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Conserved domains on  [gi|1907182206|ref|XP_036009086|]
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ubiquitin thioesterase Zranb1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AnkUBD super family cl39756
Ankyrin ubiquitin-binding domain; This is an Ankyrin repeat domain found in TRABID (also known ...
 272-361 4.45e-59

Ankyrin ubiquitin-binding domain; This is an Ankyrin repeat domain found in TRABID (also known as Ubiquitin thioesterase ZRANB1) (EC:3.4.19.12). In TRABID, the first ankyrin repeat spans residues 260-290 and is connected to the second repeat residues 313-340 by a long linker that packs against what would correspond to the concave surface in an extended ankyrin-repeat structure. Ankyrin-repeat domains mediate protein interactions through a variety of surfaces. The ankyrin domain of TRABID interacts with ubiquitin, hence it is referred to as the ankyrin ubiquitin-binding domain, or AnkUBD.


The actual alignment was detected with superfamily member pfam18418:

Pssm-ID: 408216  Cd Length: 96  Bit Score: 187.16  E-value: 4.45e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182206 272 EVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQ 351
Cdd:pfam18418   1 EVDFKKLKQIKNRMKKTDWLFLNACVGPIEGDLAAIEAFKLSGGDIAGLLDADEVRLLNRPPAFDVGYTLVHLAIRFQRQ 80

                          90
                  ....*....|
gi 1907182206 352 DMLAILLTEV 361
Cdd:pfam18418  81 DMLAILLTEV 90
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 178-201 1.40e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.53  E-value: 1.40e-05
                           10        20
                   ....*....|....*....|....
gi 1907182206  178 HWTCSVCTYENWAKAKKCVVCDHP 201
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 112-133 5.53e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 36.91  E-value: 5.53e-04
                           10        20
                   ....*....|....*....|..
gi 1907182206  112 NKWSCHMCTYLNWPRAIRCTQC 133
Cdd:smart00547   1 GDWECPACTFLNFASRSKCFAC 22
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 33-55 1.43e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 35.76  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 1907182206   33 KWACEYCTYENWPSAIKCTMCRA 55
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGA 24
 
Name Accession Description Interval E-value
AnkUBD pfam18418
Ankyrin ubiquitin-binding domain; This is an Ankyrin repeat domain found in TRABID (also known ...
 272-361 4.45e-59

Ankyrin ubiquitin-binding domain; This is an Ankyrin repeat domain found in TRABID (also known as Ubiquitin thioesterase ZRANB1) (EC:3.4.19.12). In TRABID, the first ankyrin repeat spans residues 260-290 and is connected to the second repeat residues 313-340 by a long linker that packs against what would correspond to the concave surface in an extended ankyrin-repeat structure. Ankyrin-repeat domains mediate protein interactions through a variety of surfaces. The ankyrin domain of TRABID interacts with ubiquitin, hence it is referred to as the ankyrin ubiquitin-binding domain, or AnkUBD.


Pssm-ID: 408216  Cd Length: 96  Bit Score: 187.16  E-value: 4.45e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182206 272 EVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQ 351
Cdd:pfam18418   1 EVDFKKLKQIKNRMKKTDWLFLNACVGPIEGDLAAIEAFKLSGGDIAGLLDADEVRLLNRPPAFDVGYTLVHLAIRFQRQ 80

                          90
                  ....*....|
gi 1907182206 352 DMLAILLTEV 361
Cdd:pfam18418  81 DMLAILLTEV 90
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 178-201 1.40e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.53  E-value: 1.40e-05
                           10        20
                   ....*....|....*....|....
gi 1907182206  178 HWTCSVCTYENWAKAKKCVVCDHP 201
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
175-204 7.58e-05

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 39.64  E-value: 7.58e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907182206 175 RTQHWTCSVCTYENWAKAKKCVVCDHPRPN 204
Cdd:pfam00641   1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 112-133 5.53e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 36.91  E-value: 5.53e-04
                           10        20
                   ....*....|....*....|..
gi 1907182206  112 NKWSCHMCTYLNWPRAIRCTQC 133
Cdd:smart00547   1 GDWECPACTFLNFASRSKCFAC 22
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 33-55 1.43e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 35.76  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 1907182206   33 KWACEYCTYENWPSAIKCTMCRA 55
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGA 24
 
Name Accession Description Interval E-value
AnkUBD pfam18418
Ankyrin ubiquitin-binding domain; This is an Ankyrin repeat domain found in TRABID (also known ...
 272-361 4.45e-59

Ankyrin ubiquitin-binding domain; This is an Ankyrin repeat domain found in TRABID (also known as Ubiquitin thioesterase ZRANB1) (EC:3.4.19.12). In TRABID, the first ankyrin repeat spans residues 260-290 and is connected to the second repeat residues 313-340 by a long linker that packs against what would correspond to the concave surface in an extended ankyrin-repeat structure. Ankyrin-repeat domains mediate protein interactions through a variety of surfaces. The ankyrin domain of TRABID interacts with ubiquitin, hence it is referred to as the ankyrin ubiquitin-binding domain, or AnkUBD.


Pssm-ID: 408216  Cd Length: 96  Bit Score: 187.16  E-value: 4.45e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182206 272 EVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQ 351
Cdd:pfam18418   1 EVDFKKLKQIKNRMKKTDWLFLNACVGPIEGDLAAIEAFKLSGGDIAGLLDADEVRLLNRPPAFDVGYTLVHLAIRFQRQ 80

                          90
                  ....*....|
gi 1907182206 352 DMLAILLTEV 361
Cdd:pfam18418  81 DMLAILLTEV 90
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 178-201 1.40e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.53  E-value: 1.40e-05
                           10        20
                   ....*....|....*....|....
gi 1907182206  178 HWTCSVCTYENWAKAKKCVVCDHP 201
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
175-204 7.58e-05

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 39.64  E-value: 7.58e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907182206 175 RTQHWTCSVCTYENWAKAKKCVVCDHPRPN 204
Cdd:pfam00641   1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 112-133 5.53e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 36.91  E-value: 5.53e-04
                           10        20
                   ....*....|....*....|..
gi 1907182206  112 NKWSCHMCTYLNWPRAIRCTQC 133
Cdd:smart00547   1 GDWECPACTFLNFASRSKCFAC 22
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 33-55 1.43e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 35.76  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 1907182206   33 KWACEYCTYENWPSAIKCTMCRA 55
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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