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Conserved domains on  [gi|1907081678|ref|XP_036012566|]
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G patch domain-containing protein 8 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10573383)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0046872
PubMed:  11179890|12665246|11361095|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 58-85 5.67e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.39  E-value: 5.67e-05
                           10        20
                   ....*....|....*....|....*...
gi 1907081678   58 FYCELCDKQYQKHQEFDNHINSydHAHK 85
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
4-129 6.49e-04

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081678    4 GRMEMELDYAEDATErrrvlEVEKEdTEELRQKYKDYVDKEKAIAKALEDLR-ANFYCELCDKQYQKHQEfDNHINSYDH 82
Cdd:PRK03918   387 EKLEKELEELEKAKE-----EIEEE-ISKITARIGELKKEIKELKKAIEELKkAKGKCPVCGRELTEEHR-KELLEEYTA 459

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907081678   83 AHKQRLKDLKQ-REFARNVSSRSRKDEK--KQEKALRRLHELAEQRKQAE 129
Cdd:PRK03918   460 ELKRIEKELKEiEEKERKLRKELRELEKvlKKESELIKLKELAEQLKELE 509
 
Name Accession Description Interval E-value
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 58-85 5.67e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.39  E-value: 5.67e-05
                           10        20
                   ....*....|....*....|....*...
gi 1907081678   58 FYCELCDKQYQKHQEFDNHINSydHAHK 85
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
4-129 6.49e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081678    4 GRMEMELDYAEDATErrrvlEVEKEdTEELRQKYKDYVDKEKAIAKALEDLR-ANFYCELCDKQYQKHQEfDNHINSYDH 82
Cdd:PRK03918   387 EKLEKELEELEKAKE-----EIEEE-ISKITARIGELKKEIKELKKAIEELKkAKGKCPVCGRELTEEHR-KELLEEYTA 459

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907081678   83 AHKQRLKDLKQ-REFARNVSSRSRKDEK--KQEKALRRLHELAEQRKQAE 129
Cdd:PRK03918   460 ELKRIEKELKEiEEKERKLRKELRELEKvlKKESELIKLKELAEQLKELE 509
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 16-128 8.39e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 39.35  E-value: 8.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081678   16 ATERRRVLEvekeDTEELRQKYKDYVDKEKAIAKALEDLRANFYC---ELCDKQYQKHQEFDNHINsydhAHKQRLKDLK 92
Cdd:cd00176     95 AEERRQRLE----EALDLQQFFRDADDLEQWLEEKEAALASEDLGkdlESVEELLKKHKELEEELE----AHEPRLKSLN 166

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1907081678   93 QR--EF-ARNVSSRSRKDEKKQEK---ALRRLHELAEQRKQA 128
Cdd:cd00176    167 ELaeELlEEGHPDADEEIEEKLEElneRWEELLELAEERQKK 208
 
Name Accession Description Interval E-value
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 58-85 5.67e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.39  E-value: 5.67e-05
                           10        20
                   ....*....|....*....|....*...
gi 1907081678   58 FYCELCDKQYQKHQEFDNHINSydHAHK 85
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
4-129 6.49e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081678    4 GRMEMELDYAEDATErrrvlEVEKEdTEELRQKYKDYVDKEKAIAKALEDLR-ANFYCELCDKQYQKHQEfDNHINSYDH 82
Cdd:PRK03918   387 EKLEKELEELEKAKE-----EIEEE-ISKITARIGELKKEIKELKKAIEELKkAKGKCPVCGRELTEEHR-KELLEEYTA 459

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907081678   83 AHKQRLKDLKQ-REFARNVSSRSRKDEK--KQEKALRRLHELAEQRKQAE 129
Cdd:PRK03918   460 ELKRIEKELKEiEEKERKLRKELRELEKvlKKESELIKLKELAEQLKELE 509
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 16-128 8.39e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 39.35  E-value: 8.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081678   16 ATERRRVLEvekeDTEELRQKYKDYVDKEKAIAKALEDLRANFYC---ELCDKQYQKHQEFDNHINsydhAHKQRLKDLK 92
Cdd:cd00176     95 AEERRQRLE----EALDLQQFFRDADDLEQWLEEKEAALASEDLGkdlESVEELLKKHKELEEELE----AHEPRLKSLN 166

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1907081678   93 QR--EF-ARNVSSRSRKDEKKQEK---ALRRLHELAEQRKQA 128
Cdd:cd00176    167 ELaeELlEEGHPDADEEIEEKLEElneRWEELLELAEERQKK 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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