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Conserved domains on  [gi|1907153782|ref|XP_036019460|]
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coronin-2A isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-517 4.52e-98

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 305.28  E-value: 4.52e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  10 SKFRHVYGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  88 IKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDS 167
Cdd:PTZ00421   81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 168 viagpVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLG-IVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWN 246
Cdd:PTZ00421  161 -----VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGtIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 247 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGIMP 326
Cdd:PTZ00421  236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 327 KRGLDVSSCEIFRFYKLiTTKSLIePVSMIVPRRS--ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRP----- 399
Cdd:PTZ00421  314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAvfdgt 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 400 GSELLDSQTLPPERPLSNSMVQvSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTngfdvfecsppkte 479
Cdd:PTZ00421  392 SPELMGASALSPSGKPRHSGVS-VPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ-------------- 456

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907153782 480 nELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNL 517
Cdd:PTZ00421  457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-517 4.52e-98

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 305.28  E-value: 4.52e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  10 SKFRHVYGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  88 IKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDS 167
Cdd:PTZ00421   81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 168 viagpVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLG-IVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWN 246
Cdd:PTZ00421  161 -----VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGtIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 247 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGIMP 326
Cdd:PTZ00421  236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 327 KRGLDVSSCEIFRFYKLiTTKSLIePVSMIVPRRS--ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRP----- 399
Cdd:PTZ00421  314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAvfdgt 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 400 GSELLDSQTLPPERPLSNSMVQvSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTngfdvfecsppkte 479
Cdd:PTZ00421  392 SPELMGASALSPSGKPRHSGVS-VPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ-------------- 456

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907153782 480 nELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNL 517
Cdd:PTZ00421  457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 7-70 4.41e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 4.41e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907153782   7 YRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGK 70
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-308 5.21e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 5.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  79 CGHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRnlttyrkELIGHARRVGLVEWHPTTaNILFSAGYDYKVM 158
Cdd:cd00200    48 KGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 159 VWNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSLKK 236
Cdd:cd00200   119 VWDVETGK-----CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGevNSVAFSPDGEK 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907153782 237 LLSTGtsrwNNRQMALWDQENLSVPLT-EEDLDGSSGVLFpffdSDTSMLYIVGKGDGNIRYYEVSMEKPHLT 308
Cdd:cd00200   192 LLSSS----SDGTIKLWDLSTGKCLGTlRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
80-301 5.47e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 5.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 159
Cdd:COG2319   160 GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPD-GKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 160 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGSLKKLLS 239
Cdd:COG2319   231 WDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907153782 240 TGtsrwNNRQMALWDQENLSVPLTeedLDGSSGVLFPF-FDSDTSMLyIVGKGDGNIRYYEVS 301
Cdd:COG2319   306 GS----DDGTVRLWDLATGKLLRT---LTGHTGAVRSVaFSPDGKTL-ASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 172-208 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.36e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907153782  172 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVD 208
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-517 4.52e-98

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 305.28  E-value: 4.52e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  10 SKFRHVYGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  88 IKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDS 167
Cdd:PTZ00421   81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 168 viagpVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLG-IVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWN 246
Cdd:PTZ00421  161 -----VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGtIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 247 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGIMP 326
Cdd:PTZ00421  236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 327 KRGLDVSSCEIFRFYKLiTTKSLIePVSMIVPRRS--ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRP----- 399
Cdd:PTZ00421  314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAvfdgt 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 400 GSELLDSQTLPPERPLSNSMVQvSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTngfdvfecsppkte 479
Cdd:PTZ00421  392 SPELMGASALSPSGKPRHSGVS-VPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ-------------- 456

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907153782 480 nELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNL 517
Cdd:PTZ00421  457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
PTZ00420 PTZ00420
coronin; Provisional
 19-389 4.89e-66

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 223.67  E-value: 4.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  19 PASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKlDPHYPKVCGHRGNVLDIKWNPFNDFEI 98
Cdd:PTZ00420   12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR-KPPVIKLKGHTSSILDLQFNPCFSEIL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  99 ASCSEDATIKIWNIPKQllTRNLTTYRKE---LIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSV--IAGPV 173
Cdd:PTZ00420   91 ASGSEDLTIRVWEIPHN--DESVKEIKDPqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 174 KtinchqdvILSMSFNTNGSLLATTCKDRKIRIVDPRLgivlQEAS-----YKGHRANKVLFL----GSLKKLLSTGTSR 244
Cdd:PTZ00420  169 K--------LSSLKWNIKGNLLSGTCVGKHMHIIDPRK----QEIAssfhiHDGGKNTKNIWIdglgGDDNYILSTGFSK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 245 WNNRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGI 324
Cdd:PTZ00420  237 NNMREMKLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGF 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907153782 325 MPKRGLDVSSCEIFRFYKlITTKSLIEPVSMIVPRRSES-YQEDIYPPTAAAQPSLTAHEWLSGMN 389
Cdd:PTZ00420  315 LPKQICDVYKCEIGRVYK-NENNSSIRPISFYVPRKNPTkFQEDLYPPILMHDPERSSRNWIDGKD 379
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 7-70 4.41e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 4.41e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907153782   7 YRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGK 70
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-308 5.21e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 5.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  79 CGHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRnlttyrkELIGHARRVGLVEWHPTTaNILFSAGYDYKVM 158
Cdd:cd00200    48 KGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 159 VWNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSLKK 236
Cdd:cd00200   119 VWDVETGK-----CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGevNSVAFSPDGEK 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907153782 237 LLSTGtsrwNNRQMALWDQENLSVPLT-EEDLDGSSGVLFpffdSDTSMLYIVGKGDGNIRYYEVSMEKPHLT 308
Cdd:cd00200   192 LLSSS----SDGTIKLWDLSTGKCLGTlRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-309 6.62e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 6.62e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTTaNILFSAGYDYKVMV 159
Cdd:cd00200     7 GHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASADG-TYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 160 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGivLQEASYKGHRA--NKVLFLGSlKKL 237
Cdd:cd00200    78 WDLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDwvNSVAFSPD-GTF 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907153782 238 LSTGtsrWNNRQMALWDQENLSVpltEEDLDGSSG----VLFpffdSDTSMLYIVGKGDGNIRYYEVSMEKPHLTY 309
Cdd:cd00200   150 VASS---SQDGTIKLWDLRTGKC---VATLTGHTGevnsVAF----SPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-299 7.80e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 7.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKqlltrnlTTYRKELIGHARRVGLVEWHPTTaNILFSAGYDYKVMV 159
Cdd:cd00200    91 GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-------GKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 160 WNLDTkdsviAGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSlKKL 237
Cdd:cd00200   162 WDLRT-----GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG--TLRGHENgvNSVAFSPD-GYL 233

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907153782 238 LSTGTSrwnNRQMALWDQENLSVPLTeedLDG-SSGVLFPFFDSDTSMLyIVGKGDGNIRYYE 299
Cdd:cd00200   234 LASGSE---DGTIRVWDLRTGECVQT---LSGhTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
80-301 5.47e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 5.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 159
Cdd:COG2319   160 GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPD-GKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 160 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGSLKKLLS 239
Cdd:COG2319   231 WDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907153782 240 TGtsrwNNRQMALWDQENLSVPLTeedLDGSSGVLFPF-FDSDTSMLyIVGKGDGNIRYYEVS 301
Cdd:COG2319   306 GS----DDGTVRLWDLATGKLLRT---LTGHTGAVRSVaFSPDGKTL-ASGSDDGTVRLWDLA 360
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 350-392 5.45e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 80.25  E-value: 5.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907153782 350 IEPVSMIVPRRS-ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGP 392
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
80-254 3.16e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 3.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPfNDFEIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 159
Cdd:COG2319   244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT-------GHSGGVNSVAFSPD-GKLLASGSDDGTVRL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 160 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEasYKGHRA--NKVLFLGSLKKL 237
Cdd:COG2319   315 WDLATGK-----LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT--LTGHTGavTSVAFSPDGRTL 387

                         170
                  ....*....|....*..
gi 1907153782 238 LSTGtsrwNNRQMALWD 254
Cdd:COG2319   388 ASGS----ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
80-210 3.73e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 3.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 159
Cdd:COG2319   286 GHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPD-GKTLASGSDDGTVRL 356

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907153782 160 WNLDTKdsviaGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPR 210
Cdd:COG2319   357 WDLATG-----ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
80-296 5.39e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 5.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPfNDFEIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 159
Cdd:COG2319    76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLT-------GHTGAVRSVAFSPD-GKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 160 WNLDTkdsviAGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSLKKL 237
Cdd:COG2319   147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--TLTGHTGavRSVAFSPDGKLL 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 238 LSTGtsrwNNRQMALWDQENLSVPLTeedLDG-SSGVLFPFFDSDTSMLYIVGkGDGNIR 296
Cdd:COG2319   220 ASGS----ADGTVRLWDLATGKLLRT---LTGhSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
80-164 4.38e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 4.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 159
Cdd:COG2319   328 GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLT-------GHTGAVTSVAFSPD-GRTLASGSADGTVRL 398


                  ....*
gi 1907153782 160 WNLDT 164
Cdd:COG2319   399 WDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-309 8.96e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 8.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 172 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLqeASYKGHRA--NKVLFLGSLKKLLSTGtsrwNNRQ 249
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL--RTLKGHTGpvRDVAASADGTYLASGS----SDKT 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907153782 250 MALWDQENLSVPLTeedLDG-SSGVLFPFFDSDTSMLyIVGKGDGNIRYYEVSMEKPHLTY 309
Cdd:cd00200    75 IRLWDLETGECVRT---LTGhTSYVSSVAFSPDGRIL-SSSSRDKTIKVWDVETGKCLTTL 131
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 172-208 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.36e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907153782  172 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVD 208
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-111 1.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.61e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907153782   80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWN 111
Cdd:smart00320  10 GHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
80-111 7.27e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.27e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907153782  80 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWN 111
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
172-208 1.09e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907153782 172 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVD 208
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 72-324 1.70e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782  72 DPHYPKV-CGHRGNVLDIKWNPFNDFEIASCSEDATIKIWNIPK-QLLTrnlttyrkELIGHARRVGLVEWHPTTANILF 149
Cdd:PLN00181  521 DIHYPVVeLASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARsQLVT--------EMKEHEKRVWSIDYSSADPTLLA 592

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 150 SAGYDYKVMVWNLDTKDSViaGPVKTinchQDVILSMSFNTN-GSLLATTCKDRKIRIVD---PRLGIVLQEASYKghRA 225
Cdd:PLN00181  593 SGSDDGSVKLWSINQGVSI--GTIKT----KANICCVQFPSEsGRSLAFGSADHKVYYYDlrnPKLPLCTMIGHSK--TV 664

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153782 226 NKVLFLGSlkkllSTGTSRWNNRQMALWDQENLSVPLTEEDLDGSSG--VLFPFFDSDTSMLYIVGKGDGN-IRYYEVSM 302
Cdd:PLN00181  665 SYVRFVDS-----STLVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtNVKNFVGLSVSDGYIATGSETNeVFVYHKAF 739

                         250       260
                  ....*....|....*....|..
gi 1907153782 303 EKPHLTYLteYRSYNPQKGIGI 324
Cdd:PLN00181  740 PMPVLSYK--FKTIDPVSGLEV 759
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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