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Conserved domains on  [gi|1907083009|ref|XP_036012862|]
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zinc transporter ZIP11 isoform X3 [Mus musculus]

Protein Classification

ZIP family metal transporter( domain architecture ID 10001406)

zinc transporter of the ZIP family mediates zinc uptake, but may also transport other divalent cations such as copper and cadmium ions.

Gene Ontology:  GO:0046873|GO:0030001
PubMed:  23046653|28875161
TCDB:  2.A.5

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
6-339 3.54e-64

Zinc transporter ZupT [Inorganic ion transport and metabolism];


:

Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 203.49  E-value: 3.54e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009   6 SSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSsggfgafaFFPVAVGF 85
Cdd:COG0428     2 SPLLLALLAGLLAGLATLLGALLALFFKRLSKRLLSLLLGFAAGVMLAASFFELLPEALELGEG--------PLLAALGF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  86 TLGAAFVYLADLLMPHLGATEDPQTALalnldpalmkksdprdptsllfpeselsirigstgllsdkrengevyqrkkva 165
Cdd:COG0428    74 LLGALLLFLLDRLLPHEHRGAEPAKAH----------------------------------------------------- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 atdlaegvapsgsmhgssgqpggssWRRIALLILAITIHNIPEGLAVGVGFGAVEKTASAtfesarnLAIGIGIQNFPEG 245
Cdd:COG0428   101 -------------------------LRRGLLIALGITLHNFPEGLAIGVAFAADPALGLA-------LALAIALHNIPEG 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASW 325
Cdd:COG0428   149 LAVAAPLRAAGYSRRKALLLGLLSGLVEPLGALLGYLLLSLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSRLATL 228
                         330
                  ....*....|....
gi 1907083009 326 ASILGFVVMMSLDV 339
Cdd:COG0428   229 GLLLGFLLMMLLDV 242
 
Name Accession Description Interval E-value
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
6-339 3.54e-64

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 203.49  E-value: 3.54e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009   6 SSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSsggfgafaFFPVAVGF 85
Cdd:COG0428     2 SPLLLALLAGLLAGLATLLGALLALFFKRLSKRLLSLLLGFAAGVMLAASFFELLPEALELGEG--------PLLAALGF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  86 TLGAAFVYLADLLMPHLGATEDPQTALalnldpalmkksdprdptsllfpeselsirigstgllsdkrengevyqrkkva 165
Cdd:COG0428    74 LLGALLLFLLDRLLPHEHRGAEPAKAH----------------------------------------------------- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 atdlaegvapsgsmhgssgqpggssWRRIALLILAITIHNIPEGLAVGVGFGAVEKTASAtfesarnLAIGIGIQNFPEG 245
Cdd:COG0428   101 -------------------------LRRGLLIALGITLHNFPEGLAIGVAFAADPALGLA-------LALAIALHNIPEG 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASW 325
Cdd:COG0428   149 LAVAAPLRAAGYSRRKALLLGLLSGLVEPLGALLGYLLLSLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSRLATL 228
                         330
                  ....*....|....
gi 1907083009 326 ASILGFVVMMSLDV 339
Cdd:COG0428   229 GLLLGFLLMMLLDV 242
PRK04201 PRK04201
zinc transporter ZupT; Provisional
6-335 1.19e-28

zinc transporter ZupT; Provisional


Pssm-ID: 235253  Cd Length: 265  Bit Score: 111.48  E-value: 1.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009   6 SSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSSGGfGAFAFFPVAVGF 85
Cdd:PRK04201    2 SNVSVALLLTLLAGLATGIGSLIAFFGKKPNNRFLSFSLGFAAGVMLYVSFMEILPKALAALTEAYG-EGMGPWLGYGAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  86 TLGAAFVYLADLLMPHlgatEDPQTalalNLDPALMKKSDPRDPtsllfpeselsiRIGSTGLLSdkrengevyqrkkva 165
Cdd:PRK04201   81 FGGILGIFLIDRLVPH----ENPHE----LMQKEEMEFQQPLPK------------SLKRTGILT--------------- 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 atdlaegvapsgsmhgssgqpggsswrriallILAITIHNIPEGLAVGVgfgavekTASATFESARNLAIGIGIQNFPEG 245
Cdd:PRK04201  126 --------------------------------ALAISIHNFPEGIATFV-------AALSNPELGFPIALAIAIHNIPEG 166
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAV--VLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLA 323
Cdd:PRK04201  167 IAVAVPVYYATGSKKKAFLYSFLSGLAEPLGAVLGYLLLgpFISPVVMGAIFAAVAGIMVFISLDELLPAAKEYGPHHLP 246
                         330
                  ....*....|..
gi 1907083009 324 SWASILGFVVMM 335
Cdd:PRK04201  247 SYGLIAGMAVMA 258
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
12-334 5.98e-26

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 105.54  E-value: 5.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  12 LLGTFFTWAMTAAGAALVFIFSSGQRRILDGS-----LGFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFT 86
Cdd:pfam02535   5 IYAIFAILIISLIGGLLPLLVPKISKLRPSSKllsllLAFASGVLLGTAFLHLLPEALEALESLCLSDHGWHFPFAGLIV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  87 LGAAF-VYLADLLMPHLGATEDPQTAlALNLDPALMKKSDPRDPTSLLFPESELSIRIGSTGLLSDKRENGEVYQRKKVA 165
Cdd:pfam02535  85 LLGFLlVLLVEKLLTYYKHRPTPGPA-DNSHSHLATVKSVSNVEVTESEEGEDHGHLHGHDDDSDELLHKGHQGPSDSIH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 ATDLAEGVAPSGSMhgssgqpggsswRRIALLILAITIHNIPEGLAVGVgfgavektaSATFESARNLAIGIGIQNFPEG 245
Cdd:pfam02535 164 EQSDEDGEPLASQR------------VRAILLELGIILHSFFEGLALGV---------SSSSDTGISLFIAILFHKIPEG 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAV-----VLAEPILPYALAFAAGAMVYVVMDDIIP-----EAQ 315
Cdd:pfam02535 223 LGLGAILLQAGFSRKKAVLLALLFALTTPLGILIGIGVSsignsPGADITSGILLAFSAGTFLYVALVELLPhellrNKS 302
                         330
                  ....*....|....*....
gi 1907083009 316 ISGNGKLASWASILGFVVM 334
Cdd:pfam02535 303 SEKLSLLQLLALLLGFALM 321
 
Name Accession Description Interval E-value
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
6-339 3.54e-64

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 203.49  E-value: 3.54e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009   6 SSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSsggfgafaFFPVAVGF 85
Cdd:COG0428     2 SPLLLALLAGLLAGLATLLGALLALFFKRLSKRLLSLLLGFAAGVMLAASFFELLPEALELGEG--------PLLAALGF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  86 TLGAAFVYLADLLMPHLGATEDPQTALalnldpalmkksdprdptsllfpeselsirigstgllsdkrengevyqrkkva 165
Cdd:COG0428    74 LLGALLLFLLDRLLPHEHRGAEPAKAH----------------------------------------------------- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 atdlaegvapsgsmhgssgqpggssWRRIALLILAITIHNIPEGLAVGVGFGAVEKTASAtfesarnLAIGIGIQNFPEG 245
Cdd:COG0428   101 -------------------------LRRGLLIALGITLHNFPEGLAIGVAFAADPALGLA-------LALAIALHNIPEG 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASW 325
Cdd:COG0428   149 LAVAAPLRAAGYSRRKALLLGLLSGLVEPLGALLGYLLLSLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSRLATL 228
                         330
                  ....*....|....
gi 1907083009 326 ASILGFVVMMSLDV 339
Cdd:COG0428   229 GLLLGFLLMMLLDV 242
PRK04201 PRK04201
zinc transporter ZupT; Provisional
6-335 1.19e-28

zinc transporter ZupT; Provisional


Pssm-ID: 235253  Cd Length: 265  Bit Score: 111.48  E-value: 1.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009   6 SSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSSGGfGAFAFFPVAVGF 85
Cdd:PRK04201    2 SNVSVALLLTLLAGLATGIGSLIAFFGKKPNNRFLSFSLGFAAGVMLYVSFMEILPKALAALTEAYG-EGMGPWLGYGAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  86 TLGAAFVYLADLLMPHlgatEDPQTalalNLDPALMKKSDPRDPtsllfpeselsiRIGSTGLLSdkrengevyqrkkva 165
Cdd:PRK04201   81 FGGILGIFLIDRLVPH----ENPHE----LMQKEEMEFQQPLPK------------SLKRTGILT--------------- 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 atdlaegvapsgsmhgssgqpggsswrriallILAITIHNIPEGLAVGVgfgavekTASATFESARNLAIGIGIQNFPEG 245
Cdd:PRK04201  126 --------------------------------ALAISIHNFPEGIATFV-------AALSNPELGFPIALAIAIHNIPEG 166
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAV--VLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLA 323
Cdd:PRK04201  167 IAVAVPVYYATGSKKKAFLYSFLSGLAEPLGAVLGYLLLgpFISPVVMGAIFAAVAGIMVFISLDELLPAAKEYGPHHLP 246
                         330
                  ....*....|..
gi 1907083009 324 SWASILGFVVMM 335
Cdd:PRK04201  247 SYGLIAGMAVMA 258
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
12-334 5.98e-26

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 105.54  E-value: 5.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  12 LLGTFFTWAMTAAGAALVFIFSSGQRRILDGS-----LGFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFT 86
Cdd:pfam02535   5 IYAIFAILIISLIGGLLPLLVPKISKLRPSSKllsllLAFASGVLLGTAFLHLLPEALEALESLCLSDHGWHFPFAGLIV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009  87 LGAAF-VYLADLLMPHLGATEDPQTAlALNLDPALMKKSDPRDPTSLLFPESELSIRIGSTGLLSDKRENGEVYQRKKVA 165
Cdd:pfam02535  85 LLGFLlVLLVEKLLTYYKHRPTPGPA-DNSHSHLATVKSVSNVEVTESEEGEDHGHLHGHDDDSDELLHKGHQGPSDSIH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 166 ATDLAEGVAPSGSMhgssgqpggsswRRIALLILAITIHNIPEGLAVGVgfgavektaSATFESARNLAIGIGIQNFPEG 245
Cdd:pfam02535 164 EQSDEDGEPLASQR------------VRAILLELGIILHSFFEGLALGV---------SSSSDTGISLFIAILFHKIPEG 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083009 246 LAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAV-----VLAEPILPYALAFAAGAMVYVVMDDIIP-----EAQ 315
Cdd:pfam02535 223 LGLGAILLQAGFSRKKAVLLALLFALTTPLGILIGIGVSsignsPGADITSGILLAFSAGTFLYVALVELLPhellrNKS 302
                         330
                  ....*....|....*....
gi 1907083009 316 ISGNGKLASWASILGFVVM 334
Cdd:pfam02535 303 SEKLSLLQLLALLLGFALM 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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