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Conserved domains on  [gi|1907134335|ref|XP_036013260|]
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solute carrier organic anion transporter family member 4A1 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 11-318 2.43e-134

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17462:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 427  Bit Score: 392.66  E-value: 2.43e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsi 90
Cdd:cd17462   161 TELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQLPG--------------------------------------- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  91 wlLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIR 170
Cdd:cd17462   202 --LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIK 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 171 FCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPA 250
Cdd:cd17462   280 FCLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGSVLPEGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSE 359

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907134335 251 DAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17462   360 AYSDIRNGQKVYQDCSCVAGNLSVGFGEASAGKCTSNCNHMPLLLAFVFLVILFTFLCSIPALTATLR 427
 
Name Accession Description Interval E-value
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 11-318 2.43e-134

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 392.66  E-value: 2.43e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsi 90
Cdd:cd17462   161 TELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQLPG--------------------------------------- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  91 wlLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIR 170
Cdd:cd17462   202 --LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIK 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 171 FCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPA 250
Cdd:cd17462   280 FCLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGSVLPEGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSE 359

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907134335 251 DAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17462   360 AYSDIRNGQKVYQDCSCVAGNLSVGFGEASAGKCTSNCNHMPLLLAFVFLVILFTFLCSIPALTATLR 427
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 11-377 6.96e-121

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 361.90  E-value: 6.96e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQ-QLKDHSRGAVSNPAFGKTVRDLPLS 89
Cdd:pfam03137 159 ITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHsQDIADLKKTKSLKKLGPSLKDFPKA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  90 IWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGII 169
Cdd:pfam03137 239 LKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 170 RFCLFCTLTSLLAFFVFL-MHCPNVHMAGVTTGYVGSLLPKGQLDlkAACNAIYCCQPKHYSPLCGSDGTmYYSPCYAGC 248
Cdd:pfam03137 319 KFNVITSLVSLLLSLLLFfLGCPNSPVAGITVPYGGTQQLSGNLT--SSCNSDCSCSTSAYSPVCGSDGG-YTSPCPCGA 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 249 PADAETDLGGQKVYRGCSC-ILEKASSGWGNATAGKCASTCQSK-PFLLVLVFVVIIFTFLSSIPALTATLRCVSDRQRS 326
Cdd:pfam03137 396 GCSSSSGAGKSTYICNCCCsCGSQDSGGNGSATPGKCPSDCSNKlPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKS 475

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907134335 327 FALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAM 377
Cdd:pfam03137 476 FALGLQFLILRLLGFIPGPILFGALIDSTCLLWGKTCGGRGNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 13-404 3.92e-80

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 259.66  E-value: 3.92e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHsRGAVSNPAFGKTvRDLPLSIWL 92
Cdd:TIGR00805 247 ITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKS-RGEDRKKNSGIT-KDFPKFIKR 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  93 LLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRF- 171
Cdd:TIGR00805 325 LLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFa 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 172 CLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPkgqLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPAD 251
Cdd:TIGR00805 405 ICLSTLEYLLYSPKFLITCESAPVAGVNNPSNDQPLY---VENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMS 481

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 252 AETdlGGQKVYRGCSCIlekASSGWGNATAGKCASTCQSK--PFLLVLVFVVIIfTFLSSIPALTATLRCVSDRQRSFAL 329
Cdd:TIGR00805 482 VGT--GSNMVFTNCSCI---QTPGNSSAKKGLCDPPCATSlqYFLILFIPLSFI-YFITAVPGYMVLLRCVKSEERSLGL 555

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907134335 330 GIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQC-GHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYK 404
Cdd:TIGR00805 556 GLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKcGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILAR 631
 
Name Accession Description Interval E-value
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 11-318 2.43e-134

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 392.66  E-value: 2.43e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsi 90
Cdd:cd17462   161 TELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQLPG--------------------------------------- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  91 wlLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIR 170
Cdd:cd17462   202 --LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIK 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 171 FCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPA 250
Cdd:cd17462   280 FCLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGSVLPEGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSE 359

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907134335 251 DAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17462   360 AYSDIRNGQKVYQDCSCVAGNLSVGFGEASAGKCTSNCNHMPLLLAFVFLVILFTFLCSIPALTATLR 427
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 11-377 6.96e-121

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 361.90  E-value: 6.96e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQ-QLKDHSRGAVSNPAFGKTVRDLPLS 89
Cdd:pfam03137 159 ITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHsQDIADLKKTKSLKKLGPSLKDFPKA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  90 IWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGII 169
Cdd:pfam03137 239 LKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 170 RFCLFCTLTSLLAFFVFL-MHCPNVHMAGVTTGYVGSLLPKGQLDlkAACNAIYCCQPKHYSPLCGSDGTmYYSPCYAGC 248
Cdd:pfam03137 319 KFNVITSLVSLLLSLLLFfLGCPNSPVAGITVPYGGTQQLSGNLT--SSCNSDCSCSTSAYSPVCGSDGG-YTSPCPCGA 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 249 PADAETDLGGQKVYRGCSC-ILEKASSGWGNATAGKCASTCQSK-PFLLVLVFVVIIFTFLSSIPALTATLRCVSDRQRS 326
Cdd:pfam03137 396 GCSSSSGAGKSTYICNCCCsCGSQDSGGNGSATPGKCPSDCSNKlPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKS 475

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907134335 327 FALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAM 377
Cdd:pfam03137 476 FALGLQFLILRLLGFIPGPILFGALIDSTCLLWGKTCGGRGNCWLYDNDKL 526
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 9-318 8.02e-90

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 278.75  E-value: 8.02e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335   9 PVTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPrqlpgsqryvvmraaetqqlkdhsrgavsnpafgktvrdlpl 88
Cdd:cd17403   162 SELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFP------------------------------------------ 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  89 siwlllrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGI 168
Cdd:cd17403   200 --------PTFMFLNLAGASEGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGI 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 169 IRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPkGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGC 248
Cdd:cd17403   272 LKFCIVCSIVAFLFSFILLIYCPNAPFAGVTVPYGNSPLE-GTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGC 350

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907134335 249 PadAETDLGGQKVYRGCSCILEKASSGWGNATAGK--CASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17403   351 T--TSHGDDGQKVYSNCSCIQSNSSKTSTAATGKAcpCETCCQKLYLFLAVFFLLIVFTFMSSTPALSATLR 420
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 13-404 3.92e-80

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 259.66  E-value: 3.92e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHsRGAVSNPAFGKTvRDLPLSIWL 92
Cdd:TIGR00805 247 ITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKS-RGEDRKKNSGIT-KDFPKFIKR 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  93 LLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRF- 171
Cdd:TIGR00805 325 LLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFa 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 172 CLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPkgqLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPAD 251
Cdd:TIGR00805 405 ICLSTLEYLLYSPKFLITCESAPVAGVNNPSNDQPLY---VENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMS 481

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 252 AETdlGGQKVYRGCSCIlekASSGWGNATAGKCASTCQSK--PFLLVLVFVVIIfTFLSSIPALTATLRCVSDRQRSFAL 329
Cdd:TIGR00805 482 VGT--GSNMVFTNCSCI---QTPGNSSAKKGLCDPPCATSlqYFLILFIPLSFI-YFITAVPGYMVLLRCVKSEERSLGL 555

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907134335 330 GIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQC-GHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYK 404
Cdd:TIGR00805 556 GLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKcGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILAR 631
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 11-318 2.13e-60

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 202.67  E-value: 2.13e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsi 90
Cdd:cd17463   163 VDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPKHLPG--------------------------------------- 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  91 wlLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIR 170
Cdd:cd17463   204 --LLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIK 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 171 FCLFCTLTSLLAFFVFLM-HCPNVHMAGVTTGYVGSllpkGQL-DLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGC 248
Cdd:cd17463   282 FAIITTTVSLLLLSVFIFaKCGNDPFAGVSETYNGT----GKIgNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGC 357

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907134335 249 PADAETDLGgqKVYRGCSCILEKASSGWGNAT----AGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17463   358 TNENLHDKK--KVYYNCSCIGNFTEEFSANTTkceeGKKCETTCKNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 9-318 1.55e-55

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 189.37  E-value: 1.55e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335   9 PVTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPrqlpgsqryvvmraaetqqlkdhsrgavsnpafgktvrdlpl 88
Cdd:cd17336   157 VPLGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP------------------------------------------ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  89 siwlllrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGI 168
Cdd:cd17336   195 --------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGL 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 169 IRFCLFCTLTSLLAF-FVFLMHCPNVHMAGVTTGYVGSLLPkgqldLKAACNAiYC-CQPKHYSPLCGSDGTMYYSPCYA 246
Cdd:cd17336   267 AKFVLILSLLSVILYiSLFFLGCDNPPIAGVTTPYGSSSSP-----ITSSCNS-DCnCSDSSFSPVCGSDGITYFSPCHA 340

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907134335 247 GCPadAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSK-PFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17336   341 GCT--SSDAGNGTKTYSNCSCINSGTATSSGCPPDCSVAPNCCSKlIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 13-318 1.86e-45

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 162.91  E-value: 1.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRqlpgsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsiwl 92
Cdd:cd17404   161 ISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPK--------------------------------------------- 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  93 llrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFC 172
Cdd:cd17404   196 ----MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLA 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 173 LFCTLTSLLAFF-VFLMHCPNVHMAGVTTGYVG--SLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCP 249
Cdd:cd17404   272 LICNFLSLLLFLtLFFLGCESIKLAGITIPYTTgpSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCT 351

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907134335 250 ADAETDLGGQKvYRGCSCILEKASS--GWGN----ATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17404   352 SVGNTSTGIRN-YTNCACLQSRSSIspPTVGqgsqLQAGPCSRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
 13-318 4.61e-43

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 157.62  E-value: 4.61e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLP-----GSQRYVVMRAAETQQLKDHSRgAVSNPAFGKTVRDLP 87
Cdd:cd17460   173 LEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREMPkevveLQPREKKLAKTMLKKLKSLSD-ILQNLSLLQFIKKFP 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  88 LSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSG 167
Cdd:cd17460   252 RILLRTLRNPIYLLVVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRG 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 168 IIRFCLFCTLTSL-LAFFVFLMHCPNVHMAGVTTGYVGSLlpkgQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYA 246
Cdd:cd17460   332 CGAMCVLGMLLCLfFALPLLFIGCSTQKIAGITHRTSSSP----GLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHA 407

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907134335 247 GCPADAETDLGGQKV-YRGCSCIlekASSGW-GNATAGKCASTCQS--KPFLLvLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17460   408 GCKSVNVQALDNSVVnYTDCSCV---SEGGPvGAASPGTCGSGCSHllVPFML-LVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
 3-314 2.31e-36

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 139.17  E-value: 2.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335   3 VRRLMVPVTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRyvvmRAAETQQLKDHSRGAVSNPAFGKT 82
Cdd:cd17461   167 IGRVNTATVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREMLVGKK----PSPEGDMLRKKEDEKKEEGSLLDF 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  83 VRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFK 162
Cdd:cd17461   243 IKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFG 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 163 LRGSGIIRFCLFCTLTS-LLAFFVFLMHCPNVHMAGVTTGYVGSLlpkgqLDLKAACNAIYCCQPKHYSPLCGSDGTMYY 241
Cdd:cd17461   323 FSLRAIPRFSVVILSISiMLCVPLFFMGCSTQDVAGVYPKTSNSS-----DGPHLSCSANCSCPESAFNPVCGENGIEYI 397

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907134335 242 SPCYAGCP-ADAETDLGGQKVYRGCSCIleKASSGWGNATAGKCASTCQSkpFLLVLVFVViifTFLSSIPALT 314
Cdd:cd17461   398 SPCHAGCTnSNMDSSTYRQQIYSNCSCI--PDLSGEKPAKTGSCPNSCSH--LLLPVMFLI---SFAGLIACLT 464
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 20-319 3.64e-36

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 139.22  E-value: 3.64e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  20 WVGAWWIGFLGTGIAAFLIAIPILGYPRQLP--GSQRYVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLsIWLLLRNP 97
Cdd:cd17458   224 WVGAWWLGFLICAGVNFLAGLPFWFLPKSLPkeGEENETEPSKTLTVELEENKGQETKQEMYEIAKDFLPF-LKSLFRNP 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  98 TFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKL---RGSGIIrfCLF 174
Cdd:cd17458   303 IYMLFIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKIntyQAAHIG--FWV 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 175 CTLTSLLAFFVFLMHCPNVHMAGVTTGYVG-SLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAE 253
Cdd:cd17458   381 SLLEYLLYFSAFWMGCDNSPVAGLTVSYEGiDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVG 460

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907134335 254 TdlGGQKVYRGCSCILEKASSGWGNATAGKC--ASTCQSK-PFLLVLVFVVIIFTFLSSIPALTATLRC 319
Cdd:cd17458   461 T--GKNMVFQNCSCVAASGFPSQNSSAVGQCdkGETCDKMlQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
 11-318 9.03e-35

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 133.82  E-value: 9.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  11 TELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsi 90
Cdd:cd17405   161 IEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLPG--------------------------------------- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  91 wlLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIR 170
Cdd:cd17405   202 --LLKNPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMR 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 171 FCLFCTLTSLLAF-FVFLMHCPNVHMAGVTTGYVGSllpkGQL-DLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGC 248
Cdd:cd17405   280 FILVTSVISLGLFvLIFFVECQTVTFAGINEDYDGY----GQLgNLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGC 355

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907134335 249 PADAETDLggQKVYRGCSCILE-----KASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17405   356 KASKVSNT--EKTYYNCSCIKEglaaaDDEGDFIDAIAGKCDSKCYKLPLFFAFYFSATVFSNMCSIPIILIILR 428
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
 13-319 3.08e-34

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 133.35  E-value: 3.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPgsqryvvmraaetqqlkdhsrgavsnpafgktvRDLPLSIWL 92
Cdd:cd17459   221 ITPKDARWVGAWWLGYLIAGVITLLSAVPFWFLPKSLP---------------------------------KDFLPSLKN 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  93 LLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFC 172
Cdd:cd17459   268 LLGNPVYFLYLCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLS 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 173 LFCTLTS-LLAFFVFLMHCPNVHMAGVTTGYVGS-LLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPA 250
Cdd:cd17459   348 FGTSFFGyLLLLSFFAMGCENSDVAGLTVSYNGTkQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKA 427

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907134335 251 DAETdlGGQKVYRGCSCILEKAS-SGWGNATAGKC--ASTCqSKPFLLVLVFVVII-FTF-LSSIPALTATLRC 319
Cdd:cd17459   428 SNGS--GKNTVFHNCSCIGIPSSaSGSSSAILGQCpkGNAC-ARMFLYFLAISVISsFTLsLGGTPGYILLIRC 498
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
 12-297 1.05e-31

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 125.81  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  12 ELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLpgsqryvvmraaetQQLkdhsrgavsnpafgktvRDLPLSIW 91
Cdd:cd17402   176 DITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSL--------------QQL-----------------RVIPKVTK 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  92 LLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRF 171
Cdd:cd17402   225 HLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRM 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 172 CLFCTLTSLLAFFVFL-MHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCpa 250
Cdd:cd17402   305 AMLVNLVSTACYVSFLfLGCDTGPVAGVTVPYGNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGC-- 382

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1907134335 251 dAETDLGgqkvyrGCSCiLEKASSGWGNATAGKCASTCQSKPFLLVL 297
Cdd:cd17402   383 -SSTNLS------GCAC-LSSVPAENATVVPGKCPSPGCQEAFLTFL 421
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
 13-310 7.55e-30

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 120.34  E-value: 7.55e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLpgsqryvvmraaetqqlkdhsrgavsnpafgktvRDLPLSIWL 92
Cdd:cd17401   173 LVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRFI----------------------------------KRFPCIFLR 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  93 LLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFC 172
Cdd:cd17401   219 TLRNPIFLLVVLAQVTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAIC 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 173 LFCTLTSL-LAFFVFLMHCPNVHMAGVTtgYVGSLLPKgqLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPAD 251
Cdd:cd17401   299 TTIITISMiFCVPLFFIGCSTPTIAGVY--PPSSSSSI--HPQSPACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNI 374

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907134335 252 AETDLG--GQKVYRGCSCILEKASSGWGnataGKCASTCQSkpFLLVLVFVVIIFTFLSSI 310
Cdd:cd17401   375 NMSTSAtsKQVIYTNCSCVTGGSASAKT----GSCPSPCSH--LLLPFIFLISLVSLIACL 429
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
 20-317 4.08e-24

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 104.15  E-value: 4.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  20 WVGAWWIGFLGTGIAAFLIAIPILGYPrqlpgsqryvvmraaetqqlkdhsrgavsnpafgktvrDLPLSIWLLLRNPTF 99
Cdd:cd17457   191 WVGAWWLGFLVSGLFSIISAIPFFFLP--------------------------------------GFFQSLKSILTNRLY 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 100 ILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFctlTS 179
Cdd:cd17457   233 VMFVCLTLLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACF---TS 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 180 LLAFFVFLMH----CPNVHMAGVTTGYVGSLLPKGQLDLK-AACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAET 254
Cdd:cd17457   310 VMALSFYLLYffigCENKSVAGITMTYDGNNPVTSHRDVIlSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGN 389

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907134335 255 DLGgqKVYRGCSCiLEKASSGWGN--ATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATL 317
Cdd:cd17457   390 GKP--IVFHNCSC-LEVTGSQNRNysAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYM 451
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
 13-318 4.15e-24

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 103.76  E-value: 4.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  13 LTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPrqlpgsqryvvmraaetqqlkdhsrgavsnpafgktvrdlplsiwl 92
Cdd:cd17400   177 ITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP---------------------------------------------- 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335  93 llrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFC 172
Cdd:cd17400   211 ----PIYMLFILVSVIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIG 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134335 173 LFCTLTSLLAFFV-FLMHCPNVHMAGVTTGYVGS-LLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCpa 250
Cdd:cd17400   287 CWLSVLEYLLYLLsFLMTCENSSVAGLTTSYEGIpPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGC-- 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907134335 251 daETDLGGQK--VYRGCSCIlekASSGWGNATAGKCASTCQSKP-------FLLVLVFVVIIFTFLSSIPALTATLR 318
Cdd:cd17400   365 --ETSIGTGKniVFYNCSCI---QTSGNSSANLSLCDGGCPRDPdcslmfqYFLIISVMSSFIYSLGGIPGYMLLLR 436
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
 214-268 4.52e-16

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 71.95  E-value: 4.52e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907134335 214 LKAACNAiYC-CQPKHYSPLCGSDGTMYYSPCYAGCPadAETDLGGQKVYRGCSCI 268
Cdd:cd01330     1 LTSSCNS-NCsCSESAYSPVCGENGITYFSPCHAGCT--NSTGSGGSKIYTNCSCV 53
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 224-267 3.40e-08

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 49.41  E-value: 3.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907134335 224 CQPKHYSPLCGSDGTMYYSPC---YAGCPadAETDLGGQKVYRGCSC 267
Cdd:pfam07648   6 CPKTEYEPVCGSDGVTYPSPCalcAAGCK--LGKEVKEEKVKYDGSC 50
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
 226-267 4.74e-08

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.81  E-value: 4.74e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907134335 226 PKHYSPLCGSDGTMYYSPCYAGCpaDAETDLGGQKVYRGCSC 267
Cdd:cd00104     2 PKEYDPVCGSDGKTYSNECHLGC--AACRSGRSITVAHNGPC 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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