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Conserved domains on  [gi|1720424550|ref|XP_030098939|]
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leucine-rich repeat-containing protein 27 isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-164 4.65e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 4.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  58 VLDLSQRGLRHLGK-FFKIPNLQQLHLQRNLLREIPEDFFQLlPNLTWLDLRYNKIKVLPSGIGSHKHLKTLLLERNPIK 136
Cdd:COG4886   140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 1720424550 137 MLPVELGQVTTLTALNLRHCPLEFPPRL 164
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-164 4.65e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 4.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  58 VLDLSQRGLRHLGK-FFKIPNLQQLHLQRNLLREIPEDFFQLlPNLTWLDLRYNKIKVLPSGIGSHKHLKTLLLERNPIK 136
Cdd:COG4886   140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 1720424550 137 MLPVELGQVTTLTALNLRHCPLEFPPRL 164
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR_8 pfam13855
Leucine rich repeat;
76-135 2.15e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720424550  76 PNLQQLHLQRNLLREIPEDFFQLLPNLTWLDLRYNKIKVLPSGIGSH-KHLKTLLLERNPI 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-132 1.33e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720424550  76 PNLQQLHLQRNLLREIpeDFFQLLPNLTWLDLRYNKIKVLpSGIGSHKHLKTLLLER 132
Cdd:cd21340    46 TNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
LRR smart00370
Leucine-rich repeats, outliers;
99-122 6.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.39e-03
                           10        20
                   ....*....|....*....|....
gi 1720424550   99 LPNLTWLDLRYNKIKVLPSGIGSH 122
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-164 4.65e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 4.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  58 VLDLSQRGLRHLGK-FFKIPNLQQLHLQRNLLREIPEDFFQLlPNLTWLDLRYNKIKVLPSGIGSHKHLKTLLLERNPIK 136
Cdd:COG4886   140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 1720424550 137 MLPVELGQVTTLTALNLRHCPLEFPPRL 164
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-159 4.89e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 4.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  66 LRHLGKFFKIPNLQQLHLQRNLLREIPEDFFQLlPNLTWLDLRYNKIKVLPSGIGSHKHLKTLLLERNPIKMLPVELGQV 145
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                          90
                  ....*....|....
gi 1720424550 146 TTLTALNLRHCPLE 159
Cdd:COG4886   182 TNLKELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-159 2.19e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 2.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  58 VLDLSQRGLRHLGKFF-KIPNLQQLHLQRNLLREIPEDFFQLlPNLTWLDLRYNKIKVLPSGIGSHKHLKTLLLERNPIK 136
Cdd:COG4886   163 SLDLSNNQLTDLPEELgNLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                          90       100
                  ....*....|....*....|...
gi 1720424550 137 MLPvELGQVTTLTALNLRHCPLE 159
Cdd:COG4886   242 DLP-ELGNLTNLEELDLSNNQLT 263
LRR_8 pfam13855
Leucine rich repeat;
76-135 2.15e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720424550  76 PNLQQLHLQRNLLREIPEDFFQLLPNLTWLDLRYNKIKVLPSGIGSH-KHLKTLLLERNPI 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-154 1.22e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  58 VLDLSQRGLRHLGKFF-KIPNLQQLHLQRNLLREIPEdfFQLLPNLTWLDLRYNKIKVLPSgIGSHKHLKTLLLERNPIK 136
Cdd:COG4886   209 ELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285

                          90
                  ....*....|....*...
gi 1720424550 137 MLPVELGQVTTLTALNLR 154
Cdd:COG4886   286 DLKLKELELLLGLNSLLL 303
LRR_8 pfam13855
Leucine rich repeat;
58-112 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.40e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720424550  58 VLDLSQRGLRHLGK--FFKIPNLQQLHLQRNLLREIPEDFFQLLPNLTWLDLRYNKI 112
Cdd:pfam13855   5 SLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-159 1.12e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  83 LQRNLLREIPEDFFQLLPNLTWLDLRY-----------------NKIKVLPSGIGSHKHLKTLLLERNPIKMLPVELGQV 145
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGneelsnltnlesldlsgNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNL 158

                          90
                  ....*....|....
gi 1720424550 146 TTLTALNLRHCPLE 159
Cdd:COG4886   159 TNLKSLDLSNNQLT 172
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-132 1.33e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720424550  76 PNLQQLHLQRNLLREIpeDFFQLLPNLTWLDLRYNKIKVLpSGIGSHKHLKTLLLER 132
Cdd:cd21340    46 TNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-165 6.49e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 6.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424550  59 LDLSQRGLRHLGKFFKIPNLQQLHLQRNLLREIPEdfFQLLPNLTWLDLRYNKIKVLPsGIGSHKHLKTLLLERNPIKMl 138
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISV- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720424550 139 pVE-LGQVTTLTALNLRH------CPLEFPPRLI 165
Cdd:cd21340    83 -VEgLENLTNLEELHIENqrlppgEKLTFDPRSL 115
LRR smart00370
Leucine-rich repeats, outliers;
99-122 6.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.39e-03
                           10        20
                   ....*....|....*....|....
gi 1720424550   99 LPNLTWLDLRYNKIKVLPSGIGSH 122
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
99-122 6.39e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.39e-03
                           10        20
                   ....*....|....*....|....
gi 1720424550   99 LPNLTWLDLRYNKIKVLPSGIGSH 122
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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