5WAL: Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

PDB ID: 5WALDownload
MMDB ID: 154294
PDB Deposition Date: 2017/6/26
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.45  Å
Source Organism:
Similar Structures:
Biological Unit for 5WAL: monomeric; determined by author and by software (PISA)
Molecular Components in 5WAL
Label Count Molecule
Protein (1 molecule)
1
Non-receptor Tyrosine-protein Kinase Tyk2
(Gene symbol: TYK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamideN-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303