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Conserved domains on  [gi|1720399189|ref|XP_030107031|]
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syntaphilin isoform X4 [Mus musculus]

Protein Classification

syntaphilin domain-containing protein( domain architecture ID 10633823)

syntaphilin domain-containing protein similar to Homo sapiens syntaphilin, a syntaxin-1 clamp that controls SNARE assembly, and syntabulin, a microtubule-associated protein implicated in syntaxin transport in neurons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 64-337 1.27e-158

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


:

Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 452.65  E-value: 1.27e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  64 MKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLAL 143
Cdd:pfam15290  39 GRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESENRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLAL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189 144 KEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTY 223
Cdd:pfam15290 119 KEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKLESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTY 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189 224 TKLSDPAVcGDRQPGDPSNTSAEDGADSGYVAADDTLSRTDAleassllssgvdcgLEEASLHSSFNLGPRFPASNTYEK 303
Cdd:pfam15290 199 TKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL--------------LEEVFMSTAVEAGDLAPFSSTYEK 263

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720399189 304 LL---CGMEAGVQV-----SCMQERAIQTDFVQYQPDLNTIL 337
Cdd:pfam15290 264 LMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
 
Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 64-337 1.27e-158

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 452.65  E-value: 1.27e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  64 MKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLAL 143
Cdd:pfam15290  39 GRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESENRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLAL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189 144 KEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTY 223
Cdd:pfam15290 119 KEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKLESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTY 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189 224 TKLSDPAVcGDRQPGDPSNTSAEDGADSGYVAADDTLSRTDAleassllssgvdcgLEEASLHSSFNLGPRFPASNTYEK 303
Cdd:pfam15290 199 TKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL--------------LEEVFMSTAVEAGDLAPFSSTYEK 263

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720399189 304 LL---CGMEAGVQV-----SCMQERAIQTDFVQYQPDLNTIL 337
Cdd:pfam15290 264 LMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 87-203 2.34e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.85  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  87 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLsrmqedwieeechrVEAQLALKEARKEIRQLKQVIDTVKnNLID 166
Cdd:COG1579    12 LQELDSELDRLEHRLKELPAELAELEDELAALEARL--------------EAAKTELEDLEKEIKRLELEIEEVE-ARIK 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1720399189 167 KDKGLQKyfvdiNIQN-KKLETLLHSMEVAQNGVAKEE 203
Cdd:COG1579    77 KYEEQLG-----NVRNnKEYEALQKEIESLKRRISDLE 109
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 87-188 1.31e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  87 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQlsrMQEDWIEE--------ECHRVEAQLALKEARKEIRQLKQVID 158
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---KEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQIS 345

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720399189 159 TVKNNLIDKDKGLQKYFVDINIQNKKLETL 188
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKL 375
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
94-204 1.85e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  94 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEdwIEEEchrVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQK 173
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKE--LKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720399189 174 YFVDINIQNKKLETLLHSMEVAQNGVAKEEG 204
Cdd:PRK03918  329 RIKELEEKEERLEELKKKLKELEKRLEELEE 359
 
Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 64-337 1.27e-158

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 452.65  E-value: 1.27e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  64 MKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLAL 143
Cdd:pfam15290  39 GRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESENRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLAL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189 144 KEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTY 223
Cdd:pfam15290 119 KEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKLESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTY 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189 224 TKLSDPAVcGDRQPGDPSNTSAEDGADSGYVAADDTLSRTDAleassllssgvdcgLEEASLHSSFNLGPRFPASNTYEK 303
Cdd:pfam15290 199 TKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL--------------LEEVFMSTAVEAGDLAPFSSTYEK 263

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720399189 304 LL---CGMEAGVQV-----SCMQERAIQTDFVQYQPDLNTIL 337
Cdd:pfam15290 264 LMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 87-203 2.34e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.85  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  87 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLsrmqedwieeechrVEAQLALKEARKEIRQLKQVIDTVKnNLID 166
Cdd:COG1579    12 LQELDSELDRLEHRLKELPAELAELEDELAALEARL--------------EAAKTELEDLEKEIKRLELEIEEVE-ARIK 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1720399189 167 KDKGLQKyfvdiNIQN-KKLETLLHSMEVAQNGVAKEE 203
Cdd:COG1579    77 KYEEQLG-----NVRNnKEYEALQKEIESLKRRISDLE 109
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
89-203 4.15e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.66  E-value: 4.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  89 QKEvcIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQE--DWIEEECHRVEAQLA-----LKEARKEIRQLKQVIDTVK 161
Cdd:COG4372    44 QEE--LEQLREELEQAREELEQLEEELEQARSELEQLEEelEELNEQLQAAQAELAqaqeeLESLQEEAEELQEELEELQ 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720399189 162 N---NLIDKDKGLQ----KYFVDINIQNKKLETLLHSMEVAQNGVAKEE 203
Cdd:COG4372   122 KerqDLEQQRKQLEaqiaELQSEIAEREEELKELEEQLESLQEELAALE 170
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 87-188 1.31e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  87 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQlsrMQEDWIEE--------ECHRVEAQLALKEARKEIRQLKQVID 158
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---KEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQIS 345

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720399189 159 TVKNNLIDKDKGLQKYFVDINIQNKKLETL 188
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKL 375
BAR pfam03114
BAR domain; BAR domains are dimerization, lipid binding and curvature sensing modules found in ...
 124-201 1.67e-04

BAR domain; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like pfam00169 and pfam00787 domains in beta centaurins and sorting nexins respectively.


Pssm-ID: 460810 [Multi-domain]  Cd Length: 235  Bit Score: 43.09  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399189 124 RMQEDWieEECHRVEAQLALKEARKEIRQ-LKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAK 201
Cdd:pfam03114  80 AGKDLG--EDSSFGKALEDYGEALKRLAQlLEQLDDRVETNFLDPLRNLLKEFKEIQKHRKKLERKRLDYDAAKTRVKK 156
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
94-204 1.85e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  94 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEdwIEEEchrVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQK 173
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKE--LKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720399189 174 YFVDINIQNKKLETLLHSMEVAQNGVAKEEG 204
Cdd:PRK03918  329 RIKELEEKEERLEELKKKLKELEKRLEELEE 359
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 94-191 1.31e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  94 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEeechrveAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQK 173
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNE-------LQAELEALQAEIDKLQAEIAEAEAEIEERREELGE 90

                          90       100
                  ....*....|....*....|.
gi 1720399189 174 YFVDINIQ---NKKLETLLHS 191
Cdd:COG3883    91 RARALYRSggsVSYLDVLLGS 111
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 88-202 1.33e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  88 QQKEVCIRHLKARLKDTQDRLQDRDTE-------IDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTV 160
Cdd:TIGR04523 303 QKEQDWNKELKSELKNQEKKLEEIQNQisqnnkiISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSY 382

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720399189 161 KN---NLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKE 202
Cdd:TIGR04523 383 KQeikNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKE 427
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
94-201 2.44e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  94 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQedwieEECHRVEAQlaLKEARKEIRQLKQvidtvknNLIDKDKGLQK 173
Cdd:COG4372    26 IAALSEQLRKALFELDKLQEELEQLREELEQAR-----EELEQLEEE--LEQARSELEQLEE-------ELEELNEQLQA 91

                          90       100
                  ....*....|....*....|....*...
gi 1720399189 174 YFVDINIQNKKLETLLHSMEVAQNGVAK 201
Cdd:COG4372    92 AQAELAQAQEELESLQEEAEELQEELEE 119
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 81-196 2.48e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  81 EQYLTPLQQKevcIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTV 160
Cdd:COG4942    26 EAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720399189 161 KNNLIDKDKGLQKyfvdiNIQNKKLETLLHSMEVAQ 196
Cdd:COG4942   103 KEELAELLRALYR-----LGRQPPLALLLSPEDFLD 133
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 113-188 2.76e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.39  E-value: 2.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399189 113 TEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKglqkyfvDINIQNKKLETL 188
Cdd:TIGR04523 218 SQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQK-------ELEQNNKKIKEL 286
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 94-188 2.78e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.39  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  94 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRM--QEDWIEEECHRVEAQLalKEARKEIRQLKQVIDTVKNNLIDKDKGL 171
Cdd:TIGR04523  77 IKILEQQIKDLNDKLKKNKDKINKLNSDLSKInsEIKNDKEQKNKLEVEL--NKLEKQKKENKKNIDKFLTEIKKKEKEL 154

                          90
                  ....*....|....*..
gi 1720399189 172 QKYFVDINIQNKKLETL 188
Cdd:TIGR04523 155 EKLNNKYNDLKKQKEEL 171
46 PHA02562
endonuclease subunit; Provisional
 97-214 2.93e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.38  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  97 LKARLKDTQDRLQDRDTEIDDLKTQLsRMQEDWIEE-----ECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGL 171
Cdd:PHA02562  172 NKDKIRELNQQIQTLDMKIDHIQQQI-KTYNKNIEEqrkknGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDI 250

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720399189 172 QKYFVDINiqnkKLETLLH--SMEVAQngVAKEEGTGESAGGSPA 214
Cdd:PHA02562  251 EDPSAALN----KLNTAAAkiKSKIEQ--FQKVIKMYEKGGVCPT 289
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 87-191 3.24e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.00  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  87 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQED--WIEEECHRVEAQLALKEarKEIRQLKQVI----DTV 160
Cdd:TIGR04523 365 LEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLnqQKDEQIKKLQQEKELLE--KEIERLKETIiknnSEI 442

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720399189 161 KnNLIDKDKGLQKYFVDIN----IQNKKLETLLHS 191
Cdd:TIGR04523 443 K-DLTNQDSVKELIIKNLDntreSLETQLKVLSRS 476
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 94-191 6.63e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 36.85  E-value: 6.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  94 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEEchrveaqlalKEARKEIRQLKQVIDtvknnlidkdkglqk 173
Cdd:pfam07926  59 LQALREELNELKAEIAELKAEAESAKAELEESEESWEEQK----------KELEKELSELEKRIE--------------- 113

                          90
                  ....*....|....*...
gi 1720399189 174 yfvDINIQNKkletLLHS 191
Cdd:pfam07926 114 ---DLNEQNK----LLHD 124
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 81-174 8.84e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 38.36  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399189  81 EQYLTPLQQKEVCIRHLKARLKDTQDRLQDR----DTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQV 156
Cdd:pfam13868 158 LEYLKEKAEREEEREAEREEIEEEKEREIARlraqQEKAQDEKAERDELRAKLYQEEQERKERQKEREEAEKKARQRQEL 237

                          90
                  ....*....|....*...
gi 1720399189 157 IDTVKNNLIDKDKGLQKY 174
Cdd:pfam13868 238 QQAREEQIELKERRLAEE 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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