6QCB: Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 9

PDB ID: 6QCBDownload
MMDB ID: 183522
PDB Deposition Date: 2018/12/27
Updated in MMDB: 2020/03
Experimental Method:
x-ray diffraction
Resolution: 1.55  Å
Source Organism:
Similar Structures:
Biological Unit for 6QCB: dimeric; determined by author and by software (PISA)
Molecular Components in 6QCB
Label Count Molecule
Proteins (2 molecules)
1
Cathepsin D
(Gene symbol: CTSD)
Molecule annotation
1
Cathepsin D
(Gene symbol: CTSD)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
4
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
1
PHOSPHITE IONPHOSPHITE ION
4
1
(3~{S},7~{S},8~{S})-7-oxidanyl-8-(phenylmethyl)-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione(3~{S},7~{S},8~{S})-7-oxidanyl-8-(phenylmethyl)-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione
5
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
6
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303