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Conserved domains on  [gi|1907188008|ref|XP_036009747|]
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leucine-rich repeat-containing protein 25 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
44-109 3.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907188008  44 NGTCLNFSGLGLS-LPRSPLQASHAQVLDLSKNGLQVLPgAFFDKLEKLQTLIVTHNQLDSVDRSLA 109
Cdd:COG4886   114 NLESLDLSGNQLTdLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG 179
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-109 3.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907188008  44 NGTCLNFSGLGLS-LPRSPLQASHAQVLDLSKNGLQVLPgAFFDKLEKLQTLIVTHNQLDSVDRSLA 109
Cdd:COG4886   114 NLESLDLSGNQLTdLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG 179
LRR_8 pfam13855
Leucine rich repeat;
65-105 7.92e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 7.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907188008  65 SHAQVLDLSKNGLQVLPGAFFDKLEKLQTLIVTHNQLDSVD 105
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-131 2.23e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907188008  68 QVLDLSKNGLQVLpgAFFDKLEKLQTLIVTHNQLDSVDRSLALrcdlelkadcscgLASWYALR 131
Cdd:cd21340   123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDL-------------LSSWPSLR 171
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-109 3.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907188008  44 NGTCLNFSGLGLS-LPRSPLQASHAQVLDLSKNGLQVLPgAFFDKLEKLQTLIVTHNQLDSVDRSLA 109
Cdd:COG4886   114 NLESLDLSGNQLTdLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG 179
LRR_8 pfam13855
Leucine rich repeat;
65-105 7.92e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 7.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907188008  65 SHAQVLDLSKNGLQVLPGAFFDKLEKLQTLIVTHNQLDSVD 105
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-109 8.38e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 8.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907188008  53 LGLSLPRSPLQASHAQVLDLSKNGLQVLPgAFFDKLEKLQTLIVTHNQLDSVDRSLA 109
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLG 156
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-109 9.24e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 9.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907188008  48 LNFSGLGLS-LPRSPLQASHAQVLDLSKNGLQVLPGAFFdKLEKLQTLIVTHNQLDSVDRSLA 109
Cdd:COG4886   164 LDLSNNQLTdLPEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEPLA 225
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-109 1.65e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907188008  68 QVLDLSKNGLQVLPgAFFDKLEKLQTLIVTHNQLDSVDRSLA 109
Cdd:COG4886   162 KSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLG 202
LRR_8 pfam13855
Leucine rich repeat;
68-101 9.74e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 9.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907188008  68 QVLDLSKNGLQVLPGAFFDKLEKLQTLIVTHNQL 101
Cdd:pfam13855  28 KVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-131 2.23e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907188008  68 QVLDLSKNGLQVLpgAFFDKLEKLQTLIVTHNQLDSVDRSLALrcdlelkadcscgLASWYALR 131
Cdd:cd21340   123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDL-------------LSSWPSLR 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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