|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
212-502 |
1.77e-52 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 185.93 E-value: 1.77e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 212 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 291
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 292 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 371
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 372 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 451
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 452 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 502
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-266 |
4.12e-35 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 135.85 E-value: 4.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAaqkqtalhws 98
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA---------- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 99 AYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTV 178
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI---VKLLLEAGAD---VNARDNDGETPLHLAAENGHLEI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 179 VDVLTSYEScNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKD 258
Cdd:COG0666 202 VKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
|
....*...
gi 1720407588 259 DSDLEGRT 266
Cdd:COG0666 280 AALLDLLT 287
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
278-496 |
5.40e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 102.82 E-value: 5.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 278 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 350
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 351 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 428
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720407588 429 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 496
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
336-428 |
4.42e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.33 E-value: 4.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 336 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 415
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 1720407588 416 VLMENNADPNIQD 428
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
32-359 |
1.89e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 89.70 E-value: 1.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 32 RLIVGNSALRDKEDRFGRTPLMYCV---LADRVDCADALLKAGADVNKTDHSRRTALHLAAQKQTALhwsayynnpEHAK 108
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL---------DVIK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 109 LLIKHDSNIGIPDVEGKIPLHwaanhkdpsaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVV 179
Cdd:PHA03095 102 LLIKAGADVNAKDKVGRTPLH----------VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 180 DVLTSyESCNITSYDNLFRTPLHWAALLGH--AQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQHPS 255
Cdd:PHA03095 171 RLLID-AGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 256 VKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKHTp 335
Cdd:PHA03095 249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAAT- 322
|
330 340 350
....*....|....*....|....*....|..
gi 1720407588 336 LFRACEMGHRD--------VIQTLIKGGARVD 359
Cdd:PHA03095 323 LNTASVAGGDIpsdatrlcVAKVVLRGAFSLL 354
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
19-121 |
2.53e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 19 HAAAVNGDKGALQRLIVGNSALrDKEDRFGRTPLMYCVLADRVDCADALLKaGADVNKTDHSRrtalhlaaqkqTALHWS 98
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-----------TALHYA 68
|
90 100
....*....|....*....|...
gi 1720407588 99 AYYNNPEHAKLLIKHDSNIGIPD 121
Cdd:pfam12796 69 ARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
555-828 |
7.76e-11 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 66.35 E-value: 7.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 555 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 634
Cdd:PHA03307 176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 635 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 713
Cdd:PHA03307 254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 714 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 779
Cdd:PHA03307 329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 780 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 828
Cdd:PHA03307 407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
43-276 |
1.68e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 61.57 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 43 KEDRFGRTPLMYCVLADRVDCADALLKAgadvNKTDHSRRTALhlaaqKQTALHWSAYYNNPEHAKLLikhdsnigipdv 122
Cdd:cd22192 12 QQKRISESPLLLAAKENDVQAIKKLLKC----PSCDLFQRGAL-----GETALHVAALYDNLEAAVVL------------ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 123 egkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPLHFAVADGNLTVVDVLTSYESCNIT------- 191
Cdd:cd22192 71 ------------------------MEAAPE--LVNEpmtsDLYQGETALHIAVVNQNLNLVRELIARGADVVSpratgtf 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 192 ---SYDNLF---RTPLHWAALLGHAQIVHLLLERNKSgTIPSDSQGATPLHY---AAQSNFA-ETVKVFLQHPSVKDDSD 261
Cdd:cd22192 125 frpGPKNLIyygEHPLSFAACVGNEEIVRLLIEHGAD-IRAQDSLGNTVLHIlvlQPNKTFAcQMYDLILSYDKEDDLQP 203
|
250 260
....*....|....*....|.
gi 1720407588 262 LE------GRTSFMWAAGKGN 276
Cdd:cd22192 204 LDlvpnnqGLTPFKLAAKEGN 224
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
233-439 |
7.65e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.64 E-value: 7.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 233 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 303
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 304 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 366
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 367 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 436
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 1720407588 437 WSC 439
Cdd:cd22192 240 WTY 242
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
73-287 |
1.59e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 48.92 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 73 DVNKTDHSRRTALHLAAQKQtalhwsayyNNPEHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAP 151
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIEN---------ENLELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 152 TES----LLNWQD----YEGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGHA 210
Cdd:TIGR00870 109 RKSgpleLANDQYtsefTPGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGSP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 211 QIVHLLLErNKSGTIPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMWAAGK 274
Cdd:TIGR00870 189 SIVALLSE-DPADILTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKLAAKE 267
|
250
....*....|...
gi 1720407588 275 GNDDVLRTMLSLK 287
Cdd:TIGR00870 268 GRIVLFRLKLAIK 280
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
849-874 |
4.29e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 41.37 E-value: 4.29e-05
10 20
....*....|....*....|....*.
gi 1720407588 849 RKELFRRKNKAAAVIQRAWRSYQLRK 874
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
48-76 |
1.97e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.97e-04
10 20
....*....|....*....|....*....
gi 1720407588 48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
364-393 |
3.66e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.66e-04
10 20 30
....*....|....*....|....*....|
gi 1720407588 364 DGHSLLHWAALGGNADVCQILIENKINPNV 393
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
495-521 |
5.37e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 38.29 E-value: 5.37e-04
10 20
....*....|....*....|....*..
gi 1720407588 495 AIQDIAAFKIQAVYKGYKVRKAFRDRK 521
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
170-419 |
6.51e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 170 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLG-HAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFAETV 247
Cdd:TIGR00870 24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIENeNLELTELLLNLSCRGAV-----GDTLLH-AISLEYVDAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 248 KVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDAQVD 326
Cdd:TIGR00870 98 EAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGASVP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 327 A------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------VCQI 383
Cdd:TIGR00870 156 AracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelSCQM 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1720407588 384 -------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 419
Cdd:TIGR00870 233 ynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| C11orf65 |
cd21090 |
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ... |
856-902 |
6.56e-03 |
|
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.
Pssm-ID: 411042 Cd Length: 260 Bit Score: 39.61 E-value: 6.56e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 856 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 902
Cdd:cd21090 4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
212-502 |
1.77e-52 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 185.93 E-value: 1.77e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 212 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 291
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 292 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 371
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 372 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 451
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 452 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 502
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
194-466 |
3.04e-52 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 185.16 E-value: 3.04e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 194 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAG 273
Cdd:COG0666 17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 274 KGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 353
Cdd:COG0666 97 NGDLEIVKLLLEAG--ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 354 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT 433
Cdd:COG0666 175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
|
250 260 270
....*....|....*....|....*....|...
gi 1720407588 434 ALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 466
Cdd:COG0666 255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
248-536 |
1.88e-49 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 177.07 E-value: 1.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 248 KVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDA 327
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 328 TDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 407
Cdd:COG0666 83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 408 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLE 487
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLE 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1720407588 488 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAA 536
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
189-435 |
2.04e-46 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 168.59 E-value: 2.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 189 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSF 268
Cdd:COG0666 45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 269 MWAAGKGNDDVLRtMLsLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVI 348
Cdd:COG0666 125 HLAAYNGNLEIVK-LL-LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 349 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 428
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*..
gi 1720407588 429 KEGRTAL 435
Cdd:COG0666 283 LDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-266 |
4.12e-35 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 135.85 E-value: 4.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAaqkqtalhws 98
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA---------- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 99 AYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTV 178
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI---VKLLLEAGAD---VNARDNDGETPLHLAAENGHLEI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 179 VDVLTSYEScNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKD 258
Cdd:COG0666 202 VKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
|
....*...
gi 1720407588 259 DSDLEGRT 266
Cdd:COG0666 280 AALLDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-297 |
1.29e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 131.23 E-value: 1.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKqtalhws 98
Cdd:COG0666 25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 99 ayyNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDA-APteslLNWQDYEGRTPLHFAVADGNLT 177
Cdd:COG0666 98 ---GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI---VKLLLEAgAD----VNAQDNDGNTPLHLAAANGNLE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 178 VVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVK 257
Cdd:COG0666 168 IVKLLLEA-GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADL 245
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1720407588 258 DDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDK 297
Cdd:COG0666 246 NAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
278-496 |
5.40e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 102.82 E-value: 5.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 278 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 350
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 351 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 428
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720407588 429 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 496
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
336-428 |
4.42e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.33 E-value: 4.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 336 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 415
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 1720407588 416 VLMENNADPNIQD 428
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
369-460 |
5.98e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 90.95 E-value: 5.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 369 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 448
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|..
gi 1720407588 449 LLLDFAAFPNQM 460
Cdd:pfam12796 79 LLLEKGADINVK 90
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
59-490 |
9.85e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 101.29 E-value: 9.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 59 DRVDCADALLKAGADVNKTDHSRRTALHLAAQkqtalhwsayYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDps 138
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAE----------RGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN-- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 139 aVHTVRCILDaapTESLLNWQDyegrtpLHFAVADGNLTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGH-AQIVHLL 216
Cdd:PHA02876 224 -IDTIKAIID---NRSNINKND------LSLLKAIRNEDLETSLLLYDAgFSVNSIDDCKNTPLHHASQAPSlSRLVPKL 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 217 LERNkSGTIPSDSQGATPLHYAAQSNFaetvkvflqhpsvkddsDLEGrtsfmwaagkgnddvLRTMLSLKSdiDINMSD 296
Cdd:PHA02876 294 LERG-ADVNAKNIKGETPLYLMAKNGY-----------------DTEN---------------IRTLIMLGA--DVNAAD 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 297 KYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALG 375
Cdd:PHA02876 339 RLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCG 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 376 GNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWSC-NNGYLDAIKLLLDFA 454
Cdd:PHA02876 419 TNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYACkKNCKLDVIEMLLDNG 466
|
410 420 430
....*....|....*....|....*....|....*.
gi 1720407588 455 AFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 490
Cdd:PHA02876 467 ADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
303-395 |
4.57e-21 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 88.63 E-value: 4.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 303 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 382
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 1720407588 383 ILIENKINPNVQD 395
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
235-329 |
3.77e-20 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 85.94 E-value: 3.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 235 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLksdIDINMSDkYGGTALHAAALSGHVST 314
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKD-NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 1720407588 315 VKLLLDNDAQVDATD 329
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
402-490 |
2.47e-19 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 83.63 E-value: 2.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 402 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 481
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76
|
....*....
gi 1720407588 482 IQFMLEHGA 490
Cdd:pfam12796 77 VKLLLEKGA 85
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
32-359 |
1.89e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 89.70 E-value: 1.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 32 RLIVGNSALRDKEDRFGRTPLMYCV---LADRVDCADALLKAGADVNKTDHSRRTALHLAAQKQTALhwsayynnpEHAK 108
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL---------DVIK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 109 LLIKHDSNIGIPDVEGKIPLHwaanhkdpsaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVV 179
Cdd:PHA03095 102 LLIKAGADVNAKDKVGRTPLH----------VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 180 DVLTSyESCNITSYDNLFRTPLHWAALLGH--AQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQHPS 255
Cdd:PHA03095 171 RLLID-AGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 256 VKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKHTp 335
Cdd:PHA03095 249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAAT- 322
|
330 340 350
....*....|....*....|....*....|..
gi 1720407588 336 LFRACEMGHRD--------VIQTLIKGGARVD 359
Cdd:PHA03095 323 LNTASVAGGDIpsdatrlcVAKVVLRGAFSLL 354
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
194-437 |
4.44e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 88.54 E-value: 4.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 194 DNLFRTPLHwaaLLGH------AQIVHLLLER----NKSgtipsDSQGATPLHYAAQsnFAETVkvflqhpsvkddsdle 263
Cdd:PHA03095 44 GEYGKTPLH---LYLHyssekvKDIVRLLLEAgadvNAP-----ERCGFTPLHLYLY--NATTL---------------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 264 grtsfmwaagkgndDVLRTMLSLKSDIdiNMSDKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL---- 336
Cdd:PHA03095 98 --------------DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavll 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 337 -FRACEMghrDVIQTLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNC 413
Cdd:PHA03095 161 kSRNANV---ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SC 235
|
250 260
....*....|....*....|....*...
gi 1720407588 414 MAVLM----ENNADPNIQDKEGRTALHW 437
Cdd:PHA03095 236 KRSLVlpllIAGISINARNRYGQTPLHY 263
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
126-363 |
3.19e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 85.49 E-value: 3.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 126 IPLHWAANHKDPSAVHTvrcILD--AAPTESLLNWqdyegRTPLHF-----AVADGNLTVVDVLTSYEScNITSYDNLFR 198
Cdd:PHA03100 37 LPLYLAKEARNIDVVKI---LLDngADINSSTKNN-----STPLHYlsnikYNLTDVKEIVKLLLEYGA-NVNAPDNNGI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 199 TPLHWAA--LLGHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAET--VKVFLQHpsvkdDSDLEGRTSFmwaagk 274
Cdd:PHA03100 108 TPLLYAIskKSNSYSIVEYLLDNGANVNI-KNSDGENLLHLYLESNKIDLkiLKLLIDK-----GVDINAKNRV------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 275 gndDVLrtmlsLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKG 354
Cdd:PHA03100 176 ---NYL-----LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
|
....*....
gi 1720407588 355 GARVDLVDQ 363
Cdd:PHA03100 248 GPSIKTIIE 256
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
167-261 |
3.51e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 74.77 E-value: 3.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 167 LHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGtipSDSQGATPLHYAAQSNFAET 246
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 1720407588 247 VKVFLQHPSVKDDSD 261
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
153-390 |
3.85e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 82.02 E-value: 3.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 153 ESLLNWQDYEGRTPLHFAVADGNLTVVDVLTsYESCNITSYDNLFRTPLHWAALLGHAQ-----IVHLLLERNKSGTIPs 227
Cdd:PHA03100 25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAP- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 228 DSQGATPLHYAAQ--SNFAETVKVFLQHpsvkddsdlegrtsfmwaagkgnddvlrtmlslksDIDINMSDKYGGTALHA 305
Cdd:PHA03100 103 DNNGITPLLYAISkkSNSYSIVEYLLDN-----------------------------------GANVNIKNSDGENLLHL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 306 AALSGHVST------------------VKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHS 367
Cdd:PHA03100 148 YLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
|
250 260
....*....|....*....|...
gi 1720407588 368 LLHWAALGGNADVCQILIENKIN 390
Cdd:PHA03100 228 PLHIAILNNNKEIFKLLLNNGPS 250
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
157-393 |
8.43e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 80.81 E-value: 8.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 157 NWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLfRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 236
Cdd:PHA02875 29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLH 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 237 YAAQSNfaetvkvflqhpsvkddsdlegrtsfmwaagkgNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHVSTVK 316
Cdd:PHA02875 108 LATILK---------------------------------KLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIE 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720407588 317 LLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINPNV 393
Cdd:PHA02875 153 LLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCNI 230
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
286-490 |
3.55e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 79.30 E-value: 3.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 286 LKSDIDINMSDKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 359
Cdd:PHA03095 34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 360 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 432
Cdd:PHA03095 112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 433 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 490
Cdd:PHA03095 189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
24-419 |
3.66e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 79.24 E-value: 3.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 24 NGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVN----KTDHSRRTALHLAAQKQTalhwsa 99
Cdd:PHA02874 11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINhintKIPHPLLTAIKIGAHDII------ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 100 yynnpehaKLLIKH--DSNI-GIPDVEGKiplhwaanhkdpsavhTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNL 176
Cdd:PHA02874 85 --------KLLIDNgvDTSIlPIPCIEKD----------------MIKTILDCGID---VNIKDAELKTFLHYAIKKGDL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 177 TVVDVLTSYES-CNItsydnlfrtplhwaallghaqivhlllernksgtipSDSQGATPLHYAAQSNFAETVKVFLQHPS 255
Cdd:PHA02874 138 ESIKMLFEYGAdVNI------------------------------------EDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 256 VkddsdlegrtsfmwaagkgnddvlrtmlslksdidINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTP 335
Cdd:PHA02874 182 Y-----------------------------------ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 336 LFRACeMGHRDVIQTLIKgGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGYINCM 414
Cdd:PHA02874 227 LHNAI-IHNRSAIELLIN-NASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF--KYINKD 302
|
....*
gi 1720407588 415 AVLME 419
Cdd:PHA02874 303 PVIKD 307
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
108-402 |
1.10e-14 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 77.76 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 108 KLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAApteSLLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYe 186
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAG---ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 187 SCNITSYDNLFRTPLHwAALLG---HAQIVHLLLERNKSGTiPSDSQGATPLHyaaqsnfaetvkVFLQHPSVkddsdle 263
Cdd:PHA03095 107 GADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVN-ALDLYGMTPLA------------VLLKSRNA------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 264 grtsfmwaagkgNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST--VKLLLDNDAQVDATDVMKHTPLFRACE 341
Cdd:PHA03095 166 ------------NVELLRLLI--DAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMAT 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720407588 342 MG--HRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 402
Cdd:PHA03095 232 GSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
276-474 |
1.41e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 77.31 E-value: 1.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 276 NDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 355
Cdd:PHA02874 103 EKDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 356 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRTAL 435
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPL 258
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1720407588 436 HWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 474
Cdd:PHA02874 259 HHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
292-499 |
2.08e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 76.54 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 292 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 348
Cdd:PHA02874 28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 349 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 428
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 429 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 499
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
19-121 |
2.53e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 19 HAAAVNGDKGALQRLIVGNSALrDKEDRFGRTPLMYCVLADRVDCADALLKaGADVNKTDHSRrtalhlaaqkqTALHWS 98
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-----------TALHYA 68
|
90 100
....*....|....*....|...
gi 1720407588 99 AYYNNPEHAKLLIKHDSNIGIPD 121
Cdd:pfam12796 69 ARSGHLEIVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
95-194 |
2.98e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 68.99 E-value: 2.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 95 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 174
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72
|
90 100
....*....|....*....|
gi 1720407588 175 NLTVVDVLTSYEsCNITSYD 194
Cdd:pfam12796 73 HLEIVKLLLEKG-ADINVKD 91
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
62-353 |
3.13e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 76.16 E-value: 3.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 62 DCADALLKAGADVNKTDHSRRTALHLAAQKqtalhwsayyNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHkdpSAVH 141
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKK----------GDLESIKMLFEYGADVNIEDDNGCYPIHIAIKH---NFFD 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 142 TVRCILDAApteSLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEScNITSYDNLFRTPLHwAALLGHAQIVHLLLerNK 221
Cdd:PHA02874 172 IIKLLLEKG---AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLH-NAIIHNRSAIELLI--NN 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 222 SGTIPSDSQGATPLHYAaqsnfaetvkvfLQHPSVKddsdlegrtsfmwaagkgndDVLRTMLSLKSDIDINmsDKYGGT 301
Cdd:PHA02874 245 ASINDQDIDGSTPLHHA------------INPPCDI--------------------DIIDILLYHKADISIK--DNKGEN 290
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1720407588 302 ALHAA-ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 353
Cdd:PHA02874 291 PIDTAfKYINKDPVIKDIIANAVLIKEADKLKDSDFLEHIEIKDNKEFSDFIK 343
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
312-490 |
3.27e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 75.86 E-value: 3.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 312 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 386
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 387 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 462
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1720407588 463 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 490
Cdd:PHA03100 175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
303-471 |
3.75e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 75.80 E-value: 3.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 303 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 379
Cdd:PHA02875 72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 380 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 458
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229
|
170
....*....|....
gi 1720407588 459 QMENNE-ERYTPLD 471
Cdd:PHA02875 230 IMFMIEgEECTILD 243
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
128-220 |
3.84e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 68.99 E-value: 3.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 128 LHWAANHKDPSAVHT-VRCILDAaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDnlfRTPLHWAAL 206
Cdd:pfam12796 1 LHLAAKNGNLELVKLlLENGADA-------NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAAR 70
|
90
....*....|....
gi 1720407588 207 LGHAQIVHLLLERN 220
Cdd:pfam12796 71 SGHLEIVKLLLEKG 84
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
200-475 |
1.78e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 74.15 E-value: 1.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 200 PLHWAALLGHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWaaGKGNDDV 279
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQP-DHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAF--NNRNVEI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 280 LRTMLSLKSDIDINMSDKYGGTALHAAALSGHVstVKLLLDNDAQVDATDVMK-HTPLFRACEMGHRDVIQTLIKGGARV 358
Cdd:PHA02878 117 FKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 359 DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGY---INCMAVLMENNADPNIQDK-EGRTA 434
Cdd:PHA02878 195 NIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYckdYDILKLLLEHGVDVNAKSYiLGLTA 272
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1720407588 435 LHWSCNNGylDAIKLLLDFAAFPNQMenNEERYTPLDYALL 475
Cdd:PHA02878 273 LHSSIKSE--RKLKLLLEYGADINSL--NSYKLTPLSSAVK 309
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
166-435 |
2.36e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 73.76 E-value: 2.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 166 PLHFAVADGNLTVVDVLTSyESCNITSYDNLFRTPLHWAALLGHAQ-IVHLLLERNKSGTIPSDSQGATPLHYaaqsNFA 244
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLT-RGHNVNQPDHRDLTPLHIICKEPNKLgMKEMIRSINKCSVFYTLVAIKDAFNN----RNV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 245 ETVKVFL--QHPSVKDDSDLEGRTsfmwaagKGNDDVLRTM---LSLKSDIDINMSDKYGG-TALHAAALSGHVSTVKLL 318
Cdd:PHA02878 115 EIFKIILtnRYKNIQTIDLVYIDK-------KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKDQRLTELL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 319 LDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYA 397
Cdd:PHA02878 188 LSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYI 267
|
250 260 270
....*....|....*....|....*....|....*....
gi 1720407588 398 -GRTPLQCAAYGGYIncMAVLMENNADPNIQDKEGRTAL 435
Cdd:PHA02878 268 lGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPL 304
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
204-419 |
2.36e-11 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 67.97 E-value: 2.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 204 AALLGHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSfMW------------- 270
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDI-GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA-LWnaisakhhkifri 609
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 271 -------------------AAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 328
Cdd:PLN03192 610 lyhfasisdphaagdllctAAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntd 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 329 DVMKHTPLFRAC---EMGHRDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTP 401
Cdd:PLN03192 688 DDFSPTELRELLqkrELGHSITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNE 757
|
250
....*....|....*...
gi 1720407588 402 LQCAAYGGYINCMAVLME 419
Cdd:PLN03192 758 RCCNEAGKLINLPPSLEE 775
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
555-828 |
7.76e-11 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 66.35 E-value: 7.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 555 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 634
Cdd:PHA03307 176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 635 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 713
Cdd:PHA03307 254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 714 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 779
Cdd:PHA03307 329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 780 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 828
Cdd:PHA03307 407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
240-423 |
1.69e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 65.27 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 240 QSNFAETVKVFLQH--------------PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHA 305
Cdd:PLN03192 487 QEDNVVILKNFLQHhkelhdlnvgdllgDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDI--GDSKGRTPLHI 564
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 306 AALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDlvDQDGHSLLHWAALGGNADVCQILI 385
Cdd:PLN03192 565 AASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDLTAMKELL 642
|
170 180 190
....*....|....*....|....*....|....*...
gi 1720407588 386 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 423
Cdd:PLN03192 643 KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
312-471 |
1.77e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 64.47 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 312 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 381
Cdd:PHA02798 18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 382 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 455
Cdd:PHA02798 93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172
|
170
....*....|....*.
gi 1720407588 456 FPNQMeNNEERYTPLD 471
Cdd:PHA02798 173 DINTH-NNKEKYDTLH 187
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
365-417 |
3.64e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.13 E-value: 3.64e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720407588 365 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 417
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
299-352 |
5.08e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 55.74 E-value: 5.08e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 299 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 352
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
18-205 |
7.00e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 62.73 E-value: 7.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 18 VHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVD--CADALLKAGADVNKTDHSRRTALHLAAQKQTAl 95
Cdd:PHA03095 87 LHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNALDLYGMTPLAVLLKSRNA- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 96 hwsayynNPEHAKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDPSAVHT-VRCILDAAPTESLlnwqdyeGRTPLHFAVA 172
Cdd:PHA03095 166 -------NVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRElIRAGCDPAATDML-------GNTPLHSMAT 231
|
170 180 190
....*....|....*....|....*....|....*.
gi 1720407588 173 DG---NLTVVDVLTSYESCNITsyDNLFRTPLHWAA 205
Cdd:PHA03095 232 GSsckRSLVLPLLIAGISINAR--NRYGQTPLHYAA 265
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
264-319 |
7.22e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 55.36 E-value: 7.22e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407588 264 GRTSFMWAAGKGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLL 319
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
398-451 |
1.12e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.97 E-value: 1.12e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 398 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 451
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
43-276 |
1.68e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 61.57 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 43 KEDRFGRTPLMYCVLADRVDCADALLKAgadvNKTDHSRRTALhlaaqKQTALHWSAYYNNPEHAKLLikhdsnigipdv 122
Cdd:cd22192 12 QQKRISESPLLLAAKENDVQAIKKLLKC----PSCDLFQRGAL-----GETALHVAALYDNLEAAVVL------------ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 123 egkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPLHFAVADGNLTVVDVLTSYESCNIT------- 191
Cdd:cd22192 71 ------------------------MEAAPE--LVNEpmtsDLYQGETALHIAVVNQNLNLVRELIARGADVVSpratgtf 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 192 ---SYDNLF---RTPLHWAALLGHAQIVHLLLERNKSgTIPSDSQGATPLHY---AAQSNFA-ETVKVFLQHPSVKDDSD 261
Cdd:cd22192 125 frpGPKNLIyygEHPLSFAACVGNEEIVRLLIEHGAD-IRAQDSLGNTVLHIlvlQPNKTFAcQMYDLILSYDKEDDLQP 203
|
250 260
....*....|....*....|.
gi 1720407588 262 LE------GRTSFMWAAGKGN 276
Cdd:cd22192 204 LDlvpnnqGLTPFKLAAKEGN 224
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
164-342 |
1.83e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 61.16 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 164 RTPLHFAVADGNLTVVDVLTSYEscniTSYDNLF----RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQgATPLHYAA 239
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLG----KFADDVFykdgMTPLHLATILKKLDIMKLLIARGADPDIPNTDK-FSPLHLAV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 240 QSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSlkSDIDINMSDKYGGTALHAAALSGH-VSTVKLL 318
Cdd:PHA02875 144 MMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD--SGANIDYFGKNGCVAALCYAIENNkIDIVRLF 221
|
170 180
....*....|....*....|....*..
gi 1720407588 319 LDNDAQVD-ATDVM--KHTPLFRACEM 342
Cdd:PHA02875 222 IKRGADCNiMFMIEgeECTILDMICNM 248
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
277-500 |
4.89e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 60.46 E-value: 4.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 277 DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 356
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 357 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 406
Cdd:PHA02876 236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 407 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 484
Cdd:PHA02876 316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393
|
250
....*....|....*.
gi 1720407588 485 MLEHGALSIAAIQDIA 500
Cdd:PHA02876 394 LLDYGADIEALSQKIG 409
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
368-451 |
5.98e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.91 E-value: 5.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 368 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 447
Cdd:PTZ00322 86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164
|
....
gi 1720407588 448 KLLL 451
Cdd:PTZ00322 165 QLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
302-490 |
6.63e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 59.23 E-value: 6.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 302 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 380
Cdd:PHA02875 5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 381 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 460
Cdd:PHA02875 85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163
|
170 180 190
....*....|....*....|....*....|
gi 1720407588 461 ENNEErYTPLDYALLGERHEVIQFMLEHGA 490
Cdd:PHA02875 164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
416-488 |
7.35e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.53 E-value: 7.35e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720407588 416 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 488
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
233-439 |
7.65e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.64 E-value: 7.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 233 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 303
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 304 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 366
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 367 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 436
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 1720407588 437 WSC 439
Cdd:cd22192 240 WTY 242
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
16-190 |
1.01e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.85 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 16 SQVHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKQtal 95
Cdd:PHA02875 70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG--- 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 96 hwsayynNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTesllnwQDYEGRTP----LHFAV 171
Cdd:PHA02875 147 -------DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD---IAICKMLLDSGAN------IDYFGKNGcvaaLCYAI 210
|
170 180
....*....|....*....|
gi 1720407588 172 ADGNLTVVDVLTSYES-CNI 190
Cdd:PHA02875 211 ENNKIDIVRLFIKRGAdCNI 230
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
67-218 |
2.21e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 57.97 E-value: 2.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 67 LLKAGADVNKTD-HSRRTALHLAAQKQtalhwsayynNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVrc 145
Cdd:PHA02878 153 LLSYGADINMKDrHKGNTALHYATENK----------DQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHIL-- 220
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720407588 146 ILDAAPTesllNWQDYEGRTPLHFAVAD-GNLTVVDVLTSYESC-NITSYDNLFrTPLHWAalLGHAQIVHLLLE 218
Cdd:PHA02878 221 LENGAST----DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDvNAKSYILGL-TALHSS--IKSERKLKLLLE 288
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
234-490 |
7.05e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.04 E-value: 7.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 234 PLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHaaalSGHVS 313
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFN----NRNVE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 314 TVKLLLDNDAQVDATDVMKHTplfraCEMGHRDVIQT-----LIKGGARVDLVDQD-GHSLLHWAALGGNADVCQILIEN 387
Cdd:PHA02878 116 IFKIILTNRYKNIQTIDLVYI-----DKKSKDDIIEAeitklLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 388 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCnnGYLdaikllldfaafpnqmenneery 467
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYC----------------------- 245
|
250 260
....*....|....*....|...
gi 1720407588 468 tpLDYallgerhEVIQFMLEHGA 490
Cdd:PHA02878 246 --KDY-------DILKLLLEHGV 259
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
372-458 |
8.16e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.41 E-value: 8.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 372 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 451
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
|
....*..
gi 1720407588 452 DFAAFPN 458
Cdd:PLN03192 612 HFASISD 618
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
334-385 |
1.13e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.20 E-value: 1.13e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1720407588 334 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 385
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
181-265 |
1.26e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.67 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 181 VLTSYESCNITSYDNlfRTPLHWAALLGHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPsvKDDS 260
Cdd:PTZ00322 101 LLTGGADPNCRDYDG--RTPLHIACANGHVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLSRHS--QCHF 175
|
....*
gi 1720407588 261 DLEGR 265
Cdd:PTZ00322 176 ELGAN 180
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
384-436 |
6.11e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 47.34 E-value: 6.11e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 384 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 436
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
307-384 |
2.18e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.82 E-value: 2.18e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720407588 307 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 384
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
421-473 |
2.25e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.80 E-value: 2.25e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720407588 421 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 473
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
198-251 |
2.79e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.34 E-value: 2.79e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 198 RTPLHWAALLGHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFL 251
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
354-405 |
2.99e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.42 E-value: 2.99e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1720407588 354 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 405
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
286-353 |
3.12e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.05 E-value: 3.12e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720407588 286 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 353
Cdd:PTZ00322 102 LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
431-486 |
4.09e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.96 E-value: 4.09e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407588 431 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 486
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
163-217 |
4.79e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.57 E-value: 4.79e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720407588 163 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLL 217
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
160-353 |
8.52e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 48.88 E-value: 8.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 160 DYEGRTPLHFAVADGNLTVVDVLTsyescNITSYDNLFRT--PLHWAALLGHAQIVHLLLernKSGTIPS--DSQGATPL 235
Cdd:PHA02791 27 DVHGHSALYYAIADNNVRLVCTLL-----NAGALKNLLENefPLHQAATLEDTKIVKILL---FSGMDDSqfDDKGNTAL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 236 HYAAQSNFAETVKVFLQHP-SVKDDSDLEGRTSFMWAAGKGNDDVLRTMLS-LKSDIDINMSDkyggTALHAAALSGHVS 313
Cdd:PHA02791 99 YYAVDSGNMQTVKLFVKKNwRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSeIPSTFDLAILL----SCIHITIKNGHVD 174
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1720407588 314 TVKLLLDNDAQVDATDVMKHTPLFR-ACEMGHRDVIQTLIK 353
Cdd:PHA02791 175 MMILLLDYMTSTNTNNSLLFIPDIKlAIDNKDLEMLQALFK 215
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
48-111 |
1.13e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.42 E-value: 1.13e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 48 GRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAaqkqtalhwsAYYNNPEHAKLLI 111
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFA----------ASNGNVEVLKLLL 54
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
73-287 |
1.59e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 48.92 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 73 DVNKTDHSRRTALHLAAQKQtalhwsayyNNPEHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAP 151
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIEN---------ENLELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 152 TES----LLNWQD----YEGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGHA 210
Cdd:TIGR00870 109 RKSgpleLANDQYtsefTPGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGSP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 211 QIVHLLLErNKSGTIPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMWAAGK 274
Cdd:TIGR00870 189 SIVALLSE-DPADILTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKLAAKE 267
|
250
....*....|...
gi 1720407588 275 GNDDVLRTMLSLK 287
Cdd:TIGR00870 268 GRIVLFRLKLAIK 280
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
65-260 |
2.83e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 48.33 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 65 DALLKAGADVNKTDHSRRTALHLAAQKqtalhwsayyNNPEHAKLLIKHDSNIGIPDVEGKIPLhW---AANH------- 134
Cdd:PLN03192 542 EELLKAKLDPDIGDSKGRTPLHIAASK----------GYEDCVLVLLKHACNVHIRDANGNTAL-WnaiSAKHhkifril 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 135 ------KDPSAVHTVRCIL----DAAPTESLL------NWQDYEGRTPLHFAVADGNLTVVDVL-TSYESCNITSYDNLF 197
Cdd:PLN03192 611 yhfasiSDPHAAGDLLCTAakrnDLTAMKELLkqglnvDSEDHQGATALQVAMAEDHVDMVRLLiMNGADVDKANTDDDF 690
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720407588 198 rTPLHWAALLGHAQIVHLLLERNKSGTIPSD---SQGATPLHYAAQSNFAET---VKVFLQHPSVKDDS 260
Cdd:PLN03192 691 -SPTELRELLQKRELGHSITIVDSVPADEPDlgrDGGSRPGRLQGTSSDNQCrprVSIYKGHPLLRNER 758
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
554-818 |
3.17e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.14 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 554 QLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQppaSHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKP 633
Cdd:PHA03378 575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTP 651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 634 SETP-IEHCRGPSACVHPRSWEGGNSSKNQGTSsveKRRGETNGKHRRCEEGPSSARQPLC--TGSGRPAEKGEDSSPAV 710
Cdd:PHA03378 652 HQPPqVEITPYKPTWTQIGHIPYQPSPTGANTM---LPIQWAPGTMQPPPRAPTPMRPPAAppGRAQRPAAATGRARPPA 728
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 711 ASASQQDHP-------RKPNKRQDRAARPRGASQKRR-------------------THQLRDRCSPAGSSRPGSAKGEVA 764
Cdd:PHA03378 729 AAPGRARPPaaapgraRPPAAAPGRARPPAAAPGRARppaaapgaptpqpppqappAPQQRPRGAPTPQPPPQAGPTSMQ 808
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 765 CADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRsGCKQLYEDICASPETG 818
Cdd:PHA03378 809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAA-LERQAAAGPTPSPGSG 861
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
849-874 |
4.29e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 41.37 E-value: 4.29e-05
10 20
....*....|....*....|....*.
gi 1720407588 849 RKELFRRKNKAAAVIQRAWRSYQLRK 874
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
348-418 |
5.23e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.20 E-value: 5.23e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 348 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 418
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
331-490 |
7.50e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 46.52 E-value: 7.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 331 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 410
Cdd:PHA02875 1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 411 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 489
Cdd:PHA02875 81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158
|
.
gi 1720407588 490 A 490
Cdd:PHA02875 159 A 159
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
298-329 |
1.33e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.97 E-value: 1.33e-04
10 20 30
....*....|....*....|....*....|...
gi 1720407588 298 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 329
Cdd:pfam00023 1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
157-217 |
1.47e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.66 E-value: 1.47e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 157 NWQDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLL 217
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
48-76 |
1.97e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.97e-04
10 20
....*....|....*....|....*....
gi 1720407588 48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
48-79 |
2.41e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.19 E-value: 2.41e-04
10 20 30
....*....|....*....|....*....|...
gi 1720407588 48 GRTPLMYCVL-ADRVDCADALLKAGADVNKTDH 79
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
289-336 |
2.52e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.02 E-value: 2.52e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1720407588 289 DIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 336
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
185-238 |
3.35e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.64 E-value: 3.35e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1720407588 185 YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIpSDSQGATPLHYA 238
Cdd:pfam13857 4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNL-KDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
364-393 |
3.66e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.66e-04
10 20 30
....*....|....*....|....*....|
gi 1720407588 364 DGHSLLHWAALGGNADVCQILIENKINPNV 393
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
495-521 |
5.37e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 38.29 E-value: 5.37e-04
10 20
....*....|....*....|....*..
gi 1720407588 495 AIQDIAAFKIQAVYKGYKVRKAFRDRK 521
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
59-147 |
5.82e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 43.50 E-value: 5.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 59 DRVDCadaLLKAGADVNKTDHSRRTALHLAAqkqtalhwsaYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAA--NHKD 136
Cdd:PHA03100 173 NRVNY---LLSYGVPINIKDVYGFTPLHYAV----------YNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIlnNNKE 239
|
90 100
....*....|....*....|
gi 1720407588 137 ---------PSAVHTVRCIL 147
Cdd:PHA03100 240 ifklllnngPSIKTIIETLL 259
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
33-88 |
6.04e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.87 E-value: 6.04e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407588 33 LIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLA 88
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
170-419 |
6.51e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 170 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLG-HAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFAETV 247
Cdd:TIGR00870 24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIENeNLELTELLLNLSCRGAV-----GDTLLH-AISLEYVDAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 248 KVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDAQVD 326
Cdd:TIGR00870 98 EAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGASVP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 327 A------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------VCQI 383
Cdd:TIGR00870 156 AracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelSCQM 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1720407588 384 -------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 419
Cdd:TIGR00870 233 ynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
258-306 |
6.86e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 6.86e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1720407588 258 DDSDLEGRTSFMWAAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAA 306
Cdd:pfam13857 10 NRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
430-458 |
7.13e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.95 E-value: 7.13e-04
10 20
....*....|....*....|....*....
gi 1720407588 430 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 458
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
67-131 |
7.43e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 7.43e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407588 67 LLKAG-ADVNKTDHSRRTALHLAaqkqtalhwsAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 131
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVA----------AKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
364-395 |
1.01e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 1.01e-03
10 20 30
....*....|....*....|....*....|...
gi 1720407588 364 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 395
Cdd:pfam00023 1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
364-393 |
1.08e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 37.24 E-value: 1.08e-03
10 20 30
....*....|....*....|....*....|
gi 1720407588 364 DGHSLLHWAALGGNADVCQILIENKINPNV 393
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
398-429 |
1.23e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.27 E-value: 1.23e-03
10 20 30
....*....|....*....|....*....|...
gi 1720407588 398 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 429
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
47-129 |
1.24e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 41.34 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 47 FGRTPLMYCVLADRV--DCADALLKAGADVN-KTDHSRRTALHlaaqkqtalHWSAYYNN--PEHAKLLIKHDSNIGIPD 121
Cdd:PHA02859 50 LYETPIFSCLEKDKVnvEILKFLIENGADVNfKTRDNNLSALH---------HYLSFNKNvePEILKILIDSGSSITEED 120
|
....*...
gi 1720407588 122 VEGKIPLH 129
Cdd:PHA02859 121 EDGKNLLH 128
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
398-426 |
1.32e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.18 E-value: 1.32e-03
10 20
....*....|....*....|....*....
gi 1720407588 398 GRTPLQCAAYGGYINCMAVLMENNADPNI 426
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
264-439 |
2.13e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 41.79 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 264 GRTSFMWAAGKGNDDVLRTML----------SLKSDIDINMSDKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 328
Cdd:cd21882 26 GKTCLHKAALNLNDGVNEAIMllleaapdsgNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatg 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 329 DVMKHTPL-----------FRACeMGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----I 383
Cdd:cd21882 106 RFFRKSPGnlfyfgelplsLAAC-TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllL 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 384 LIENKINPNVQ-----DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 439
Cdd:cd21882 185 SYGAHLDPTQQleeipNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
47-76 |
2.19e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 2.19e-03
10 20 30
....*....|....*....|....*....|
gi 1720407588 47 FGRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
93-141 |
2.19e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 2.19e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1720407588 93 TALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 141
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
301-327 |
2.30e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.30e-03
|
| PRK12678 |
PRK12678 |
transcription termination factor Rho; Provisional |
497-747 |
2.37e-03 |
|
transcription termination factor Rho; Provisional
Pssm-ID: 237171 [Multi-domain] Cd Length: 672 Bit Score: 41.81 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 497 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMKH-EQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLP 572
Cdd:PRK12678 21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAAiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 573 CPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCP----GRASQGDSSIDLQGTASRKPSETPIEHCRGPSACV 648
Cdd:PRK12678 101 KAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAarkaGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 649 HPRSWEGGNSSKNQGTSSvEKRRGETNGKHRRCEEGPSSARQplctGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDR 728
Cdd:PRK12678 181 RQAEAERGERGRREERGR-DGDDRDRRDRREQGDRREERGRR----DGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG 255
|
250
....*....|....*....
gi 1720407588 729 AARPRGASQKRRThqlRDR 747
Cdd:PRK12678 256 EGRGGRRGRRFRD---RDR 271
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
580-823 |
2.54e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.08 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 580 EASKQDATPSKQPPASHTVQSPDPeHSRPPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRsweggNSS 659
Cdd:PHA03307 12 EAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPAN-----ESR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 660 KNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSgrPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKR 739
Cdd:PHA03307 86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP--PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 740 RTHQlrdrcSPAGSSRPGSAKGEVACADQS---------SLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYED 810
Cdd:PHA03307 164 SDAA-----SSRQAALPLSSPEETARAPSSppaepppstPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238
|
250
....*....|...
gi 1720407588 811 ICASPETGVAHGP 823
Cdd:PHA03307 239 SSSSESSGCGWGP 251
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
127-182 |
3.00e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 3.00e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407588 127 PLHWAANHKDPSAVHtvRCILDAAPteslLNWQDYEGRTPLHFAVADGNLTVVDVL 182
Cdd:pfam13637 4 ALHAAAASGHLELLR--LLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
298-327 |
3.06e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.08 E-value: 3.06e-03
10 20 30
....*....|....*....|....*....|
gi 1720407588 298 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 327
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
124-284 |
3.08e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 41.40 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 124 GKIPLHWAANHKDPSAVHTVRCILDAAPT----ESLLNWQD----YEGRTPLHFAVADGNLTVVDVLTSY-ESCNITSYD 194
Cdd:cd21882 26 GKTCLHKAALNLNDGVNEAIMLLLEAAPDsgnpKELVNAPCtdefYQGQTALHIAIENRNLNLVRLLVENgADVSARATG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 195 NLFRT-----------PLHWAALLGHAQIVHLLLER--NKSGTIPSDSQGATPLHYAAQ--SNFAETVKVFLQ------- 252
Cdd:cd21882 106 RFFRKspgnlfyfgelPLSLAACTNQEEIVRLLLENgaQPAALEAQDSLGNTVLHALVLqaDNTPENSAFVCQmynllls 185
|
170 180 190
....*....|....*....|....*....|....*....
gi 1720407588 253 -----HPSVKDD--SDLEGRTSFMWAAGKGNDDVLRTML 284
Cdd:cd21882 186 ygahlDPTQQLEeiPNHQGLTPLKLAAVEGKIVMFQHIL 224
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
347-523 |
3.12e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 41.59 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 347 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 426
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 427 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 505
Cdd:PHA02876 240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306
|
170
....*....|....*...
gi 1720407588 506 AVYKGYKVRKAFRDRKNL 523
Cdd:PHA02876 307 GETPLYLMAKNGYDTENI 324
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
42-185 |
3.18e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 41.59 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 42 DKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKtdhsrrtalhLAAQKQTALHWSAYYNNP-EHAKLLIKHDSNIGIP 120
Cdd:PHA02876 369 NARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA----------LSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSK 438
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720407588 121 DVEGKIPLHWAAnhKDPSAVHTVRCILDAAPTESLLNWQDyegRTPLHFAVadGNLTVVDVLTSY 185
Cdd:PHA02876 439 NKDLSTPLHYAC--KKNCKLDVIEMLLDNGADVNAINIQN---QYPLLIAL--EYHGIVNILLHY 496
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
198-222 |
3.27e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 3.27e-03
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
155-204 |
3.63e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.56 E-value: 3.63e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1720407588 155 LLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWA 204
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
90-117 |
5.35e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.26 E-value: 5.35e-03
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
198-220 |
5.47e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 35.31 E-value: 5.47e-03
|
| C11orf65 |
cd21090 |
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ... |
856-902 |
6.56e-03 |
|
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.
Pssm-ID: 411042 Cd Length: 260 Bit Score: 39.61 E-value: 6.56e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720407588 856 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 902
Cdd:cd21090 4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
32-206 |
7.72e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 39.86 E-value: 7.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 32 RLIVGNSALRDKEDR-FGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKqtalhwsayYNNPEhAKLL 110
Cdd:PHA02878 151 KLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKH---------YNKPI-VHIL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407588 111 IKHDSNIGIPDVEGKIPLHWAANH-KDpsaVHTVRCILDAAPTeslLNWQDY-EGRTPLHFAVADGNltVVDVLTSYES- 187
Cdd:PHA02878 221 LENGASTDARDKCGNTPLHISVGYcKD---YDILKLLLEHGVD---VNAKSYiLGLTALHSSIKSER--KLKLLLEYGAd 292
|
170
....*....|....*....
gi 1720407588 188 CNITSYDNLfrTPLHWAAL 206
Cdd:PHA02878 293 INSLNSYKL--TPLSSAVK 309
|
|
| |
