6G90,1ZR9


Conserved Protein Domain Family
zf-C2H2_jaz
?
pfam12171: zf-C2H2_jaz 
Click on image for an interactive view with Cn3D
Zinc-finger double-stranded RNA-binding
This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
Links
?
Statistics
?
PSSM-Id: 432381
Aligned: 111 rows
Threshold Bit Score: 30.6012
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
6G90_T        279 GIYCPFCSRWFKTSSVFESHLVG--KIHK 305  baker's yeast
EDW38106      218 PFYCDLCEYQTNTRYSFLRHKKS--KKHQ 244 
Q9HA38        245 QFYCSMCNVGAGEEMEFRQHLES--KQHK 271  human
EAY14533      267 KFYCEYCNRDLKTEERFKVHQTE--KSHL 293 
XP_011603122  354 KFYCYLCSITCHNQQNFRSHMNS--VSHQ 380 
Q6BQQ0         25 RFYCQICEKQCRDANGFKNHINS--LSHQ 51   Debaryomyces hansenii
Q5KJJ3        261 GIWCQYCQKNYSKQTVYDAHLNS--KGHK 287  Cryptococcus neoformans
Q2H3Q5         22 SFYCQLCQKGYSRMNDYEAHLSSydHSHK 50   Chaetomium globosum CBS 148.51
O59706        242 AFYCEVCQKFFGKITVFEAHKKS--KAHN 268  Schizosaccharomyces pombe 972h-
XP_009895856   57 NFYCELCDKQYQKHQEFDNHINSydHAHK 85   Downy woodpecker
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap