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Conserved domains on  [gi|1720403525|ref|XP_030108370|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 53-278 1.02e-169

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23975:

Pssm-ID: 480271  Cd Length: 226  Bit Score: 468.26  E-value: 1.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 132
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 212
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403525 213 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 278
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 53-278 1.02e-169

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 468.26  E-value: 1.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 132
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 212
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403525 213 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 278
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 53-268 7.96e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 88.82  E-value: 7.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVP---------------------L 111
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 112 LLKNPDYFF---------KEASRTIYVIWGPFRNMRKDGNGIVYNmlkktvdayPDAQIYVTteqqmthcdRVFKDETGK 182
Cdd:pfam00777 123 PFKGRDLLWlpafltkgnVSRSLRVLYTLKEVKIPVDPDKVLFLH---------PDFLRYVA---------NFWLRSHGL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 183 DrvqsGSYLSTGWFTFILAMDACYSIHVYGMINEtycktEGYRKVPYHYYEQGKDecneyllHEHAPYGGHRFITEKKVF 262
Cdd:pfam00777 185 K----GRRPSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLL 248


                  ....*.
gi 1720403525 263 AKWAKK 268
Cdd:pfam00777 249 QKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 53-278 1.02e-169

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 468.26  E-value: 1.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 132
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 212
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403525 213 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 278
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 53-276 3.42e-125

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 355.78  E-value: 3.42e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPD-YFFKEASRTIYVIW 131
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAIlLLAGTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 132 GPFRNMRKDGNGIvYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVY 211
Cdd:cd23965    81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403525 212 GMINETYCKTEGYRKVPYHYYEQ-GKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHP 276
Cdd:cd23965   160 GMVPENYCREHPNSKVPYHYYEPgGLKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 53-279 1.30e-118

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 339.14  E-value: 1.30e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 132
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 212
Cdd:cd23977    81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720403525 213 MINETYCKTEGYRKVPYHYYEQGK-DECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWT 279
Cdd:cd23977   161 MVSDSYCRNKNHSSVPYHYYEKGRlDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 53-278 2.80e-89

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 264.79  E-value: 2.80e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 132
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 212
Cdd:cd23978    81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403525 213 MINETYC-KTEGYRKVPYHYYE-QGKDECNEYLLHEHAPYGG-HRFITEKKVFAKWAKKHRIVFTHPNW 278
Cdd:cd23978   161 MVPPNYCsKRPTPKKMPYHYYEpKGPDECVTYIQNEHGRRGNhHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 39-278 9.14e-86

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 256.33  E-value: 9.14e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  39 GYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDY 118
Cdd:cd23976     1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 119 FFKEASRTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTF 198
Cdd:cd23976    81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 199 ILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYE-QGKDECNEYLLHEHAPYGG-HRFITEKKVFAKWAKKHRIVFTHP 276
Cdd:cd23976   161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEpSGPDECTMYISHERGRKGShHRFITEKRVFANWARTFNIHFYQP 240


                  ..
gi 1720403525 277 NW 278
Cdd:cd23976   241 DW 242
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 56-265 1.16e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 154.83  E-value: 1.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  56 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFF---KEASRTIYVIWG 132
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGChplPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 PFRNMRKDgngivynmLKKTVDAYPDAQIYVTTEQQ--MTHCDRVFKDETGKDrVQSGSYLSTGWFTFILAMDACYSIHV 210
Cdd:cd19952    81 AAAADFKR--------LKRRKKRHDNAVLLLTDPAPdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720403525 211 YGMINEtyckTEGYRKVPYHYYEQGKDECneyllhehaPYGGHRFITEKKVFAKW 265
Cdd:cd19952   152 YGFGVD----SGHAPKVPYHYYDLVEAEE---------GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 53-268 7.96e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 88.82  E-value: 7.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVP---------------------L 111
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 112 LLKNPDYFF---------KEASRTIYVIWGPFRNMRKDGNGIVYNmlkktvdayPDAQIYVTteqqmthcdRVFKDETGK 182
Cdd:pfam00777 123 PFKGRDLLWlpafltkgnVSRSLRVLYTLKEVKIPVDPDKVLFLH---------PDFLRYVA---------NFWLRSHGL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 183 DrvqsGSYLSTGWFTFILAMDACYSIHVYGMINEtycktEGYRKVPYHYYEQGKDecneyllHEHAPYGGHRFITEKKVF 262
Cdd:pfam00777 185 K----GRRPSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLL 248


                  ....*.
gi 1720403525 263 AKWAKK 268
Cdd:pfam00777 249 QKLHKE 254
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 48-269 5.66e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 79.03  E-value: 5.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  48 PLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVS-HTSVPLLLKNPDYFFKEASRT 126
Cdd:cd23973    78 PGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTaHSITSSLMILQKRGFKNIPQD 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 127 IYVIWGPFRNMRKDGNGIVYNMLKKTVDAYP----DAQIYVTTEQQMT-----HCD--RVFKDETGKDRVQSGSYL---- 191
Cdd:cd23973   158 KDIKYILFPEGPRDYQWLEALLKNKTIPSGAyygrRPRSYFSGDFTEDkylvlHPDflRYVKNRFLRSKTLKGKYWaiyr 237

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403525 192 -STGWFTFILAMDACYSIHVYGMInetyckTEGYRKVPYHYYEQGKDECneyllhehAPYGGHRFITEKKVfakWAKKH 269
Cdd:cd23973   238 pTTGAFLLLTALHLCDTVSAYGFI------TEDYRKYPDHYYDKKKTKL--------VFYINHDFRLEKKL---WKRLH 299
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 25-133 1.39e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 74.61  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  25 PLPYTFRQPLRTHYgyinvrtQEPLQLNCNH---CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMV 101
Cdd:cd23968    21 TSPFKDLLSLRYPF-------PESSLENTKRyntCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTL 93

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720403525 102 RVVSHTsvpLLLKNPDYFFKEASRT--IYVIWGP 133
Cdd:cd23968    94 RLINSQ---ILSKPEFNFLTDPLYRnvTLLVWDP 124
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 56-236 5.00e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 73.06  E-value: 5.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  56 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGY----MTMVRVVSHTSVPLLLKNPDY-FFKEASRTI--Y 128
Cdd:cd23963    66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRktnlTTLNPSILKRRYNSLKKNRDRdKFLNRLKEYngS 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 129 VIWGPfrnmrKDGNGIVYNMLKKTVDAYPDaqiyVTTEQQMTHCDRVFKDETGK--DRVQSGSYLSTGWFTFILAMDACY 206
Cdd:cd23963   146 ILWYP-----KFSFKSSTNLLLKAARALKK----NGLNLTVVYSNPEHFLAVQKfwKRRGLEKRPSTGLYLVSLALTFCD 216

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1720403525 207 SIHVYG----MINETycktegYRKVPYHYYEQGK 236
Cdd:cd23963   217 EIHLYGfwpfPTDPN------GRPVPYHYYDDLS 244
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 56-237 1.29e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 71.79  E-value: 1.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  56 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTsvplLLKNPDYFFKEAS---RTIYVIWG 132
Cdd:cd23986    52 CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHFIDSSlykDVILVAWD 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 133 P---FRNMRKDGNGIVYNMLKKTVD---AYPDAQIYVTTEQQMTHCDRVFKDETgKDRVQSGSyLSTGWFTFILAMDACY 206
Cdd:cd23986   128 PapySANLHKWYKKPDYNLFTPYVQyrkRNPNQPFYILHPKFIWQLWDIIQENT-QEKIQPNP-PSSGFIGILIMMSMCR 205

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720403525 207 SIHVYGMInetycktEGYRKVPY-HYYEQGKD 237
Cdd:cd23986   206 EVHVYEYI-------PSVRQTDLcHYHERYYD 230
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 53-273 6.51e-13

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 67.31  E-value: 6.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV---------SHTSVPLL-LKNPDY-FFK 121
Cdd:cd23966    77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMypesavdldPGVHLVLVpFKVLDLqWLI 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 122 EASRTIYVIWGPFRnmrkdgngivynmLKKTVDAYPD-AQIYVTTEQQMTHcDRVFKDEtgkdrvqsGSYLSTGWFTFIL 200
Cdd:cd23966   157 SALTTGEITRTYTP-------------VKRFIKADKDkVLVINPAFIKYVH-DNWTEHH--------GRYPSTGFLALIF 214

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720403525 201 AMDACYSIHVYGMINETYckteGYRkvpYHYYEqgkdecNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVF 273
Cdd:cd23966   215 ALHICDEVSVFGFGADSK----GNW---HHYWE------KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 53-270 9.82e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 63.82  E-value: 9.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG-----YMTMVR--VVSHTSVPLLLKNPDYFFkEASR 125
Cdd:cd23964    82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGtktsfYTFFPEslHNSLLKHVPQDKDTKYLF-IPFK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 126 T---IYVI----WGPFRNMrKDGNGIVYNMLKKTVDA------YPDAQIYVtteqqmtHCDRVfkdetgkdRVQSGSYLS 192
Cdd:cd23964   161 IrdyDYLDavlsGKPVPDG-CDKGKRPPPLFGPKLNAtnvrllHPDFIRYL-------FNRWL--------NSSTSYRPT 224

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403525 193 TGWFTFILAMDACYSIHVYGMINEtycktegyRKVPYHYYEQGKdecneyllHEHAP-YGGHRFITEKKVfakWAKKHR 270
Cdd:cd23964   225 TGALMLLTALHTCDQVSVYGFGYD--------PRFSLHYYDKTF--------VKFTVfYANHDFTNERKL---WRKLHE 284
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 53-104 1.50e-11

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 62.31  E-value: 1.50e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV 104
Cdd:cd23967     2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMF 53
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 46-212 3.56e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 62.21  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  46 QEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSvplllknpdyfFKEASR 125
Cdd:cd23980    74 LEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPES-----------FRELAQ 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 126 TIYVIWGPFR--NMRKDGNGIVYNMLKKTVDAYPdAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMD 203
Cdd:cd23980   143 NVSMILVPFKtlDLEWVISATTTGTISHTYVPVP-RKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLH 221


                  ....*....
gi 1720403525 204 ACYSIHVYG 212
Cdd:cd23980   222 VCDEVDLYG 230
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 56-133 3.71e-11

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 62.03  E-value: 3.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  56 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTsvplLLKNPDYFFKEAS---RTIYVIWG 132
Cdd:cd23985    48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKFLKDSlynEGILIVWD 123


                  .
gi 1720403525 133 P 133
Cdd:cd23985   124 P 124
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 45-233 4.11e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 62.03  E-value: 4.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  45 TQEPLQLNC-NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRvvshTSVPLLLknpDYFFKEA 123
Cdd:cd23970    59 EVSPFQNKHyNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSIL---EKYYNNL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 124 SrTIYVIWGPFRNMRKDGNGIVY---------NMLKKTVDAYPDAQIYVTTEQQ------MTHCDRVFKDETGKDRvqsg 188
Cdd:cd23970   132 L-TIQDRNNFFLSLKKLDGAILWipafffhtsATVTRTLVDFFVEHRGQLKVQLawpgniMQHVNRYWKTKHLSPK---- 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720403525 189 sYLSTGWFTFILAMDACYSIHVYGMINETYCKTEgyRKVPYHYYE 233
Cdd:cd23970   207 -RLSTGILMYTLASAICEEIHLYGFWPFGFDPTG--TPLPYHYYD 248
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 53-235 7.02e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 60.45  E-value: 7.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV---SHTSVPLLLKNPDYF-----FKEAS 124
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypeSAQFDPGIENDPDTLlvlvpFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 125 -RTIYVIWGPFRNMRKDGngivYNMLKKTVDAYPdAQIYVTTEQQMTHCDRVFKDETGKDrvQSGSYLSTGWFTFILAMD 203
Cdd:cd23982    82 fYWLYEILSNEKRVRKGF----WKQPPRIWDANP-KQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALH 154

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1720403525 204 ACYSIHVYGMinetyckteGY-----RKVPYHYYEQG 235
Cdd:cd23982   155 LCDEVHIAGF---------GYpdngnSNQPIHYYNQI 182
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 44-99 9.00e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 57.96  E-value: 9.00e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403525  44 RTQEPLQlnCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT 99
Cdd:cd23979    73 RSWDPSR--CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRT 126
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 52-103 6.10e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.93  E-value: 6.10e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403525  52 NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRV 103
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 53-111 6.92e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 54.74  E-value: 6.92e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPL 111
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPK 60
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 54-236 1.96e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 53.96  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  54 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNPDY-FFKEASRTIY 128
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGtksnLTTMNPSVIPHAYGDLVNATDKeKFVERLRQLG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 129 --VIWGP-FrnMRKDG-------NGIVYNMLKKTVDAYPDAQIYvtteqqmtHCDRVFKDETgKDRVQSGsylSTGWFTF 198
Cdd:cd23969   145 dsILWIPaF--VSKGGeehvqwtNEIILKHKLNVKTAYPPLRLN--------HAIRGYWLTT-KFRIKRP---STGLLMY 210

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720403525 199 ILAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYEQGK 236
Cdd:cd23969   211 TLATRFCDEIHLYGFY--PFSEDGNGRAVKYHYYDNRK 246
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 54-236 1.99e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 54.19  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  54 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNPD---YFFKEASRT 126
Cdd:cd23988    65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdFITMNPSVVQRAFGGFRNESDrekFVHRLSMLN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 127 IYVIWGPfRNMRKDG-------NGIVYNMLKKTVDAYPDAqiyvtteqQMTHCDRVFKdETGKDRVQSGsylSTGWFTFI 199
Cdd:cd23988   145 DSVLWIP-AFMVKGGekhvewvNALILKNKLKVRTAYPSL--------RLIHAVRGYW-LTNKVNIKRP---STGLLMYT 211

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1720403525 200 LAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYEQGK 236
Cdd:cd23988   212 LATRFCDEIHLYGFW--PFPKDANGNPVKYHYYDDLK 246
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 53-236 2.12e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 54.06  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT-------------MVRVVSH--TSVPlLLKNPD 117
Cdd:cd23972    82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygftvntmknsLISYWNLgfTRTP-QGQDLQ 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 118 YFFKEASRTIYVI-----------------------WGPFRNMRKdgngivYNMLkktvdaYPDAQIYVTteqqmthcDR 174
Cdd:cd23972   161 YIFIPSDIRDYVMlrsailgvpvpegldkgdrphkyFGPEASAKK------FKLL------HPDFISYLT--------DR 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720403525 175 VFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMInetyckTEGYRKVPYHYYEQGK 236
Cdd:cd23972   221 FLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFI------TSNYWKFSDHYYERKK 276
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 53-102 1.12e-07

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 51.29  E-value: 1.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720403525  53 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVR 102
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFR 51
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 52-99 5.37e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 50.14  E-value: 5.37e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720403525  52 NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT 99
Cdd:cd23974    83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRT 130
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 56-233 1.46e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 45.32  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  56 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNP--DYFFKE-ASRTIY 128
Cdd:cd23987    67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGtktdLVTMNPSVVQRAFEDLVNETwkEKFLQRlQSLNGS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 129 VIWGPfRNMRKDGNGIVY----NMLKKTVD---AYPDAqiyvtteqQMTHCDRVFKdETGKDRVQSGsylSTGWFTFILA 201
Cdd:cd23987   147 ILWIP-AFMAKGGEERVEwvndLILKHHINvrtAYPSL--------RLLHAVRGYW-LTNKVHIKRP---TTGLLMYTLA 213

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720403525 202 MDACYSIHVYGMIneTYCKTEGYRKVPYHYYE 233
Cdd:cd23987   214 TRFCNRIHLYGFW--PFPRDQNQNPVKYHYYD 243
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 48-233 3.60e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 44.44  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525  48 PLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAP-TKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYffkeaSRT 126
Cdd:cd23989    58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSIIDKRFQNLLW-----SRK 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403525 127 IYViwgpfRNMRKDGNGIVYN---MLKKTVDayPDAQIYVT-----TEQQMTHCDRVFKDETG---KDRVQSGSYLSTGW 195
Cdd:cd23989   133 SFV-----ESMKVYGRSYIYMpafSMKTGTD--PSLRVYYTladvgANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGL 205

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720403525 196 FTFILAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYE 233
Cdd:cd23989   206 FLVSAALGLCEEVTIYGFW--PFSVDLDERTISHHYYD 241
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 54-99 3.30e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 41.28  E-value: 3.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720403525  54 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKG-FEEDVGYMT 99
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT 111
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 54-99 8.85e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 39.93  E-value: 8.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720403525  54 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKgFEEDVGYMT 99
Cdd:cd23971    65 KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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