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Conserved domains on  [gi|1907150267|ref|XP_036018955|]
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ADAMTS-like protein 4 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 450-563 3.43e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 118.06  E-value: 3.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 450 LVSGNLTdRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYTAIGTVFQYNRPPREe 528
Cdd:pfam05986   1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907150267 529 gkGESLSAEGPTTQPVDVYMIFQED---NPGVFYQYVI 563
Cdd:pfam05986  79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 691-747 1.80e-16

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 74.03  E-value: 1.80e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150267 691 WEAGEWTSCSRSCGPGTQHRQLLCRQEfgGGGSSVPPERCGHLPRPNITQPCQLHLC 747
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 750-805 1.19e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 1.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907150267 750 WEISsPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREACDMGPC 805
Cdd:pfam19030   1 WVAG-PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 170-360 5.14e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  170 HRPGQPKNSSTGE------GMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTS 243
Cdd:PHA03247  2587 RRPDAPPQSARPRapvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  244 SFGDSRSFQGSL---GPRMPPSPGSWSSPQGAERRHPPPFSPVPRSQQ-SRRHWRPPGPHRSPDGWLPLTRDSSPLWSIF 319
Cdd:PHA03247  2667 ARRLGRAAQASSppqRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHAlVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1907150267  320 APSIPAPNCSGESEQMRACSQEPCPPEQP---DPRALQCAAFDS 360
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGPPAPAPPAAPaagPPRRLTRPAVAS 2790
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 46-70 1.83e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....*
gi 1907150267   46 WGPWGRWASCSQPCGVGVQRRSRTC 70
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 638-687 6.24e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 6.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907150267 638 SECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASpEPCHGPPC 687
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 354-448 6.52e-05

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 43.16  E-value: 6.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 354 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GSLDICVAGRCL 421
Cdd:pfam19236   9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                          90       100
                  ....*....|....*....|....*..
gi 1907150267 422 SPGCDGVLGSGRRPDGCGVCGGDGSTC 448
Cdd:pfam19236  89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 450-563 3.43e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 118.06  E-value: 3.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 450 LVSGNLTdRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYTAIGTVFQYNRPPREe 528
Cdd:pfam05986   1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907150267 529 gkGESLSAEGPTTQPVDVYMIFQED---NPGVFYQYVI 563
Cdd:pfam05986  79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 691-747 1.80e-16

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 74.03  E-value: 1.80e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150267 691 WEAGEWTSCSRSCGPGTQHRQLLCRQEfgGGGSSVPPERCGHLPRPNITQPCQLHLC 747
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 750-805 1.19e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 1.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907150267 750 WEISsPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREACDMGPC 805
Cdd:pfam19030   1 WVAG-PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PHA03247 PHA03247
large tegument protein UL36; Provisional
 170-360 5.14e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  170 HRPGQPKNSSTGE------GMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTS 243
Cdd:PHA03247  2587 RRPDAPPQSARPRapvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  244 SFGDSRSFQGSL---GPRMPPSPGSWSSPQGAERRHPPPFSPVPRSQQ-SRRHWRPPGPHRSPDGWLPLTRDSSPLWSIF 319
Cdd:PHA03247  2667 ARRLGRAAQASSppqRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHAlVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1907150267  320 APSIPAPNCSGESEQMRACSQEPCPPEQP---DPRALQCAAFDS 360
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGPPAPAPPAAPaagPPRRLTRPAVAS 2790
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 46-70 1.83e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....*
gi 1907150267   46 WGPWGRWASCSQPCGVGVQRRSRTC 70
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 747-805 2.23e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 2.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907150267  747 CGHWeisSPWSQCSVRCGRGQRSRQVRCVGSNGDeVDKQECasgPPPPPSREACDMGPC 805
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 638-687 6.24e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 6.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907150267 638 SECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASpEPCHGPPC 687
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 354-448 6.52e-05

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 43.16  E-value: 6.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 354 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GSLDICVAGRCL 421
Cdd:pfam19236   9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                          90       100
                  ....*....|....*....|....*..
gi 1907150267 422 SPGCDGVLGSGRRPDGCGVCGGDGSTC 448
Cdd:pfam19236  89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 47-69 8.51e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.03  E-value: 8.51e-04
                          10        20
                  ....*....|....*....|...
gi 1907150267  47 GPWGRWASCSQPCGVGVQRRSRT 69
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRT 26
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 691-747 1.30e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 1.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150267  691 WEAGEWTSCSRSCGPGTQHRQLLCRqefgGGGSSVPPERCGHLPRpnITQPCQLHLC 747
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 747-795 1.72e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907150267 747 CGHWEissPWSQCSVRCGRGQRSRQ-----VRCVGSNGDEVDKQECASGPPPPP 795
Cdd:PTZ00441  240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEECPVEPEPLP 290
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 450-563 3.43e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 118.06  E-value: 3.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 450 LVSGNLTdRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYTAIGTVFQYNRPPREe 528
Cdd:pfam05986   1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907150267 529 gkGESLSAEGPTTQPVDVYMIFQED---NPGVFYQYVI 563
Cdd:pfam05986  79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 691-747 1.80e-16

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 74.03  E-value: 1.80e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150267 691 WEAGEWTSCSRSCGPGTQHRQLLCRQEfgGGGSSVPPERCGHLPRPNITQPCQLHLC 747
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 750-805 1.19e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 1.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907150267 750 WEISsPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREACDMGPC 805
Cdd:pfam19030   1 WVAG-PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PHA03247 PHA03247
large tegument protein UL36; Provisional
 170-360 5.14e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  170 HRPGQPKNSSTGE------GMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTS 243
Cdd:PHA03247  2587 RRPDAPPQSARPRapvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  244 SFGDSRSFQGSL---GPRMPPSPGSWSSPQGAERRHPPPFSPVPRSQQ-SRRHWRPPGPHRSPDGWLPLTRDSSPLWSIF 319
Cdd:PHA03247  2667 ARRLGRAAQASSppqRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHAlVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1907150267  320 APSIPAPNCSGESEQMRACSQEPCPPEQP---DPRALQCAAFDS 360
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGPPAPAPPAAPaagPPRRLTRPAVAS 2790
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 46-70 1.83e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....*
gi 1907150267   46 WGPWGRWASCSQPCGVGVQRRSRTC 70
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 747-805 2.23e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 2.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907150267  747 CGHWeisSPWSQCSVRCGRGQRSRQVRCVGSNGDeVDKQECasgPPPPPSREACDMGPC 805
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 638-687 6.24e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 6.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907150267 638 SECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASpEPCHGPPC 687
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 354-448 6.52e-05

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 43.16  E-value: 6.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 354 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GSLDICVAGRCL 421
Cdd:pfam19236   9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                          90       100
                  ....*....|....*....|....*..
gi 1907150267 422 SPGCDGVLGSGRRPDGCGVCGGDGSTC 448
Cdd:pfam19236  89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 47-69 8.51e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.03  E-value: 8.51e-04
                          10        20
                  ....*....|....*....|...
gi 1907150267  47 GPWGRWASCSQPCGVGVQRRSRT 69
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRT 26
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 691-747 1.30e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 1.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150267  691 WEAGEWTSCSRSCGPGTQHRQLLCRqefgGGGSSVPPERCGHLPRpnITQPCQLHLC 747
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 747-795 1.72e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907150267 747 CGHWEissPWSQCSVRCGRGQRSRQ-----VRCVGSNGDEVDKQECASGPPPPP 795
Cdd:PTZ00441  240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEECPVEPEPLP 290
TSP_1 pfam00090
Thrombospondin type 1 domain;
47-70 2.74e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 2.74e-03
                          10        20
                  ....*....|....*....|....
gi 1907150267  47 GPWGRWASCSQPCGVGVQRRSRTC 70
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTC 24
TSP_1 pfam00090
Thrombospondin type 1 domain;
754-805 4.19e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 4.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907150267 754 SPWSQCSVRCGRGQRSRQVRCvgsngdevDKQECASGPPPPPSRE--ACDMGPC 805
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTC--------KSPFPGGEPCTGDDIEtqACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 694-747 6.74e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 6.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907150267 694 GEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPErcghlprpNITQPCQLHLC 747
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL--------LERRPCNLPPC 52
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
90-324 6.78e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267  90 RPRGQGSRpQTPRDPQSLYRPQPRGRGGPLRAPASQVGREETQEPQGAQRFRVRDPIKPGMFGYGRVPFALPLHRSRRHP 169
Cdd:PRK12323  364 RPGQSGGG-AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 170 HRPGQPKNSSTGEGM-VPSQPPSTELASEKHGPHMQPPEPRSHSAETprsgTAQTEVLPRTSSAPSYTGTPAPTSSFGDS 248
Cdd:PRK12323  443 GPGGAPAPAPAPAAApAAAARPAAAGPRPVAAAAAAAPARAAPAAAP----APADDDPPPWEELPPEFASPAPAQPDAAP 518

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907150267 249 RSFQGSLGPRmppSPGSWSSPQGAERRHPPPFSPVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSplWSIFAPSIP 324
Cdd:PRK12323  519 AGWVAESIPD---PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGD--WPALAARLP 589
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 110-303 9.62e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 9.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 110 PQPRGRGGPLRAPASQVGREETQEPQGAQRfrvrdPIKPGMFGYGRVPFALPLHRSRRHPHRPGQPKNSSTGEGMVPSQP 189
Cdd:PRK07764  603 PASSGPPEEAARPAAPAAPAAPAAPAPAGA-----AAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150267 190 PSTElasekhGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTSSFGDSRSFQGSLGPRMPPSPGSWSSP 269
Cdd:PRK07764  678 PAAP------PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDP 751

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907150267 270 QGAERRHPPPFSPVPRSQQSRrhwRPPGPHRSPD 303
Cdd:PRK07764  752 AGAPAQPPPPPAPAPAAAPAA---APPPSPPSEE 782
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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