLLRHEEtgk--------iiMKVSRMGCS-CTFTSMTlHAGATLEVQVTahQrHL 111
XP_011961534  55 SLNVKFDPQTTKLTWDCKENTTYGECALIHKEkgl--------ikKKVKHSDCQ-CTFPDCSlHGGVTLTVEVSvnQrRL 125
XP_012919898  62 ITNLQLDSRKRMLTWNYIRNVSQQECMISTPPnsptmpsfsttqaPKVREDSTYfCIFRNRVlHRGANLTVRVTcdGaKF 141

6NMY_F        72 STWILFP 78 
XP_023398511 148 QEVLTFN 154
XP_027819122 103 SEELAFN 109
XP_003435540 106 QELLVFA 112
KYO41147     116 YDMVSYS 122
XP_023397670  96 EQELLYD 102
XP_021789208 169 QQKLLYP 175
XP_008249544 112 RETLVYA 118
XP_011961534 126 SEMLVYT 132
XP_012919898 142 QEVLLFA 148
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap