Conserved Protein Domain Family
MLIP

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pfam15274: MLIP 
Muscular LMNA-interacting protein
MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.
Statistics
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PSSM-Id: 405866
Aligned: 4 rows
Threshold Bit Score: 351.702
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5VWP3       119 MQQSDLFKAEYVLIVDSEGEDEAASRKVE-QGPPGGIGTAAVR------------------------------------- 160  human
XP_027310896 117 MQENDLFKAEFILITDSGDEDEAAAASINiQRPSNGYGPISAQllatshvspgpetrkpsdghlpgaglshsttdqqkqq 196  mallard
XP_025004974 115 MQENDLFKAEFILITDSGDEDEAGAASINaQRPSNGFGPISAQ------------------------------------- 157  chicken
KFP94088      96 MQENDLFKAEFILITDSGDEDEVAAASSNvHRPSNGYGPISAQllatshvsp---------------------------- 147  white-tailed e...
Q5VWP3           --------------------------------------------------------------------------------      human
XP_027310896 197 listlsdhlsskppavhlisptnlkvacgamvnlnqassledshnnwqsairsskqdsslyfqsashssapsmskissca 276  mallard
XP_025004974     --------------------------------------------------------------------------------      chicken
KFP94088         --------------------------------------------------------------------------------      white-tailed e...
Q5VWP3           --------------------------------------------------------------------------------      human
XP_027310896 277 snicysspqlygnlqtpslhspvcvckmgdfttssipakslsvfpkpscsaeiqesssqplspssskrlkalsplpvrit 356  mallard
XP_025004974     --------------------------------------------------------------------------------      chicken
KFP94088         --------------------------------------------------------------------------------      white-tailed e...
Q5VWP3           --------------------------------------------------------------------------------      human
XP_027310896 357 thslspspkplsppslygsssticsvnepctqissrgylaksgvrsplptrltlltailrsgssqrrplspascptfsps 436  mallard
XP_025004974     --------------------------------------------------------------------------------      chicken
KFP94088         --------------------------------------------------------------------------------      white-tailed e...
Q5VWP3           --------------------------------------------------------------------------------      human
XP_027310896 437 slcsstlaidqkckttpptprksissppvrpdspsreehwssgwaqhvplhskphpaprarslsprrhlpvrtpspdsrs 516  mallard
XP_025004974     --------------------------------------------------------------------------------      chicken
KFP94088         --------------------------------------------------------------------------------      white-tailed e...
Q5VWP3           --------------------------------------------------------------------------------      human
XP_027310896 517 pqlspisshrksianpgwqsmlpalamppsapahsslahptspppeglhhpasrsqapqrcqrvhtyspiftcqsyplls 596  mallard
XP_025004974     --------------------------------------------------------------------------------      chicken
KFP94088         --------------------------------------------------------------------------------      white-tailed e...
Q5VWP3           --------------------------------------------------------------------------------      human
XP_027310896 597 ptrlsgtfsptqekqlspspslststsrsksdssqksaqelstpsptpssvskqwslsrpdsaspvlqtcsinphplqlh 676  mallard
XP_025004974     --------------------------------------------------------------------------------      chicken
KFP94088         --------------------------------------------------------------------------------      white-tailed e...
Q5VWP3       161 ----------------------PKSLAISSslVSDVVRPKTQGT-DLKTSSHPEMLHGM-APQQKHGQQYKTKSSYKAFA 216  human
XP_027310896 677 sslmhrsyrsnsqsprpeksatSPVLKCRS--PVSNKSPCTLPSrPRELTSPQSFSLPS-DHENIKPKQYKIKTSYKAFA 753  mallard
XP_025004974 158 ----------------------LLATSHVSpgMESRKPPSDG------HLPSATLSHST-ADQQN--------------- 193  chicken
KFP94088     148 -------------gtgagrppgDGHVPGPA------------------------LSHSAaDPQKQ--QQYKIKTSYKAFA 188  white-tailed e...
Q5VWP3       217 AIPTNTLLLEQKALDEPAKTESVSKDNTLEPPVELYFPAQLRQQTEELCATIDKVLQDSLSMHSSD-SPSRSPKTLLGSD 295  human
XP_027310896 754 AIPTNTLLMEQKALEEPTKTASVIEGTALDTHSEMCSPAQLRQQTEELCAVIDQVLQDPLTMRRCE-SSPSFLQMNTESD 832  mallard
XP_025004974 194 ----------QQALEEPTKAADVTEGSILDTHSEMCSPAQLRQQTEELCAVIDQVLQDPLTMRRCE-SSPSFLHMNTESD 262  chicken
KFP94088     189 AIPTNTLLMEQKALEEPTKTASVTEGTALDTHSEMCSPAQLRQQTEELCAVIDQVLQDPLTMVTRQyFPADEHGVRCWQV 268  white-tailed e...
Q5VWP3       296 TVKTPTTLPRAAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKeEEVYEPNPFSKYLEDNSDLFSEQ 371  human
XP_027310896 833 GGKVSSTLQRAAGRETRYANLYKSTPMVAESQMTKPGVIRPVLVKAKSAQQK-EEPYQPNPFKKYLEEISDQDIEQ 907  mallard
XP_025004974 263 VGKVSTTLQRAAGRETRYANLYKSTPVVAESQMTKPGVIRPVLVKGRIAQQK-EELYQPNPFKKYLEEISDQDVEQ 337  chicken
KFP94088     269 FYKVSTTLQRAAGRETRYANLYKSAPMVTESQLTKPGVIRPVLVKGKSAQQK-EEPYQPNPFKKYLEEIGDQDTEQ 343  white-tailed eagle
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