4PFC: Crystal structure of insulin degrading enzyme complexed with inhibitor

PDB ID: 4PFCDownload
MMDB ID: 130045
PDB Deposition Date: 2014/4/28
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.21  Å
Source Organism:
Similar Structures:
Biological Unit for 4PFC: dimeric; determined by author
Molecular Components in 4PFC
Label Count Molecule
Proteins (2 molecules)
2
Insulin-degrading Enzyme
(Gene symbol: IDE)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamatemethyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
2
2
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303