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Conserved domains on  [gi|1370466730|ref|XP_024305713|]
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complex I intermediate-associated protein 30, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

CIA30 family protein( domain architecture ID 10554017)

CIA30 family protein similar to eukaryotic complex I intermediate-associated protein 30, a chaperone protein involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIA30 pfam08547
Complex I intermediate-associated protein 30 (CIA30); This protein is associated with ...
 125-278 2.99e-47

Complex I intermediate-associated protein 30 (CIA30); This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation.


:

Pssm-ID: 462515  Cd Length: 156  Bit Score: 155.44  E-value: 2.99e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466730 125 WQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQsALLYGTLSSEapqdgesTRSGYCAMISRIprgafeRKMSYDWSQ 204
Cdd:pfam08547   1 FDFTSPESLDKWRSVNDRVMGGVSTSSLKLSVDGT-ARFSGNLSLE-------NNGGFASVRSRN------FDPPLDLSG 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370466730 205 FNTLYLRVRGDGRPWMVNIKEDtdfFQRTNQMYSYFMFTRGGPyWQEVKIPFSKFFFSNRGRIRDVQHELPLDK 278
Cdd:pfam08547  67 YDGLELRVKGDGRTYKLNLRTE---SLRDGDSYQADFYTTPGE-WQTVKIPFSDFVPTFRGRVVDDAPPLDLSK 136
 
Name Accession Description Interval E-value
CIA30 pfam08547
Complex I intermediate-associated protein 30 (CIA30); This protein is associated with ...
 125-278 2.99e-47

Complex I intermediate-associated protein 30 (CIA30); This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation.


Pssm-ID: 462515  Cd Length: 156  Bit Score: 155.44  E-value: 2.99e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466730 125 WQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQsALLYGTLSSEapqdgesTRSGYCAMISRIprgafeRKMSYDWSQ 204
Cdd:pfam08547   1 FDFTSPESLDKWRSVNDRVMGGVSTSSLKLSVDGT-ARFSGNLSLE-------NNGGFASVRSRN------FDPPLDLSG 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370466730 205 FNTLYLRVRGDGRPWMVNIKEDtdfFQRTNQMYSYFMFTRGGPyWQEVKIPFSKFFFSNRGRIRDVQHELPLDK 278
Cdd:pfam08547  67 YDGLELRVKGDGRTYKLNLRTE---SLRDGDSYQADFYTTPGE-WQTVKIPFSDFVPTFRGRVVDDAPPLDLSK 136
 
Name Accession Description Interval E-value
CIA30 pfam08547
Complex I intermediate-associated protein 30 (CIA30); This protein is associated with ...
 125-278 2.99e-47

Complex I intermediate-associated protein 30 (CIA30); This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation.


Pssm-ID: 462515  Cd Length: 156  Bit Score: 155.44  E-value: 2.99e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466730 125 WQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQsALLYGTLSSEapqdgesTRSGYCAMISRIprgafeRKMSYDWSQ 204
Cdd:pfam08547   1 FDFTSPESLDKWRSVNDRVMGGVSTSSLKLSVDGT-ARFSGNLSLE-------NNGGFASVRSRN------FDPPLDLSG 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370466730 205 FNTLYLRVRGDGRPWMVNIKEDtdfFQRTNQMYSYFMFTRGGPyWQEVKIPFSKFFFSNRGRIRDVQHELPLDK 278
Cdd:pfam08547  67 YDGLELRVKGDGRTYKLNLRTE---SLRDGDSYQADFYTTPGE-WQTVKIPFSDFVPTFRGRVVDDAPPLDLSK 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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