5Y2F: Human SIRT6 in complex with allosteric activator MDL-801

PDB ID: 5Y2FDownload
MMDB ID: 168399
PDB Deposition Date: 2017/7/25
Updated in MMDB: 2018/11
Experimental Method:
x-ray diffraction
Resolution: 2.53  Å
Source Organism:
Similar Structures:
Biological Unit for 5Y2F: dimeric; determined by author and by software (PISA)
Molecular Components in 5Y2F
Label Count Molecule
Proteins (2 molecules)
1
Nad-dependent Protein Deacetylase Sirtuin-6
(Gene symbol: SIRT6)
Molecule annotation
1
9-mer Peptide Qtarkstgg
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
1
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
2
1
5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid
3
1
ZINC IONZINC ION
4
5
GLYCEROLGLYCEROL
5
7
SULFATE IONSULFATE ION
6
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
7
1
HEXADECANE-1-SULFINIC ACIDHEXADECANE-1-SULFINIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303