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Conserved domains on  [gi|1907113784|ref|XP_036015429|]
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reticulophagy regulator 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 50-242 4.53e-136

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


:

Pssm-ID: 411699  Cd Length: 198  Bit Score: 389.88  E-value: 4.53e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  50 ALTWLLGEPVLWLGW-----RADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRT 124
Cdd:cd22560     1 AQTWLLGEPVLWLGCgsplcRFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 125 RGAQLWRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSY 204
Cdd:cd22560    81 RGAQLWRSLSESWEVIDSKPDERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSY 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907113784 205 LLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGE 242
Cdd:cd22560   161 LLLLCAFLCPLFKCNEFGQKVYSKVKSVLQKLDFGIGE 198
 
Name Accession Description Interval E-value
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 50-242 4.53e-136

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411699  Cd Length: 198  Bit Score: 389.88  E-value: 4.53e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  50 ALTWLLGEPVLWLGW-----RADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRT 124
Cdd:cd22560     1 AQTWLLGEPVLWLGCgsplcRFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 125 RGAQLWRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSY 204
Cdd:cd22560    81 RGAQLWRSLSESWEVIDSKPDERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSY 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907113784 205 LLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGE 242
Cdd:cd22560   161 LLLLCAFLCPLFKCNEFGQKVYSKVKSVLQKLDFGIGE 198
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 68-216 6.23e-05

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 43.24  E-value: 6.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  68 ELLSWKRPLRSLLTFLGAnLLFWFLALtpWRVYHLISVmiLGRVIMqiikeMVLSRTrgaQLWRSLTESWEVINSK---- 143
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGA-TALWLLFE--VLGYSLLSL--VSKLLL-----LLLLVL---FLWAEYAGKLNRPPPPipel 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907113784 144 --PDERARLSQCIAESWMNFsmFLQEM-SLFKQQSPGKFCLLVCSVCtFFTILGSYIPGVILSYLLLLFAFLCPLF 216
Cdd:pfam02453  70 elSEETVRELADSLRVLINF--ALSELrRIALGEDLKLFLKVAVVLW-ILSYVGSLFSFLTLLYIGVVLAFTVPLL 142
 
Name Accession Description Interval E-value
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 50-242 4.53e-136

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411699  Cd Length: 198  Bit Score: 389.88  E-value: 4.53e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  50 ALTWLLGEPVLWLGW-----RADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRT 124
Cdd:cd22560     1 AQTWLLGEPVLWLGCgsplcRFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 125 RGAQLWRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSY 204
Cdd:cd22560    81 RGAQLWRSLSESWEVIDSKPDERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSY 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907113784 205 LLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGE 242
Cdd:cd22560   161 LLLLCAFLCPLFKCNEFGQKVYSKVKSVLQKLDFGIGE 198
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 50-242 3.08e-86

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411697  Cd Length: 192  Bit Score: 262.62  E-value: 3.08e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  50 ALTWLLGEPVLWLGwRADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRTRGAQL 129
Cdd:cd22558     1 KLTRLLGPYEPVIM-RAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 130 WRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLF 209
Cdd:cd22558    80 PEEDPESWTPIHPRLLSVPELCRHLAESWVSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLS 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907113784 210 AFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGE 242
Cdd:cd22558   160 LLLWPLVVYHRVPQKIYTKLEPVLMQLEYSMKI 192
Arl6IP1_RETR3-like cd21102
ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and ...
 67-239 3.54e-75

ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins; This family contains ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1) and the N-terminal reticulon-homology domain (RHD) of Reticulophagy regulators 1-3. Arl6IP1 is an endoplasmic reticulum (ER) protein that has an important role in cell conduction and material transport. Arl6IP1, a tetraspan membrane protein, is an anti-apoptotic protein specific to multicellular organisms, and is a potential player in shaping the ER tubules in mammalian cells. In Drosophila, knockdown of the Arl6IP1 gene leads to progressive motor deficit. An Arl6IP1 variant has also been associated with hereditary spastic paraplegia (HSP), motor and sensory polyneuropathy, and acromutilation. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Arl6IP1 shows some sequence similarity to the RHD of reticulophagy regulators, which may function in inducing membrane curvature.


Pssm-ID: 411696  Cd Length: 178  Bit Score: 233.87  E-value: 3.54e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  67 DELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVL--SRTRGAQLWRSLTESWEVINSKP 144
Cdd:cd21102     1 QEALVWERPLRSLAIYAALNLLFWFLYYLSLRVFSLLSVFLMFICLIDYWKPIIWrgLRPRGARSNKSTSEVGFEFHPML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 145 DERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKCNDIGQK 224
Cdd:cd21102    81 LSVPELCHNIAESWMSAVIFLLELLQLKEQNPGKFCLLVCVGLAVLAILGQYIPGVLLSYLILTSLLLWPLLNYHGLIDK 160

                         170
                  ....*....|....*...
gi 1907113784 225 IY---SKVKSILLKLDFG 239
Cdd:cd21102   161 LYgmaKRLHPKLLKLDES 178
RETR3_RHD cd22562
N-terminal reticulon-homology domain of Reticulophagy regulator 3; Reticulophagy regulator 3 ...
 50-240 3.31e-43

N-terminal reticulon-homology domain of Reticulophagy regulator 3; Reticulophagy regulator 3 (RETR3 or RETREG3), also called FAM134C (family with sequence similarity 134, member C), mediates NRF1-enhanced neurite outgrowth. It interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. RETREG3/FAM134C contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411701  Cd Length: 192  Bit Score: 151.05  E-value: 3.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  50 ALTWLLG--EPVLWlgwRADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRTRGA 127
Cdd:cd22562     1 TLLEVLGpyEPLLS---YVQAVLVWERPAHSALWCLGLNAAFWFFALTSLRLVFLLAFSLMIIVCIDQWKNKIWPEIKVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 128 QLWRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLL 207
Cdd:cd22562    78 RPDELDNESWGFVHPRLLSVPELCHHVAEVWVSGTNFLRNLLLFKKQNPGKFCLLVCGVLTFLAVLGRYIPGLLLSYLLL 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907113784 208 LFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGI 240
Cdd:cd22562   158 LFVLLWPLAVYHRLGQRIYVKLEPALQRLDFSV 190
RETR2_RHD cd22561
N-terminal reticulon-homology domain of Reticulophagy regulator 2; Reticulophagy regulator 2 ...
 46-238 3.02e-36

N-terminal reticulon-homology domain of Reticulophagy regulator 2; Reticulophagy regulator 2 (RETR2 or RETREG2), also called FAM134A (family with sequence similarity 134, member A), C2orf17, or MAG2, interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. RETREG2/FAM134A contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411700  Cd Length: 199  Bit Score: 132.60  E-value: 3.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  46 RVAAALTWLLG--EPVLWLGWRadeLLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSR 123
Cdd:cd22561     1 RLATRLRLRLRgwEPVLAAAQR---LLVWERPLHSLVTAAALNGLFWLLSSTSLRPFFLLSVSLLGYFLLERWKPRLLPD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 124 TRgAQLWRSLTESWEVINSKPDERA----RLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPG 199
Cdd:cd22561    78 VS-APSPEEPHSDSEGAGSGAQPHLlsvpELCHYLAESWLTFQLYLQELLQYKRQNPGQFCARVCSGCAVLAVLGHYVPG 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907113784 200 VILSYLLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDF 238
Cdd:cd22561   157 IMISYIVLLSVLLWPLVVYHELIQRMYTRLEPVLMKLDY 195
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 68-216 6.23e-05

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 43.24  E-value: 6.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  68 ELLSWKRPLRSLLTFLGAnLLFWFLALtpWRVYHLISVmiLGRVIMqiikeMVLSRTrgaQLWRSLTESWEVINSK---- 143
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGA-TALWLLFE--VLGYSLLSL--VSKLLL-----LLLLVL---FLWAEYAGKLNRPPPPipel 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907113784 144 --PDERARLSQCIAESWMNFsmFLQEM-SLFKQQSPGKFCLLVCSVCtFFTILGSYIPGVILSYLLLLFAFLCPLF 216
Cdd:pfam02453  70 elSEETVRELADSLRVLINF--ALSELrRIALGEDLKLFLKVAVVLW-ILSYVGSLFSFLTLLYIGVVLAFTVPLL 142
Arl6IP1 cd22559
ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like 6 ...
 67-236 1.88e-04

ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), also called apoptotic regulator in the membrane of the endoplasmic reticulum (ARMER), is an endoplasmic reticulum (ER) protein that has an important role in cell conduction and material transport. Arl6IP1, a tetraspan membrane protein, is an anti-apoptotic protein specific to multicellular organisms, and is a potential player in shaping the ER tubules in mammalian cells. In neurons, Arl6IP1 has been associated with the regulation of glutamate, a major excitatory neurotransmitter in excitatory synapses. In Drosophila, knockdown of the Arl6IP1 gene leads to progressive motor deficit. An Arl6IP1 variant has also been associated with hereditary spastic paraplegia (HSP), motor and sensory polyneuropathy, and acromutilation. Arl6IP1 shows some sequence similarity to the reticulon-homology domain (RHD) of reticulophagy regulators, which may function in inducing membrane curvature.


Pssm-ID: 411698  Cd Length: 167  Bit Score: 41.86  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784  67 DELLSWKRP-----LRSLLTFLgaNLLFWFLALTpwrVYHLISVMILGRVIMQIIKEMVLSRTRGAQLWRSLTEswevin 141
Cdd:cd22559     1 DKVLRWEKPyypgiIFGVISLL--FLLIWYLDPS---VLTGVSLLGMILCLLDYLVPTVAPRIFGSNKWTGDQE------ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113784 142 skpderARLSQCIAE---------SWMNfsmflqemSLF--KQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFA 210
Cdd:cd22559    70 ------QRFEEICSNlvntkrrlvGWWN--------RLFnlKEEKPKMYFISVMGSLAAVAWIGNQVHNLLLTYLIVLFL 135

                         170       180
                  ....*....|....*....|....*.
gi 1907113784 211 FLCPLFKCNDIGQKIYSKVKSILLKL 236
Cdd:cd22559   136 LLLPGLKHHGILQKYIGMAKRVINKL 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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