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Conserved domains on  [gi|1370464933|ref|XP_024305334|]
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leucine-rich repeat-containing protein 9 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 1.30e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 117.96  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464933  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 878-1066 2.85e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 94.08  E-value: 2.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  878 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 948
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  949 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 1019
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1370464933 1020 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1066
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1116-1331 1.38e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 85.99  E-value: 1.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1116 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1193
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1194 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1267
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464933 1268 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPM 1331
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
631-1016 2.74e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  631 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 710
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  711 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 789
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  790 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 865
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  866 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 945
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933  946 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 1016
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 1.30e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 117.96  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464933  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 878-1066 2.85e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 94.08  E-value: 2.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  878 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 948
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  949 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 1019
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1370464933 1020 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1066
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1116-1331 1.38e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 85.99  E-value: 1.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1116 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1193
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1194 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1267
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464933 1268 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPM 1331
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
631-1016 2.74e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  631 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 710
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  711 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 789
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  790 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 865
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  866 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 945
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933  946 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 1016
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1023-1330 2.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 2.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1023 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 1102
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1103 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 1182
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1183 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1259
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933 1260 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNP 1330
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-828 8.08e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 8.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 743
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  744 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 823
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 1370464933  824 ISEEE 828
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 1.06e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886    159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1370464933  109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886    239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR_9 pfam14580
Leucine-rich repeat;
941-1085 4.95e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 4.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  941 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 1020
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370464933 1021 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 1085
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR_8 pfam13855
Leucine rich repeat;
1250-1306 1.93e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370464933 1250 LQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGK--LQSLVKLEKLFLGYNKI 1306
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-177 2.57e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.57e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
716-772 3.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.66e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933  716 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 772
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 1.30e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 117.96  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464933  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 878-1066 2.85e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 94.08  E-value: 2.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  878 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 948
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  949 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 1019
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1370464933 1020 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1066
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1116-1331 1.38e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 85.99  E-value: 1.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1116 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1193
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1194 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1267
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464933 1268 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPM 1331
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
631-1016 2.74e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  631 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 710
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  711 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 789
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  790 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 865
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  866 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 945
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933  946 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 1016
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1023-1330 2.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 2.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1023 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 1102
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1103 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 1182
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1183 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1259
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933 1260 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNP 1330
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-828 8.08e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 8.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 743
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  744 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 823
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 1370464933  824 ISEEE 828
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 1.06e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886    159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1370464933  109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886    239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
797-1283 5.28e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 5.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  797 NPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEERPRILSIWPSAKILTQVSKLG 876
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  877 PHLHLSGNCYLKiTALNLDGQHLFEITNLEKLENLKWASFSNNNLTKM-EGLESCINLEELTLDGNCISKI-EGISKMTK 954
Cdd:COG4886     82 LSLLLLGLTDLG-DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  955 LTRLSINNNLLTGWEEHtFDNMLHLHSLSLENNRITSLSG-LQKSFTLVELYISNNYIavNQEMHNLKGLCNLVILDMCG 1033
Cdd:COG4886    161 LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQL--TDLPEPLANLTNLETLDLSN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1034 NIIIwnqenyrlfvifHLPELkaldgipiepsetdsakdlfggrltsdmiaerqghSNFKQMQELNwtsssirtvdlipv 1113
Cdd:COG4886    238 NQLT------------DLPEL-----------------------------------GNLTNLEELD-------------- 256

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1114 dqfrnvcnvnLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImpRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRDIMS 1193
Cdd:COG4886    257 ----------LSNNQLTDLPPLANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1194 SENLPPIMHSLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFNDSAFAKPSS 1273
Cdd:COG4886    325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404

                          490
                   ....*....|
gi 1370464933 1274 LLALHLEENR 1283
Cdd:COG4886    405 LALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1112-1359 2.09e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 2.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1112 PVDQFRNVCNVNLQNNHLTSFSGLI-YLPNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRD 1190
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1191 IMSS---ENLPPI---MHSLEVLHLGYNGICNLiQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFN 1264
Cdd:COG4886    188 DLSNnqiTDLPEPlgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1265 DSafAKPSSLLALHLEENRLRE--LGKLQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPMLDGSPVNSDDR 1342
Cdd:COG4886    267 PL--ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                          250
                   ....*....|....*..
gi 1370464933 1343 AKAEFHLAELQAKKNSL 1359
Cdd:COG4886    345 SLLALLTLLLLLNLLSL 361
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
698-895 4.10e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 4.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  698 SLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSG 776
Cdd:COG4886    209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  777 NEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEER 856
Cdd:COG4886    289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1370464933  857 PRILSIWPSAKILTQVSKLGPHLHLSGNCYLKITALNLD 895
Cdd:COG4886    369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
694-1006 5.86e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 5.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  694 SHIVSLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWN 770
Cdd:COG4886    113 TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  771 QLKKSGNEINMLckhtTSLLTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSL 846
Cdd:COG4886    193 QITDLPEPLGNL----TNLEELDLSGN--------QLTdlpePLANLTNLETLD---------------LSNNQLTDLPE 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  847 LRHSSTKEErpriLSIwpSAKILTQVSKLGP-----HLHLSGNcylKITALNLDGQHLFEITNLEKLENLKWASFSNNNL 921
Cdd:COG4886    246 LGNLTNLEE----LDL--SNNQLTDLPPLANltnlkTLDLSNN---QLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  922 TKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTL 1001
Cdd:COG4886    317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396


                   ....*
gi 1370464933 1002 VELYI 1006
Cdd:COG4886    397 TAGVL 401
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-177 2.32e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 2.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   88 IEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLI- 154
Cdd:COG5238    254 IALAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIg 333

                           90       100
                   ....*....|....*....|....*..
gi 1370464933  155 ----NSIGRCLDSNEQLERLNLSGNQI 177
Cdd:COG5238    334 aqgaIALAKALQENTTLHSLDLSDNQI 360
LRR_9 pfam14580
Leucine-rich repeat;
941-1085 4.95e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 4.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  941 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 1020
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370464933 1021 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 1085
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-189 6.06e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 6.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNH 129
Cdd:COG4886     26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464933  130 NtikniEGLQTLKNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQI----CSFKELTNLTRL 189
Cdd:COG4886    106 N-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLtdlpEPLGNLTNLKSL 164
LRR_8 pfam13855
Leucine rich repeat;
1250-1306 1.93e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370464933 1250 LQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGK--LQSLVKLEKLFLGYNKI 1306
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-177 2.57e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.57e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
716-772 3.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.66e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933  716 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 772
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-138 1.92e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.00  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1370464933   99 NLEKLYLYFNKISKIENLEKLIKLKVLWLNHNT-IKNIEGL 138
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
932-989 8.72e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 8.72e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  932 NLEELTLDGNCISKIEGIS--KMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRI 989
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
953-1011 9.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 9.07e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370464933  953 TKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGlqKSFT----LVELYISNNYI 1011
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP--GAFSglpsLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
885-1313 1.30e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  885 CYLKITALNLDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNL 964
Cdd:COG4886      1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  965 LTGWE---EHTFDNMLHLHSLSLENNRitSLSGLQKsftLVELYISNNYI-AVNQEMHNLKglcNLVILDMCGNIIiwnq 1040
Cdd:COG4886     81 LLSLLllgLTDLGDLTNLTELDLSGNE--ELSNLTN---LESLDLSGNQLtDLPEELANLT---NLKELDLSNNQL---- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1041 eNYRLFVIFHLPELKALdgipiepsetdsakDLFGGRLTSdmIAErqghsNFKQMQELNWtsssirtvdlipvdqfrnvc 1120
Cdd:COG4886    149 -TDLPEPLGNLTNLKSL--------------DLSNNQLTD--LPE-----ELGNLTNLKE-------------------- 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1121 nVNLQNNHLTSFSGLIY-LPNVKVLCLNYNHIESIMPRLKPqthltsrqllyqkvpssgygqqgisktnrdimssenlpp 1199
Cdd:COG4886    187 -LDLSNNQITDLPEPLGnLTNLEELDLSGNQLTDLPEPLAN--------------------------------------- 226

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1200 iMHSLEVLHLGYNGICNLIQLQlnRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHL 1279
Cdd:COG4886    227 -LTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1370464933 1280 EENRLRELGKLQSLVKLEKLFLGYNKIQDITELE 1313
Cdd:COG4886    304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR_8 pfam13855
Leucine rich repeat;
694-750 2.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 2.07e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933  694 SHIVSLNLHGNSLSKLRD--LSKLTGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHV 750
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
98-154 2.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 2.07e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933   98 RNLEKLYLYFNKISKI--ENLEKLIKLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLI 154
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-152 2.89e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.89e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370464933  121 KLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGN 152
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-178 3.46e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   84 AECCIEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKNI------EGLQTLKNLKDLNLAG 151
Cdd:cd00116    151 GASCEALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGD 230

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370464933  152 NLINSIGRC------LDSNEQLERLNLSGNQIC 178
Cdd:cd00116    231 NNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
LRR_9 pfam14580
Leucine-rich repeat;
108-242 5.26e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 5.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  108 NKISKIENLEKLIKLKVLWLNHNTIKNI-EGL-QTLKNLKDLNLAGNLINSIGrcldsneQLERLnlsgnqiCSFKELTN 185
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELG-------DLDPL-------ASLKKLTF 117

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464933  186 LTRLpclkdlclndpqytTNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:pfam14580  118 LSLL--------------RNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR_8 pfam13855
Leucine rich repeat;
1203-1260 1.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.14e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1203 SLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRI 1260
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
901-1340 1.31e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  901 EITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLltgweehTFDNMLHLH 980
Cdd:COG4886     44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  981 SLSLENNRITSLSGLQKSFT-LVELYISNNYIAVNQEmhNLKGLCNLVILDMCGNiiiwnqenyrlfvifhlpelkALDG 1059
Cdd:COG4886    117 SLDLSGNQLTDLPEELANLTnLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN---------------------QLTD 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1060 IPIEpsetdsakdlfggrltsdmiaerqghsnFKQMQELNWtsssirtvdlipvdqfrnvcnVNLQNNHLTSFSGLIY-L 1138
Cdd:COG4886    174 LPEE----------------------------LGNLTNLKE---------------------LDLSNNQITDLPEPLGnL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1139 PNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVpssgygqqgisktnrdimssENLPPI--MHSLEVLHLGYNGICN 1216
Cdd:COG4886    205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL--------------------TDLPELgnLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933 1217 LiqLQLNRLRNLKFLFLQGNEISQVEgLDNLVVLQELVVDHNRIRSFNDSAFAkpSSLLALHLEENRLRELGKLQSLVKL 1296
Cdd:COG4886    265 L--PPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLNLLELL--ILLLLLTTLLLLLLLLKGLLVTLTT 339

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1370464933 1297 EKLFLGYNKIQDITELEKLDVISTLRELTVYGNPMLDGSPVNSD 1340
Cdd:COG4886    340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-242 2.63e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIeNLEKLIKLKVLWLNH 129
Cdd:COG4886    224 LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLL 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933  130 NTIKNIEGLQTLKNLKDLNLAgNLINSIGRCLDSNEQLERLNLSGNQICSFKELTNLTRLPCLKDLCLNDPQYTTNPVCL 209
Cdd:COG4886    303 LLLLLLNLLELLILLLLLTTL-LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1370464933  210 LCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:COG4886    382 LALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-118 4.25e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 4.25e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1370464933   77 QLKELWIAECCIEKIEGLQECRNLEKLYLYFN-KISKIENLEK 118
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 932-963 7.38e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 7.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370464933  932 NLEELTLDGNCISKIEGISKMTKLTRLSINNN 963
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
1226-1284 8.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 8.72e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464933 1226 RNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRL 1284
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-177 9.06e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 9.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464933   99 NLEKLYLYFNKISKiENLEKLIK-------LKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLIN-----SIGRC 160
Cdd:COG5238    181 SVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGdegviALAEA 259

                           90
                   ....*....|....*..
gi 1370464933  161 LDSNEQLERLNLSGNQI 177
Cdd:COG5238    260 LKNNTTVETLYLSGNQI 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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