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Conserved domains on  [gi|1720400619|ref|XP_030107919|]
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N-acetylgalactosamine kinase isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 2-432 4.21e-159

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 458.40  E-value: 4.21e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHT-LQLANTDPLYP--DFSTTANNiCIDK 78
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDKYTtcTFPADPDQ-EVDL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  79 TKPLWHNYFLCGFKGIQEHFGLSK--LP---GMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAK 153
Cdd:PLN02521  118 ANHKWGNYFICGYKGVFEFLKSKGvdVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCK 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 154 SERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANSCMEMNKAATSH--FNVRVMECRLAAKVLA 231
Cdd:PLN02521  198 CERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLA 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 232 KHKGLQWD----NVLRLEEVQsKLGISLEE------MLLVTEDALHPEPYSREEICRCLGISLERLRTQilTPNTQDELT 301
Cdd:PLN02521  278 VKLGMSAEeaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLK 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 302 ----FKLYQRAKHVYSEAARVLQFKQVCEDAPDNAVQL--LGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRL 375
Cdd:PLN02521  355 aakhFKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEKLkkLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARL 434

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720400619 376 TGAGWGGCTVSLVPADMLSSFLASVHEAYYQgntSRLAQEKHS-------LFATKPGGGALVFR 432
Cdd:PLN02521  435 TGAGWGGCAVALVKEAIVPQFILALKEKFYK---SRIEKGVIKeedlglyVFASKPSSGAAILK 495
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-432 4.21e-159

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 458.40  E-value: 4.21e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHT-LQLANTDPLYP--DFSTTANNiCIDK 78
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDKYTtcTFPADPDQ-EVDL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  79 TKPLWHNYFLCGFKGIQEHFGLSK--LP---GMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAK 153
Cdd:PLN02521  118 ANHKWGNYFICGYKGVFEFLKSKGvdVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCK 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 154 SERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANSCMEMNKAATSH--FNVRVMECRLAAKVLA 231
Cdd:PLN02521  198 CERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLA 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 232 KHKGLQWD----NVLRLEEVQsKLGISLEE------MLLVTEDALHPEPYSREEICRCLGISLERLRTQilTPNTQDELT 301
Cdd:PLN02521  278 VKLGMSAEeaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLK 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 302 ----FKLYQRAKHVYSEAARVLQFKQVCEDAPDNAVQL--LGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRL 375
Cdd:PLN02521  355 aakhFKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEKLkkLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARL 434

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720400619 376 TGAGWGGCTVSLVPADMLSSFLASVHEAYYQgntSRLAQEKHS-------LFATKPGGGALVFR 432
Cdd:PLN02521  435 TGAGWGGCAVALVKEAIVPQFILALKEKFYK---SRIEKGVIKeedlglyVFASKPSSGAAILK 495
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-428 1.66e-85

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 266.25  E-value: 1.66e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHTLQLANTDplYPD-FSTTANNICIDKTK 80
Cdd:COG0153     9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  81 PlWHNYFLcG-FKGIQEHfGLsKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSE-RYI 158
Cdd:COG0153    87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 159 GTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLP-SGAVFVIANScmemNK---AATSHFNVRVMECRLAAKVLAKhk 234
Cdd:COG0153   163 GVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDT----NVkhsLADSEYNERRAECEAAAAILGV-- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 235 glqwdNVLRleEVqsklgiSLEEmllvtedalhpepysreeicrclgisLERLRTQILTPntqdeltfKLYQRAKHVYSE 314
Cdd:COG0153   237 -----KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTE 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 315 AARVLQFKQVCEdapDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKF-GAKGSRLTGAGWGGCTVSLVPADML 393
Cdd:COG0153   270 NQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAV 346

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1720400619 394 SSFLASVHEAYYQGntsrlAQEKHSLFATKPGGGA 428
Cdd:COG0153   347 DEFIEAVAEAYAEK-----TGLEPDFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-404 1.29e-78

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 248.59  E-value: 1.29e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTH--TLQLANTDPLYPDFSTtanNICIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  80 KPL-WHNYFLCGFKGIQEHFGLSKLpGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELA-EICAKSERY 157
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILlRIQVAENHF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLP-SGAVFVIANSCMEMNkAATSHFNVRVMECRLAAKVLAKhkgl 236
Cdd:TIGR00131 164 VGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA---- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 237 qwDNVLRLEEVQsklgisleemllvtedalhPEPYSREEicrclgislERLrtQILTPNTQdeltfklyQRAKHVYSEAA 316
Cdd:TIGR00131 239 --TDKGALRDFM-------------------NEYFARYI---------ARL--TKMLPLVE--------ERAKHVVSENL 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 317 RVLQFKQVCEdapDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICR-KFGAKGSRLTGAGWGGCTVSLVPADMLSS 395
Cdd:TIGR00131 279 RVLKAVKAMK---DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDK 355


                  ....*....
gi 1720400619 396 FLASVHEAY 404
Cdd:TIGR00131 356 VRQAVADKY 364
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 3.00e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 86.35  E-value: 3.00e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-432 4.21e-159

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 458.40  E-value: 4.21e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHT-LQLANTDPLYP--DFSTTANNiCIDK 78
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDKYTtcTFPADPDQ-EVDL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  79 TKPLWHNYFLCGFKGIQEHFGLSK--LP---GMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAK 153
Cdd:PLN02521  118 ANHKWGNYFICGYKGVFEFLKSKGvdVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCK 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 154 SERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANSCMEMNKAATSH--FNVRVMECRLAAKVLA 231
Cdd:PLN02521  198 CERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLA 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 232 KHKGLQWD----NVLRLEEVQsKLGISLEE------MLLVTEDALHPEPYSREEICRCLGISLERLRTQilTPNTQDELT 301
Cdd:PLN02521  278 VKLGMSAEeaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLK 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 302 ----FKLYQRAKHVYSEAARVLQFKQVCEDAPDNAVQL--LGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRL 375
Cdd:PLN02521  355 aakhFKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEKLkkLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARL 434

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720400619 376 TGAGWGGCTVSLVPADMLSSFLASVHEAYYQgntSRLAQEKHS-------LFATKPGGGALVFR 432
Cdd:PLN02521  435 TGAGWGGCAVALVKEAIVPQFILALKEKFYK---SRIEKGVIKeedlglyVFASKPSSGAAILK 495
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-428 1.66e-85

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 266.25  E-value: 1.66e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHTLQLANTDplYPD-FSTTANNICIDKTK 80
Cdd:COG0153     9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  81 PlWHNYFLcG-FKGIQEHfGLsKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSE-RYI 158
Cdd:COG0153    87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 159 GTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLP-SGAVFVIANScmemNK---AATSHFNVRVMECRLAAKVLAKhk 234
Cdd:COG0153   163 GVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDT----NVkhsLADSEYNERRAECEAAAAILGV-- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 235 glqwdNVLRleEVqsklgiSLEEmllvtedalhpepysreeicrclgisLERLRTQILTPntqdeltfKLYQRAKHVYSE 314
Cdd:COG0153   237 -----KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTE 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 315 AARVLQFKQVCEdapDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKF-GAKGSRLTGAGWGGCTVSLVPADML 393
Cdd:COG0153   270 NQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAV 346

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1720400619 394 SSFLASVHEAYYQGntsrlAQEKHSLFATKPGGGA 428
Cdd:COG0153   347 DEFIEAVAEAYAEK-----TGLEPDFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-404 1.29e-78

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 248.59  E-value: 1.29e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTH--TLQLANTDPLYPDFSTtanNICIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  80 KPL-WHNYFLCGFKGIQEHFGLSKLpGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELA-EICAKSERY 157
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILlRIQVAENHF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLP-SGAVFVIANSCMEMNkAATSHFNVRVMECRLAAKVLAKhkgl 236
Cdd:TIGR00131 164 VGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA---- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 237 qwDNVLRLEEVQsklgisleemllvtedalhPEPYSREEicrclgislERLrtQILTPNTQdeltfklyQRAKHVYSEAA 316
Cdd:TIGR00131 239 --TDKGALRDFM-------------------NEYFARYI---------ARL--TKMLPLVE--------ERAKHVVSENL 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 317 RVLQFKQVCEdapDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICR-KFGAKGSRLTGAGWGGCTVSLVPADMLSS 395
Cdd:TIGR00131 279 RVLKAVKAMK---DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDK 355


                  ....*....
gi 1720400619 396 FLASVHEAY 404
Cdd:TIGR00131 356 VRQAVADKY 364
PRK05101 PRK05101
galactokinase; Provisional
 1-406 7.32e-48

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 168.18  E-value: 7.32e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   1 MFNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHTLQL--ANTDPLYPDFSTTAnNICIDK 78
Cdd:PRK05101   10 LFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViaADYDNQQDEFSLDA-PIVPHP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  79 TKpLWHNYFLCGFKGIQEHfgLSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSE-RY 157
Cdd:PRK05101   89 EQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAEnQF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANScmemNKA---ATSHFNVRVMECRLAAKVLakhk 234
Cdd:PRK05101  166 VGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINS----NVKrglVDSEYNTRRQQCETAARFF---- 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 235 glqwdNVLRLEEVqsklgisleemllvtedalhpepysreeicrclgiSLERLRTQiltpntQDELTFKLYQRAKHVYSE 314
Cdd:PRK05101  238 -----GVKALRDV-----------------------------------TLEQFNAV------AAELDPVVAKRARHVITE 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 315 AARVLQFKQVCEdapDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICR-KFGAKGS-RLTGAGWGGCTVSLVPADM 392
Cdd:PRK05101  272 NARTLEAASALA---AGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALVPEEL 348

                         410
                  ....*....|....
gi 1720400619 393 LSSFLASVHEAYYQ 406
Cdd:PRK05101  349 VEAVRQAVAEQYEA 362
PRK05322 PRK05322
galactokinase; Provisional
 2-404 1.28e-45

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 162.33  E-value: 1.28e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619   2 FNSKFGSTPK--FYvrAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHTLQLANTDplYPD---FSTTANNICI 76
Cdd:PRK05322   10 FAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDLDDLSF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  77 DKtKPLWHNYFLCGFKGIQEHfGLSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSE- 155
Cdd:PRK05322   86 DK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTEn 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 156 RYIGTEGGGMDQSISFLAEEGTAKLI-------EFSPLratnvKLpSGAVFVIANScmemNKA---ATSHFNVRVMECRL 225
Cdd:PRK05322  164 EFIGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPL-----DL-GDYVIVIMNT----NKRrelADSKYNERRAECEK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 226 AakvlakhkglqwdnvlrLEEVQSKLGI-SLEEmllvtedalhpepysreeicrclgislerlrtqiLTPNTQDELTF-- 302
Cdd:PRK05322  234 A-----------------LEELQKKLDIkSLGE----------------------------------LTEEEFDEYSYli 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 303 ---KLYQRAKHVYSEAARVLQFKQVCEdapDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKF-GAKGSRLTGA 378
Cdd:PRK05322  263 kdeTLLKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGA 339

                         410       420
                  ....*....|....*....|....*.
gi 1720400619 379 GWGGCTVSLVPADMLSSFLASVHEAY 404
Cdd:PRK05322  340 GFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK03817 PRK03817
galactokinase; Provisional
 14-405 5.88e-41

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 148.99  E-value: 5.88e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  14 VRAPGRVNIIGEHIDYC-GYsVIPMAVEQDMLIAVEPV-KTHtlqlantdpLYPDFSTTANNICIDKTKPL--WHNYFLC 89
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSeKFI---------FYSENFNEEKTFELDKLEKLnsWADYIKG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  90 GFKGIQEHFGlsKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSER-YIGTEGGGMDQS 168
Cdd:PRK03817   73 VIWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 169 ISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANSCMEmNKAATSHFNVRVMECRLAAKVLAKHkglqwdnvlrleevq 248
Cdd:PRK03817  151 AVAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKK--------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 249 sklgiSLEEmllVTEDalhpepysreeicrclgiSLERLrtqiltpntqDELTFKlyqRAKHVYSEAARVLQFKQVCEda 328
Cdd:PRK03817  215 -----SSKE---VTEE------------------DLSKL----------PPLLRK---RAGYVLRENERVLKVRDALK-- 253

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720400619 329 pDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLVPADMLSSFLASVHEAYY 405
Cdd:PRK03817  254 -EGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYK 329
PRK00555 PRK00555
galactokinase; Provisional
 16-428 6.81e-31

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 121.89  E-value: 6.81e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  16 APGRVNIIGEHIDY-CGYSvIPMAVEQDMLIAVEPVKTHTLQLANtdplypDFSTTANNICIDkTKPL----WHNYFLCG 90
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  91 FKGIQEHFglSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSER-YIGTEGGGMDQSI 169
Cdd:PRK00555   79 IWALRGAG--HPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 170 SFLAEEGTAKLIEFSPLRATNVKLPSGA--VFVIANSCMEMNKAATSHFNVRVMECRLAAKVLAkhkglqwdnVLRLEEV 247
Cdd:PRK00555  157 ALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLG---------VSSLRAV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 248 QSKLGISLEEmllvtedalhpepysreeicrclgislerlrtqiltpnTQDELTFKlyqRAKHVYSEAARVLQFKQVCED 327
Cdd:PRK00555  228 QDRGLAALGA--------------------------------------IADPIDAR---RARHVLTENQRVLDFAAALAD 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 328 APDNAVqllGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLVPADMLSSFLASVHEAYYQG 407
Cdd:PRK00555  267 SDFTAA---GQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTA 343

                         410       420
                  ....*....|....*....|.
gi 1720400619 408 NTSRlaqekHSLFATKPGGGA 428
Cdd:PRK00555  344 GYPE-----PAVSRTYAAPGA 359
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 3.00e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 86.35  E-value: 3.00e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720400619   2 FNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PLN02865 PLN02865
galactokinase
 14-430 8.58e-18

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 84.85  E-value: 8.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  14 VRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEP-----VKTHTLQLANTDPLYPDFSTTANNICIDKTKP--LWHNY 86
Cdd:PLN02865   33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPsgdpeVLLRSAQFEGEVRFRVDEIQHPIANVSSDSKEesNWGDY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  87 FLCGFKGIQEhFGLSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTL-TVLGLRLSKVELAEICAKSE-RYIGTEGGG 164
Cdd:PLN02865  113 ARGAVYALQS-RGHALSQGITGYISGSEGLDSSGLSSSAAVGVAYLLALeNANNLTVSPEDNIELDRLIEnEYLGLRNGI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 165 MDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAV-------FVIANSCMEMNKAATSHFNVRVMECRLAAKVLAKHKGLq 237
Cdd:PLN02865  192 LDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARFLLEASGN- 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 238 wdnvlrlEEVQSKLGisleemllvtedALHPEPYSREeicrclgislerlrtqiltpntQDELTFKLYQRAKHVYSEAAR 317
Cdd:PLN02865  271 -------DELEPLLC------------NVEPEVYEAH----------------------KCKLEAVLARRAEHYFSENMR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 318 VLqfKQVcEDAPDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKF-GAKGSRLTGAGWGGCTVSLVPADMLSSF 396
Cdd:PLN02865  310 VI--KGV-EAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEEA 386

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1720400619 397 LASVHEAYYQGN---TSRLAQEKHSLFaTKPGGGALV 430
Cdd:PLN02865  387 ASFVRDEYEKAQpelASNINGDKPVLI-CEAGDCARV 422
PTZ00290 PTZ00290
galactokinase; Provisional
 16-430 1.57e-17

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 84.49  E-value: 1.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  16 APGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVK---THTLQLANTDPLYPDfsttannicIDKTKPLWHN----YFL 88
Cdd:PTZ00290   42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKhfcDHKLRFATETDEHFV---------LDHLGGAKHNkawtTFV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  89 CGFKGIQ-EHFGLS----KLPGMNCLVDGNIPPSSGLSSSSAL-VCCAGLVTLTVLGL----------------RLSKVE 146
Cdd:PTZ00290  113 RGAATLRlNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASFgVALLNAINTVVTRRykgcptspgrrysilpPMSKEE 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 147 LAEIcAKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratnvkLPSGAVFVIANScmemnka 211
Cdd:PTZ00290  193 LIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDS------- 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 212 atshfnvrvmecrlaakvLAKHKGL----QWDNVLR--LEEVQSKLGisleemllvtEDALHPEPYSREEICRCLGISLE 285
Cdd:PTZ00290  259 ------------------MIKHDLLggtaGMYNTVRsdQEGAQKKIG----------KHRYRGKPFTFSDLVRNPKKYTF 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 286 RLRTQILTPNTQDELTFKLYQRAKHVYSEAARVLQFKQVCEDA----PDNAVQLLGELMNQSHRSCRDMYECSCPELDQL 361
Cdd:PTZ00290  311 DGDVVAFMESCKPLMTPGEFERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFI 390

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 362 VD-ICRKFGAKGSRLTGAGWGGCTVSLVPADMLSSFLASVHEAYyqgnTSRLAQEkHSLFATKPGGGALV 430
Cdd:PTZ00290  391 HElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKF----KARFGVE-NDVYPVVAGDGAFV 455
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 16-388 6.66e-15

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 74.49  E-value: 6.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  16 APGRVNIIGEHID-YcGYSVIPMAVEQDMLIAVEPVKTHTLQLaNTDPLYPDFSTTANnicidkTKPLWHnYFLCGFKGI 94
Cdd:COG1577     1 APGKLILFGEHAVvY-GQPAIAVAVDRRATVTVEPSDDDKLRI-ESPDLGGTLDLDPL------ADAALR-YIKAAIEAA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  95 QEHFGLsKLPGMNCLVDGNIPPSsglssssalvccAGL-----VT-------LTVLGLRLSKVELAEICAKSERYIGTEG 162
Cdd:COG1577    72 LEYLGL-PLKGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 163 GGMDQSISFLaeEGtakLIEF-SPLRATNVKLPSGAVFVIANSCmemNKAATSHfnvrvmecrLAAKVLAkhkglqwdnv 241
Cdd:COG1577   139 SGLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTG---VPASTKE---------LVAKVRK---------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 242 lRLEEvqsklgisleemllvtedalHPEPYSReeicrclgislerlrtqiltpntqdeltfkLYQRAKHVYSEAARVLQf 321
Cdd:COG1577   192 -LKER--------------------NPELYEA------------------------------FLEEIGDLVEEAIEALE- 219

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720400619 322 kqvcedapDNAVQLLGELMNQSHRSCRDMYeCSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLV 388
Cdd:COG1577   220 --------EGDLEALGELMNENHGLLRALG-VSTPELDRLVEAARKAGALGAKLTGAGGGGCVIALA 277
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 303-387 8.60e-12

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 66.03  E-value: 8.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 303 KLYQRAKHVYSEAARVLQfkqvcedapDNAVQLLGELMNQSHRSCRDMyECSCPELDQLVDICRKFGAKGSRLTGAGWGG 382
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1720400619 383 CTVSL 387
Cdd:PTZ00298  288 LVVAL 292
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 16-387 2.23e-11

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 63.85  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  16 APGRVNIIGEHIDYCGYSVIPMAVEQDM-LIAVEPVKTHTLQLANTDPLYPDFSTTANNIcidktkplwhnyFLCGFKGI 94
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTtVTVIESSDGSFIESDLGRGSLDDAPDELDGL------------KYVLAEFL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619  95 QeHFGLSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSERYIGTEGGGMDQSISflAE 174
Cdd:TIGR00549  69 S-RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATS--TS 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 175 EGTAKLIEFSPLRATNVKLPsgAVFVIANScmemnkaatshfnvrvmecrlaakvlakhkglqwdnvlrleevqsklGIS 254
Cdd:TIGR00549 146 GGPVYFEKGEGEFTKLISLD--GYFVIADT-----------------------------------------------GVS 176

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 255 LEemllvTEDALhpepysreeicrclgislERLRtQILTPNtqDELTFKLYQRAKHVYSEAARVLQfkqvcedapDNAVQ 334
Cdd:TIGR00549 177 GS-----TKEAV------------------ARVR-QLLERF--PELIDSIMDAIGELTLEAKAALQ---------DGDVE 221

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720400619 335 LLGELMNQSHrSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSL 387
Cdd:TIGR00549 222 SLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMIAL 273
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 326-389 6.30e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 52.86  E-value: 6.30e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720400619 326 EDAPDNAVQLLGELMNQSHRSC--RDMYECSCPELDQLVDICRKFGaKGSRLTGAGWGGCTVSLVP 389
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFK 67
PRK03926 PRK03926
mevalonate kinase; Provisional
 336-391 2.59e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.06  E-value: 2.59e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720400619 336 LGELMNQSHrSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLVPAD 391
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPE 270
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 306-391 8.34e-04

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 41.32  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720400619 306 QRAKHVYSEAARVLQFKQVCEDAPD--NAVQ-----LLGELMNQSHRSCRDMYE-CSCPELDQLVDICRKFGAKGSRLTG 377
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELALEmkEALLkgdldEFGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLLG 284

                          90
                  ....*....|....
gi 1720400619 378 AGWGGCTVSLVPAD 391
Cdd:COG2605   285 AGGGGFLLFYAPPE 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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