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Conserved domains on  [gi|1907070446|ref|XP_036009650|]
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transforming growth factor-beta receptor-associated protein 1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 318-426 4.29e-44

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


:

Pssm-ID: 402126  Cd Length: 109  Bit Score: 149.71  E-value: 4.29e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446 318 VDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSEREL 397
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*....
gi 1907070446 398 CQLCQNPFGEPVFVRYPNGGLVHTHCAAS 426
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFRR 109
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 28-130 3.04e-34

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


:

Pssm-ID: 371008  Cd Length: 108  Bit Score: 123.51  E-value: 3.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446  28 IDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIV---NGDIQDSTRSD 104
Cdd:pfam10366   1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELAdetTGDETDSTLKG 80

                          90       100
                  ....*....|....*....|....*...
gi 1907070446 105 LYEYIVDFLTYC--LDQELVWTHADWLL 130
Cdd:pfam10366  81 PKETIIQYLQKLgpSDLDLILEYSDWVL 108
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 165-279 7.24e-06

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 45.32  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446 165 KYPKALVKYLEHLVIDRRLQKEEYHTHLAILYLEevlrqrvstggkdveaTETQAKLRRLLQKSDLYRVHLLKEKVQGAG 244
Cdd:pfam00637  21 GLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907070446 245 LPMESAILHGKLGEHEKALHiLVHEMGDFSAAEDY 279
Cdd:pfam00637  85 LYEEAVILYKKIGNWKEAIS-LLKKLGDYKDAIEY 118
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 318-426 4.29e-44

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 149.71  E-value: 4.29e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446 318 VDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSEREL 397
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*....
gi 1907070446 398 CQLCQNPFGEPVFVRYPNGGLVHTHCAAS 426
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFRR 109
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 28-130 3.04e-34

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 123.51  E-value: 3.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446  28 IDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIV---NGDIQDSTRSD 104
Cdd:pfam10366   1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELAdetTGDETDSTLKG 80

                          90       100
                  ....*....|....*....|....*...
gi 1907070446 105 LYEYIVDFLTYC--LDQELVWTHADWLL 130
Cdd:pfam10366  81 PKETIIQYLQKLgpSDLDLILEYSDWVL 108
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 165-279 7.24e-06

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 45.32  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446 165 KYPKALVKYLEHLVIDRRLQKEEYHTHLAILYLEevlrqrvstggkdveaTETQAKLRRLLQKSDLYRVHLLKEKVQGAG 244
Cdd:pfam00637  21 GLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907070446 245 LPMESAILHGKLGEHEKALHiLVHEMGDFSAAEDY 279
Cdd:pfam00637  85 LYEEAVILYKKIGNWKEAIS-LLKKLGDYKDAIEY 118
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 318-426 4.29e-44

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 149.71  E-value: 4.29e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446 318 VDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSEREL 397
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*....
gi 1907070446 398 CQLCQNPFGEPVFVRYPNGGLVHTHCAAS 426
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFRR 109
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 28-130 3.04e-34

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 123.51  E-value: 3.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446  28 IDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIV---NGDIQDSTRSD 104
Cdd:pfam10366   1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELAdetTGDETDSTLKG 80

                          90       100
                  ....*....|....*....|....*...
gi 1907070446 105 LYEYIVDFLTYC--LDQELVWTHADWLL 130
Cdd:pfam10366  81 PKETIIQYLQKLgpSDLDLILEYSDWVL 108
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 165-279 7.24e-06

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 45.32  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070446 165 KYPKALVKYLEHLVIDRRLQKEEYHTHLAILYLEevlrqrvstggkdveaTETQAKLRRLLQKSDLYRVHLLKEKVQGAG 244
Cdd:pfam00637  21 GLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907070446 245 LPMESAILHGKLGEHEKALHiLVHEMGDFSAAEDY 279
Cdd:pfam00637  85 LYEEAVILYKKIGNWKEAIS-LLKKLGDYKDAIEY 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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