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Conserved domains on  [gi|1720424076|ref|XP_030098830|]
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leucine-rich repeat-containing protein 51 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
52-141 2.17e-08

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNVLNDLKDFnqvvsqlLQHPENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVnkLAVLPRLRS 131
Cdd:COG4886   116 ESLDLSGNQLTDLPEE-------LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   187 LDLSNNQITD 196
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 2.17e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNVLNDLKDFnqvvsqlLQHPENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVnkLAVLPRLRS 131
Cdd:COG4886   116 ESLDLSGNQLTDLPEE-------LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   187 LDLSNNQITD 196
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-146 2.79e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720424076  85 DLSFNDLTTIDPvLTTFFNLSVLYLHGNGIHRLGEVNK-LAVLPRLRSLTLHGNPIEEEKGYR 146
Cdd:cd21340   126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYR 187
LRR_8 pfam13855
Leucine rich repeat;
80-139 5.17e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 5.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720424076  80 NLAWIDLSFNDLTTIDPvlTTFFNLS---VLYLHGNGIHRLGEvNKLAVLPRLRSLTLHGNPI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD--GAFKGLSnlkVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 2.17e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNVLNDLKDFnqvvsqlLQHPENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVnkLAVLPRLRS 131
Cdd:COG4886   116 ESLDLSGNQLTDLPEE-------LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   187 LDLSNNQITD 196
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.44e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNVLNDLKDFnqvvsqlLQHPENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEvnkLAVLPRLRS 131
Cdd:COG4886   185 KELDLSNNQITDLPEP-------LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEE 254

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   255 LDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 2.48e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNvlnDLKDFNQVVSQLlqhpENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVnkLAVLPRLRS 131
Cdd:COG4886   162 KSLDLSNN---QLTDLPEELGNL----TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLET 232

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   233 LDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 8.00e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 8.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNvlnDLKDFNQVVSQLlqhpENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVnkLAVLPRLRS 131
Cdd:COG4886   139 KELDLSNN---QLTDLPEPLGNL----TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEE 209

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   210 LDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.56e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  52 QSLWLNNNVLNDLKDFnqvvsqlLQHPENLAWIDLSFNDLTTIdPVLTTFFNLSVLYLHGNGIHRLGEvnkLAVLPRLRS 131
Cdd:COG4886   208 EELDLSGNQLTDLPEP-------LANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPP---LANLTNLKT 276

                          90
                  ....*....|
gi 1720424076 132 LTLHGNPIEE 141
Cdd:COG4886   277 LDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-141 5.53e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 5.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424076  61 LNDLKDFNQVVSQLLQHPENLAWIDLSFNDLTTIDPVLTTFFNLSVLYLHGNGIHRLGEVnkLAVLPRLRSLTLHGNPIE 140
Cdd:COG4886    95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLT 172


                  .
gi 1720424076 141 E 141
Cdd:COG4886   173 D 173
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-146 2.79e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720424076  85 DLSFNDLTTIDPvLTTFFNLSVLYLHGNGIHRLGEVNK-LAVLPRLRSLTLHGNPIEEEKGYR 146
Cdd:cd21340   126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYR 187
LRR_8 pfam13855
Leucine rich repeat;
80-139 5.17e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 5.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720424076  80 NLAWIDLSFNDLTTIDPvlTTFFNLS---VLYLHGNGIHRLGEvNKLAVLPRLRSLTLHGNPI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD--GAFKGLSnlkVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
89-146 2.18e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 36.67  E-value: 2.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720424076  89 NDLTTIDPVLTTFF-NLSVLYLHGNGIHRLGEVNKLAVLPRLRSLTLHGNPIEEEKGYR 146
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYR 132
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-141 3.03e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 36.30  E-value: 3.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720424076  86 LSFND--LTTIDpVLTTFFNLSVLYLHGNGIHRLgevNKLAVLPRLRSLTLHGNPIEE 141
Cdd:cd21340     7 LYLNDknITKID-NLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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