|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
35-432 |
4.21e-167 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 478.69 E-value: 4.21e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 35 AQLWLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVPCLPVRIP 114
Cdd:cd17399 17 AMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNFIGAVIRVISSLPFVDP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 115 S-PFAFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADDIPMMLGIYIGP 193
Cdd:cd17399 97 SfRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIVKSSEDIFLLLSIYTIP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 194 AALACLLATVCLWESVPPTPPSTGAANStSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEF 273
Cdd:cd17399 177 ALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLEQILCPSGYSNNF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 274 SGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVME 353
Cdd:cd17399 256 AGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGFAIYPVGLE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 354 LAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVR-----RTGPSFSTCQQGEDPLDWTVSLLLLAGLCTLFTCVL 428
Cdd:cd17399 336 LAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPlsvydLPIQCASSASGNITPLDWTVPLLVMAGLAAVLAIIF 415
|
....
gi 1907163438 429 VIFF 432
Cdd:cd17399 416 VVFF 419
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
35-432 |
9.12e-109 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 329.36 E-value: 9.12e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 35 AQLWLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVPClpVRIP 114
Cdd:cd17334 17 AMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPL--GQQP 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 115 sPFAFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADD-IPMMLGIYIGP 193
Cdd:cd17334 95 -KFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPKGtKKEFGAVFYGE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 194 AALACLLATVCLWESVPPTPPSTGAANSTSE-------SFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCA 266
Cdd:cd17334 174 FGFACLLLALVLALFPPKPKYPPSAASARQQnsehvilELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSVLAQILLP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 267 SGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQ---LQGQTLALAAICSLFGLF 343
Cdd:cd17334 254 FGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLPYVTLAFYLLCGLLGFF 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 344 GFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVrrtgpsfstcqqgedPLDWTVSLLLLAGLCTL 423
Cdd:cd17334 334 QNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------PTPTESKYLLWFILCTV 398
|
....*....
gi 1907163438 424 FTCVLVIFF 432
Cdd:cd17334 399 GSCLGALFF 407
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
38-389 |
1.10e-55 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 191.30 E-value: 1.10e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRavpCLPVRiPSPF 117
Cdd:cd17398 20 WIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNCLGAWLK---LFSSS-PDLF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADDIP------MMLGIYI 191
Cdd:cd17398 96 WVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSENKDeigkglSILFYGV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 192 GPAALACLLATVCLWESVPPTPPSTGAA-----NSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQ-ILC 265
Cdd:cd17398 176 AGICTALFILVIIFFKEKPPIPPSRAQAaaqelRSEDQSYLGSLKRLFKNKGFLLLLITYGINTGVYYAISTLLNQmVLE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 266 ASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATkIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGF 345
Cdd:cd17398 256 YFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMT 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1907163438 346 SVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTAL 389
Cdd:cd17398 335 GYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
38-390 |
2.85e-37 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 141.51 E-value: 2.85e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRavpCLPVRiPSPF 117
Cdd:cd17455 20 WIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNCLGAWVK---CASVR-PDLF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADDIPMMLG-----IYIG 192
Cdd:cd17455 96 GVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTVDDIDLMGhnisiMFYG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 193 PAALACLL--ATVCLWESVPPTPPSTGAA-----NSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILC 265
Cdd:cd17455 176 TAAVSTLLfiLTIIVFKEKPPLPPSQAQAvlqgiPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMII 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 266 ASGYSNEF-SGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLqGQTLALAAICSLFGLFG 344
Cdd:cd17455 256 THYEGEEVnAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL-GYLIVVFVTGGVLGFFM 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1907163438 345 FSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALT 390
Cdd:cd17455 335 TGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
38-387 |
5.37e-35 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 134.73 E-value: 5.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRavpCLPVRIPSPF 117
Cdd:cd17397 20 WNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVAAGTGLR---CIPVPNHLAT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkkaddipmMLGIYIgpAALA 197
Cdd:cd17397 97 WLIHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL--------MYLEFG--WSAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 198 CLLATVCLWESVPPTPPSTgAANSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEFSGLC 277
Cdd:cd17397 167 IFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLDVNLTPFGVSQVEAGWI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 278 GALFIVFGILGALLLGLYVDRTKHFTEatKIGLCLTSMTSVAFALVSQLQ-----GQTLALAAICSLFGLFGFSVAPVVM 352
Cdd:cd17397 246 GFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLIClkllpFSTVSLYTSCILLGVFLNGSVPLFY 323
|
330 340 350
....*....|....*....|....*....|....*
gi 1907163438 353 ELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLT 387
Cdd:cd17397 324 ELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
38-381 |
9.73e-33 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 129.13 E-value: 9.73e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRavpcLPVRIPSPF 117
Cdd:cd17456 20 WIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNCLGAWIK----TGSARPDLF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADDIPMMLG----IYIGP 193
Cdd:cd17456 96 PVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDDLDELAYhisiMFYGT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 194 AALACLL--ATVCLWESVPPTPPSTGAA-----NSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCA 266
Cdd:cd17456 176 AAVATLLfiLVIIVFQEKPKIPPSQAQAaiqsiPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLNRMVIF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 267 SGYSNEFS-GLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLqGQTLALAAICSLFGLFGF 345
Cdd:cd17456 256 HYPGEEVNaGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNL-GHLWVVFITAGTLGFFMT 334
|
330 340 350
....*....|....*....|....*....|....*.
gi 1907163438 346 SVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGML 381
Cdd:cd17456 335 GYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGII 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
37-398 |
3.14e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.24 E-value: 3.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 37 LWLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVPclpvripSP 116
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-------PS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 117 FAFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkKADDIPMMLGIYIgpAAL 196
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAVFLI--AAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 197 ACLLATVCLWESVPPTPPSTGAANSTSE--SFLRGLKLLIQNKAYVLLA-VCFGGGIGVFSSFSALLEQILCASGYSNEF 273
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASskSVLKLLKRVLKNPGLWLLLlAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 274 SGLCGALFIVFGILGALLLGLYVDRtkHFTEATKIGLCLTSMTSVAFALVsqLQGQTLALAAICSLFGLFGFSVAPVVME 353
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907163438 354 LAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVRRTGPSF 398
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
38-389 |
3.14e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.23 E-value: 3.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWL----SLIYFVLSIPFGMAAiwvlDSVGLRGATILGAwlnfsgsVLRAVPCLPVRI 113
Cdd:COG2223 21 WYLWSVLAPPLAEEFGLSAAQLGLLfaipVLVGALLRIPLGFLV----DRFGPRRVLLIGL-------LLLGIGLLLLAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 114 PSPFAFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkKADDIPMMLGIYigp 193
Cdd:COG2223 90 AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI-AAFGWRNAFLIL--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 194 aALACLLATVCLWESVPPTPPSTGAANSTSesfLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQIL-CASGYSNE 272
Cdd:COG2223 166 -GILLLVVAVLAWLFLRDPPAGAAAAAKAS---LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 273 FSGLCGALFIVFGILGALLLGLYVDRTKhfteATKIGLCLTSMTSVAFALVSQLQGQ-TLALAAICSLFGLFGFSVAPVV 351
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350
....*....|....*....|....*....|....*....
gi 1907163438 352 MELAVecSFPVGE-GASAGLIFVLGQAEGMLIMLLLTAL 389
Cdd:COG2223 318 ALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
38-357 |
1.23e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.60 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVpclpvrIPSPF 117
Cdd:COG2807 34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL------APSVA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMsGQSLCALAQTLVVSSPAKLAALWFPEHqRATANMISTMSNPLGLLIANVLSPALVKkADDIPMMLGIYIGPAALA 197
Cdd:COG2807 108 LLLA-GTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAA-ALGWRGALAVWALLALLA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 198 CLLATVCLWESVPPTPPSTGAAnstsesflrGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEFSGLC 277
Cdd:COG2807 185 LLLWLPLLRRRPAAAAAAPAAA---------SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 278 GALFIVFGILGALLLGLYVDRTKHfteatKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVMELAVE 357
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGL 330
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
38-381 |
1.29e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 72.07 E-value: 1.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVPclpvripSPF 117
Cdd:pfam07690 13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA-------SSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkkadDIPMMLGIYIGPAALa 197
Cdd:pfam07690 86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA----SLFGWRAAFLILAIL- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 198 CLLATVCLWESVPPTPPSTGAANSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEFSGLC 277
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 278 GALFIVFGILGALLLGLYVDRTKHFTeaTKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVMELAVE 357
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRR--RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....
gi 1907163438 358 CSFPVGEGASAGLIFVLGQAEGML 381
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
41-377 |
7.43e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.45 E-value: 7.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 41 FAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVpclpvrIPSpFAFF 120
Cdd:COG2814 29 VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL------APS-LWLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 121 MSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkKADDIPMMLGIyigpAALACLL 200
Cdd:COG2814 102 LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA-DLFGWRWVFLV----NAVLALL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 201 ATVCLWESVPPTPPSTGAANSTSESFLRGLKLLIQnkAYVLLAVCFGGGIGVFSSFSALLEQILcasGYSNEFSGLCGAL 280
Cdd:COG2814 177 ALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASAAGLLLAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 281 FIVFGILGALLLGLYVDRTKHFTeATKIGLCLTSMTSVAFALVSQLqgqtLALAAICSLFGLFGFSVAPVVMELAVECSF 360
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330
....*....|....*..
gi 1907163438 361 PVGEGASAGLIFVLGQA 377
Cdd:COG2814 327 PEARGRASGLYNSAFFL 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-395 |
9.14e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 9.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 40 SFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVpclpvrIPSPFAF 119
Cdd:COG2271 28 NLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF------ATSFWQL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 120 FMsGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkKADDIPMMLGIYIGPAALACL 199
Cdd:COG2271 102 LL-LRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL-AAFGWRAAFLILGLPGLLLAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 200 LATVCLWesvpptppstgaanstsesflrglklliqnkayvLLAVCFGGGIGVFSSFS-ALLEQILcasGYSNEFSGLCG 278
Cdd:COG2271 180 LRFWLLA----------------------------------LAYFLVYFALYGFLTWLpTYLVEVR---GLSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 279 ALFIVFGILGALLLGLYVDRtkhFTEATKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVMELAVEC 358
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350
....*....|....*....|....*....|....*..
gi 1907163438 359 SFPVGEGASAGLIFVLGQAeGMLIMLLLTALTVRRTG 395
Cdd:COG2271 300 FPKKARGTASGLVNTFGFL-GGALGPLLVGYLLDATG 335
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-399 |
1.94e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 40 SFAPVADTIAQHFFLSMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVlravpcLPVRIPSpFAF 119
Cdd:COG0738 26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL------LFALAPS-YPL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 120 FMSGQSLCALAQTLVVSSPAKLAALWFPEHQRATANMISTMsNPLGLLIANVLSPALVKKADDIPMMLGiYIGPAALACL 199
Cdd:COG0738 99 LLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLILLGLSLSWHLP-YLILAVLLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 200 LATVCLWESVPPTPPSTGAANSTSESFLRglklLIQNKAYVLLAVCF----GGGIGVFSSFSALLEQILcasGYSNEFSG 275
Cdd:COG0738 177 LALLFLRSKLPEIEEEEEEAAGSAASLKS----LLKNPRLLLGGLAIflyvGAEGAIGDWLPLYLKDVL---GLSEATAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 276 LCGALFIVFGILGALLLGLYVDRTKhfteATKIGLCLTSMTSVAFALVSQLQGQTLALAAicslFGLFGFSVA---PVVM 352
Cdd:COG0738 250 LGLSLFWGGMTIGRFLGGFLLKRFG----PVRLLRLSALLAAVGLLLALLAPGPWLALIG----LALVGLGLSlmfPTIF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1907163438 353 ELAVEcSFPVGEGASAGLIFVLGQAeGMLIMLLLTALTVRRTGPSFS 399
Cdd:COG0738 322 SLALD-GLGKRTAAAVSAVLIMGIV-GGAIGPPLIGFLADAFGLRAA 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
149-352 |
8.88e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 149 HQRATANMISTMSNPLGLLIANVLSPALVK-----KADDIPMMLGIYIGPAALACLLATVCLWESVPPTPPSTgaansts 223
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 224 eSFLRGLKLLIQNKAY-VLLAVCFGGGIGVFSSFSALLEQILCASGYSNEFSGLCGALFIVFGILGALLLGLYVDRT-KH 301
Cdd:COG2211 216 -SLKESLKALLKNRPFlLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKK 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907163438 302 FTeaTKIGLCLTSMTSVAFALVSqlQGQTLALAAICSLFGLF--GFSVAPVVM 352
Cdd:COG2211 295 KA--FIIGLLLAALGLLLLFFLG--PGNLWLLLVLAALAGIGlgAILVLPWAM 343
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
55-264 |
1.87e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.75 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 55 SMDQVNWLSLIYFVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSVLRAVpclpvrIPSPFAFFMSGQSLCALAQTLV 134
Cdd:cd17353 36 SLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAF------AISLPLLFLGYGVLGGIGAGIG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 135 VSSPAKLAALWFPEHqRATANMISTMSNPLGLLIANVLSPALVKKADDIPMMLGIYIGPAALACLLATVCLWESVPPTPP 214
Cdd:cd17353 110 YITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPP 188
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907163438 215 STGAANSTSESFLRGL---KLLIQNKAYVL-LAVCFG--GGIGVFSSFSALLEQIL 264
Cdd:cd17353 189 GVDPLANNAENSPRDYtprEMLRTPTFWLLwLMFFLNatAGLMLIGQAKPIGQEFA 244
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
145-395 |
5.07e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 145 WFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADDIPMMLGiyigpAALACLLATVCLWESVPPTPPSTGAANSTSE 224
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV-----AGLVSILAAVLFWLFYREPPAASAATESAST 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 225 SFlRGLKLLIQNKAyvLLAVCFGGGIGVFSSFSALLEQILcasgYSNEFSGL-----CGALFIVFGILGALLLGLYVDRT 299
Cdd:cd17475 187 LL-RSLKEVLRNRD--VWLIAIAGALLVAPQFALLTFLLL----FLHDHLGLsvvaaGALLAVAQLGGALGRIGLGRVSD 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 300 KHFTEATKIGLCLTSMTSVA-FALVSQLQGQT--LALAAICSLFGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQ 376
Cdd:cd17475 260 RVFGGRRRPVLVITAAIAAAaLLVLSLLSPGTplWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINF 339
|
250
....*....|....*....
gi 1907163438 377 AeGMLIMLLLTALTVRRTG 395
Cdd:cd17475 340 I-GIAIGPPLFGLLVDATH 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
147-397 |
6.11e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 6.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 147 PEHQRATANMISTMSNPLGLlianVLSPALVKKADDIPMMLGIYIGPAALACLLATVCLWESVPPTPPSTGaanstsesf 226
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGF----ALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAES--------- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 227 LRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLeqiLCASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFteat 306
Cdd:cd17477 181 ISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLY---GLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRR---- 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 307 KIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVMELAVEcSFPVGEGASAGLIFVLGQAEGMLIMLLL 386
Cdd:cd17477 254 RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGD-RLPGDELVAANAALLLLYGLGSVIGPLL 332
|
250
....*....|.
gi 1907163438 387 TALTVRRTGPS 397
Cdd:cd17477 333 AGALMDAFGPH 343
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-359 |
8.67e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 8.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 42 APVADTIAQHFFLSMDQVNWL----SLIYFVLSIPFGMAAiwvlDSVGLRGATILGAWLNFSGSVLRAvpclpvrIPSPF 117
Cdd:cd17324 19 QGLLPDIARDFGVSVAQAGLLvsayALGYALGALLLGPLS----DRIERRRLLLVLLLLFILGNLLAA-------LAPSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 118 AFFMSGQSLCALAQTLVVSSPAKLAALWFPEHQR--ATANMISTMS------NPLGLLIANVLSPALVkkaddipmMLGI 189
Cdd:cd17324 88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRgrAIGLVFSGLTlglvlgRPLGGLLGQLLGWRAA--------FLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 190 yigpaALACLLATVCLWESVPPTPPStgaaNSTSESFLRGLKLLIQNK----AYVLLAVCFGGGIGVFSSFSALLEQIlc 265
Cdd:cd17324 160 -----AVLALLAALLLWRLLPSLPPK----KPGSLGLLSSLLLLLRNPrlrlAYLITFLLFGGFFALYTYLAPFLTDV-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 266 aSGYSNEFSGLCGALFIVFGILGALLLGLYVDRtkHFTEATKIGLCLTSMTSVAFALVSQLqgqTLALAAICSLFGLFGF 345
Cdd:cd17324 229 -PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR--GGRRALLIALLLLAAALLLLTLLGPS---PLLLLVGLVLWGLGFF 302
|
330
....*....|....
gi 1907163438 346 SVAPVVMELAVECS 359
Cdd:cd17324 303 AAHSALQTRVLRLA 316
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
38-261 |
1.32e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.13 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 38 WLSFAPVA-DTIAQHFFLSMDQVNWLSLI----YFVLSIPFGMAaiwvLDSVGLRGATILGAwlnfsgsVLRAVPCLPVR 112
Cdd:TIGR00886 17 WFAFSPLAvFLIKDDLGLSTAQLGNLVAVpvlaGAVLRIILGFL----VDIFGPRYTTALSL-------LLLAIPCLWAG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 113 IP-SPFAFFMSGQSLCALA-QTLVVSSPakLAALWFPEHQRATANMISTMSNPLGLLIANVLSPALV-----------KK 179
Cdd:TIGR00886 86 LAvQSYSVLLLIRLFIGIAgGSFASCMP--WISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIgslifgggqpaHL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 180 ADDIPMMLGIYIGPAALACLLATVCLWEsvPPTPPSTGAANSTS-ESFLRGLKLLIQNKAYVllaVCFGGGIGVFSSFSA 258
Cdd:TIGR00886 164 AWGWAFVIVPAGILLLPALLIFFVGADT--PPGKPATGKLSFKEaLKVFGNRHTWILALLYS---VTFGSFLGVSSIFAM 238
|
...
gi 1907163438 259 LLE 261
Cdd:TIGR00886 239 LFK 241
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-389 |
1.45e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 63 SLIYFVLSIPFGMAAiwvlDSVGLRGATILGAWLNFSGSVLRAVpclpVRIPSPFAFFMSGQSLCALAQTLVVSSpakLA 142
Cdd:cd17325 41 ALAQLLFSPPAGRLS----DRFGRKRLLLLGLLLLAVSTLLFAF----ATSYWQLLLARFLQGLASAAVWPAAMA---LI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 143 ALWFPEHQRATANMISTMSNPLGLLIANVLSPALVkkadDIPMMLGIYIGPAALAcLLATVCLWESVPPTPPSTGAANST 222
Cdd:cd17325 110 ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA----DALGYRAPFLVCAALA-LLALVLALLLLPEPRPPPNKRAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 223 SESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALL----EQILCASgysnefSGLCGALFIVFGILGALLLGLYVDR 298
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLplyaAELGGLS------PAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 299 TKHFTEATKIGLCLTSMtSVAFALVSqLQGQTLALAAICSLFGLFGFSVAPVVMELAVECSFPVGEGASAGL---IFVLG 375
Cdd:cd17325 259 SDRIGRKPLILIGLLLS-AVALLLLP-LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLfntAFSLG 336
|
330
....*....|....
gi 1907163438 376 QAEGMLIMLLLTAL 389
Cdd:cd17325 337 MVLGPLLGGFLYDA 350
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
61-376 |
8.91e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 61 WLSLIYFVLSIPFGMAAI---WVLDSVGLRGATILGAWLNFSGSVLRAVpclpvrIPSPFAFFMSGqSLCALAQTLVVSS 137
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPfvgRLLDRFGPRRVMLLGLLLLAAGLVLLAL------ATSLWQLYLLW-GLLGGGGAGTLAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 138 PAKLA-ALWFPEHQRATANMISTMSNPLGLLIANVLSPALVKKADDIPMMLGIyiGPAALACLLATVCLWESVPPTPPST 216
Cdd:cd17355 112 VAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVL--ALLALLVLVPVLLLLRRRPADLALR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 217 GAANSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEFSGLCGALFIVFGILGALLLGLYV 296
Cdd:cd17355 190 AYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163438 297 DRtkhfTEATKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVMELAVEcSFPVGEGASA-GLIFVLG 375
Cdd:cd17355 270 DR----YSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAAR-YFGARSYGTLfGLVFAPH 344
|
.
gi 1907163438 376 Q 376
Cdd:cd17355 345 Q 345
|
|
| |
