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Conserved domains on  [gi|1907117313|ref|XP_036015762|]
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palmitoyl-protein thioesterase ABHD10, mitochondrial isoform X1 [Mus musculus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 56-179 2.74e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 63.48  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  56 NLAYKRLKGKTPGIIFIPGYLSNMNGIKAVAvEEFCKslGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEG 135
Cdd:COG0596    13 RLHYREAGPDGPPVVLLHGLPGSSYEWRPLI-PALAA--GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907117313 136 PQILVGSSLGGWLMLHAAIARPEKVIALIGIATAADGLVTQYHA 179
Cdd:COG0596    90 RVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLRR 133
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 56-179 2.74e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 63.48  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  56 NLAYKRLKGKTPGIIFIPGYLSNMNGIKAVAvEEFCKslGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEG 135
Cdd:COG0596    13 RLHYREAGPDGPPVVLLHGLPGSSYEWRPLI-PALAA--GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907117313 136 PQILVGSSLGGWLMLHAAIARPEKVIALIGIATAADGLVTQYHA 179
Cdd:COG0596    90 RVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLRR 133
PLN02578 PLN02578
hydrolase
 102-164 4.34e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 49.45  E-value: 4.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907117313 102 DYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEGPQILVGSSLGGWLMLHAAIARPEKVIALI 164
Cdd:PLN02578  119 DLLGFGWSDKALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVA 181
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 135-166 1.01e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 42.23  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907117313 135 GPQILVGSSLGGWLMLHAAIARPEKVIALIGI 166
Cdd:cd12808   188 GPCIVVAHSQGGGFAFEAARARPDLVRAVVAL 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 69-175 7.44e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.41  E-value: 7.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  69 IIFIPGYLSNMNG----IKAVAveefckSLGHAFIRFDYSGIGSSDGNLAECTVGKW--RKDVLSILDDVAEGPQILVGS 142
Cdd:pfam00561   3 VLLLHGLPGSSDLwrklAPALA------RDGFRVIALDLRGFGKSSRPKAQDDYRTDdlAEDLEYILEALGLEKVNLVGH 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907117313 143 SLGGWLMLHAAIARPEKVIALIGIATAADGLVT 175
Cdd:pfam00561  77 SMGGLIALAYAAKYPDRVKALVLLGALDPPHEL 109
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 69-164 4.04e-03

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 37.10  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  69 IIFIPGYLSNMNGIKAVAV---EEFCKsLGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSI---LDDVAEGPQILVGS 142
Cdd:TIGR03101  28 VIYLPPFAEEMNKSRRMVAlqaRAFAA-GGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAyrwLIEQGHPPVTLWGL 106

                          90       100
                  ....*....|....*....|..
gi 1907117313 143 SLGGWLMLHAAIARPEKVIALI 164
Cdd:TIGR03101 107 RLGALLALDAANPLAAKCNRLV 128
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 56-179 2.74e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 63.48  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  56 NLAYKRLKGKTPGIIFIPGYLSNMNGIKAVAvEEFCKslGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEG 135
Cdd:COG0596    13 RLHYREAGPDGPPVVLLHGLPGSSYEWRPLI-PALAA--GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907117313 136 PQILVGSSLGGWLMLHAAIARPEKVIALIGIATAADGLVTQYHA 179
Cdd:COG0596    90 RVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLRR 133
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
62-169 7.86e-11

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 59.57  E-value: 7.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  62 LKGKTPGIIFIPGYLSNMNGIKAVAveEFCKSLGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEG--PQIL 139
Cdd:COG1647    11 LEGGRKGVLLLHGFTGSPAEMRPLA--EALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGydKVIV 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907117313 140 VGSSLGGWLMLHAAIARPEkVIALIGIATA 169
Cdd:COG1647    89 IGLSMGGLLALLLAARYPD-VAGLVLLSPA 117
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
69-169 6.22e-09

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 53.85  E-value: 6.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  69 IIFIPGYLSNMNGIKAVAvEEFCKSlGHAFIRFDYSGIGSSDGNLAEC-TVGKWRKDVLSILDDVAE---GPQILVGSSL 144
Cdd:COG2267    31 VVLVHGLGEHSGRYAELA-EALAAA-GYAVLAFDLRGHGRSDGPRGHVdSFDDYVDDLRAALDALRArpgLPVVLLGHSM 108

                          90       100
                  ....*....|....*....|....*
gi 1907117313 145 GGWLMLHAAIARPEKVIALIGIATA 169
Cdd:COG2267   109 GGLIALLYAARYPDRVAGLVLLAPA 133
PLN02578 PLN02578
hydrolase
 102-164 4.34e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 49.45  E-value: 4.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907117313 102 DYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEGPQILVGSSLGGWLMLHAAIARPEKVIALI 164
Cdd:PLN02578  119 DLLGFGWSDKALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVA 181
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
63-171 4.34e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 48.86  E-value: 4.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  63 KGKTPGIIFIPGYLSNMNGIKAVAVEEFCkSLGHAFIRFDYSGIGSSDGNLAectvGKWRKDVLSILDDVAEGPQI---- 138
Cdd:COG1506    20 GKKYPVVVYVHGGPGSRDDSFLPLAQALA-SRGYAVLAPDYRGYGESAGDWG----GDEVDDVLAAIDYLAARPYVdpdr 94

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907117313 139 --LVGSSLGGWLMLHAAIARPEKVIALIGIATAAD 171
Cdd:COG1506    95 igIYGHSYGGYMALLAAARHPDRFKAAVALAGVSD 129
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 135-166 1.01e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 42.23  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907117313 135 GPQILVGSSLGGWLMLHAAIARPEKVIALIGI 166
Cdd:cd12808   188 GPCIVVAHSQGGGFAFEAARARPDLVRAVVAL 219
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
91-170 3.34e-04

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 40.15  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  91 CKSLGHAFIRFDYSGIGSSDGNLAEcTVGKwRKDVLSILDDVAE---GPQILVGSSLGGWLMLHAAIARPEkVIALIGIA 167
Cdd:COG2945    51 LVAAGFAVLRFNFRGVGRSEGEFDE-GRGE-LDDAAAALDWLRAqnpLPLWLAGFSFGAYVALQLAMRLPE-VEGLILVA 127


                  ...
gi 1907117313 168 TAA 170
Cdd:COG2945   128 PPV 130
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 69-175 7.44e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.41  E-value: 7.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  69 IIFIPGYLSNMNG----IKAVAveefckSLGHAFIRFDYSGIGSSDGNLAECTVGKW--RKDVLSILDDVAEGPQILVGS 142
Cdd:pfam00561   3 VLLLHGLPGSSDLwrklAPALA------RDGFRVIALDLRGFGKSSRPKAQDDYRTDdlAEDLEYILEALGLEKVNLVGH 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907117313 143 SLGGWLMLHAAIARPEKVIALIGIATAADGLVT 175
Cdd:pfam00561  77 SMGGLIALAYAAKYPDRVKALVLLGALDPPHEL 109
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 95-172 9.00e-04

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 39.54  E-value: 9.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907117313  95 GHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEGPQILVGSSLGGWLMLHAAIARPEKVIALIGIATAADG 172
Cdd:PRK14875  157 GRPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIERAHLVGHSMGGAVALRLAARAPQRVASLTLIAPAGLG 234
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 94-171 1.63e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 38.36  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  94 LGHAFIRFDYSGIGSSDGNLAEctVGK-WRKDV------LSILDDVAEGPQILVGSSLGGWLMLHAAIARPEkVIALIGI 166
Cdd:COG1073    63 LGFNVLAFDYRGYGESEGEPRE--EGSpERRDAraavdyLRTLPGVDPERIGLLGISLGGGYALNAAATDPR-VKAVILD 139


                  ....*
gi 1907117313 167 ATAAD 171
Cdd:COG1073   140 SPFTS 144
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
93-161 2.71e-03

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 37.94  E-value: 2.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907117313  93 SLGHAFIRFDYSGIGSS-DGNLAECTVGK--W-RKDVLSILDDVAE----GPQILVGSSLGGWLM-LHAAIARPEKVI 161
Cdd:COG4757    57 ERGFAVLTYDYRGIGLSrPGSLRGFDAGYrdWgELDLPAVLDALRArfpgLPLLLVGHSLGGQLLgLAPNAERVDRLV 134
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 88-169 3.34e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 37.58  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  88 EEFCKSL---GHAFIRFDYSGIGSSDGNLAECT-VGKWRKDVLSILDDVAEG----PQILVGSSLGGWLMLHAAIARPEK 159
Cdd:pfam12146  21 AHLADALaaqGFAVYAYDHRGHGRSDGKRGHVPsFDDYVDDLDTFVDKIREEhpglPLFLLGHSMGGLIAALYALRYPDK 100

                          90
                  ....*....|
gi 1907117313 160 VIALIGIATA 169
Cdd:pfam12146 101 VDGLILSAPA 110
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 69-164 4.04e-03

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 37.10  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  69 IIFIPGYLSNMNGIKAVAV---EEFCKsLGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSI---LDDVAEGPQILVGS 142
Cdd:TIGR03101  28 VIYLPPFAEEMNKSRRMVAlqaRAFAA-GGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAyrwLIEQGHPPVTLWGL 106

                          90       100
                  ....*....|....*....|..
gi 1907117313 143 SLGGWLMLHAAIARPEKVIALI 164
Cdd:TIGR03101 107 RLGALLALDAANPLAAKCNRLV 128
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 69-173 8.08e-03

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 36.30  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117313  69 IIFIPGYlsnmnGIKAVAVEEFCKSlGHAFIRFDYSGIGSSDGNLAECTVgkwRKDVLSILDDVAEGPQ-ILVGSSLGGW 147
Cdd:pfam12697   1 VVLVHGA-----GLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLDLAD---LADLAALLDELGAARPvVLVGHSLGGA 71

                          90       100
                  ....*....|....*....|....*.
gi 1907117313 148 LMLHAAIARPEKVIALIGIATAADGL 173
Cdd:pfam12697  72 VALAAAAAALVVGVLVAPLAAPPGLL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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