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Conserved domains on  [gi|1720428311|ref|XP_030099613|]
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glucose-fructose oxidoreductase domain-containing protein 2 isoform X4 [Mus musculus]

Protein Classification

-; -; Gfo/Idh/MocA family oxidoreductase; Gfo/Idh/MocA family oxidoreductase( domain architecture ID 11430574)

-; -; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to biliverdin reductase A (BLVRA)

CATH:  3.40.50.720
Gene Ontology:  GO:0016491|GO:0016651
PubMed:  26749496

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
20-163 1.24e-17

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 80.74  E-value: 1.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311  20 VGNVLRFLPAFVRMKQLIAEHYVGAVMICDARiYSGSLLSPSYGWICD-ELMGGGGLHTMGTYIVDLLTHLTGQKAEKVH 98
Cdd:COG0673   120 VGFNRRFDPAVRAARELIDSGAIGEIRSVRAR-FGHPRPAGPADWRFDpELAGGGALLDLGIHDIDLARWLLGSEPESVS 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428311  99 GLLKTFVRQNATIrgirhvtsDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVM-VVGSAGRLVAR 163
Cdd:COG0673   199 ATGGRLVPDRVEV--------DDTAAATLRFANGAVATLEASWVAPGGERDERLeVYGTKGTLFVD 256
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
20-163 1.24e-17

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 80.74  E-value: 1.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311  20 VGNVLRFLPAFVRMKQLIAEHYVGAVMICDARiYSGSLLSPSYGWICD-ELMGGGGLHTMGTYIVDLLTHLTGQKAEKVH 98
Cdd:COG0673   120 VGFNRRFDPAVRAARELIDSGAIGEIRSVRAR-FGHPRPAGPADWRFDpELAGGGALLDLGIHDIDLARWLLGSEPESVS 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428311  99 GLLKTFVRQNATIrgirhvtsDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVM-VVGSAGRLVAR 163
Cdd:COG0673   199 ATGGRLVPDRVEV--------DDTAAATLRFANGAVATLEASWVAPGGERDERLeVYGTKGTLFVD 256
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 34-260 2.25e-05

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 44.33  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311  34 KQLIAEHYVGAVMICDARIYSGSLL-SPSYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVhgllktfvrqnatir 112
Cdd:pfam02894   1 KELIENGVLGEVVMVTVHTRDPFRPpQEFKRWRVDPEKSGGALYDLGIHTIDLLIYLFGEPPSVV--------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311 113 giRHVTSDDFCFFQM-LMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQEELLVRDSLAVGAGL 191
Cdd:pfam02894  66 --AVYASEDTAFATLeFKNGAVGTLETSGGSIVEANGHRISIHGTKGSIELDGIDDGLLSVTVVGEPGWATDDPMVRKGG 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720428311 192 PEQGPQDVPLLYLKGMVYmvQALRQSFQGQGDrrtwdrtpvsMAASFEDGLYMQSVVDAIKRSSRSGEW 260
Cdd:pfam02894 144 DEVPEFLGSFAGGYLLEY--DAFLEAVRGGKV----------VLVDAEDGLYALAVIEAAYESAEEGRP 200
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
20-163 1.24e-17

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 80.74  E-value: 1.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311  20 VGNVLRFLPAFVRMKQLIAEHYVGAVMICDARiYSGSLLSPSYGWICD-ELMGGGGLHTMGTYIVDLLTHLTGQKAEKVH 98
Cdd:COG0673   120 VGFNRRFDPAVRAARELIDSGAIGEIRSVRAR-FGHPRPAGPADWRFDpELAGGGALLDLGIHDIDLARWLLGSEPESVS 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428311  99 GLLKTFVRQNATIrgirhvtsDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVM-VVGSAGRLVAR 163
Cdd:COG0673   199 ATGGRLVPDRVEV--------DDTAAATLRFANGAVATLEASWVAPGGERDERLeVYGTKGTLFVD 256
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 34-260 2.25e-05

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 44.33  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311  34 KQLIAEHYVGAVMICDARIYSGSLL-SPSYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVhgllktfvrqnatir 112
Cdd:pfam02894   1 KELIENGVLGEVVMVTVHTRDPFRPpQEFKRWRVDPEKSGGALYDLGIHTIDLLIYLFGEPPSVV--------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428311 113 giRHVTSDDFCFFQM-LMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQEELLVRDSLAVGAGL 191
Cdd:pfam02894  66 --AVYASEDTAFATLeFKNGAVGTLETSGGSIVEANGHRISIHGTKGSIELDGIDDGLLSVTVVGEPGWATDDPMVRKGG 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720428311 192 PEQGPQDVPLLYLKGMVYmvQALRQSFQGQGDrrtwdrtpvsMAASFEDGLYMQSVVDAIKRSSRSGEW 260
Cdd:pfam02894 144 DEVPEFLGSFAGGYLLEY--DAFLEAVRGGKV----------VLVDAEDGLYALAVIEAAYESAEEGRP 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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