NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720404911|ref|XP_030108640|]
View 

phosphomevalonate kinase isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
P-mevalo_kinase super family cl04466
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 1-114 6.47e-31

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


The actual alignment was detected with superfamily member TIGR01223:

Pssm-ID: 471038  Cd Length: 182  Bit Score: 108.24  E-value: 6.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404911   1 MICWGEQKRQADPGFFCRKIVEGVSQPIWLVSDTRRTSDIQWFQEAYGAVIQTVRVVASEQSRQQRGWVFTPGVDDAESE 80
Cdd:TIGR01223  66 MIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESE 145

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720404911  81 CGLDNFGNFDWVIENHGDEQCLEDQLEHLLGFIQ 114
Cdd:TIGR01223 146 CGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIR 179
 
Name Accession Description Interval E-value
Pmev_kin_anim TIGR01223
phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of ...
 1-114 6.47e-31

phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220). [Central intermediary metabolism, Other]


Pssm-ID: 130290  Cd Length: 182  Bit Score: 108.24  E-value: 6.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404911   1 MICWGEQKRQADPGFFCRKIVEGVSQPIWLVSDTRRTSDIQWFQEAYGAVIQTVRVVASEQSRQQRGWVFTPGVDDAESE 80
Cdd:TIGR01223  66 MIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESE 145

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720404911  81 CGLDNFGNFDWVIENHGDEQCLEDQLEHLLGFIQ 114
Cdd:TIGR01223 146 CGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIR 179
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 1-48 3.98e-24

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


Pssm-ID: 461247  Cd Length: 112  Bit Score: 88.79  E-value: 3.98e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720404911   1 MICWGEQKRQADPGFFCRKIVE--GVSQPIWLVSDTRRTSDIQWFQEAYG 48
Cdd:pfam04275  63 MIRWGEEKRNKDPGYFCRAAIEmaDAQKPVWIVSDARRKTDLQWFRENYP 112
 
Name Accession Description Interval E-value
Pmev_kin_anim TIGR01223
phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of ...
 1-114 6.47e-31

phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220). [Central intermediary metabolism, Other]


Pssm-ID: 130290  Cd Length: 182  Bit Score: 108.24  E-value: 6.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404911   1 MICWGEQKRQADPGFFCRKIVEGVSQPIWLVSDTRRTSDIQWFQEAYGAVIQTVRVVASEQSRQQRGWVFTPGVDDAESE 80
Cdd:TIGR01223  66 MIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESE 145

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720404911  81 CGLDNFGNFDWVIENHGDEQCLEDQLEHLLGFIQ 114
Cdd:TIGR01223 146 CGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIR 179
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 1-48 3.98e-24

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


Pssm-ID: 461247  Cd Length: 112  Bit Score: 88.79  E-value: 3.98e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720404911   1 MICWGEQKRQADPGFFCRKIVE--GVSQPIWLVSDTRRTSDIQWFQEAYG 48
Cdd:pfam04275  63 MIRWGEEKRNKDPGYFCRAAIEmaDAQKPVWIVSDARRKTDLQWFRENYP 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH