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Conserved domains on  [gi|1720365438|ref|XP_030101702|]
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notchless protein homolog 1 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-394 1.57e-96

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 293.74  E-value: 1.57e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  36 PRYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGL 115
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSV 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 116 SWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQ 194
Cdd:COG2319   169 AF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 195 GHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKP 274
Cdd:COG2319   244 GHSGSVRSVAFSPD---------------------------------------GR---LLASGSADGTVRLWD-LATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 275 LARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 354
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1720365438 355 AQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 394
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-394 1.57e-96

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 293.74  E-value: 1.57e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  36 PRYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGL 115
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSV 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 116 SWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQ 194
Cdd:COG2319   169 AF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 195 GHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKP 274
Cdd:COG2319   244 GHSGSVRSVAFSPD---------------------------------------GR---LLASGSADGTVRLWD-LATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 275 LARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 354
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1720365438 355 AQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 394
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-394 1.12e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 256.88  E-value: 1.12e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  58 PHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLSWEPLHmnpecRYVASSSKDGS 137
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADG-----TYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 138 VRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgaf 216
Cdd:cd00200    75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 217 epaeatvnaqdlqgslkelkerassrynlvrgqgPERLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRI 296
Cdd:cd00200   147 ----------------------------------GTFVASSSQDGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 297 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSP 376
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                         330
                  ....*....|....*...
gi 1720365438 377 DGQRVASGGKDKCLRIWR 394
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 69-353 1.33e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  69 VLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 141
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 142 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 215
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 216 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 288
Cdd:PLN00181  635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720365438 289 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 353
Cdd:PLN00181  715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 313-352 2.24e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720365438  313 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 352
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-352 3.56e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.56e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720365438 314 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-394 1.57e-96

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 293.74  E-value: 1.57e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  36 PRYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGL 115
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSV 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 116 SWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQ 194
Cdd:COG2319   169 AF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 195 GHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKP 274
Cdd:COG2319   244 GHSGSVRSVAFSPD---------------------------------------GR---LLASGSADGTVRLWD-LATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 275 LARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 354
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1720365438 355 AQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 394
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
10-395 5.46e-86

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 266.78  E-value: 5.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  10 WLGSRNTHAQCLRVGPTTAAVKRPLFPRYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQ 89
Cdd:COG2319    22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  90 VLLWDPSTGLQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG- 168
Cdd:COG2319   102 VRLWDLATGLLL-RTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGk 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 169 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrG 248
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD---------------------------------------G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 249 QgpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 328
Cdd:COG2319   217 K---LLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN 292

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365438 329 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 395
Cdd:COG2319   293 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-394 1.12e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 256.88  E-value: 1.12e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  58 PHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLSWEPLHmnpecRYVASSSKDGS 137
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADG-----TYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 138 VRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgaf 216
Cdd:cd00200    75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 217 epaeatvnaqdlqgslkelkerassrynlvrgqgPERLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRI 296
Cdd:cd00200   147 ----------------------------------GTFVASSSQDGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 297 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSP 376
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                         330
                  ....*....|....*...
gi 1720365438 377 DGQRVASGGKDKCLRIWR 394
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-354 6.01e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.38  E-value: 6.01e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  37 RYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLS 116
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 117 WeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQG 195
Cdd:COG2319   212 F-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTG 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 196 HGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKPL 275
Cdd:COG2319   287 HSGGVNSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-LATGKLL 323

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720365438 276 ARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 354
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-352 2.65e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 248.40  E-value: 2.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  36 PRYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGL 115
Cdd:cd00200    21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG-ECVRTLTGHTSYVSSV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 116 SWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQ 194
Cdd:cd00200   100 AF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDLRTGKCVATLT 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 195 GHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgPERLVSGSDDFTLFLWSPAEdKKP 274
Cdd:cd00200   175 GHTGEVNSVAFSPD------------------------------------------GEKLLSSSSDGTIKLWDLST-GKC 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720365438 275 LARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 352
Cdd:cd00200   212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-393 4.29e-73

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 233.65  E-value: 4.29e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  39 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLSWE 118
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 119 PLHmnpecRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 197
Cdd:COG2319    88 PDG-----RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 198 HWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKPLAR 277
Cdd:COG2319   163 GAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-LATGKLLRT 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 278 MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 357
Cdd:COG2319   200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1720365438 358 LATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 393
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
73-394 7.31e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.67  E-value: 7.31e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  73 SWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLhmnpecRYVASSSKDGSVRVWDTTAGRCERIL 152
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDG------ARLAAGAGDLTLLLLDAAAGALLATL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 153 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgs 231
Cdd:COG2319    75 LGHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD----------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 232 lkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDG 311
Cdd:COG2319   132 ----------------GK---TLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 312 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 391
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271


                  ...
gi 1720365438 392 IWR 394
Cdd:COG2319   272 LWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-183 1.31e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.87  E-value: 1.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  35 FPRYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGrTLTGHSKWITG 114
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG-TLRGHENGVNS 224

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 115 LSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWR 183
Cdd:cd00200   225 VAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-186 3.34e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 3.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  37 RYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLS 116
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVA 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720365438 117 WeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHD 186
Cdd:COG2319   338 F-----SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 69-353 1.33e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  69 VLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 141
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 142 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 215
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 216 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 288
Cdd:PLN00181  635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720365438 289 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 353
Cdd:PLN00181  715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 313-352 2.24e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720365438  313 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 352
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 251-366 3.15e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 3.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 251 PERLVSGSDDFTLFLWS-PAEDKK-----PLARMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 323
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720365438 324 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHA 366
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-94 6.31e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 6.31e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720365438   55 TETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 94
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 69-196 1.29e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.44  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  69 VLSISWSP-DGKKLASGCKNGQVLLWD-PSTGLQVGRT-----LTGHSKWITGLSWEPLHMNpecrYVASSSKDGSVRVW 141
Cdd:PTZ00421   78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720365438 142 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 196
Cdd:PTZ00421  154 DVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
314-352 3.56e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.56e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720365438 314 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-310 7.30e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 7.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720365438  271 DKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 310
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 280-392 1.04e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 280 GHQALINQVLFSP-DSRIVASASFDKSIKLWD-------GRTGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKV 350
Cdd:PTZ00421   73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720365438 351 WDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 392
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 362-393 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720365438  362 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 393
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 39-182 2.30e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  39 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP-DGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSW 117
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720365438 118 EplhmnpECRYVASSSKDGSVRVWDTTAGR---CERIltGHTQSVTCLRWGGDGLLYSASQDRTIKVW 182
Cdd:PLN00181  628 E------SGRSLAFGSADHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
272-310 2.57e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720365438 272 KKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 310
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-182 3.47e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720365438  146 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 182
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
357-393 5.81e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720365438 357 KLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 393
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-142 7.83e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.83e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720365438  103 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 142
Cdd:smart00320   6 KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
57-94 9.67e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 9.67e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720365438  57 TPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 94
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
146-182 1.26e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720365438 146 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 33-186 1.86e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  33 PLFPRYLASGSGDTTVRFWDLSTE-------TPHFTCKGHRHWVLSISWSPDGKK-LASGCKNGQVLLWDPSTGLqVGRT 104
Cdd:PTZ00421   85 PFDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGK-AVEV 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 105 LTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGH--TQSVTCLrWGGDGLL-----YSASQDR 177
Cdd:PTZ00421  164 IKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasAKSQRCL-WAKRKDLiitlgCSKSQQR 237


                  ....*....
gi 1720365438 178 TIKVWRAHD 186
Cdd:PTZ00421  238 QIMLWDTRK 246
WD40 pfam00400
WD domain, G-beta repeat;
103-142 1.90e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720365438 103 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 142
Cdd:pfam00400   5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 284-393 2.84e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 284 LINQVLFSPDSRIVASASFDKSIKLW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWDVKA 355
Cdd:PLN00181  485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720365438 356 QKLATDLPGHADEVYAVDW-SPDGQRVASGGKDKCLRIW 393
Cdd:PLN00181  565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 69-117 5.59e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.19  E-value: 5.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720365438  69 VLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLSW 117
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENG-KIVHHFSAGSDLITCLGW 88
PTZ00420 PTZ00420
coronin; Provisional
 272-359 3.51e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 272 KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKY--------LASLRGHVAAVYQIAWSADSRLLVSG 342
Cdd:PTZ00420   64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCS 143

                          90
                  ....*....|....*...
gi 1720365438 343 SS-DSTLKVWDVKAQKLA 359
Cdd:PTZ00420  144 SGfDSFVNIWDIENEKRA 161
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 288-382 4.61e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 45.80  E-value: 4.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  288 VLFSPDSRIVASASfDKSiklwdGRTGKYLASLRGHVAA----------VYQIAWSADSRLLVSGSSDSTLKVWDV---K 354
Cdd:COG4946    348 PAWSPDGKSIAYFS-DAS-----GEYELYIAPADGSGEPkqltlgdlgrVFNPVWSPDGKKIAFTDNRGRLWVVDLasgK 421

                           90       100
                   ....*....|....*....|....*...
gi 1720365438  355 AQKLATDlpGHADEVYAVDWSPDGQRVA 382
Cdd:COG4946    422 VRKVDTD--GYGDGISDLAWSPDSKWLA 447
PTZ00420 PTZ00420
coronin; Provisional
 252-310 9.17e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 9.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365438 252 ERLVSGSDDFTLFLWS-PAED------KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 310
Cdd:PTZ00420   88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 38-184 6.65e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.04  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  38 YLASGSGDTTVRFWDLSTETPH-FTckGHRHWVLSISWSPDGKKLA---SGCKNGQVLLWDPSTGLQvgRTLTGHSKWIT 113
Cdd:COG0823     3 FTLSRDGNSDIYVVDLDGGEPRrLT--NSPGIDTSPAWSPDGRRIAftsDRGGGPQIYVVDADGGEP--RRLTFGGGYNA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720365438 114 GLSWeplhmNPECRYVA-SSSKDGSVRVW--DTTAGRcERILTGHTQSVTclrWGGDG--LLYSASQDRTIKVWRA 184
Cdd:COG0823    79 SPSW-----SPDGKRLAfVSRSDGRFDIYvlDLDGGA-PRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYVV 145
PTZ00420 PTZ00420
coronin; Provisional
 58-214 1.59e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  58 PHFTCKGHRHWVLSISWSP-DGKKLASGCKNGQVLLWD-PSTGLQVGRT------LTGHSKWITGLSWEPLHMNPECryv 129
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiPHNDESVKEIkdpqciLKGHKKKISIIDWNPMNYYIMC--- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 130 aSSSKDGSVRVWDT-TAGRCERILTghTQSVTCLRWGGDGLLYSAS-QDRTIKVWRAHDGVLCRTLQGHGH-------WV 200
Cdd:PTZ00420  143 -SSGFDSFVNIWDIeNEKRAFQINM--PKKLSSLKWNIKGNLLSGTcVGKHMHIIDPRKQEIASSFHIHDGgkntkniWI 219

                         170
                  ....*....|....
gi 1720365438 201 NTMALSTDYALRTG 214
Cdd:PTZ00420  220 DGLGGDDNYILSTG 233
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 71-386 3.04e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.02  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438   71 SISWSPDGKKLASGC-KNGQVLLW-DPSTGLQVGRTLT-GHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGR 147
Cdd:COG4946    347 LPAWSPDGKSIAYFSdASGEYELYiAPADGSGEPKQLTlGDLGRVFNPVW-----SPDGKKIAFTDNRGRLWVVDLASGK 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  148 CERILTG-HTQSVTCLRWGGDG--LLYSASQD---RTIKVWRAHDGVLcrtlqghgHWVnTMALSTDY------------ 209
Cdd:COG4946    422 VRKVDTDgYGDGISDLAWSPDSkwLAYSKPGPnqlSQIFLYDVETGKT--------VQL-TDGRYDDGspafspdgkyly 492

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  210 --ALRTgaFEPAEAtvnaqDLQGSLKELkeRASSRYNLV-RGQGPERLVSGSDDFTlfLWSPAEDKKPLARMTghqalin 286
Cdd:COG4946    493 flSSRD--FNPTYG-----DLDFDLAFP--RTTRIYAVPlRKDAPSPFAPESDEEA--AKKEEDEKKKKKKKD------- 554

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  287 qvlfspdsrivASASFDKSIKL-WDGrtgkylasLRGHVAAV------YQIAWSADSRLL-----VSGSSDSTLKVWDVK 354
Cdd:COG4946    555 -----------DKKKKPKPVKIdFDG--------IEDRIVALpvpagnYSDLAAGKGGVLyllepVEGAPGGTLYRYDLE 615

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1720365438  355 AQKlATDLpghADEVYAVDWSPDGQR--VASGGK 386
Cdd:COG4946    616 KRK-TETL---ADGVSSYELSADGKKllVRSGGR 645
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 301-387 3.60e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 301 SFdKSIKLWDGRTgkyLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV--------KAQKLATDLP--------- 363
Cdd:pfam20426 105 SF-QVISLNDGRM---VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEFPrkdhviaet 180

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720365438 364 ------GHADEVYAVDWSPDGQRVASGGKD 387
Cdd:pfam20426 181 pfhilcGHDDIITCLYVSVELDIVISGSKD 210
PTZ00420 PTZ00420
coronin; Provisional
 320-393 4.20e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.16  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 320 LRGHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDVKAQKLATD--------LPGHADEVYAVDWSPDGQRV-ASGGKDKC 389
Cdd:PTZ00420   70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDWNPMNYYImCSSGFDSF 149


                  ....
gi 1720365438 390 LRIW 393
Cdd:PTZ00420  150 VNIW 153
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 265-354 8.10e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 38.00  E-value: 8.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438 265 LWSPAEDKKPLARMTghqaLINQVLFSPDSRIVAS-------ASFD-KSIKLWDGRTGKYLASLRGHVAAVYqiawsADS 336
Cdd:cd22850   219 LYDTSAGRRPVFSEK----PIKKPEEDLDGHTVYVgdtsgdlALIDiRTGKLLGRLLGKYGGSITGAVRHPE-----LFD 289

                          90
                  ....*....|....*...
gi 1720365438 337 RLLVSGSSDSTLKVWDVK 354
Cdd:cd22850   290 PYLASGGLDRYLRVFDIE 307
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 72-165 8.42e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365438  72 ISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERI 151
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAW-----RPDGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|....
gi 1720365438 152 LTGHTQSVTCLRWG 165
Cdd:pfam12894  76 FSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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