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Conserved domains on  [gi|1907173989|ref|XP_036008299|]
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ankyrin repeat and SOCS box protein 15 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
129-318 7.14e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.93  E-value: 7.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 129 KTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAK 208
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 209 QGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYG 288
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907173989 289 GSGNVPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 554-605 1.59e-24

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03731:

Pssm-ID: 470605  Cd Length: 56  Bit Score: 96.44  E-value: 1.59e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 605
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQ 52
Ank_2 pfam12796
Ankyrin repeats (3 copies);
302-400 9.63e-14

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 9.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 302 IHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIEngfdvnalladHISQSYDDERKTALYFAV 380
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1907173989 381 SNNDIHCTEVLLAAGADPNL 400
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-163 5.93e-07

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  69 LVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLwefkTCDGETPLTLAVKAGLVEN 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 1907173989 149 VKTLLDKGVWPNTKN 163
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 357-467 4.63e-03

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 357 NALLADHISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLN--CLLVAVRANRH------EIVRLLLSYGANV 428
Cdd:PHA03100   20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNnsTPLHYLSNIKYnltdvkEIVKLLLEYGANV 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907173989 429 NCYFMHVNdTRFPSAIQYALNDEIMLRLLLNNGYQVELC 467
Cdd:PHA03100  100 NAPDNNGI-TPLLYAISKKSNSYSIVEYLLDNGANVNIK 137
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
129-318 7.14e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.93  E-value: 7.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 129 KTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAK 208
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 209 QGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYG 288
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907173989 289 GSGNVPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 554-605 1.59e-24

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 96.44  E-value: 1.59e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 605
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQ 52
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 121-293 9.29e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 91.98  E-value: 9.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 121 SYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPN-TKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKR 199
Cdd:PHA02875   56 KHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 200 WSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDG-ASVLFEAAGGGNP 278
Cdd:PHA02875  136 FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKI 215

                         170
                  ....*....|....*
gi 1907173989 279 DCISLLLKYGGSGNV 293
Cdd:PHA02875  216 DIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-229 1.36e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 1.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 137 LTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQpcVKRWSAMHEAAKQGRKDIIT 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1907173989 217 LLLNHRGNVHLRD 229
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
302-400 9.63e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 9.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 302 IHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIEngfdvnalladHISQSYDDERKTALYFAV 380
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1907173989 381 SNNDIHCTEVLLAAGADPNL 400
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 555-596 1.19e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 59.49  E-value: 1.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173989 555 NPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLL 596
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 269-464 2.33e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 269 LFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSgLTPIHSAAEGQNAQCLEL 348
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT-LVAIKDAFNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 349 LIENGFDVN----------------------ALLADH---ISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLdPL 403
Cdd:PHA02878  120 ILTNRYKNIqtidlvyidkkskddiieaeitKLLLSYgadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNI-PD 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907173989 404 NC----LLVAVRANRHEIVRLLLSYGANVNCYFMHVNdTRFPSAIQYALNDEImLRLLLNNGYQV 464
Cdd:PHA02878  199 KTnnspLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYCKDYDI-LKLLLEHGVDV 261
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 557-598 1.96e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.40  E-value: 1.96e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907173989  557 CSLKHLCRLKIRRVMGLqrlcqpasIQMLPLPAAMRRYLLFK 598
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-163 5.93e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  69 LVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLwefkTCDGETPLTLAVKAGLVEN 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 1907173989 149 VKTLLDKGVWPNTKN 163
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 265-358 6.31e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 265 GASVLFEAAGGGNP-DCISLLLKYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSKH-------AIQKS---- 329
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKSgplelanDQYTSeftp 127

                          90       100
                  ....*....|....*....|....*....
gi 1907173989 330 GLTPIHSAAEGQNAQCLELLIENGFDVNA 358
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVPA 156
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 134-318 3.60e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 134 ETPLTLAVKAGLVENVKTLLD-KGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSL-DQPCV----KRWSAMHEAA 207
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvNEPMTsdlyQGETALHIAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 208 KQGRKDIITLLLNHRGNV----------HLRDG----FGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAA 273
Cdd:cd22192    98 VNQNLNLVRELIARGADVvspratgtffRPGPKnliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILV 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173989 274 GGGN--PDC--ISLLLKYGGSGN------VPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:cd22192   178 LQPNktFACqmYDLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLV 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 330-358 4.36e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 4.36e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173989  330 GLTPIHSAAEGQNAQCLELLIENGFDVNA 358
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 357-467 4.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 357 NALLADHISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLN--CLLVAVRANRH------EIVRLLLSYGANV 428
Cdd:PHA03100   20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNnsTPLHYLSNIKYnltdvkEIVKLLLEYGANV 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907173989 429 NCYFMHVNdTRFPSAIQYALNDEIMLRLLLNNGYQVELC 467
Cdd:PHA03100  100 NAPDNNGI-TPLLYAISKKSNSYSIVEYLLDNGANVNIK 137
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 404-430 5.41e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 5.41e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907173989  404 NCLLVAVRANRHEIVRLLLSYGANVNC 430
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 132-160 6.85e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.85e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173989  132 DGETPLTLAVKAGLVENVKTLLDKGVWPN 160
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
129-318 7.14e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.93  E-value: 7.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 129 KTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAK 208
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 209 QGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYG 288
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907173989 289 GSGNVPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
90-362 5.42e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.62  E-value: 5.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  90 ALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETP 169
Cdd:COG0666    11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 170 LLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLE 249
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 250 HLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-HAIQK 328
Cdd:COG0666   171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADlNAKDK 250

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1907173989 329 SGLTPIHSAAEGQNAQCLELLIENGFDVNALLAD 362
Cdd:COG0666   251 DGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
200-460 2.25e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.61  E-value: 2.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 200 WSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPD 279
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 280 CISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvtsKH-----AIQKSGLTPIHSAAEGQNAQCLELLIENGF 354
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL----EAgadvnAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 355 DVNALladhisqsyDDERKTALYFAVSNNDIHCTEVLLAAGADPNL---DPLNCLLVAVRANRHEIVRLLLSYGANVNCY 431
Cdd:COG0666   178 DVNAR---------DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                         250       260
                  ....*....|....*....|....*....
gi 1907173989 432 FMHVNDTRFPSAIQYALNDEIMLRLLLNN 460
Cdd:COG0666   249 DKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
152-429 5.80e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 5.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 152 LLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGF 231
Cdd:COG0666     7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 232 GVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHY 311
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 312 LALKYLIpvtsKH-----AIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIH 386
Cdd:COG0666   167 EIVKLLL----EAgadvnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK---------DNDGKTALDLAAENGNLE 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173989 387 CTEVLLAAGADPNLDPLNC---LLVAVRANRHEIVRLLLSYGANVN 429
Cdd:COG0666   234 IVKLLLEAGADLNAKDKDGltaLLLAAAAGAALIVKLLLLALLLLA 279
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-302 9.10e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.68  E-value: 9.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  16 IDIQGADMDINDDSNDDHLASYDIQLCIQESIEASQAIFHPKRLVQLSDQNRKLVEAIRQGRIFELQEYVQYKYALEEAD 95
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  96 EKGWFPLHEAVVQPIQQILETVLDAsyKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIK 175
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEA--GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 176 RGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 255
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1907173989 256 GDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPI 302
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
213-461 9.47e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 9.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 213 DIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGN 292
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 293 VPNRAGHLPIHRAAYEGHYLALKYLIpvtsKH-----AIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALladhisqs 367
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLL----EAgadvnARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ-------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 368 yDDERKTALYFAVSNNDIHCTEVLLAAGADPNL---DPLNCLLVAVRANRHEIVRLLLSYGANVNcyfmhVNDTRFPSAI 444
Cdd:COG0666   150 -DNDGNTPLHLAAANGNLEIVKLLLEAGADVNArdnDGETPLHLAAENGHLEIVKLLLEAGADVN-----AKDNDGKTAL 223

                         250
                  ....*....|....*....
gi 1907173989 445 QYAL--NDEIMLRLLLNNG 461
Cdd:COG0666   224 DLAAenGNLEIVKLLLEAG 242
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 554-605 1.59e-24

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 96.44  E-value: 1.59e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 605
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQ 52
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 121-293 9.29e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 91.98  E-value: 9.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 121 SYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPN-TKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKR 199
Cdd:PHA02875   56 KHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 200 WSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDG-ASVLFEAAGGGNP 278
Cdd:PHA02875  136 FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKI 215

                         170
                  ....*....|....*
gi 1907173989 279 DCISLLLKYGGSGNV 293
Cdd:PHA02875  216 DIVRLFIKRGADCNI 230
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 554-605 1.20e-16

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 74.11  E-value: 1.20e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 605
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQ 52
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 135-386 3.43e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.25  E-value: 3.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 135 TPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPL-----LIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAA-- 207
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIsk 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 208 KQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCD--VLEHLIHKGGDVFALaddgasvlfeaagggnpDCISLLL 285
Cdd:PHA03100  117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAK-----------------NRVNYLL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 286 KYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALladhi 364
Cdd:PHA03100  180 SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI----- 254

                         250       260
                  ....*....|....*....|..
gi 1907173989 365 sqsyddeRKTALYFAVSNNDIH 386
Cdd:PHA03100  255 -------IETLLYFKDKDLNTI 269
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-229 1.36e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 1.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 137 LTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQpcVKRWSAMHEAAKQGRKDIIT 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1907173989 217 LLLNHRGNVHLRD 229
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 135-352 9.58e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 9.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 135 TPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIK--YNTS-LDQPCV-------------- 197
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDngVDTSiLPIPCIekdmiktildcgid 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 198 ------KRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVlehlihkggdvfaladdgasvlfe 271
Cdd:PHA02874  117 vnikdaELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDI------------------------ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 272 aagggnpdcISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQ-KSGLTPIHSAAEgQNAQCLELLI 350
Cdd:PHA02874  173 ---------IKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAII-HNRSAIELLI 242


                  ..
gi 1907173989 351 EN 352
Cdd:PHA02874  243 NN 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
269-358 6.65e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 6.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 269 LFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvtsKHAIQK---SGLTPIHSAAEGQNAQC 345
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL----EHADVNlkdNGRTALHYAARSGHLEI 76

                          90
                  ....*....|...
gi 1907173989 346 LELLIENGFDVNA 358
Cdd:pfam12796  77 VKLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-424 7.29e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 74.29  E-value: 7.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 133 GETPLTLAVKAGL---VENVKTLLDKGVWPNTKNDKGETPLLIAIKRGS-YDMVSALIKYNTSLDQPCVKRWSAMHE--A 206
Cdd:PHA03095   47 GKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVylS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 207 AKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDV--LEHLIHKGGDVFALADDGASVL------FEAagggNP 278
Cdd:PHA03095  127 GFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAVDDRFRSLLhhhlqsFKP----RA 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 279 DCISLLLKYGGSGNVPNRAGHLPIHRAAYEG---HYLALKYLIPVTSKHAIQKSGLTPIHSAAEGQNAQCLELLIENGFD 355
Cdd:PHA03095  203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGAD 282

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907173989 356 VNALladhisqSYDDErkTALYFAVSNNDIHCTEVLLAagADPNLDP----LNCLLVAVRANRHEIVRLLLSY 424
Cdd:PHA03095  283 INAV-------SSDGN--TPLSLMVRNNNGRAVRAALA--KNPSAETvaatLNTASVAGGDIPSDATRLCVAK 344
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 554-598 8.72e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.59  E-value: 8.72e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLEL---IKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
302-400 9.63e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 9.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 302 IHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIEngfdvnalladHISQSYDDERKTALYFAV 380
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1907173989 381 SNNDIHCTEVLLAAGADPNL 400
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
236-318 1.29e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 236 LGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNraGHLPIHRAAYEGHYLALK 315
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78


                  ...
gi 1907173989 316 YLI 318
Cdd:pfam12796  79 LLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
334-429 1.90e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 334 IHSAAEGQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIHCTEVLLA-AGADPNLDPLNCLLVAVRA 412
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*..
gi 1907173989 413 NRHEIVRLLLSYGANVN 429
Cdd:pfam12796  72 GHLEIVKLLLEKGADIN 88
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 239-437 2.35e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 239 AAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 319 PVTS--KHAIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNA----------------------LLADHISQS--YDDER 372
Cdd:PHA02875   89 DLGKfaDDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIpntdkfsplhlavmmgdikgieLLIDHKACLdiEDCCG 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173989 373 KTALYFAVSNNDIHCTEVLLAAGADPNLDPLN----CLLVAVRANRHEIVRLLLSYGANVNCYFMHVND 437
Cdd:PHA02875  169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgcvaALCYAIENNKIDIVRLFIKRGADCNIMFMIEGE 237
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-290 3.85e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.62  E-value: 3.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  88 KYALEEA---DEKGWF---PLHEAVVQPIQQILETVLDASYKTlwEFKTCDGETPLTLAVKAGLVEN-----VKTLLDKG 156
Cdd:PHA03100   19 KYIIMEDdlnDYSYKKpvlPLYLAKEARNIDVVKILLDNGADI--NSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 157 VWPNTKNDKGETPLLIAI--KRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKD--IITLLLNHRGNVH------ 226
Cdd:PHA03100   97 ANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvn 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907173989 227 ----------LRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGS 290
Cdd:PHA03100  177 yllsygvpinIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 135-359 7.15e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.63  E-value: 7.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 135 TPLTLAVKA-GLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGsYDM--VSALIKYNTSLDQPCVKRWSAMHEAAKQGR 211
Cdd:PHA02876  275 TPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG-YDTenIRTLIMLGADVNAADRLYITPLHQASTLDR 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 212 -KDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPdcislllkyggs 290
Cdd:PHA02876  354 nKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNP------------ 421

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907173989 291 gnvpnraghlpihraayeghYLALKYLIP----VTSKHaiqKSGLTPIHSAAEGQ-NAQCLELLIENGFDVNAL 359
Cdd:PHA02876  422 --------------------YMSVKTLIDrganVNSKN---KDLSTPLHYACKKNcKLDVIEMLLDNGADVNAI 472
Ank_2 pfam12796
Ankyrin repeats (3 copies);
203-295 8.45e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.37  E-value: 8.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 203 MHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI-HKGGDVFalaDDGASVLFEAAGGGNPDCI 281
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLeHADVNLK---DNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 1907173989 282 SLLLKYGGSGNVPN 295
Cdd:pfam12796  78 KLLLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 555-598 1.56e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 62.10  E-value: 1.56e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907173989 555 NPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDL---IDKLPLPPRLKDYLLYK 41
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 555-596 1.19e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 59.49  E-value: 1.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173989 555 NPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLL 596
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 102-269 1.77e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.53  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 102 LHEAVVQPIQQILETVLDasYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDM 181
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFE--YGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 182 VSALIKYNTSLDQPCVKRWSAMHEAAKQGRKdIITLLLNHRgNVHLRDGFGVTPLGVAAEYgHC--DVLEHLIHKGGDVF 259
Cdd:PHA02874  206 IKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNA-SINDQDIDGSTPLHHAINP-PCdiDIIDILLYHKADIS 282

                         170
                  ....*....|
gi 1907173989 260 ALADDGASVL 269
Cdd:PHA02874  283 IKDNKGENPI 292
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 136-392 2.09e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.44  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 136 PLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAI----KRGSYDMVSALIKYNTSLDQPCVK------------- 198
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnKLGMKEMIRSINKCSVFYTLVAIKdafnnrnveifki 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 199 ---------RWSAMHEAAKQGRKD-----IITLLLNHRGNVHLRD-GFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALAD 263
Cdd:PHA02878  120 iltnrykniQTIDLVYIDKKSKDDiieaeITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 264 DGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAA-----YEGHYLALKYLIPVTSKHAIQksGLTPIHSAA 338
Cdd:PHA02878  200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgyckdYDILKLLLEHGVDVNAKSYIL--GLTALHSSI 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173989 339 egQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSN-NDIHCTEVLL 392
Cdd:PHA02878  278 --KSERKLKLLLEYGADINSL---------NSYKLTPLSSAVKQyLCINIGRILI 321
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-253 5.08e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  35 ASYDIQLCI-QESIEASQAIFHPK-RLVQLS--DQNRKLVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAV---- 106
Cdd:PHA02874    1 ASQDLRMCIySGDIEAIEKIIKNKgNCINISvdETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIkiga 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 107 ---------------VQPI----QQILETVLDASYKTlwEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGE 167
Cdd:PHA02874   81 hdiikllidngvdtsILPIpcieKDMIKTILDCGIDV--NIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 168 TPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHcDV 247
Cdd:PHA02874  159 YPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SA 237


                  ....*.
gi 1907173989 248 LEHLIH 253
Cdd:PHA02874  238 IELLIN 243
PHA03095 PHA03095
ankyrin-like protein; Provisional
 181-460 1.52e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 181 MVSALIKYNTSLDQPCVkrwsamheaakqgrkDIITLLLNHRGNVHLRDGFGVTPLGVaaeYGHCdvlehlihKGGDVfa 260
Cdd:PHA03095   11 MEAALYDYLLNASNVTV---------------EEVRRLLAAGADVNFRGEYGKTPLHL---YLHY--------SSEKV-- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 261 laddgasvlfeaagggnPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLA-LKYLIP----VTSKHaiqKSGLTPIH 335
Cdd:PHA03095   63 -----------------KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDvIKLLIKagadVNAKD---KVGRTPLH 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 336 SAAEGQN--AQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIhCTEV---LLAAGADP------NLDPLN 404
Cdd:PHA03095  123 VYLSGFNinPKVIRLLLRKGADVNAL---------DLYGMTPLAVLLKSRNA-NVELlrlLIDAGADVyavddrFRSLLH 192

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907173989 405 CLLVAVRAnRHEIVRLLLSYGANVNCYFMHVNDTRFPSAIQYALNDEIMLRLLLNN 460
Cdd:PHA03095  193 HHLQSFKP-RARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAG 247
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 243-464 2.48e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.06  E-value: 2.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 243 GHCDVLEHLIHKGGDVFALA-DDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvt 321
Cdd:PHA02874   12 GDIEAIEKIIKNKGNCINISvDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI--- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 322 sKHAIQKSGLtPIHSAaegqNAQCLELLIENGFDVNalladhisqSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLD 401
Cdd:PHA02874   89 -DNGVDTSIL-PIPCI----EKDMIKTILDCGIDVN---------IKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173989 402 PLNC---LLVAVRANRHEIVRLLLSYGANVNcyfmhVNDTRFPSAIQYALN--DEIMLRLLLNNGYQV 464
Cdd:PHA02874  154 DDNGcypIHIAIKHNFFDIIKLLLEKGAYAN-----VKDNNGESPLHNAAEygDYACIKLLIDHGNHI 216
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 152-481 2.78e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.16  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 152 LLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRD-- 229
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDls 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 230 -------------------GFGV--------TPLGVAAEYGHCDVL-EHLIHKGGDVFALADDGASVLFEAAGGG-NPDC 280
Cdd:PHA02876  244 llkairnedletslllydaGFSVnsiddcknTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGyDTEN 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 281 ISLLLKYGGSGNVPNRAGHLPIHRAAYEGHY-----LALKYLIPVTSKHAIQKsglTPIHSAAEGQNAQCLELLIENGFD 355
Cdd:PHA02876  324 IRTLIMLGADVNAADRLYITPLHQASTLDRNkdiviTLLELGANVNARDYCDK---TPIHYAAVRNNVVIINTLLDYGAD 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 356 VNALladhiSQSYDderkTALYFAV-SNNDIHCTEVLLAAGAD---PNLDPLNCLLVAVRAN-RHEIVRLLLSYGANVNC 430
Cdd:PHA02876  401 IEAL-----SQKIG----TALHFALcGTNPYMSVKTLIDRGANvnsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNA 471

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173989 431 YFMHvndTRFPSAIqyALNDEIMLRLLLNNGYQV---ELCFDCMHGNIFGNSFV 481
Cdd:PHA02876  472 INIQ---NQYPLLI--ALEYHGIVNILLHYGAELrdsRVLHKSLNDNMFSFRYI 520
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-258 6.16e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 6.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  85 VQYKYALEEADEKGWFPLHEAVVQPIQQ--ILETVLDASYKTlwEFKTCDGETPLTLAVKAGLVEN--VKTLLDKGVWPN 160
Cdd:PHA03100   93 LEYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGANV--NIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDIN 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 161 TKNDkgetplliaikrgsydmVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAA 240
Cdd:PHA03100  171 AKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233

                         170
                  ....*....|....*...
gi 1907173989 241 EYGHCDVLEHLIHKGGDV 258
Cdd:PHA03100  234 LNNNKEIFKLLLNNGPSI 251
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 178-465 8.76e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.62  E-value: 8.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 178 SYDMVSALIKYNTSLDqpcvkrwsamhEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGD 257
Cdd:PHA02876  135 HYDKINESIEYMKLIK-----------ERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGAD 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 258 VFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSkhaIQKSGLTPIHSA 337
Cdd:PHA02876  204 VNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNS---IDDCKNTPLHHA 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 338 AEGQN-AQCLELLIENGFDVNAlladhisqsYDDERKTALYFAVSNN-DIHCTEVLLAAGADPN------LDPLNcllVA 409
Cdd:PHA02876  281 SQAPSlSRLVPKLLERGADVNA---------KNIKGETPLYLMAKNGyDTENIRTLIMLGADVNaadrlyITPLH---QA 348

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173989 410 VRANRH-EIVRLLLSYGANVNcyfmhVNDTRFPSAIQYAL--NDEIMLRLLLNNGYQVE 465
Cdd:PHA02876  349 STLDRNkDIVITLLELGANVN-----ARDYCDKTPIHYAAvrNNVVIINTLLDYGADIE 402
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 233-461 6.22e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 6.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 233 VTPLGVAAEYGHCDVLEHLIHKGGDV--FALADDGASVLFEAAG---GGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAY 307
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADInsSTKNNSTPLHYLSNIKynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 308 E--GHYLALKYLIPVTSKHAIQKS-GLTPIHSAAEG--QNAQCLELLIENGFDVNAlladhisqsydderktalyfavsn 382
Cdd:PHA03100  116 KksNSYSIVEYLLDNGANVNIKNSdGENLLHLYLESnkIDLKILKLLIDKGVDINA------------------------ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 383 ndihCTEV--LLAAGADPNLdPLNC----LLVAVRANRHEIVRLLLSYGANVNcYFMHVNDTrfPSAIQYALNDEIMLRL 456
Cdd:PHA03100  172 ----KNRVnyLLSYGVPINI-KDVYgftpLHYAVYNNNPEFVKYLLDLGANPN-LVNKYGDT--PLHIAILNNNKEIFKL 243


                  ....*
gi 1907173989 457 LLNNG 461
Cdd:PHA03100  244 LLNNG 248
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 170-318 6.97e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 58.73  E-value: 6.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 170 LLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLE 249
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 250 HLIHkggdvFALADD---GASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:PLN03192  609 ILYH-----FASISDphaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 269-464 2.33e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 269 LFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSgLTPIHSAAEGQNAQCLEL 348
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT-LVAIKDAFNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 349 LIENGFDVN----------------------ALLADH---ISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLdPL 403
Cdd:PHA02878  120 ILTNRYKNIqtidlvyidkkskddiieaeitKLLLSYgadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNI-PD 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907173989 404 NC----LLVAVRANRHEIVRLLLSYGANVNCYFMHVNdTRFPSAIQYALNDEImLRLLLNNGYQV 464
Cdd:PHA02878  199 KTnnspLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYCKDYDI-LKLLLEHGVDV 261
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 554-598 4.90e-08

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 49.25  E-value: 4.90e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03719     1 AEPHSLLHLSRLCVRHALGDTRLGQ---VSALPLPPAMKRYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
135-186 1.03e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 1.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 135 TPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALI 186
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 556-598 1.46e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 48.07  E-value: 1.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173989 556 PCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLLFK 598
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRL---EEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 558-599 1.51e-07

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 48.25  E-value: 1.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173989 558 SLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKE 599
Cdd:cd03722     5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 557-598 1.96e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.40  E-value: 1.96e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907173989  557 CSLKHLCRLKIRRVMGLqrlcqpasIQMLPLPAAMRRYLLFK 598
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 133-193 2.51e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 2.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173989 133 GETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLD 193
Cdd:PHA03100  192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_4 pfam13637
Ankyrin repeats (many copies);
199-252 3.38e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 3.38e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173989 199 RWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 252
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 554-596 5.90e-07

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 46.14  E-value: 5.90e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907173989  554 ENPCSLKHLCRLKIRRVMGLQrlcqpaSIQMLPLPAAMRRYLL 596
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD------QIKTLPLPPKLKDYLS 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-163 5.93e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989  69 LVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLwefkTCDGETPLTLAVKAGLVEN 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 1907173989 149 VKTLLDKGVWPNTKN 163
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
330-392 1.98e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.98e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907173989 330 GLTPIHSAAEGQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIHCTEVLL 392
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAV---------DGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 556-598 2.27e-06

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 44.44  E-value: 2.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173989 556 PCSLKHLCRLKIRRVMGLQRLcqPASIQMLPLPAAMRRYLLFK 598
Cdd:cd03727     3 PGTLKALARYAVRRSLGVQYL--PEAVKQLPLPRSVKEYLLLL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
267-318 2.31e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 2.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 267 SVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 558-598 3.27e-06

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 44.03  E-value: 3.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173989 558 SLKHLCRLKIRRVMGLQRlcqpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03746     5 SLQHLCRMAIRRVMPTQQ------VKELPIPSKLLEFLTYR 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 133-258 5.50e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 5.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 133 GETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKY------NTSLDQPCvkrwsamhEA 206
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFasisdpHAAGDLLC--------TA 629

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 207 AKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDV 258
Cdd:PLN03192  630 AKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 558-598 6.28e-06

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 43.18  E-value: 6.28e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173989 558 SLKHLCRLKIRRVMGLQRlcqpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03733     5 SLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTYR 39
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 555-596 1.02e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.81  E-value: 1.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173989 555 NPCSLKHLCRLKIRRVMGlqRLCQpASIQMLPLPAAMRRYLL 596
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLG--SRCH-KLVPQLSLPTSLKNYLL 40
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 556-598 1.24e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 42.66  E-value: 1.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173989 556 PCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSE---IHTLPLPASLKNYLLYQ 42
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 554-599 1.75e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 42.16  E-value: 1.75e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173989 554 ENPCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLLFKE 599
Cdd:cd03721     1 EPPRPLAHLCRLKVRTLIGINRI---KLIDTLPLPPRLIRYLNHQE 43
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 555-596 1.90e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 42.02  E-value: 1.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173989 555 NPCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLL 596
Cdd:cd03720     2 NPRSLLSLCRIAVRRALGKQRL---SLICSLPLPDPIKKFLL 40
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 265-358 6.31e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 265 GASVLFEAAGGGNP-DCISLLLKYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSKH-------AIQKS---- 329
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKSgplelanDQYTSeftp 127

                          90       100
                  ....*....|....*....|....*....
gi 1907173989 330 GLTPIHSAAEGQNAQCLELLIENGFDVNA 358
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVPA 156
Ank_4 pfam13637
Ankyrin repeats (many copies);
301-350 6.39e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 6.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173989 301 PIHRAAYEGHYLALKYLI----PVtskHAIQKSGLTPIHSAAEGQNAQCLELLI 350
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLekgaDI---NAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 556-598 6.62e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 40.32  E-value: 6.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173989 556 PCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 598
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHH---IQSLPLPQTLKNYLQYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 101-239 7.56e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 101 PLHEAVVQPIQQILETVLdaSYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKR-GSY 179
Cdd:PHA02878  171 ALHYATENKDQRLTELLL--SYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDY 248

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173989 180 DMVSALIKYNTSLD-QPCVKRWSAMHEAAKQGRKdiITLLLNHRGNVHLRDGFGVTPLGVA 239
Cdd:PHA02878  249 DILKLLLEHGVDVNaKSYILGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSA 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
232-285 7.78e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 7.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173989 232 GVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLL 285
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02730 PHA02730
ankyrin-like protein; Provisional
 344-449 1.22e-04

ankyrin-like protein; Provisional


Pssm-ID: 165098 [Multi-domain]  Cd Length: 672  Bit Score: 45.02  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 344 QCLELLIENGFDVNALLADHISQsYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLNCLLVAV------RANRHEI 417
Cdd:PHA02730  435 HCYETILIDVFDILSKYMDDIDM-IDNENKTLLYYAVDVNNIQFARRLLEYGASVNTTSRSIINTAIqkssyrRENKTKL 513

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907173989 418 VRLLLSY---------GANVNCYFMH------------VNDTRFPSAIQYALN 449
Cdd:PHA02730  514 VDLLLSYhptletmidAFNRDIRYLYpepllaciryalILDNDFPSKVKYDIA 566
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 149-285 1.34e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 44.73  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 149 VKTLLDKGVWP-NTKNDKGETPLLIAIKRG----SYDMVSALIKYNTSLDQPCVKRWSAM------HEAAKQGRKDIITL 217
Cdd:PHA02989  163 IKILLSFGVNLfEKTSLYGLTPMNIYLRNDidviSIKVIKYLIKKGVNIETNNNGSESVLesfldnNKILSKKEFKVLNF 242

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173989 218 LLNHRgNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLL 285
Cdd:PHA02989  243 ILKYI-KINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRIL 309
PHA03095 PHA03095
ankyrin-like protein; Provisional
 131-286 2.22e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 131 CDGETPLTLAVKAG--LVENVKTLLDKGVWPNTKNDKGETPLLIAIK--RGSYDMVSALIKYNTSLDQPCVKRWSAMHEA 206
Cdd:PHA03095  150 LYGMTPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNTPLHSM 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 207 AKQG--RKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLL 284
Cdd:PHA03095  230 ATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAA 309


                  ..
gi 1907173989 285 LK 286
Cdd:PHA03095  310 LA 311
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 558-596 2.70e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 38.73  E-value: 2.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907173989 558 SLKHLCRLKIRRVMGLQrlcqpaSIQMLPLPAAMRRYLL 596
Cdd:cd03717     5 SLQHLCRFVIRQCTRRD------LIDQLPLPRRLKDYLK 37
Ank_5 pfam13857
Ankyrin repeats (many copies);
217-269 3.18e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 3.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907173989 217 LLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVL 269
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 134-318 3.60e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 134 ETPLTLAVKAGLVENVKTLLD-KGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSL-DQPCV----KRWSAMHEAA 207
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvNEPMTsdlyQGETALHIAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 208 KQGRKDIITLLLNHRGNV----------HLRDG----FGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAA 273
Cdd:cd22192    98 VNQNLNLVRELIARGADVvspratgtffRPGPKnliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILV 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173989 274 GGGN--PDC--ISLLLKYGGSGN------VPNRAGHLPIHRAAYEGHYLALKYLI 318
Cdd:cd22192   178 LQPNktFACqmYDLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLV 232
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 123-254 3.73e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 123 KTLWEFKTCD-------GETPLTLAVKAGLVENVKTLLDKGvwPNTKND-------KGETPLLIAIKRGSYDMVSALIKY 188
Cdd:cd22192    34 KKLLKCPSCDlfqrgalGETALHVAALYDNLEAAVVLMEAA--PELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIAR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 189 NTSLDQPCVK----RWSA----------MHEAAKQGRKDIITLLLNHRGNVHLRDGF----------------------- 231
Cdd:cd22192   112 GADVVSPRATgtffRPGPknliyygehpLSFAACVGNEEIVRLLIEHGADIRAQDSLgntvlhilvlqpnktfacqmydl 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907173989 232 --------------------GVTPLGVAAEYGHCDVLEHLIHK 254
Cdd:cd22192   192 ilsydkeddlqpldlvpnnqGLTPFKLAAKEGNIVMFQHLVQK 234
Ank_5 pfam13857
Ankyrin repeats (many copies);
133-173 6.78e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 6.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173989 133 GETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIA 173
Cdd:pfam13857  16 GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
152-206 7.55e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 7.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907173989 152 LLDKGVW-PNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEA 206
Cdd:pfam13857   1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-219 7.94e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 7.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173989 168 TPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLL 219
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 335-424 1.01e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 335 HSAAEGqNAQCLELLIENGFDVNalladhiSQSYDDerKTALYFAVSNNDIHCTEVLLAAGADPNL---DPLNCLLVAVR 411
Cdd:PTZ00322   88 QLAASG-DAVGARILLTGGADPN-------CRDYDG--RTPLHIACANGHVQVVRVLLEFGADPTLldkDGKTPLELAEE 157

                          90
                  ....*....|...
gi 1907173989 412 ANRHEIVRLLLSY 424
Cdd:PTZ00322  158 NGFREVVQLLSRH 170
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 346-429 3.49e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.11  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 346 LELLIENGFDVNalladhiSQSYDDERKTAL---YFAVSNNDIHCTEVLLAAGADPNLDPLN------CLLVAVRANRHE 416
Cdd:PHA02989   53 VKLLIDNGADVN-------YKGYIETPLCAVlrnREITSNKIKKIVKLLLKFGADINLKTFNgvspivCFIYNSNINNCD 125

                          90
                  ....*....|...
gi 1907173989 417 IVRLLLSYGANVN 429
Cdd:PHA02989  126 MLRFLLSKGINVN 138
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 558-602 3.79e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 35.32  E-value: 3.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907173989 558 SLKHLCRLKIRRVMglqrlcqpASIQMLPLPAAMRRYLLFKEFDL 602
Cdd:cd03734     5 SLQHLCRLVINRLV--------TDVDCLPLPRRMADYLRQYPFQL 41
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 556-601 4.21e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 35.59  E-value: 4.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173989 556 PCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLLFKEFD 601
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNL---KLLDELPIAKVMKDYLKHKFDD 45
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 330-358 4.36e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 4.36e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173989  330 GLTPIHSAAEGQNAQCLELLIENGFDVNA 358
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 357-467 4.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 357 NALLADHISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLN--CLLVAVRANRH------EIVRLLLSYGANV 428
Cdd:PHA03100   20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNnsTPLHYLSNIKYnltdvkEIVKLLLEYGANV 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907173989 429 NCYFMHVNdTRFPSAIQYALNDEIMLRLLLNNGYQVELC 467
Cdd:PHA03100  100 NAPDNNGI-TPLLYAISKKSNSYSIVEYLLDNGANVNIK 137
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 404-430 5.41e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 5.41e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907173989  404 NCLLVAVRANRHEIVRLLLSYGANVNC 430
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 132-188 5.75e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 5.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907173989 132 DGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKY 188
Cdd:PTZ00322  114 DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 132-160 6.85e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.85e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173989  132 DGETPLTLAVKAGLVENVKTLLDKGVWPN 160
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 376-431 8.61e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.43  E-value: 8.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907173989 376 LYFAVSNNDIHCTEVLLAAGADPNLD-PL------NCLLVAVRANRHEIVRLLLSYGANVNCY 431
Cdd:PHA02884   37 LYSSIKFHYTDIIDAILKLGADPEAPfPLsensktNPLIYAIDCDNDDAAKLLIRYGADVNRY 99
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 259-358 8.78e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 39.01  E-value: 8.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173989 259 FALADDGASVLFEAA---GGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHylalkylipvtskhaiqksglTPIH 335
Cdd:cd22193    23 FTESSTGKTCLMKALlnlNPGTNDTIRILLDIAEKTDNLKRFINAEYTDEYYEGQ---------------------TALH 81

                          90       100
                  ....*....|....*....|...
gi 1907173989 336 SAAEGQNAQCLELLIENGFDVNA 358
Cdd:cd22193    82 IAIERRQGDIVALLVENGADVHA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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