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Conserved domains on  [gi|1907116668|ref|XP_036015677|]
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protein HIRA isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 734-916 3.82e-59

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 201.69  E-value: 3.82e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 734 LHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGS---------DMTVSQILLTQHGIPVMNLSDGKAYCFNPS 804
Cdd:pfam07569  17 LECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGVPIVTLSNGDGYLYDKS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 805 LSTWNLVSDKQDSLA-QCADFRNSLPSQDAMLCSGPLAIIQGRTSN--SGRQAARLFSVPHVV----------QQETTLA 871
Cdd:pfam07569  97 LETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKTNEelLRKGRGRLLQRLAKTllmkegfenfETVVTLA 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907116668 872 YLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICKDL 916
Cdd:pfam07569 177 HLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
25-308 4.97e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 104
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 105 CSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 184
Cdd:COG2319   222 GSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSV 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 185 SWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSTkpscpycccAVGSKDRS 264
Cdd:COG2319   295 AFSPDGKLLASG----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---------ASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1907116668 265 LSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSV 308
Cdd:COG2319   354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
Treacle super family cl25490
Treacher Collins syndrome protein Treacle;
439-668 3.37e-06

Treacher Collins syndrome protein Treacle;


The actual alignment was detected with superfamily member pfam03546:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 50.84  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 439 PLSSSLAgtmLSSPSGQQLLPLDSSTPSFGASKPCTEPVAATSARPTG------------ESVSKDSMNATSTPAASS-- 504
Cdd:pfam03546 113 TLTTSPA---QVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAplvqvgkkeedsESSSEESDSEGEAPPAATqa 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 505 -PSVLTTPSKIEPMKAFDSRFTERSKATPGApslTSViptAVERLKEQnlvkelrSRELESSSDSDEKVHLAKPSSLSKR 583
Cdd:pfam03546 190 kPSGKILQVRPASGPAKGAAPAPPQKAGPVA---TQV---KAERSKED-------SESSEESSDSEEEAPAAATPAQAKP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 584 KLELEvETVEKKKKGRP--RKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALAlklpiPGPQRAFTLQVSSDPSMYIEVE 661
Cdd:pfam03546 257 ALKTP-QTKASPRKGTPitPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVA-----RGAQRPEEDSSSSEESESEEET 330


                  ....*..
gi 1907116668 662 NEVTTVG 668
Cdd:pfam03546 331 APAAAVG 337
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 734-916 3.82e-59

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 201.69  E-value: 3.82e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 734 LHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGS---------DMTVSQILLTQHGIPVMNLSDGKAYCFNPS 804
Cdd:pfam07569  17 LECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGVPIVTLSNGDGYLYDKS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 805 LSTWNLVSDKQDSLA-QCADFRNSLPSQDAMLCSGPLAIIQGRTSN--SGRQAARLFSVPHVV----------QQETTLA 871
Cdd:pfam07569  97 LETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKTNEelLRKGRGRLLQRLAKTllmkegfenfETVVTLA 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907116668 872 YLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICKDL 916
Cdd:pfam07569 177 HLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
25-308 4.97e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 104
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 105 CSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 184
Cdd:COG2319   222 GSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSV 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 185 SWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSTkpscpycccAVGSKDRS 264
Cdd:COG2319   295 AFSPDGKLLASG----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---------ASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1907116668 265 LSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSV 308
Cdd:COG2319   354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-308 2.56e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 2.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWKRAT------------------YIGPSTVFGSSG-----KLANVEQWRCVS 81
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrtlkghtgpvrdvaASADGTYLASGSsdktiRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  82 ILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLD 161
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 162 WQLETSItkpfdecggTTH---VLRLSWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP--KI 236
Cdd:cd00200   167 GKCVATL---------TGHtgeVNSVAFSPDGEKLLSS----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPdgYL 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907116668 237 FkkkqkngsstkpscpycccAVGSKDRSLSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSV 308
Cdd:cd00200   234 L-------------------ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 76-115 2.34e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.34e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907116668   76 QWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 115
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
77-115 3.83e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.83e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907116668  77 WRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 115
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
439-668 3.37e-06

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 50.84  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 439 PLSSSLAgtmLSSPSGQQLLPLDSSTPSFGASKPCTEPVAATSARPTG------------ESVSKDSMNATSTPAASS-- 504
Cdd:pfam03546 113 TLTTSPA---QVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAplvqvgkkeedsESSSEESDSEGEAPPAATqa 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 505 -PSVLTTPSKIEPMKAFDSRFTERSKATPGApslTSViptAVERLKEQnlvkelrSRELESSSDSDEKVHLAKPSSLSKR 583
Cdd:pfam03546 190 kPSGKILQVRPASGPAKGAAPAPPQKAGPVA---TQV---KAERSKED-------SESSEESSDSEEEAPAAATPAQAKP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 584 KLELEvETVEKKKKGRP--RKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALAlklpiPGPQRAFTLQVSSDPSMYIEVE 661
Cdd:pfam03546 257 ALKTP-QTKASPRKGTPitPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVA-----RGAQRPEEDSSSSEESESEEET 330


                  ....*..
gi 1907116668 662 NEVTTVG 668
Cdd:pfam03546 331 APAAAVG 337
PTZ00420 PTZ00420
coronin; Provisional
 83-157 2.96e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  83 LRSHSGDVMDVAWSP-HDAWLASCSVDNTVVIW---------NAVKFPeiLATLRGHSGLVKGLTWDPVGKYI-ASQADD 151
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndesvKEIKDP--QCILKGHKKKISIIDWNPMNYYImCSSGFD 147


                  ....*.
gi 1907116668 152 RSLKVW 157
Cdd:PTZ00420  148 SFVNIW 153
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 734-916 3.82e-59

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 201.69  E-value: 3.82e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 734 LHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGS---------DMTVSQILLTQHGIPVMNLSDGKAYCFNPS 804
Cdd:pfam07569  17 LECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGVPIVTLSNGDGYLYDKS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 805 LSTWNLVSDKQDSLA-QCADFRNSLPSQDAMLCSGPLAIIQGRTSN--SGRQAARLFSVPHVV----------QQETTLA 871
Cdd:pfam07569  97 LETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKTNEelLRKGRGRLLQRLAKTllmkegfenfETVVTLA 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907116668 872 YLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICKDL 916
Cdd:pfam07569 177 HLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
25-308 4.97e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 104
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 105 CSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 184
Cdd:COG2319   222 GSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSV 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 185 SWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSSTkpscpycccAVGSKDRS 264
Cdd:COG2319   295 AFSPDGKLLASG----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL---------ASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1907116668 265 LSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSV 308
Cdd:COG2319   354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-308 2.56e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 2.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWKRAT------------------YIGPSTVFGSSG-----KLANVEQWRCVS 81
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrtlkghtgpvrdvaASADGTYLASGSsdktiRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  82 ILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLD 161
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 162 WQLETSItkpfdecggTTH---VLRLSWSPDGHYLVSAhamnNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP--KI 236
Cdd:cd00200   167 GKCVATL---------TGHtgeVNSVAFSPDGEKLLSS----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPdgYL 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907116668 237 FkkkqkngsstkpscpycccAVGSKDRSLSVWLTCLKRPLVVIHElFDKSIMDISWTLNGLGILVCSMDGSV 308
Cdd:cd00200   234 L-------------------ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
25-323 7.94e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 7.94e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 104
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLW-------------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 105 CSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 184
Cdd:COG2319   180 GSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT------GHSGSVRSV 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 185 SWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSStkpscpyccCAVGSKDRS 264
Cdd:COG2319   253 AFSPDGRLLASGSA----DGTVRLWDLATGELLRTLTGHSGGVNSVAFSP--------DGKL---------LASGSDDGT 311

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907116668 265 LSVWlTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 323
Cdd:COG2319   312 VRLW-DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
25-323 1.96e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 1.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 104
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLW-------------------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 105 CSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRL 184
Cdd:COG2319   138 GSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT------GHTGAVRSV 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 185 SWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSStkpscpyccCAVGSKDRS 264
Cdd:COG2319   211 AFSPDGKLLASGSA----DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRL---------LASGSADGT 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907116668 265 LSVWLTCLKRPLVVIHELFDkSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLS 323
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-196 1.59e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.59e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  12 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATY-----------------IGPSTVFGSSG----- 69
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGkclttlrghtdwvnsvaFSPDGTFVASSsqdgt 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  70 -KLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQ 148
Cdd:cd00200   159 iKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907116668 149 ADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSA 196
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLS------GHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
25-159 4.47e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 4.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSG-----------------------KLANVEQWRCVS 81
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvnsvafspdgkllasgsddgtvRLWDLATGKLLR 324

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907116668  82 ILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRT 159
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
62-323 6.28e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 6.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  62 STVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPV 141
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 142 GKYIASQADDRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAHamnnSGPTAQIIEREGWKTNMDFV 221
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLRTLT------GHSGAVTSVAFSPDGKLLASGS----DDGTVRLWDLATGKLLRTLT 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 222 GHRKAVTVVKFNP--KIFkkkqkngsstkpscpycccAVGSKDRSLSVW-LTclKRPLVVIHELFDKSIMDISWTLNGLG 298
Cdd:COG2319   202 GHTGAVRSVAFSPdgKLL-------------------ASGSADGTVRLWdLA--TGKLLRTLTGHSGSVRSVAFSPDGRL 260

                         250       260
                  ....*....|....*....|....*
gi 1907116668 299 ILVCSMDGSVAFLDFSQDELGDPLS 323
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLT 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-158 3.95e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 3.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  25 HLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWSPHDAWLAS 104
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLW-------------------DLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907116668 105 CSVDNTVVIWNAVKFpEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR 158
Cdd:cd00200   237 GSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-328 6.27e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 6.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  79 CVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNaVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWr 158
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 159 tlDWQLETSITKPFDECGGtthVLRLSWSPDGHYLVSAHAMNnsgpTAQIIEREGWKTNMDFVGHRKAVTVVKFNPkifk 238
Cdd:cd00200    79 --DLETGECVRTLTGHTSY---VSSVAFSPDGRILSSSSRDK----TIKVWDVETGKCLTTLRGHTDWVNSVAFSP---- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 239 kkqkNGSSTkpscpycccAVGSKDRSLSVW-LTCLKrpLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDE 317
Cdd:cd00200   146 ----DGTFV---------ASSSQDGTIKLWdLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250
                  ....*....|.
gi 1907116668 318 LGDPLSEEEKS 328
Cdd:cd00200   211 CLGTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
71-323 2.86e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  71 LANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKfPEILATLRGHSGLVKGLTWDPVGKYIASQAD 150
Cdd:COG2319    20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 151 DRSLKVWRTLDWQLETSITkpfdecGGTTHVLRLSWSPDGHYLVSAHAmnnsGPTAQIIEREGWKTNMDFVGHRKAVTVV 230
Cdd:COG2319    99 DGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPDGKTLASGSA----DGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 231 KFNPkifkkkqkNGSSTkpscpycccAVGSKDRSLSVWLTCLKRPLVVI--HelfDKSIMDISWTLNGLGILVCSMDGSV 308
Cdd:COG2319   169 AFSP--------DGKLL---------ASGSDDGTVRLWDLATGKLLRTLtgH---TGAVRSVAFSPDGKLLASGSADGTV 228

                         250
                  ....*....|....*
gi 1907116668 309 AFLDFSQDELGDPLS 323
Cdd:COG2319   229 RLWDLATGKLLRTLT 243
WD40 COG2319
WD40 repeat [General function prediction only];
16-116 9.31e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 9.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  16 PKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAW 95
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-------------------DLATGELLRTLTGHTGAVTSVAF 380

                          90       100
                  ....*....|....*....|.
gi 1907116668  96 SPHDAWLASCSVDNTVVIWNA 116
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-115 1.50e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  17 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWkratyigpstvfgssgklaNVEQWRCVSILRSHSGDVMDVAWS 96
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW-------------------DLRTGECVQTLSGHTNSVTSLAWS 270

                          90
                  ....*....|....*....
gi 1907116668  97 PHDAWLASCSVDNTVVIWN 115
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 76-115 2.34e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.34e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907116668   76 QWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 115
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
77-115 3.83e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.83e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907116668  77 WRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWN 115
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 17-54 2.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907116668   17 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK 54
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
439-668 3.37e-06

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 50.84  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 439 PLSSSLAgtmLSSPSGQQLLPLDSSTPSFGASKPCTEPVAATSARPTG------------ESVSKDSMNATSTPAASS-- 504
Cdd:pfam03546 113 TLTTSPA---QVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAplvqvgkkeedsESSSEESDSEGEAPPAATqa 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 505 -PSVLTTPSKIEPMKAFDSRFTERSKATPGApslTSViptAVERLKEQnlvkelrSRELESSSDSDEKVHLAKPSSLSKR 583
Cdd:pfam03546 190 kPSGKILQVRPASGPAKGAAPAPPQKAGPVA---TQV---KAERSKED-------SESSEESSDSEEEAPAAATPAQAKP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668 584 KLELEvETVEKKKKGRP--RKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALAlklpiPGPQRAFTLQVSSDPSMYIEVE 661
Cdd:pfam03546 257 ALKTP-QTKASPRKGTPitPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVA-----RGAQRPEEDSSSSEESESEEET 330


                  ....*..
gi 1907116668 662 NEVTTVG 668
Cdd:pfam03546 331 APAAAVG 337
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-157 4.96e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 4.96e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907116668  121 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 157
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
17-53 2.49e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907116668  17 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVW 53
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 83-157 2.96e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668  83 LRSHSGDVMDVAWSP-HDAWLASCSVDNTVVIW---------NAVKFPeiLATLRGHSGLVKGLTWDPVGKYI-ASQADD 151
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndesvKEIKDP--QCILKGHKKKISIIDWNPMNYYImCSSGFD 147


                  ....*.
gi 1907116668 152 RSLKVW 157
Cdd:PTZ00420  148 SFVNIW 153
WD40 pfam00400
WD domain, G-beta repeat;
121-157 3.73e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 3.73e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907116668 121 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 157
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 85-201 9.96e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.57  E-value: 9.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116668   85 SHSGDVMD--VAWSPHDAWLASCS-VDNTVVIW----NAVKFPEILATlrGHSGLVKGLTWDPVGKYIASQADDRSLKVw 157
Cdd:COG4946    338 TNTPGVRErlPAWSPDGKSIAYFSdASGEYELYiapaDGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWV- 414

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907116668  158 rtLDwqLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNN 201
Cdd:COG4946    415 --VD--LASGKVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPN 454
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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