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Conserved domains on  [gi|1907073138|ref|XP_036011455|]
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apoptotic protease-activating factor 1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-748 9.30e-78

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.76  E-value: 9.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 164 FSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQV 243
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 244 NCCHFTnkSNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSIn 323
Cdd:COG2319    82 LSVAFS--PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 324 vkrfflssedppedvevivkccswsadgdkiivaaknkvllfdihtsgllaeihtghhstiqycdfspydhlavialsqy 403
Cdd:COG2319       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 404 cvelwnidsrlkvadcRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKkvcknsaivlkqeidvvfqenetmvlavdn 483
Cdd:COG2319   159 ----------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA------------------------------ 192

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 484 irglqliagkTGQidylpeaqvsccclsphleyvafgdedgaiKIIELPnnrvfssgvGHKKAVRHIQFTADGKTLISSS 563
Cdd:COG2319   193 ----------TGK------------------------------LLRTLT---------GHTGAVRSVAFSPDGKLLASGS 223

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 564 EDSVIQVWNWQTGDYVF-LQAHQETVKDFRLLQDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKF 641
Cdd:COG2319   224 ADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 642 SSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHScapisveegTATHGGW 721
Cdd:COG2319   304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---------LTGHTGA 374

                         570       580
                  ....*....|....*....|....*....
gi 1907073138 722 VTDVCFSPDSKTLVSAG--GYLKWWNVAT 748
Cdd:COG2319   375 VTSVAFSPDGRTLASGSadGTVRLWDLAT 403
APAF1_C pfam17908
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ...
 1-128 1.14e-69

APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.


:

Pssm-ID: 465560  Cd Length: 135  Bit Score: 225.00  E-value: 1.14e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138   1 MVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKDCA 80
Cdd:pfam17908   8 LVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHILDENDCA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907073138  81 VCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYRQAKLQAKQE 128
Cdd:pfam17908  88 VLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
eIF2A super family cl37576
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 337-472 2.09e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


The actual alignment was detected with superfamily member pfam08662:

Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 43.03  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 337 DVEVIVKCCSWSADGDKIIVA---AKNKVLLFDiHTSGLLAEIHTGHHSTIQycdFSPYDHLAVIA----LSQYcVELWN 409
Cdd:pfam08662  57 DKEGPIHDVAWSPNGKEFAVIygyMPAKVSFFD-LKGNVIHSFGEQPRNTIF---WSPFGRLVLLAgfgnLAGD-IEFWD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907073138 410 IDSRLKVADCRGhlSWVHGVMFSPDGSSFLTASD------DQTIRVWETkkvckNSAIVLKQEIDVVFQ 472
Cdd:pfam08662 132 VVNKKKIATAEA--SNATLCEWSPDGRYFLTATTaprlrvDNGFKIWHY-----NGALVYKYDFDELYQ 193
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-748 9.30e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.76  E-value: 9.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 164 FSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQV 243
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 244 NCCHFTnkSNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSIn 323
Cdd:COG2319    82 LSVAFS--PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 324 vkrfflssedppedvevivkccswsadgdkiivaaknkvllfdihtsgllaeihtghhstiqycdfspydhlavialsqy 403
Cdd:COG2319       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 404 cvelwnidsrlkvadcRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKkvcknsaivlkqeidvvfqenetmvlavdn 483
Cdd:COG2319   159 ----------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA------------------------------ 192

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 484 irglqliagkTGQidylpeaqvsccclsphleyvafgdedgaiKIIELPnnrvfssgvGHKKAVRHIQFTADGKTLISSS 563
Cdd:COG2319   193 ----------TGK------------------------------LLRTLT---------GHTGAVRSVAFSPDGKLLASGS 223

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 564 EDSVIQVWNWQTGDYVF-LQAHQETVKDFRLLQDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKF 641
Cdd:COG2319   224 ADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 642 SSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHScapisveegTATHGGW 721
Cdd:COG2319   304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---------LTGHTGA 374

                         570       580
                  ....*....|....*....|....*....
gi 1907073138 722 VTDVCFSPDSKTLVSAG--GYLKWWNVAT 748
Cdd:COG2319   375 VTSVAFSPDGRTLASGSadGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-451 3.72e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 237.62  E-value: 3.72e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 148 SRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDS 227
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 228 ATGKLVHTYDEHSEQVNCCHFTNksNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGT 307
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 308 LRLWDVRsanerkSINVKRFFLSSEDPpedveviVKCCSWSADGDKIIVAAKNK-VLLFDIHTSGLLAEIhTGHHSTIQY 386
Cdd:cd00200   159 IKLWDLR------TGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTL-RGHENGVNS 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907073138 387 CDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 451
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
APAF1_C pfam17908
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ...
 1-128 1.14e-69

APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.


Pssm-ID: 465560  Cd Length: 135  Bit Score: 225.00  E-value: 1.14e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138   1 MVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKDCA 80
Cdd:pfam17908   8 LVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHILDENDCA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907073138  81 VCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYRQAKLQAKQE 128
Cdd:pfam17908  88 VLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 164-313 1.02e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.57  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 164 FSQDGQRIASCGADKTLQVFKAETGEK--------LLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHT 235
Cdd:PLN00181  491 FDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTE 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 236 YDEHSEQVNCCHFTNkSNHLLLATGSNDFFLKLWDLNQK-------------------------------------ECRN 278
Cdd:PLN00181  571 MKEHEKRVWSIDYSS-ADPTLLASGSDDGSVKLWSINQGvsigtiktkaniccvqfpsesgrslafgsadhkvyyyDLRN 649

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907073138 279 ------TMFGHTNSVNHCRFSpDDELLASCSADGTLRLWDV 313
Cdd:PLN00181  650 pklplcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-312 1.02e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907073138  273 QKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWD 312
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
274-312 3.65e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.65e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907073138 274 KECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWD 312
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 337-472 2.09e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 43.03  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 337 DVEVIVKCCSWSADGDKIIVA---AKNKVLLFDiHTSGLLAEIHTGHHSTIQycdFSPYDHLAVIA----LSQYcVELWN 409
Cdd:pfam08662  57 DKEGPIHDVAWSPNGKEFAVIygyMPAKVSFFD-LKGNVIHSFGEQPRNTIF---WSPFGRLVLLAgfgnLAGD-IEFWD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907073138 410 IDSRLKVADCRGhlSWVHGVMFSPDGSSFLTASD------DQTIRVWETkkvckNSAIVLKQEIDVVFQ 472
Cdd:pfam08662 132 VVNKKKIATAEA--SNATLCEWSPDGRYFLTATTaprlrvDNGFKIWHY-----NGALVYKYDFDELYQ 193
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-748 9.30e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.76  E-value: 9.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 164 FSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQV 243
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 244 NCCHFTnkSNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSIn 323
Cdd:COG2319    82 LSVAFS--PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 324 vkrfflssedppedvevivkccswsadgdkiivaaknkvllfdihtsgllaeihtghhstiqycdfspydhlavialsqy 403
Cdd:COG2319       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 404 cvelwnidsrlkvadcRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKkvcknsaivlkqeidvvfqenetmvlavdn 483
Cdd:COG2319   159 ----------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA------------------------------ 192

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 484 irglqliagkTGQidylpeaqvsccclsphleyvafgdedgaiKIIELPnnrvfssgvGHKKAVRHIQFTADGKTLISSS 563
Cdd:COG2319   193 ----------TGK------------------------------LLRTLT---------GHTGAVRSVAFSPDGKLLASGS 223

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 564 EDSVIQVWNWQTGDYVF-LQAHQETVKDFRLLQDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKF 641
Cdd:COG2319   224 ADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 642 SSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHScapisveegTATHGGW 721
Cdd:COG2319   304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---------LTGHTGA 374

                         570       580
                  ....*....|....*....|....*....
gi 1907073138 722 VTDVCFSPDSKTLVSAG--GYLKWWNVAT 748
Cdd:COG2319   375 VTSVAFSPDGRTLASGSadGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
149-453 1.39e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 253.29  E-value: 1.39e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 149 RLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSA 228
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 229 TGKLVHTYDEHSEQVNCCHFTNKSNhlLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTL 308
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 309 RLWDVRSANERKSInvkrfflssedppEDVEVIVKCCSWSADGDKIIVAAKNK-VLLFDIHTSGLLAEiHTGHHSTIQYC 387
Cdd:COG2319   271 RLWDLATGELLRTL-------------TGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRT-LTGHTGAVRSV 336

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907073138 388 DFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETK 453
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
149-575 2.19e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 247.52  E-value: 2.19e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 149 RLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSA 228
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 229 TGKLVHTYDEHSEQVNCCHFTNKSNhlLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTL 308
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGK--LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 309 RLWDVRSANERKSInvkrfflssedppedvevivkccswsadgdkiivaaknkvllfdihtsgllaeihTGHHSTIQYCD 388
Cdd:COG2319   229 RLWDLATGKLLRTL-------------------------------------------------------TGHSGSVRSVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 389 FSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWetkkvcknsaivlkqeid 468
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------------------ 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 469 vvfqenetmvlavdNIRGLQLIAGKTGQIDylpeaQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVR 548
Cdd:COG2319   316 --------------DLATGKLLRTLTGHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                         410       420
                  ....*....|....*....|....*..
gi 1907073138 549 HIQFTADGKTLISSSEDSVIQVWNWQT 575
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-451 3.72e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 237.62  E-value: 3.72e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 148 SRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDS 227
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 228 ATGKLVHTYDEHSEQVNCCHFTNksNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGT 307
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 308 LRLWDVRsanerkSINVKRFFLSSEDPpedveviVKCCSWSADGDKIIVAAKNK-VLLFDIHTSGLLAEIhTGHHSTIQY 386
Cdd:cd00200   159 IKLWDLR------TGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTL-RGHENGVNS 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907073138 387 CDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 451
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
346-776 5.03e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 238.66  E-value: 5.03e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 346 SWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSW 425
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 426 VHGVMFSPDGSSFLTASDDQTIRVWETKkvcknsaivlkqeidvvfqenetmvlavdnirglqliAGKTGQIDYLPEAQV 505
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLA-------------------------------------TGLLLRTLTGHTGAV 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 506 SCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVF-LQAH 584
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGH 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 585 QETVKDFRLLQDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHE 663
Cdd:COG2319   204 TGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 664 LKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCAPisveegtatHGGWVTDVCFSPDSKTLVSAG--GYL 741
Cdd:COG2319   284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---------HTGAVRSVAFSPDGKTLASGSddGTV 354

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1907073138 742 KWWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVT 776
Cdd:COG2319   355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
APAF1_C pfam17908
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ...
 1-128 1.14e-69

APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.


Pssm-ID: 465560  Cd Length: 135  Bit Score: 225.00  E-value: 1.14e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138   1 MVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKDCA 80
Cdd:pfam17908   8 LVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHILDENDCA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907073138  81 VCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYRQAKLQAKQE 128
Cdd:pfam17908  88 VLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 502-776 1.37e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 1.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 502 EAQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVF- 580
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRt 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 581 LQAHQETVKDFRLLQDSRLLSWS-FDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLS 659
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 660 PLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCAPisveegtatHGGWVTDVCFSPDSKTLVSAG- 738
Cdd:cd00200   169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---------HENGVNSVAFSPDGYLLASGSe 239

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1907073138 739 -GYLKWWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVT 776
Cdd:cd00200   240 dGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-612 2.42e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.47  E-value: 2.42e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 194 IKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFTNKSNhlLLATGSNDFFLKLWDLNQ 273
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT--YLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 274 KECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSInvkrfflssedppedvevivkccswsadgdk 353
Cdd:cd00200    83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL------------------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 354 iivaaknkvllfdihtsgllaeihtghhstiqycdfspydhlavialsqycvelwnidsrlkvadcRGHLSWVHGVMFSP 433
Cdd:cd00200   132 ------------------------------------------------------------------RGHTDWVNSVAFSP 145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 434 DGSSFLTASDDQTIRVWEtkkvcknsaivlkqeidvvfqenetmvlaVDNIRGLQLIAGKTGqidylpeaQVSCCCLSPH 513
Cdd:cd00200   146 DGTFVASSSQDGTIKLWD-----------------------------LRTGKCVATLTGHTG--------EVNSVAFSPD 188

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 514 LEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVF-LQAHQETVKDFR 592
Cdd:cd00200   189 GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQtLSGHTNSVTSLA 268

                         410       420
                  ....*....|....*....|.
gi 1907073138 593 LLQD-SRLLSWSFDGTVKVWN 612
Cdd:cd00200   269 WSPDgKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 420-745 1.14e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 1.14e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 420 RGHLSWVHGVMFSPDGSSFLTASDDQTIRVWetkkvcknsaivlkqeidvvfqenetmvlavdNIRGLQLIAGKTGQIDy 499
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVW--------------------------------DLETGELLRTLKGHTG- 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 500 lpeaQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYV 579
Cdd:cd00200    53 ----PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 580 F-LQAHQETVKDFRLLQDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDL 657
Cdd:cd00200   129 TtLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 658 LSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCapisveEGtatHGGWVTDVCFSPDSKTLVSA 737
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL------SG---HTNSVTSLAWSPDGKRLASG 279

                         330
                  ....*....|
gi 1907073138 738 G--GYLKWWN 745
Cdd:cd00200   280 SadGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
510-788 2.79e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 2.79e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 510 LSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVF-LQAHQETV 588
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRtLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 589 KDFRLLQD-SRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGH 667
Cdd:COG2319   124 RSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 668 NGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHScapisveegTATHGGWVTDVCFSPDSKTLVSAG--GYLKWWN 745
Cdd:COG2319   204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT---------LTGHSGSVRSVAFSPDGRLLASGSadGTVRLWD 274

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1907073138 746 VATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQV 788
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 542-755 9.96e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 9.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 542 GHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVF-LQAHQETVKDFRLLQDS-RLLSWSFDGTVKVWNVITGRIE 619
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 620 RDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSD 699
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907073138 700 GQLLHSCapisveegtATHGGWVTDVCFSPDSKTLVSAG--GYLKWWNVATGDSSQTF 755
Cdd:cd00200   167 GKCVATL---------TGHTGEVNSVAFSPDGEKLLSSSsdGTIKLWDLSTGKCLGTL 215
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 620-785 1.26e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 620 RDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSD 699
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 700 GQLLHScapisveegTATHGGWVTDVCFSPDSKTLVSAG--GYLKWWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVTV 777
Cdd:cd00200    83 GECVRT---------LTGHTSYVSSVAFSPDGRILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153


                  ....*...
gi 1907073138 778 DNLGILYI 785
Cdd:cd00200   154 SQDGTIKL 161
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 660-755 6.19e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 6.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 660 PLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCapisveegtATHGGWVTDVCFSPDSKTLVSAG- 738
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---------KGHTGPVRDVAASADGTYLASGSs 71

                          90
                  ....*....|....*...
gi 1907073138 739 -GYLKWWNVATGDSSQTF 755
Cdd:cd00200    72 dKTIRLWDLETGECVRTL 89
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 164-313 1.02e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.57  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 164 FSQDGQRIASCGADKTLQVFKAETGEK--------LLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHT 235
Cdd:PLN00181  491 FDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTE 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 236 YDEHSEQVNCCHFTNkSNHLLLATGSNDFFLKLWDLNQK-------------------------------------ECRN 278
Cdd:PLN00181  571 MKEHEKRVWSIDYSS-ADPTLLASGSDDGSVKLWSINQGvsigtiktkaniccvqfpsesgrslafgsadhkvyyyDLRN 649

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907073138 279 ------TMFGHTNSVNHCRFSpDDELLASCSADGTLRLWDV 313
Cdd:PLN00181  650 pklplcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-312 1.02e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907073138  273 QKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWD 312
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
274-312 3.65e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.65e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907073138 274 KECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWD 312
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-226 3.74e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 3.74e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907073138  187 TGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWD 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 410-737 8.85e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 8.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 410 IDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKKVCKNSAivlkqeiDVVFQENEtmvlavdnirglql 489
Cdd:PLN00181  470 VKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGR-------DIHYPVVE-------------- 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 490 IAGKTgqidylpeaQVSCCCLSPHLE-YVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQF-TADGKTLISSSEDSV 567
Cdd:PLN00181  529 LASRS---------KLSGICWNSYIKsQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGS 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 568 IQVWNWQTGDYVFLQAHQETVKDFRLLQDS-RLLSW-SFDGTVKVWNVITGRIER-DFTCHQGTVlSCAISSDATKFSST 644
Cdd:PLN00181  600 VKLWSINQGVSIGTIKTKANICCVQFPSESgRSLAFgSADHKVYYYDLRNPKLPLcTMIGHSKTV-SYVRFVDSSTLVSS 678

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 645 SADKTAKIWSFDLL------SPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVS-----DGQLLHSCAPIS-VE 712
Cdd:PLN00181  679 STDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAfpmpvLSYKFKTIDPVSgLE 758

                         330       340
                  ....*....|....*....|....*
gi 1907073138 713 EGTATHggWVTDVCFSPDSKTLVSA 737
Cdd:PLN00181  759 VDDASQ--FISSVCWRGQSSTLVAA 781
WD40 pfam00400
WD domain, G-beta repeat;
188-226 3.02e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.02e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907073138 188 GEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWD 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 416-451 1.83e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.83e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073138  416 VADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 451
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 659-696 2.78e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907073138  659 SPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWN 696
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 597-768 3.30e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 597 SRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISS-DATKFSSTSADKTAKIWSFDLLSPLHELKGH-NGCvrCS 674
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKaNIC--CV 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 675 AFSLD-GILLATGDDNGEIRIWNVSDGQLlhscaPISVEEGtatHGGWVTDVCFSpDSKTLVSAG--GYLKWWNVATGDS 751
Cdd:PLN00181  624 QFPSEsGRSLAFGSADHKVYYYDLRNPKL-----PLCTMIG---HSKTVSYVRFV-DSSTLVSSStdNTLKLWDLSMSIS 694

                         170       180
                  ....*....|....*....|....*
gi 1907073138 752 --------SQTFYTNGTNLKKIHVS 768
Cdd:PLN00181  695 ginetplhSFMGHTNVKNFVGLSVS 719
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 165-360 4.45e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 4.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 165 SQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDeVLCCAFSSDDSY-IATCSADKKVKIWDSATGKL-VHTYDEHSEQ 242
Cdd:PLN00181  585 SADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRsLAFGSADHKVYYYDLRNPKLpLCTMIGHSKT 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 243 VNCCHFTNKSNhllLATGSNDFFLKLWDLN------QKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWdvrsa 316
Cdd:PLN00181  664 VSYVRFVDSST---LVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY----- 735

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1907073138 317 NERKSINVKRFFLSSEDPPEDVEV-----IVKCCSWSADGDKIIVAAKN 360
Cdd:PLN00181  736 HKAFPMPVLSYKFKTIDPVSGLEVddasqFISSVCWRGQSSTLVAANST 784
WD40 pfam00400
WD domain, G-beta repeat;
659-696 6.83e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.83e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907073138 659 SPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWN 696
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 651-706 9.90e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 9.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907073138 651 KIWSFDLlsplhelKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSC 706
Cdd:pfam12894  28 RVWTLSP-------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
WD40 pfam00400
WD domain, G-beta repeat;
416-451 1.82e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907073138 416 VADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 451
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 229-270 3.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.11e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073138  229 TGKLVHTYDEHSEQVNCCHFTNKSNHllLATGSNDFFLKLWD 270
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY--LASGSDDGTIKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 337-472 2.09e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 43.03  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 337 DVEVIVKCCSWSADGDKIIVA---AKNKVLLFDiHTSGLLAEIHTGHHSTIQycdFSPYDHLAVIA----LSQYcVELWN 409
Cdd:pfam08662  57 DKEGPIHDVAWSPNGKEFAVIygyMPAKVSFFD-LKGNVIHSFGEQPRNTIF---WSPFGRLVLLAgfgnLAGD-IEFWD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907073138 410 IDSRLKVADCRGhlSWVHGVMFSPDGSSFLTASD------DQTIRVWETkkvckNSAIVLKQEIDVVFQ 472
Cdd:pfam08662 132 VVNKKKIATAEA--SNATLCEWSPDGRYFLTATTaprlrvDNGFKIWHY-----NGALVYKYDFDELYQ 193
WD40 pfam00400
WD domain, G-beta repeat;
230-270 2.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907073138 230 GKLVHTYDEHSEQVNCCHFTnkSNHLLLATGSNDFFLKLWD 270
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS--PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-184 2.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073138  151 VVRPHTDAVYHACFSQDGQRIASCGADKTLQVFK 184
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 615-654 2.93e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907073138  615 TGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWS 654
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 542-572 5.61e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.61e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073138  542 GHKKAVRHIQFTADGKTLISSSEDSVIQVWN 572
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
542-572 6.09e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 6.09e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907073138 542 GHKKAVRHIQFTADGKTLISSSEDSVIQVWN 572
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 171-275 6.62e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 171 IASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEH-SEQVNCCHFT 249
Cdd:PTZ00421  141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHaSAKSQRCLWA 220

                          90       100
                  ....*....|....*....|....*....
gi 1907073138 250 NKSNhLLLATGSNDF---FLKLWDLNQKE 275
Cdd:PTZ00421  221 KRKD-LIITLGCSKSqqrQIMLWDTRKMA 248
WD40 pfam00400
WD domain, G-beta repeat;
616-654 8.51e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907073138 616 GRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWS 654
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 585-698 8.67e-04

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 42.44  E-value: 8.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 585 QETVKDFRLLQDSRLLSWSFD--------GTVKVWNVITGRIERDftcHQGTVLSCAISSDATKFSSTSADKTAKIWS-- 654
Cdd:pfam16529 140 DDESKLLVLLRGDKAEIWNVDmivsehgsGPLQPAALESGYIEIE---EHSLLVDAAFSPDGTALATASLDGEVKFFQiy 216

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907073138 655 -FDLLSP--LHELKGHNGCVRCSAFSLDGI-----------LLATGDDNGEIRIWNVS 698
Cdd:pfam16529 217 lFDNRNPrcLHEWKPHDGKPLSSLFFLDNHkkppevqfwrfAITGADNNSELKLWSCE 274
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 718-745 2.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.10e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073138  718 HGGWVTDVCFSPDSKTLVSAG--GYLKWWN 745
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSddGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 173-231 2.40e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.83  E-value: 2.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 173 SCGA-DKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGK 231
Cdd:pfam20426  98 SCGNwENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
WD40 pfam00400
WD domain, G-beta repeat;
151-183 2.80e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.80e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907073138 151 VVRPHTDAVYHACFSQDGQRIASCGADKTLQVF 183
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 200-249 4.31e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 4.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907073138 200 EVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFT 249
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 209-315 6.70e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 6.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073138 209 DDSYIATCSADKKVKIWD--------SATGKLVHtYDEHSEQVNCCHFTNKSNHLLLATGSnDFFLKLWDLNQKECRNTM 280
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGipeegltqNISDPIVH-LQGHTKKVGIVSFHPSAMNVLASAGA-DMVVNVWDVERGKAVEVI 164

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907073138 281 FGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRS 315
Cdd:PTZ00421  165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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