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Conserved domains on  [gi|1720374486|ref|XP_030102980|]
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A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc super family cl00064
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 1-86 1.37e-43

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


The actual alignment was detected with superfamily member cd04273:

Pssm-ID: 469599  Cd Length: 207  Bit Score: 156.24  E-value: 1.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGhEAAKLMAAHITANTNPFSWSACSRDYITSFLDSG 80
Cdd:cd04273   123 MCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDGNSCGPEG-KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTG 201


                  ....*.
gi 1720374486  81 RGTCLD 86
Cdd:cd04273   202 DGNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 340-450 7.53e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 136.55  E-value: 7.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486 340 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTID-WPRKFDVSGTAFHYKRPTDEPE 418
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720374486 419 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 450
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 101-169 2.79e-17

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 76.61  E-value: 2.79e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720374486 101 PGQVYDADEQCRFQYGATSRQCKYGE--VCRELWC-LSKSNRCVTNSIPAAEGTLCqtgnIEKGWCYQGDCV 169
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNGDedVCSKLWCsNPGGSTCTTKNLPAADGTPC----GNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 465-520 7.27e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.40  E-value: 7.27e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720374486 465 WTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPEnQRACNTEPC 520
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 182-234 1.52e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 65.30  E-value: 1.52e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720374486  182 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 234
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 524-580 4.26e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 4.26e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720374486 524 WFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtlDYGDCLTHRPVEKESCNNQSC 580
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVP--DSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 239-337 3.12e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.96  E-value: 3.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486 239 DFREKQCADFDSMPFRGKHYNWKPYTGGGVKP-------CALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDICI 305
Cdd:pfam19236   4 EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPhsqgdalCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLCV 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720374486 306 NGECKHVGCDNILGSDAREDRCRVCGGDGSTC 337
Cdd:pfam19236  84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 584-638 7.71e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 7.71e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720374486 584 WVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRC 638
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 643-692 7.31e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 7.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720374486 643 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV---DCPETVRPPSMQQCDSK 692
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpdsECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 704-736 7.03e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 45.99  E-value: 7.03e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720374486 704 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 736
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 1-86 1.37e-43

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 156.24  E-value: 1.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGhEAAKLMAAHITANTNPFSWSACSRDYITSFLDSG 80
Cdd:cd04273   123 MCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDGNSCGPEG-KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTG 201


                  ....*.
gi 1720374486  81 RGTCLD 86
Cdd:cd04273   202 DGNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 340-450 7.53e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 136.55  E-value: 7.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486 340 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTID-WPRKFDVSGTAFHYKRPTDEPE 418
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720374486 419 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 450
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 101-169 2.79e-17

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 76.61  E-value: 2.79e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720374486 101 PGQVYDADEQCRFQYGATSRQCKYGE--VCRELWC-LSKSNRCVTNSIPAAEGTLCqtgnIEKGWCYQGDCV 169
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNGDedVCSKLWCsNPGGSTCTTKNLPAADGTPC----GNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 465-520 7.27e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.40  E-value: 7.27e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720374486 465 WTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPEnQRACNTEPC 520
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 1-89 8.94e-14

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 70.79  E-value: 8.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIG---LGSAFTIAHEIGHNFGMNHDGIGN--SCGTKGheaAKLMAAHITAnTNPFSWSACSRDYITS 75
Cdd:pfam01421 111 MCSLEYSGGVNEDHSknlESFAVTMAHELGHNLGMQHDDFNGgcKCPPGG---GCIMNPSAGS-SFPRKFSNCSQEDFEQ 186

                          90
                  ....*....|....
gi 1720374486  76 FLDSGRGTCLDNEP 89
Cdd:pfam01421 187 FLTKQKGACLFNKP 200
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 182-234 1.52e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 65.30  E-value: 1.52e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720374486  182 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 234
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 524-580 4.26e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 4.26e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720374486 524 WFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtlDYGDCLTHRPVEKESCNNQSC 580
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVP--DSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 239-337 3.12e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.96  E-value: 3.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486 239 DFREKQCADFDSMPFRGKHYNWKPYTGGGVKP-------CALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDICI 305
Cdd:pfam19236   4 EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPhsqgdalCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLCV 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720374486 306 NGECKHVGCDNILGSDAREDRCRVCGGDGSTC 337
Cdd:pfam19236  84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 584-638 7.71e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 7.71e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720374486 584 WVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRC 638
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 643-692 7.31e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 7.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720374486 643 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV---DCPETVRPPSMQQCDSK 692
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpdsECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 704-736 7.03e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 45.99  E-value: 7.03e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720374486 704 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 736
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP_1 pfam00090
Thrombospondin type 1 domain;
185-233 1.25e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.79  E-value: 1.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720374486 185 WSLWGECSRTCGGGVSSSLRHCDSPAPsgGGKYCLGERKRYRSCNTDPC 233
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 527-581 1.58e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 1.58e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720374486  527 GDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtldygDClTHRPVEKESCNNQSCP 581
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGG-----PC-TGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 464-521 3.55e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 3.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720374486  464 MWTYQPWAECSATCAGGVQRQEVVCkrLDDNSIVQNNFCDPDSKppeNQRACNTEPCP 521
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC--CSPPPQNGGGPCTGEDV---ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 643-690 3.58e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 3.58e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720374486  643 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV-DCPET---VRPPSMQQCD 690
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgPCTGEdveTRACNEQPCP 53
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 1-86 1.37e-43

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 156.24  E-value: 1.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGhEAAKLMAAHITANTNPFSWSACSRDYITSFLDSG 80
Cdd:cd04273   123 MCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDGNSCGPEG-KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTG 201


                  ....*.
gi 1720374486  81 RGTCLD 86
Cdd:cd04273   202 DGNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 340-450 7.53e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 136.55  E-value: 7.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486 340 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTID-WPRKFDVSGTAFHYKRPTDEPE 418
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720374486 419 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 450
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 101-169 2.79e-17

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 76.61  E-value: 2.79e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720374486 101 PGQVYDADEQCRFQYGATSRQCKYGE--VCRELWC-LSKSNRCVTNSIPAAEGTLCqtgnIEKGWCYQGDCV 169
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNGDedVCSKLWCsNPGGSTCTTKNLPAADGTPC----GNKKWCLNGKCV 68
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 1-87 3.92e-17

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 80.35  E-value: 3.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIG---LGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHeaakLMAAHITanTNPFSWSACSRDYITSFL 77
Cdd:cd04269   111 MCSPKYSGGVVQDHSrnlLLFAVTMAHELGHNLGMEHDDGGCTCGRSTC----IMAPSPS--SLTDAFSNCSYEDYQKFL 184

                          90
                  ....*....|
gi 1720374486  78 DSGRGTCLDN 87
Cdd:cd04269   185 SRGGGQCLLN 194
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 465-520 7.27e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.40  E-value: 7.27e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720374486 465 WTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPEnQRACNTEPC 520
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 1-78 5.51e-14

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 70.91  E-value: 5.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIG--LGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMaAHITANTNPFSWSACSRDYITSFLD 78
Cdd:cd04267   114 MCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEHDGGDELAFECDGGGNYIM-APVDSGLNSYRFSQCSIGSIREFLD 192
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 1-89 8.94e-14

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 70.79  E-value: 8.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIG---LGSAFTIAHEIGHNFGMNHDGIGN--SCGTKGheaAKLMAAHITAnTNPFSWSACSRDYITS 75
Cdd:pfam01421 111 MCSLEYSGGVNEDHSknlESFAVTMAHELGHNLGMQHDDFNGgcKCPPGG---GCIMNPSAGS-SFPRKFSNCSQEDFEQ 186

                          90
                  ....*....|....
gi 1720374486  76 FLDSGRGTCLDNEP 89
Cdd:pfam01421 187 FLTKQKGACLFNKP 200
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 182-234 1.52e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 65.30  E-value: 1.52e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720374486  182 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 234
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 524-580 4.26e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 4.26e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720374486 524 WFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtlDYGDCLTHRPVEKESCNNQSC 580
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVP--DSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 239-337 3.12e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.96  E-value: 3.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486 239 DFREKQCADFDSMPFRGKHYNWKPYTGGGVKP-------CALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDICI 305
Cdd:pfam19236   4 EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPhsqgdalCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLCV 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720374486 306 NGECKHVGCDNILGSDAREDRCRVCGGDGSTC 337
Cdd:pfam19236  84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 584-638 7.71e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 7.71e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720374486 584 WVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRC 638
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 643-692 7.31e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 7.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720374486 643 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV---DCPETVRPPSMQQCDSK 692
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpdsECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 704-736 7.03e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 45.99  E-value: 7.03e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720374486 704 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 736
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 1-77 1.35e-06

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 49.06  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374486   1 MCEPERSCSINEDIGLGS---AFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAK----------LMAAHITANT--NPFSW 65
Cdd:cd00203    76 VCDSLRGVGVLQDNQSGTkegAQTIAHELGHALGFYHDHDRKDRDDYPTIDDTlnaedddyysVMSYTKGSFSdgQRKDF 155

                          90
                  ....*....|..
gi 1720374486  66 SACSRDYITSFL 77
Cdd:cd00203   156 SQCDIDQINKLY 167
TSP_1 pfam00090
Thrombospondin type 1 domain;
185-233 1.25e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.79  E-value: 1.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720374486 185 WSLWGECSRTCGGGVSSSLRHCDSPAPsgGGKYCLGERKRYRSCNTDPC 233
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 19-85 1.93e-05

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 46.58  E-value: 1.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720374486  19 AFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAK--------LMAAHITAnTNPFSWSACSRDYITSFLDSGRGTCL 85
Cdd:cd04272   146 VYTMTHELAHLLGAPHDGSPPPSWVKGHPGSLdcpwddgyIMSYVVNG-ERQYRFSQCSQRQIRNVFRRLGASCL 219
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 21-84 2.76e-05

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 46.21  E-value: 2.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374486  21 TIAHEIGHNFGMNHDGIGNSCGTKGHEAAK-LMAAHIT----ANTNPFswSACSRDYITSFLDSGRGTC 84
Cdd:cd04270   170 VTAHELGHNFGSPHDPDIAECAPGESQGGNyIMYARATsgdkENNKKF--SPCSKKSISKVLEVKSNSC 236
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 183-233 9.03e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.73  E-value: 9.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720374486 183 GSWSLWGECSRTCGGGVSSSLRHCDSPaPSGGGKYCLGERKRyRSCNTDPC 233
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPCPELLER-RPCNLPPC 52
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 2-35 1.01e-04

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 42.36  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720374486   2 CEPERSCSINEDI---GLGSAFTIAHEIGHNFGMNHD 35
Cdd:pfam13582  86 CNSGSKFGVNSGSgpvGDTGADTFAHEIGHNFGLNHT 122
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 527-581 1.58e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 1.58e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720374486  527 GDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtldygDClTHRPVEKESCNNQSCP 581
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGG-----PC-TGEDVETRACNEQPCP 53
Reprolysin_4 pfam13583
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 21-43 3.19e-03

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 404471  Cd Length: 203  Bit Score: 39.52  E-value: 3.19e-03
                          10        20
                  ....*....|....*....|...
gi 1720374486  21 TIAHEIGHNFGMNHDGIGNSCGT 43
Cdd:pfam13583 138 IFAHEIGHTFGAVHDCSSQGEGL 160
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 464-521 3.55e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 3.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720374486  464 MWTYQPWAECSATCAGGVQRQEVVCkrLDDNSIVQNNFCDPDSKppeNQRACNTEPCP 521
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC--CSPPPQNGGGPCTGEDV---ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 643-690 3.58e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 3.58e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720374486  643 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV-DCPET---VRPPSMQQCD 690
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgPCTGEdveTRACNEQPCP 53
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
21-64 4.78e-03

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 38.94  E-value: 4.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720374486  21 TIAHEIGHNFGMNHD-----GIGNSCGTKGHEAAK---LMAAHITANTNPFS 64
Cdd:pfam13688 140 VFAHEIGHNFGAVHDcdsstSSQCCPPSNSTCPAGgryIMNPSSSPNSTDFS 191
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 188-233 6.90e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 6.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720374486 188 WGECSRTCGGGVSSSLRHCDSPAPSG--GGKYCLGERK--RYRSCNTDPC 233
Cdd:pfam19030   6 WGECSVTCGGGVQTRLVQCVQKGGGSivPDSECSAQKKppETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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