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Conserved domains on  [gi|1720394316|ref|XP_030106537|]
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REST corepressor 2 isoform X2 [Mus musculus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10446569)

SANT/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 157-200 3.96e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.74  E-value: 3.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720394316 157 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYR 200
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
216-348 8.26e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 8.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394316 216 QDGAPAAPVPTEEARRGAPVPATALEeddevQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPP 295
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPAAAAP-----AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASA 441

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394316 296 LQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPtlVGAPLEPPAPS 348
Cdd:PRK12323  442 RGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA--RAAPAAAPAPA 492
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 157-200 3.96e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.74  E-value: 3.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720394316 157 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYR 200
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 157-199 1.87e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.10  E-value: 1.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720394316 157 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSY 199
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
157-202 2.96e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 43.75  E-value: 2.96e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720394316  157 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSYRRR 202
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
216-348 8.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 8.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394316 216 QDGAPAAPVPTEEARRGAPVPATALEeddevQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPP 295
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPAAAAP-----AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASA 441

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394316 296 LQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPtlVGAPLEPPAPS 348
Cdd:PRK12323  442 RGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA--RAAPAAAPAPA 492
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 157-200 3.96e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.74  E-value: 3.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720394316 157 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYR 200
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 157-199 1.87e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.10  E-value: 1.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720394316 157 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSY 199
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
157-202 2.96e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 43.75  E-value: 2.96e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720394316  157 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSYRRR 202
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_7 pfam15963
Myb DNA-binding like;
157-207 7.63e-05

Myb DNA-binding like;


Pssm-ID: 464956 [Multi-domain]  Cd Length: 85  Bit Score: 40.60  E-value: 7.63e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720394316 157 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKtffvsyrRRFNLEE 207
Cdd:pfam15963  10 RWSKEETELFYKALSMFGTDFSLIAQLFPGRTRRQIK-------LKFKREE 53
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 158-217 6.98e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 34.59  E-value: 6.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394316 158 WTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVktfFVSYRRRFNLEEVLQEWEAEQD 217
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQC---FDRWRRKLNPKISRGPWSKEED 57
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
216-348 8.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 8.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394316 216 QDGAPAAPVPTEEARRGAPVPATALEeddevQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPP 295
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPAAAAP-----AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASA 441

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394316 296 LQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPtlVGAPLEPPAPS 348
Cdd:PRK12323  442 RGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA--RAAPAAAPAPA 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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