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Conserved domains on  [gi|1720400815|ref|XP_030107971|]
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zinc finger protein 2 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
113-377 8.41e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 8.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 113 HQMSAPSK---KALTKHQDQ-ECSECGKTFFDHSSLIRHQRTHTGEKPYDC--PECGKAFSHRSSLSRHLMFHTGESPYE 186
Cdd:COG5048    14 SVLSSTPKstlKSLSNAPRPdSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 187 CDACG------KAFFDRSSLTVHQRIHTGEKPFKCND------------------------------------------- 217
Cdd:COG5048    94 NSKSLplsnskASSSSLSSSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 218 ---CGKAFFDRSSLTRHQRIHTGESPYECQQCGKAFSQKSILTRHLLTHTgRKPYECRDCGKAFYGVTSLNRHQKVHTEE 294
Cdd:COG5048   174 nslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 295 PRYQCSECGKAFFDRSSLTQHQKIHTG-------DKPYECGECGKAFSQRCRLTRHQR--VHTGE--KPFEC--SVCGKE 361
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKL 332

                         330
                  ....*....|....*.
gi 1720400815 362 FSSKSSIIQHQRRYAK 377
Cdd:COG5048   333 FSRNDALKRHILLHTS 348
KRAB super family cl42959
krueppel associated box;
12-34 1.32e-03

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.80  E-value: 1.32e-03
                           10        20
                   ....*....|....*....|...
gi 1720400815   12 SLGLPVPRPDVILQFKRRGEPWI 34
Cdd:smart00349  39 SLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
113-377 8.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 8.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 113 HQMSAPSK---KALTKHQDQ-ECSECGKTFFDHSSLIRHQRTHTGEKPYDC--PECGKAFSHRSSLSRHLMFHTGESPYE 186
Cdd:COG5048    14 SVLSSTPKstlKSLSNAPRPdSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 187 CDACG------KAFFDRSSLTVHQRIHTGEKPFKCND------------------------------------------- 217
Cdd:COG5048    94 NSKSLplsnskASSSSLSSSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 218 ---CGKAFFDRSSLTRHQRIHTGESPYECQQCGKAFSQKSILTRHLLTHTgRKPYECRDCGKAFYGVTSLNRHQKVHTEE 294
Cdd:COG5048   174 nslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 295 PRYQCSECGKAFFDRSSLTQHQKIHTG-------DKPYECGECGKAFSQRCRLTRHQR--VHTGE--KPFEC--SVCGKE 361
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKL 332

                         330
                  ....*....|....*.
gi 1720400815 362 FSSKSSIIQHQRRYAK 377
Cdd:COG5048   333 FSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
143-168 2.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 2.80e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720400815 143 SLIRHQRTHTGEKPYDCPECGKAFSH 168
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 131-177 1.43e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 1.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720400815 131 CSECGKTFFDHSSLIRHQRTHTgekpYDCPECGKAFSHRSSLSRHLM 177
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCL 46
KRAB smart00349
krueppel associated box;
12-34 1.32e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.80  E-value: 1.32e-03
                           10        20
                   ....*....|....*....|...
gi 1720400815   12 SLGLPVPRPDVILQFKRRGEPWI 34
Cdd:smart00349  39 SLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
113-377 8.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 8.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 113 HQMSAPSK---KALTKHQDQ-ECSECGKTFFDHSSLIRHQRTHTGEKPYDC--PECGKAFSHRSSLSRHLMFHTGESPYE 186
Cdd:COG5048    14 SVLSSTPKstlKSLSNAPRPdSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 187 CDACG------KAFFDRSSLTVHQRIHTGEKPFKCND------------------------------------------- 217
Cdd:COG5048    94 NSKSLplsnskASSSSLSSSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 218 ---CGKAFFDRSSLTRHQRIHTGESPYECQQCGKAFSQKSILTRHLLTHTgRKPYECRDCGKAFYGVTSLNRHQKVHTEE 294
Cdd:COG5048   174 nslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 295 PRYQCSECGKAFFDRSSLTQHQKIHTG-------DKPYECGECGKAFSQRCRLTRHQR--VHTGE--KPFEC--SVCGKE 361
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKL 332

                         330
                  ....*....|....*.
gi 1720400815 362 FSSKSSIIQHQRRYAK 377
Cdd:COG5048   333 FSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
142-360 1.63e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 142 SSLIRHQRTHTGEKPYDCPECGKAFSHRSSLSRHLMFHTGESPYECDACGKAFFDRSSLTVHQRIHTGE-------KPFK 214
Cdd:COG5048   212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIK 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 215 CNDCGKAFFDRSSLTRHQR--IHTGES--PYEC--QQCGKAFSQKSILTRHLLTHTGRKPYEC--RDCGKAFYG------ 280
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnep 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 281 VTSLNRHQKVHTEEPRYQCSECGKAFFDRSSLTQHQKI-HTGDKPYEC--GECGKAFSQRCRLTRHQRVHTGEKPFECSV 357
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIItHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451


                  ...
gi 1720400815 358 CGK 360
Cdd:COG5048   452 LKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
42-288 3.94e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815  42 EKTWPESVSLDLETKPETLDASRGTLREIHRKQSSLCPKREIQTLTGGPEPEKESPKARTCKKPLSLDKGLHQMSAPSKK 121
Cdd:COG5048   206 SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 122 ALTKHQdqeCSECGKTFFDHSSLIRHQRT--HTGE--KPYDCPE--CGKAFSHRSSLSRHLMFHTGESPYECDAC----- 190
Cdd:COG5048   286 FSLPIK---SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssk 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400815 191 --GKAFFDRSSLTVHQRIHTGEKPFKC--NDCGKAFFDRSSLTRHQRIHTGESPYECQ--QCGKAFSQKSILTRHLLTHT 264
Cdd:COG5048   363 fsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442

                         250       260
                  ....*....|....*....|....
gi 1720400815 265 GRKPYECRDCGKAFYGVTSLNRHQ 288
Cdd:COG5048   443 NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
143-168 2.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 2.80e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720400815 143 SLIRHQRTHTGEKPYDCPECGKAFSH 168
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-252 8.71e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.71e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720400815 227 SLTRHQRIHTGESPYECQQCGKAFSQ 252
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 131-177 1.43e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 1.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720400815 131 CSECGKTFFDHSSLIRHQRTHTgekpYDCPECGKAFSHRSSLSRHLM 177
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCL 46
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 2.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720400815 339 RLTRHQRVHTGEKPFECSVCGKEFSS 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 3.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.61e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720400815 311 SLTQHQKIHTGDKPYECGECGKAFSQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-222 4.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.23e-04
                          10        20
                  ....*....|....*....|....
gi 1720400815 199 SLTVHQRIHTGEKPFKCNDCGKAF 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 213-235 6.19e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.19e-04
                          10        20
                  ....*....|....*....|...
gi 1720400815 213 FKCNDCGKAFFDRSSLTRHQRIH 235
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
KRAB smart00349
krueppel associated box;
12-34 1.32e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.80  E-value: 1.32e-03
                           10        20
                   ....*....|....*....|...
gi 1720400815   12 SLGLPVPRPDVILQFKRRGEPWI 34
Cdd:smart00349  39 SLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-278 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|...
gi 1720400815 256 LTRHLLTHTGRKPYECRDCGKAF 278
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
171-194 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....
gi 1720400815 171 SLSRHLMFHTGESPYECDACGKAF 194
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 297-319 4.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|...
gi 1720400815 297 YQCSECGKAFFDRSSLTQHQKIH 319
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 190-235 6.00e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 6.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720400815 190 CGKAFFDRSSLTVHQRIHTgekpFKCNDCGKAFFDRSSLTRH-QRIH 235
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 130-151 6.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.03e-03
                          10        20
                  ....*....|....*....|..
gi 1720400815 130 ECSECGKTFFDHSSLIRHQRTH 151
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 157-179 7.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.05e-03
                          10        20
                  ....*....|....*....|...
gi 1720400815 157 YDCPECGKAFSHRSSLSRHLMFH 179
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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