Conserved Protein Domain Family
PRK05579

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PRK05579: PRK05579 
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
Statistics
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PSSM-Id: 235513
Aligned: 391 rows
Threshold Bit Score: 396.814
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
285017190   6 ERPLQGRRVLLCVGGGIAAYKALELVRRLRDVGAEVQVAMTAGAQQFVTALSFQALSGHITRTTlwdsSAEQAMGHLELA 85 
48478212   10 AGMLKGRKIVVATSASISIYRVPDLVRDLRREGADVKVAMSDASQKMVSPEVMKWASGHDVVT-----DITGNIEHITLF 84 
13541804   10 ARMLEGRTVIVATTASISIYRIPDLIRDLRREGAEVIVGMSESSEELVGPETMRWASEHDVVTK-----ITGNVEHINLF 84 
14520924   13 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSPSATKIIHPYAMEFATGNPVIT-----EITGSIEHVELA 87 
14591235   13 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMTPSATKIIHPYAMEFATGNPVITE-----ITGFIEHVELA 87 
18977812   13 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITE-----ITGFIEHVELA 87 
212223947  13 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSESATKIVHPYAMEFATGNPVVTE-----ITGFIEHVELA 87 
240103726  13 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSENAQKIIHPYAMEFATGNPVVT-----EITGFIEHVELA 87 
242398477  17 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSPSAQKIIHPYAMEFATGNPVVTE-----ITGFVEHVELA 91 
57640452   13 SRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSENATKIIHPYAMEFATGNPVVTE-----ITGFIEHVELA 87 
285017190  86 R----WAQQVVVAPATADLLARLAHGLADDLVGTLCLAS---TA-PLTVCPAMNHRMWLHPATQANVATLRQRGAHVVGP 157
48478212   85 D----SDTLLLLAPATYDTIGKMASGIADNIPSLFFSYAlkaTG-HIVIVPAMHRNMMENRINLENIEKLKNLGCLIVEP 159
13541804   85 Ind-kDKKALLIAPASYDTIGKMASGVTDTIPPLFFSFAfgyGV-KTIVAPAMHRSMMENPINKENVEKLRRLGVDIVDP 162
14520924   88 GehenKADLILVCPATANTISKIACGIDDTPVTTVVTTAf--PHiPIMIAPAMHESMYKHPIVRENIEKLKKLGVEFIGP 165
14591235   88 GehenKADLILVCPATANTISKIACGIDDTPVTTVVTTAf-pHI-PIMIAPAMHESMYKHPIVRENIEKLKKLGVEFIGP 165
18977812   88 GehenKADLILVCPATANTISKIACGIDDTPVTTVVTTAf-pHI-PIMIAPAMHETMYRHPIVRENIERLKKLGVEFIGP 165
212223947  88 GdhenKADLVLVCPATANTISKIACGIDDTPVTTVVTTAf-aHT-PIMIAPAMHSTMYEHPIVAENIEKLKRLGIEFIGP 165
240103726  88 GehenKADLILVCPATANTIGKIACGIDDTPVTTVVTTAf-sHT-PIMIAPAMHSTMYEHPIVKENIEKLRKLGVEFIGP 165
242398477  92 GehenKVDLVLVCPATANTISKIACGIDDTPVTTVVTTAf-aHT-PIMIAPAMHFTMYEHPIVKENIEKLKKLGVEFIGS 169
57640452   88 GehenKADLVLVCPATANTISKIACGIDDTPVTTVVTTAf-aHT-PIMIAPAMHSTMYDHPIVKENIEKLKKLGVEFIEP 165
285017190 158 NDGPLAEGESGPGRLAEPQQIVAalagignaaaqpatpleaIVPARSatpsTtsrdGALRGLRLLISAGPTYEDLDPVRY 237
48478212  160 EYDEEK------AKIADNDRIID------------------YVCRSFy-------gEKLKNKNILIIGGRSELSIDPVRF 208
13541804  163 ------IYDEEKAKLSGNQCIID------------------HVCRAFy--------NKYDGKSILIISGRGEERIDPVRS 210
14520924  166 ------RIEEGKAKVATIDEIVY------------------RVIKKLh---P----KTLEGKRVLITAGATREYIDPIRF 214
14591235  166 ------RIEEGKAKVASIDEIVY------------------RVIRKLh---P----KTLKGKRVLVTAGATREYIDPIRF 214
18977812  166 ------RIEEGKAKVASIDEIVY------------------RVIKKLh---K----KTLEGKRVLVTAGATREYIDPIRF 214
212223947 166 ------RFEEGKAKVATTEEIVY------------------RVIKKLh---Q----KDLKGKRVLVTAGATREYIDPIRY 214
240103726 166 ------RFEEGKAKVASIDEIVY------------------RVIRKLh---P----KSLEGKRVLVTAGATREYIDPIRY 214
242398477 170 ------RFEEGKAKVASVEEIVY------------------HVIKKLh---R----KDLAGKRVLVTAGATREYIDPIRF 218
57640452  166 ------RFEEGKAKVASIEEIVY------------------RVIRKLh---P----KSLEGKRVLVTAGATREYIDPIRY 214
285017190 238 LGNRSSGKMGYALAAAAVRRGAQVVLVSGPVQLPTPDGVQRIDVRSAVQMRQAVLGA--LP-----ADIYIGTAAVADYT 310
48478212  209 ISNRSTGYTGYWLARMSFRLGADQIVYVGNSNYRMPNYVNFIQRTNLREIIIEVN----TVinvykFDIIVMCMAVLDFD 284
13541804  211 ITNDSTGYTGYWIARVAYRMGFSHITYIGNSIVDLPTYVNYRAAYTVDEFERLSEEEasNN-----YDYIVVNAALPDFK 285
14520924  215 ITNASSGKMGVALAEEAEFRGAEVTLIRTRGSVKSFVE-NQIEVETVEEMLGAIEEE--LTkk--kYDVVIMAAAVSDFK 289
14591235  215 ITNASSGKMGVALAEEAEFRGAEVTLIKTKGSVNSFV-ENQIQVETVEEMLAAIEKE--LTek--kYDVVIMAAAVSDFK 289
18977812  215 ITNASSGKMGVALAEEADFRGAEVTLIRTKGSVKSFV-ENQIEVETVEEMLSAIENE--LRsk--kYDVVIMAAAVSDFR 289
212223947 215 ITNASSGKMGVAMAEEADFRGAEVTLIRTKGSVPSFV-ENQIEVETVEEMLQAIENE--LKsk--kYDIVVLTAAVSDFR 289
240103726 215 ITNASSGRMGVAIAEEADFRGAEVTLIRTKGSVPSFVE-NQIEVETVEEMLEAIENElkVRk----YDVVVLAAAVSDFR 289
242398477 219 ITNRSSGKMGVALAEEAEFRGAEVTLIRTKGSVPSFV-ENQVEVETVEEMLEVIENE--LNsk--kYDIVILAAAVSDFR 293
57640452  215 ITNASSGKMGVAIAEEAEFRGAEVTLIRTKSSVPSFV-ENQIEVETVEEMLEAIESE--LKgk--kYDVVVLAAAVSDFR 289
285017190 311 PKQVLTEKIKKNRdtLILELIRTPDILAEVA---AqtQa-Lk-LVVGFAAETH-DI----ERYARGKLADKHLDLIIANQ 380
48478212  285 IKEEKEKITSSEK--HVIELEPRNKLRNRIR------QmsPssILVLFELEGD-------LKYNDEKFKDSRPDMVIVNS 349
13541804  286 VIEKSEKKYSSNEs-HKLTLEPREKLVDKLSni--skG--K---IVAFRLTEN-------IGEDPFKHFSKRIDMAVVNS 350
14520924  290 PKIKAKEKIKSDKs-ITLELVPNPKIIRKIKeiqSd-V-----FLVGFKAETSmEKl---ISEAKKQIESAGSDLVIGN- 358
14591235  290 PKIKAEDKIKSNKs-ITIELVPNPKIIDRIKelqPd-V--F---LVGFKAET---TmeklIQEAKKQIERAKSDIVIGNT 359
18977812  290 PKIKAEGKIKSDRs-ITIELVPNPKIIDRIKeiqPn-V--F---LVGFKAET---SkeklIEEGKRQIERAKADLVVGNT 359
212223947 290 VKNRAGVKIKSGKe-LVLELEPTPKIIDRVKelqPd-V--F---LVGFKAETG-LGeeelISAARKQMERAKSDLVVANT 361
240103726 290 VKNRADAKIKSGKs-LILELEPTPKIIDRVKelqPd-V-----FLVGFKAETSeDKl---IEEARKQTERAGSDMVVAN- 358
242398477 294 IKDKVSVKIKSGKa-LTLELEPTPKIIDRVKelqPd-V--F---LVGFKAETG-LSedelIEAARKQIERAGSDIVVANT 365
57640452  290 VKNKADVKIKSGQp-LVLELEPTPKIIDRVKelqPg-V--F---LVGFKAETG-LSeeelISAARKQIERAGSDLVVANT 361
285017190 381 VgvVGNGFESDQNAATAYWQHGARS-FPAVVKTQLAEQLLDLIAERLH 427
48478212  350 Y--KNSAFGESSQEYIIV-SGNNKEnINA-EKSVLSRIILERASSINK 393
13541804  351 Y--KTGPFGKTENEYRFV-SKKFDVdLGRMPKPILAKNLVERLGDL-- 393
14520924  359 ---TLEAFGSEESKVVIV-GKDFVKeLPRMKKRELAERIWDEIEKKI- 401
14591235  360 L----EAFGSDESKVIIIG-RNFEKeLPKMNKRELAERIWDEIEKRL- 401
18977812  360 L----EAFGSEENQVVLIG-RDFTKeLPKMKKRELAERIWDEIEKLLS 402
212223947 362 L----QAFSSEENEVLLVT-KEDVKrLPRMGKRELAERLWDEILQRIL 404
240103726 359 ---TLKAFGSEENEVFLV-TRNEVKrLPRMNKRELAERLWDEIEMLI- 401
242398477 366 L----KAFGSEENEAILVG-KDFTKkLPRMNKRELAERLFDEIISMIS 408
57640452  362 L----KAFGSEENEVVLVG-RDFAKkLPRMTKRELAERLWDEI-EKML 403
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