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Conserved domains on  [gi|1720403217|ref|XP_030108294|]
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potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X2 [Mus musculus]

Protein Classification

cyclic nucleotide-binding domain-containing protein( domain architecture ID 10034975)

cyclic nucleotide-binding domain-containing protein binds cyclic nucleotides (cAMP or cGMP)

CATH:  2.60.120.10
Gene Ontology:  GO:0030551
SCOP:  4000272

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 123-231 1.61e-26

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


:

Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 103.56  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 123 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRGRR 197
Cdd:cd00038     1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREqivgfLGPGDLFGELALLGNGPR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720403217 198 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF 231
Cdd:cd00038    81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 300-467 2.76e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  300 PLVHAPLQAAAVTSNVAIALTHQRGPLPLSPdSPATLLARSARRSAGSPASPLVP----VRAGPLLARGPWASTSRLPAP 375
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAA 2877

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  376 PARTLHASLSRTGRSQVSLLGP-PPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPP----------SG 444
Cdd:PHA03247  2878 PARPPVRRLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdpagagepSG 2957

                          170       180
                   ....*....|....*....|....*....
gi 1720403217  445 LLAKP------PGTVQPPRSSVPEPVTPR 467
Cdd:PHA03247  2958 AVPQPwlgalvPGRVAVPRFRVPQPAPSR 2986
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 123-231 1.61e-26

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 103.56  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 123 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRGRR 197
Cdd:cd00038     1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREqivgfLGPGDLFGELALLGNGPR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720403217 198 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF 231
Cdd:cd00038    81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 123-232 5.88e-19

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 82.45  E-value: 5.88e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  123 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRR 197
Cdd:smart00100   1 LFKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGeeqivGTLGPGDFFGELALLTNSRR 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720403217  198 TASVRADTY--CRLYSLSVDHFNAVLEEFPMMRRAFE 232
Cdd:smart00100  81 AASAAAVALelATLLRIDFRDFLQLLPELPQLLLELL 117
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 124-255 1.35e-18

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 83.88  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 124 FAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLT-----DGSYFGEICLLTRGRRT 198
Cdd:COG0664     1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQIlgflgPGDFFGELSLLGGEPSP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720403217 199 ASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSE 255
Cdd:COG0664    81 ATAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAE 137
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 141-223 4.71e-17

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 76.11  E-value: 4.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 141 FEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD 215
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGreqilAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPRE 80


                  ....*...
gi 1720403217 216 HFNAVLEE 223
Cdd:pfam00027  81 DFLELLER 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
 300-467 2.76e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  300 PLVHAPLQAAAVTSNVAIALTHQRGPLPLSPdSPATLLARSARRSAGSPASPLVP----VRAGPLLARGPWASTSRLPAP 375
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAA 2877

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  376 PARTLHASLSRTGRSQVSLLGP-PPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPP----------SG 444
Cdd:PHA03247  2878 PARPPVRRLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdpagagepSG 2957

                          170       180
                   ....*....|....*....|....*....
gi 1720403217  445 LLAKP------PGTVQPPRSSVPEPVTPR 467
Cdd:PHA03247  2958 AVPQPwlgalvPGRVAVPRFRVPQPAPSR 2986
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
150-245 9.10e-04

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 40.74  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 150 VVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRG-RRTASVRADTYCRLYSLSVDHFNAVLEE 223
Cdd:PRK11753   31 LIHAGEKAETLYYIVKGSVAVLIKDEEGkemilSYLNQGDFIGELGLFEEGqERSAWVRAKTACEVAEISYKKFRQLIQV 110

                          90       100
                  ....*....|....*....|..
gi 1720403217 224 FPMMRRAFETVAMDRLRRIGKK 245
Cdd:PRK11753  111 NPDILMALSAQMARRLQNTSRK 132
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 123-231 1.61e-26

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 103.56  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 123 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRGRR 197
Cdd:cd00038     1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREqivgfLGPGDLFGELALLGNGPR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720403217 198 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF 231
Cdd:cd00038    81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 123-232 5.88e-19

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 82.45  E-value: 5.88e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  123 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRR 197
Cdd:smart00100   1 LFKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGeeqivGTLGPGDFFGELALLTNSRR 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720403217  198 TASVRADTY--CRLYSLSVDHFNAVLEEFPMMRRAFE 232
Cdd:smart00100  81 AASAAAVALelATLLRIDFRDFLQLLPELPQLLLELL 117
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 124-255 1.35e-18

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 83.88  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 124 FAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLT-----DGSYFGEICLLTRGRRT 198
Cdd:COG0664     1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQIlgflgPGDFFGELSLLGGEPSP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720403217 199 ASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSE 255
Cdd:COG0664    81 ATAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAE 137
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 141-223 4.71e-17

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 76.11  E-value: 4.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 141 FEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD 215
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGreqilAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPRE 80


                  ....*...
gi 1720403217 216 HFNAVLEE 223
Cdd:pfam00027  81 DFLELLER 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
 300-467 2.76e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  300 PLVHAPLQAAAVTSNVAIALTHQRGPLPLSPdSPATLLARSARRSAGSPASPLVP----VRAGPLLARGPWASTSRLPAP 375
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAA 2877

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  376 PARTLHASLSRTGRSQVSLLGP-PPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPP----------SG 444
Cdd:PHA03247  2878 PARPPVRRLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdpagagepSG 2957

                          170       180
                   ....*....|....*....|....*....
gi 1720403217  445 LLAKP------PGTVQPPRSSVPEPVTPR 467
Cdd:PHA03247  2958 AVPQPwlgalvPGRVAVPRFRVPQPAPSR 2986
PHA03247 PHA03247
large tegument protein UL36; Provisional
 281-469 3.79e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 3.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  281 RGLAPGTGARLSGKPVLWEPlvhaPLQAAAVTSNVAIALTHQRGPLPLSPDSPATllarsarrsagsPASPLVPvraGPL 360
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRR----RAARPTVGSLTSLADPPPPPPTPEPAPHALV------------SATPLPP---GPA 2726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  361 LARGPWASTSRLPAPPAR----TLHASLSRTGRSQVSLLGP-------PPGGGARRL-GPRGRPLSASQPSLPQRATGDG 428
Cdd:PHA03247  2727 AARQASPALPAAPAPPAVpagpATPGGPARPARPPTTAGPPapappaaPAAGPPRRLtRPAVASLSESRESLPSPWDPAD 2806

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1720403217  429 SPRRKGSGSERLPPSgllAKPPGTVQPPRSSVP-EPVTPRGP 469
Cdd:PHA03247  2807 PPAAVLAPAAALPPA---ASPAGPLPPPTSAQPtAPPPPPGP 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-470 2.02e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  283 LAPGTGARLSGKPVLwePLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPAtllarSARRSAGSPASPLVPVRAGPLLA 362
Cdd:PHA03247  2721 LPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA-----PPAAPAAGPPRRLTRPAVASLSE 2793

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  363 RGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPrGRPLSASQPSLPQratgDGSPRRKGSGSERLPP 442
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPL----GGSVAPGGDVRRRPPS 2868

                          170       180
                   ....*....|....*....|....*...
gi 1720403217  443 SGLLAKPPGTVQPPRSSVPEPVTPRGPQ 470
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLARPAVSRSTE 2896
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 281-470 8.62e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 8.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 281 RGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAialthQRGPLPLSPDSPATllaRSARRSAGSPASPLVPVRAGPL 360
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAP-----APAGAAAAPAEASA---APAPGVAAPEHHPKHVAVPDAS 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 361 LARGPWASTSRLPAPPARTlhASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERL 440
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPP--PAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         170       180       190
                  ....*....|....*....|....*....|
gi 1720403217 441 PPSGLLakPPGTVQPPRSSVPEPVTPRGPQ 470
Cdd:PRK07764  742 PPEPDD--PPDPAGAPAQPPPPPAPAPAAA 769
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
283-473 2.60e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 283 LAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPV-----RA 357
Cdd:PRK12323  363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAarqasAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 358 GPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQP-SLPQRATGDGSPRRKGSG 436
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPpEFASPAPAQPDAAPAGWV 522

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1720403217 437 SERLPPSGLL----AKPPGTVQPPRSSVPEPVTPRGPQISA 473
Cdd:PRK12323  523 AESIPDPATAdpddAFETLAPAPAAAPAPRAAAATEPVVAP 563
PHA03247 PHA03247
large tegument protein UL36; Provisional
 284-470 3.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  284 APGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSA----GSPASPLVP----V 355
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAlppaASPAGPLPPptsaQ 2835

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  356 RAGPLLARGPWASTsrLPAPPARTLHASLSRTGRSQvsllgPPPGGGARRLGPRGRPLSA---SQPSLPQRATGDGSPRR 432
Cdd:PHA03247  2836 PTAPPPPPGPPPPS--LPLGGSVAPGGDVRRRPPSR-----SPAAKPAAPARPPVRRLARpavSRSTESFALPPDQPERP 2908

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1720403217  433 KGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQ 470
Cdd:PHA03247  2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 323-475 7.69e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 7.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  323 RGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLhASLSRTGRSQVSLLGPPPGGG 402
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPL-SSPEETARAPSSPPAEPPPST 197

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720403217  403 ARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISANM 475
Cdd:PHA03307   198 PPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIW 270
PHA03378 PHA03378
EBNA-3B; Provisional
 322-473 8.15e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 8.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 322 QRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPaRTLHASLSRTGRSQVSLLGPPPGG 401
Cdd:PHA03378  622 RQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQP-SPTGANTMLPIQWAPGTMQPPPRA 700

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720403217 402 GARRLGPRGRPlSASQPslPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISA 473
Cdd:PHA03378  701 PTPMRPPAAPP-GRAQR--PAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAA 769
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
150-245 9.10e-04

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 40.74  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 150 VVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRG-RRTASVRADTYCRLYSLSVDHFNAVLEE 223
Cdd:PRK11753   31 LIHAGEKAETLYYIVKGSVAVLIKDEEGkemilSYLNQGDFIGELGLFEEGqERSAWVRAKTACEVAEISYKKFRQLIQV 110

                          90       100
                  ....*....|....*....|..
gi 1720403217 224 FPMMRRAFETVAMDRLRRIGKK 245
Cdd:PRK11753  111 NPDILMALSAQMARRLQNTSRK 132
PHA03247 PHA03247
large tegument protein UL36; Provisional
 300-469 9.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 9.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  300 PLVHAPLQAAAVTSnvaiALTHQRGPLPLSPdspaTLLARSARRSA-GSPASPLVPVrAGPLLARGPWASTSRLPAPPAR 378
Cdd:PHA03247  2554 PLPPAAPPAAPDRS----VPPPRPAPRPSEP----AVTSRARRPDApPQSARPRAPV-DDRGDPRGPAPPSPLPPDTHAP 2624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  379 TLHASLSRTGRSQvsllgpPPGGGARRLGPRGRPLSASQP---SLPQRATGDGSPRRKGSGSERLPPSGL---------L 446
Cdd:PHA03247  2625 DPPPPSPSPAANE------PDPHPPPTVPPPERPRDDPAPgrvSRPRRARRLGRAAQASSPPQRPRRRAArptvgsltsL 2698

                          170       180
                   ....*....|....*....|...
gi 1720403217  447 AKPPGTVQPPRSSvPEPVTPRGP 469
Cdd:PHA03247  2699 ADPPPPPPTPEPA-PHALVSATP 2720
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
255-469 1.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 255 EPSPGSSGGVMEQHLVQhdrdMARGVRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPA 334
Cdd:PRK07003  359 EPAVTGGGAPGGGVPAR----VAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPA 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 335 TLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRL-------PAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLG 407
Cdd:PRK07003  435 TADRGDDAADGDAPVPAKANARASADSRCDERDAQPPAdsgsasaPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPA 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 408 PRGR-----PLSASQPSLPQRATGDGSPRRKGSG----------------SERLPPSGLLAKPPG------TVQPPRSSV 460
Cdd:PRK07003  515 AASRedapaAAAPPAPEARPPTPAAAAPAARAGGaaaaldvlrnagmrvsSDRGARAAAAAKPAAapaaapKPAAPRVAV 594


                  ....*....
gi 1720403217 461 PEPvTPRGP 469
Cdd:PRK07003  595 QVP-TPRAR 602
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 295-473 2.25e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  295 PVLWEPLVHAPLQAAAVTSNVAIALT-HQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLP 373
Cdd:PHA03307    35 LLSGSQGQLVSDSAELAAVTVVAGAAaCDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSP 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  374 APPARTlhaslsrtgrsQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTV 453
Cdd:PHA03307   115 DPPPPT-----------PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETA 183

                          170       180
                   ....*....|....*....|
gi 1720403217  454 QPPrSSVPEPVTPRGPQISA 473
Cdd:PHA03307   184 RAP-SSPPAEPPPSTPPAAA 202
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 317-473 2.93e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 317 IALtHQRGPLPLSPDSPA----TLLARSARRSAGSPASPLVPVRAGPllargpwastsrlpAPPARTLHASLSRTGRSQV 392
Cdd:PRK14951  336 ICL-HGRAELGLAPDEYAaltmVLLRLLAFKPAAAAEAAAPAEKKTP--------------ARPEAAAPAAAPVAQAAAA 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 393 SLLGPPPGGGARrlgPRGRPLSASQPSLPQR--ATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQ 470
Cdd:PRK14951  401 PAPAAAPAAAAS---APAAPPAAAPPAPVAApaAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAP 477


                  ...
gi 1720403217 471 ISA 473
Cdd:PRK14951  478 APA 480
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 326-475 4.34e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 326 LPLSPDSPATLLARSARRSAGSPAsplvpvrAGPLLARGPWASTSRLPAPPArtlhaslsrtgrsqvsllGPPPGGGARR 405
Cdd:PRK07764  364 LPSASDDERGLLARLERLERRLGV-------AGGAGAPAAAAPSAAAAAPAA------------------APAPAAAAPA 418

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 406 LGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISANM 475
Cdd:PRK07764  419 AAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAP 488
PHA03247 PHA03247
large tegument protein UL36; Provisional
 299-469 5.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 5.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  299 EPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRL--PAPP 376
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217  377 ARTLHASlsrtGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKG-----SGSER-LPPSGLLAKPP 450
Cdd:PHA03247  2705 PPTPEPA----PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArppttAGPPApAPPAAPAAGPP 2780

                          170
                   ....*....|....*....
gi 1720403217  451 GTVQPPRSSVPEPVTPRGP 469
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLP 2799
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
258-469 5.46e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 5.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 258 PGSSGGvmeqhlvqhDRDMARGVRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLL 337
Cdd:PRK12323  365 PGQSGG---------GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 338 ARSA------RRSAGSPASPLVPVRAGPllargPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPgggARRLGPRGR 411
Cdd:PRK12323  436 ARQAsargpgGAPAPAPAPAAAPAAAAR-----PAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP---WEELPPEFA 507

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720403217 412 PLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGP 469
Cdd:PRK12323  508 SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
321-470 6.60e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.09  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 321 HQRGPLPLSPDSPA----TLLARSARRSAGS--PASPlVPVRAGPLLARGPWASTSRlPAPPARTlHASLSRTGRSQVSL 394
Cdd:PRK12323  338 LGRSELALAPDEYAgftmTLLRMLAFRPGQSggGAGP-ATAAAAPVAQPAPAAAAPA-AAAPAPA-APPAAPAAAPAAAA 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 395 LGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGS----GSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQ 470
Cdd:PRK12323  415 AARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAaapaAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADD 494
PHA03378 PHA03378
EBNA-3B; Provisional
 281-468 9.27e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 38.51  E-value: 9.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 281 RGLAPGTGARLSGkPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASP--LVPVRAG 358
Cdd:PHA03378  612 QSHIPETSAPRQW-PMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAntMLPIQWA 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403217 359 PLLARGPWASTSRLPAPPARTLHASLSRTGRSQVsllgPPPGGGARRLGPrgrPLSASQPSLPQRATGDGSPRRKGSGSE 438
Cdd:PHA03378  691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA----RPPAAAPGRARP---PAAAPGRARPPAAAPGRARPPAAAPGR 763

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1720403217 439 RLPPSGLLAKPpgTVQPPRSSVPEPVT-PRG 468
Cdd:PHA03378  764 ARPPAAAPGAP--TPQPPPQAPPAPQQrPRG 792
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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