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Conserved domains on  [gi|1720409404|ref|XP_030109545|]
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GPI ethanolamine phosphate transferase 3 isoform X2 [Mus musculus]

Protein Classification

alkaline phosphatase family protein( domain architecture ID 581061)

alkaline phosphatase (ALP) family protein may catalyze the hydrolysis of substrates; the ALP superfamily includes alkaline phosphatases and sulfatases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ALP_like super family cl23718
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
 1-65 1.50e-27

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


The actual alignment was detected with superfamily member cd16023:

Pssm-ID: 474031  Cd Length: 289  Bit Score: 113.42  E-value: 1.50e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720409404   1 MTMNGDHGGDSELEVSAALFLYSPTALFPS---------VPPEEPEVIPQVSLVPTLALLLGLPIPFGNTGEVM 65
Cdd:cd16023   216 MTETGDHGGDSDEEVDAALFAYSKRPFNNSdepiesngpGDPSKVRSVPQIDLVPTLSLLLGLPIPFSNLGTVI 289
 
Name Accession Description Interval E-value
GPI_EPT_3 cd16023
GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is ...
 1-65 1.50e-27

GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293747  Cd Length: 289  Bit Score: 113.42  E-value: 1.50e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720409404   1 MTMNGDHGGDSELEVSAALFLYSPTALFPS---------VPPEEPEVIPQVSLVPTLALLLGLPIPFGNTGEVM 65
Cdd:cd16023   216 MTETGDHGGDSDEEVDAALFAYSKRPFNNSdepiesngpGDPSKVRSVPQIDLVPTLSLLLGLPIPFSNLGTVI 289
 
Name Accession Description Interval E-value
GPI_EPT_3 cd16023
GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is ...
 1-65 1.50e-27

GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293747  Cd Length: 289  Bit Score: 113.42  E-value: 1.50e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720409404   1 MTMNGDHGGDSELEVSAALFLYSPTALFPS---------VPPEEPEVIPQVSLVPTLALLLGLPIPFGNTGEVM 65
Cdd:cd16023   216 MTETGDHGGDSDEEVDAALFAYSKRPFNNSdepiesngpGDPSKVRSVPQIDLVPTLSLLLGLPIPFSNLGTVI 289
GPI_EPT cd16019
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in ...
 1-65 1.84e-17

GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293743 [Multi-domain]  Cd Length: 292  Bit Score: 83.56  E-value: 1.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409404   1 MTMNGDHGGDSELEVSAALFLYSPTALFPS------------------VPPEEPEVIPQVSLVPTLALLLGLPIPFGNTG 62
Cdd:cd16019   210 MNNDGNHGGSSTEETSSFFFFISKKGFFKKrpidqiekikqnneqqkiDPSEYIRIIYQIDILPTICYLLGIPIPFNNIG 289


                  ...
gi 1720409404  63 EVM 65
Cdd:cd16019   290 III 292
GPI_EPT_2 cd16024
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ...
 1-62 4.21e-14

GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293748 [Multi-domain]  Cd Length: 274  Bit Score: 73.37  E-value: 4.21e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720409404   1 MTMNGDHGGDSELEVSAALFLYSP----TALFPSVPPEEPEVIPQVSLVPTLALLLGLPIPFGNTG 62
Cdd:cd16024   206 MTDAGNHGGSSPGETSVPLLFISPkfssKPSNADGELSYYETVQQVDLAPTLALLLGLPIPKNSVG 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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