cysteine protease ATG4B isoform X2 [Mus musculus]
Protein Classification
cysteine protease ATG4( domain architecture ID 10506323)
cysteine protease ATG4 is required in the cytoplasm for vacuole transport (Cvt) and autophagy
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| Peptidase_C54 | pfam03416 | Peptidase family C54; |
1-166 | 5.14e-73 | ||||
Peptidase family C54; : Pssm-ID: 460915 Cd Length: 269 Bit Score: 222.38 E-value: 5.14e-73
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| ATG4_LIR | pfam20166 | ATG4, F-type LIR motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs ... |
194-222 | 5.96e-08 | ||||
ATG4, F-type LIR motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. ATG8 proteins are highly conserved in eukaryotes and play a key role in selective autophagy as they recognize and bind different autophagy receptors and adaptors containing a specific class of SLiMs. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry is the F-type LIR motif from ATG4, which contains the seqeunce FEI/VL. There are acidic residues at the N-terminal of this motif (Asp and Glu), which may contribute to stabilize the binding or may provide specificity toward a certain class of ATG8 proteins. : Pssm-ID: 466317 Cd Length: 29 Bit Score: 47.25 E-value: 5.96e-08
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| Name | Accession | Description | Interval | E-value | ||||
| Peptidase_C54 | pfam03416 | Peptidase family C54; |
1-166 | 5.14e-73 | ||||
Peptidase family C54; Pssm-ID: 460915 Cd Length: 269 Bit Score: 222.38 E-value: 5.14e-73
|
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| ATG4_LIR | pfam20166 | ATG4, F-type LIR motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs ... |
194-222 | 5.96e-08 | ||||
ATG4, F-type LIR motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. ATG8 proteins are highly conserved in eukaryotes and play a key role in selective autophagy as they recognize and bind different autophagy receptors and adaptors containing a specific class of SLiMs. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry is the F-type LIR motif from ATG4, which contains the seqeunce FEI/VL. There are acidic residues at the N-terminal of this motif (Asp and Glu), which may contribute to stabilize the binding or may provide specificity toward a certain class of ATG8 proteins. Pssm-ID: 466317 Cd Length: 29 Bit Score: 47.25 E-value: 5.96e-08
|
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| Name | Accession | Description | Interval | E-value | ||||
| Peptidase_C54 | pfam03416 | Peptidase family C54; |
1-166 | 5.14e-73 | ||||
Peptidase family C54; Pssm-ID: 460915 Cd Length: 269 Bit Score: 222.38 E-value: 5.14e-73
|
||||||||
| ATG4_LIR | pfam20166 | ATG4, F-type LIR motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs ... |
194-222 | 5.96e-08 | ||||
ATG4, F-type LIR motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. ATG8 proteins are highly conserved in eukaryotes and play a key role in selective autophagy as they recognize and bind different autophagy receptors and adaptors containing a specific class of SLiMs. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry is the F-type LIR motif from ATG4, which contains the seqeunce FEI/VL. There are acidic residues at the N-terminal of this motif (Asp and Glu), which may contribute to stabilize the binding or may provide specificity toward a certain class of ATG8 proteins. Pssm-ID: 466317 Cd Length: 29 Bit Score: 47.25 E-value: 5.96e-08
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| Blast search parameters | ||||
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